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Protein

Zinc finger protein 76

Gene

Znf76

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri165 – 189C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri195 – 219C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri225 – 249C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri255 – 279C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri285 – 309C2H2-type 5PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri315 – 339C2H2-type 6PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri345 – 368C2H2-type 7PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 76
Alternative name(s):
Zinc finger protein 523
Gene namesi
Name:Znf76
Synonyms:Zfp523
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:2687278. Zfp523.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003530961 – 568Zinc finger protein 76Add BLAST568

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki24Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ8BMU0.
PeptideAtlasiQ8BMU0.
PRIDEiQ8BMU0.

PTM databases

iPTMnetiQ8BMU0.
PhosphoSitePlusiQ8BMU0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000024220.
ExpressionAtlasiQ8BMU0. baseline and differential.
GenevisibleiQ8BMU0. MM.

Interactioni

Protein-protein interaction databases

BioGridi230298. 1 interactor.
STRINGi10090.ENSMUSP00000002318.

Structurei

3D structure databases

ProteinModelPortaliQ8BMU0.
SMRiQ8BMU0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati34 – 451Add BLAST12
Repeati62 – 732Add BLAST12
Repeati88 – 993Add BLAST12

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni34 – 993 X 12 AA approximate repeatsAdd BLAST66

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri165 – 189C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri195 – 219C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri225 – 249C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri255 – 279C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri285 – 309C2H2-type 5PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri315 – 339C2H2-type 6PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri345 – 368C2H2-type 7PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118771.
HOGENOMiHOG000118073.
HOVERGENiHBG053078.
InParanoidiQ8BMU0.
KOiK20828.
OMAiHTHCKPY.
OrthoDBiEOG091G0N38.
PhylomeDBiQ8BMU0.
TreeFamiTF333498.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR013087. Znf_C2H2_type.
IPR013083. Znf_RING/FYVE/PHD.
SMARTiView protein in SMART
SM00355. ZnF_C2H2. 7 hits.
SUPFAMiSSF57667. SSF57667. 4 hits.
PROSITEiView protein in PROSITE
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BMU0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESLGLQTVR LSDGTTAYVQ QAVKGEKLLE GQVIQLEDGT TAYIHQVTIQ
60 70 80 90 100
KESFSFEDGQ PVQLEDGSMA YIHHTPKEGC DPSALEAVQL EDGSTAYIHH
110 120 130 140 150
PVPVPSDSAI LAVQTEAGLE DLAAEDEEGF GTDTVVALEQ YASKVLHDSP
160 170 180 190 200
ASHNGKGQQV GDRAFRCGYK GCGRLYTTAH HLKVHERAHT GDRPYRCDFP
210 220 230 240 250
SCGKAFATGY GLKSHVRTHT GEKPYKCPEE LCSKAFKTSG DLQKHVRTHT
260 270 280 290 300
GERPFRCPFE GCGRSFTTSN IRKVHVRTHT GERPYTCPEP HCGRGFTSAT
310 320 330 340 350
NYKNHVRIHT GEKPYVCTVP GCGKRFTEYS SLYKHHVVHT HCKPYTCSSC
360 370 380 390 400
GKTYRQTSTL AMHKRSAHGE LEATEESEQA LYEQQQLEAA SAAEESPPPK
410 420 430 440 450
PTHIAYLSEV KEESSAIPTQ VAMVTEEDGP PQVALITQDG TQQVSLSPED
460 470 480 490 500
LQALGSAISV VTQHGSTTLT IPGHHEELAT SGTHTVTMVS ADGTQTQPVT
510 520 530 540 550
IITSGALVTE DSSVASLHHQ QVALLATANG THIAVQLEDQ QTLEEAISVA
560
TAAMQQGAVT LETTESGC
Length:568
Mass (Da):61,454
Last modified:March 1, 2003 - v1
Checksum:i1A3A1684C766CA7F
GO
Isoform 2 (identifier: Q8BMU0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     312-316: EKPYV → GPAGV
     317-568: Missing.

Show »
Length:316
Mass (Da):34,563
Checksum:iEC8D8BFAC2E183C9
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_035628312 – 316EKPYV → GPAGV in isoform 2. 1 Publication5
Alternative sequenceiVSP_035629317 – 568Missing in isoform 2. 1 PublicationAdd BLAST252

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028222 mRNA. Translation: BAC25822.1.
CT009658 Genomic DNA. Translation: CAQ51698.1.
BC058346 mRNA. Translation: AAH58346.1.
BC060611 mRNA. Translation: AAH60611.1.
CCDSiCCDS28573.1. [Q8BMU0-1]
RefSeqiNP_766205.1. NM_172617.3. [Q8BMU0-1]
XP_006524155.1. XM_006524092.3. [Q8BMU0-1]
XP_017172898.1. XM_017317409.1. [Q8BMU0-1]
UniGeneiMm.267359.

Genome annotation databases

EnsembliENSMUST00000002318; ENSMUSP00000002318; ENSMUSG00000024220. [Q8BMU0-1]
ENSMUST00000073534; ENSMUSP00000073226; ENSMUSG00000024220. [Q8BMU0-1]
GeneIDi224656.
KEGGimmu:224656.
UCSCiuc008bqg.2. mouse. [Q8BMU0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiZNF76_MOUSE
AccessioniPrimary (citable) accession number: Q8BMU0
Secondary accession number(s): Q6P9T2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 4, 2008
Last sequence update: March 1, 2003
Last modified: August 30, 2017
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families