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Protein

Zinc finger protein 76

Gene

Znf76

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri165 – 189C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri195 – 219C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri225 – 249C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri255 – 279C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri285 – 309C2H2-type 5PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri315 – 339C2H2-type 6PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri345 – 368C2H2-type 7PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 76
Alternative name(s):
Zinc finger protein 523
Gene namesi
Name:Znf76
Synonyms:Zfp523
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:2687278. Zfp523.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003530961 – 568Zinc finger protein 76Add BLAST568

Proteomic databases

PaxDbiQ8BMU0.
PeptideAtlasiQ8BMU0.
PRIDEiQ8BMU0.

PTM databases

iPTMnetiQ8BMU0.
PhosphoSitePlusiQ8BMU0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000024220.
ExpressionAtlasiQ8BMU0. baseline and differential.
GenevisibleiQ8BMU0. MM.

Interactioni

Protein-protein interaction databases

BioGridi230298. 1 interactor.
STRINGi10090.ENSMUSP00000002318.

Structurei

3D structure databases

ProteinModelPortaliQ8BMU0.
SMRiQ8BMU0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati34 – 451Add BLAST12
Repeati62 – 732Add BLAST12
Repeati88 – 993Add BLAST12

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni34 – 993 X 12 AA approximate repeatsAdd BLAST66

Sequence similaritiesi

Contains 7 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri165 – 189C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri195 – 219C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri225 – 249C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri255 – 279C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri285 – 309C2H2-type 5PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri315 – 339C2H2-type 6PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri345 – 368C2H2-type 7PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118771.
HOGENOMiHOG000118073.
HOVERGENiHBG053078.
InParanoidiQ8BMU0.
KOiK20828.
OMAiKRPRIAY.
OrthoDBiEOG091G0N38.
PhylomeDBiQ8BMU0.
TreeFamiTF333498.

Family and domain databases

Gene3Di3.30.160.60. 7 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 7 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BMU0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESLGLQTVR LSDGTTAYVQ QAVKGEKLLE GQVIQLEDGT TAYIHQVTIQ
60 70 80 90 100
KESFSFEDGQ PVQLEDGSMA YIHHTPKEGC DPSALEAVQL EDGSTAYIHH
110 120 130 140 150
PVPVPSDSAI LAVQTEAGLE DLAAEDEEGF GTDTVVALEQ YASKVLHDSP
160 170 180 190 200
ASHNGKGQQV GDRAFRCGYK GCGRLYTTAH HLKVHERAHT GDRPYRCDFP
210 220 230 240 250
SCGKAFATGY GLKSHVRTHT GEKPYKCPEE LCSKAFKTSG DLQKHVRTHT
260 270 280 290 300
GERPFRCPFE GCGRSFTTSN IRKVHVRTHT GERPYTCPEP HCGRGFTSAT
310 320 330 340 350
NYKNHVRIHT GEKPYVCTVP GCGKRFTEYS SLYKHHVVHT HCKPYTCSSC
360 370 380 390 400
GKTYRQTSTL AMHKRSAHGE LEATEESEQA LYEQQQLEAA SAAEESPPPK
410 420 430 440 450
PTHIAYLSEV KEESSAIPTQ VAMVTEEDGP PQVALITQDG TQQVSLSPED
460 470 480 490 500
LQALGSAISV VTQHGSTTLT IPGHHEELAT SGTHTVTMVS ADGTQTQPVT
510 520 530 540 550
IITSGALVTE DSSVASLHHQ QVALLATANG THIAVQLEDQ QTLEEAISVA
560
TAAMQQGAVT LETTESGC
Length:568
Mass (Da):61,454
Last modified:March 1, 2003 - v1
Checksum:i1A3A1684C766CA7F
GO
Isoform 2 (identifier: Q8BMU0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     312-316: EKPYV → GPAGV
     317-568: Missing.

Show »
Length:316
Mass (Da):34,563
Checksum:iEC8D8BFAC2E183C9
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_035628312 – 316EKPYV → GPAGV in isoform 2. 1 Publication5
Alternative sequenceiVSP_035629317 – 568Missing in isoform 2. 1 PublicationAdd BLAST252

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028222 mRNA. Translation: BAC25822.1.
CT009658 Genomic DNA. Translation: CAQ51698.1.
BC058346 mRNA. Translation: AAH58346.1.
BC060611 mRNA. Translation: AAH60611.1.
CCDSiCCDS28573.1. [Q8BMU0-1]
RefSeqiNP_766205.1. NM_172617.3. [Q8BMU0-1]
XP_006524155.1. XM_006524092.3. [Q8BMU0-1]
XP_017172898.1. XM_017317409.1. [Q8BMU0-1]
UniGeneiMm.267359.

Genome annotation databases

EnsembliENSMUST00000002318; ENSMUSP00000002318; ENSMUSG00000024220. [Q8BMU0-1]
ENSMUST00000073534; ENSMUSP00000073226; ENSMUSG00000024220. [Q8BMU0-1]
GeneIDi224656.
KEGGimmu:224656.
UCSCiuc008bqg.2. mouse. [Q8BMU0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028222 mRNA. Translation: BAC25822.1.
CT009658 Genomic DNA. Translation: CAQ51698.1.
BC058346 mRNA. Translation: AAH58346.1.
BC060611 mRNA. Translation: AAH60611.1.
CCDSiCCDS28573.1. [Q8BMU0-1]
RefSeqiNP_766205.1. NM_172617.3. [Q8BMU0-1]
XP_006524155.1. XM_006524092.3. [Q8BMU0-1]
XP_017172898.1. XM_017317409.1. [Q8BMU0-1]
UniGeneiMm.267359.

3D structure databases

ProteinModelPortaliQ8BMU0.
SMRiQ8BMU0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230298. 1 interactor.
STRINGi10090.ENSMUSP00000002318.

PTM databases

iPTMnetiQ8BMU0.
PhosphoSitePlusiQ8BMU0.

Proteomic databases

PaxDbiQ8BMU0.
PeptideAtlasiQ8BMU0.
PRIDEiQ8BMU0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000002318; ENSMUSP00000002318; ENSMUSG00000024220. [Q8BMU0-1]
ENSMUST00000073534; ENSMUSP00000073226; ENSMUSG00000024220. [Q8BMU0-1]
GeneIDi224656.
KEGGimmu:224656.
UCSCiuc008bqg.2. mouse. [Q8BMU0-1]

Organism-specific databases

CTDi224656.
MGIiMGI:2687278. Zfp523.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118771.
HOGENOMiHOG000118073.
HOVERGENiHBG053078.
InParanoidiQ8BMU0.
KOiK20828.
OMAiKRPRIAY.
OrthoDBiEOG091G0N38.
PhylomeDBiQ8BMU0.
TreeFamiTF333498.

Miscellaneous databases

PROiQ8BMU0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024220.
ExpressionAtlasiQ8BMU0. baseline and differential.
GenevisibleiQ8BMU0. MM.

Family and domain databases

Gene3Di3.30.160.60. 7 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 7 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZNF76_MOUSE
AccessioniPrimary (citable) accession number: Q8BMU0
Secondary accession number(s): Q6P9T2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 4, 2008
Last sequence update: March 1, 2003
Last modified: November 30, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.