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Protein

Ras association domain-containing protein 2

Gene

Rassf2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • bone remodeling Source: MGI
  • cell cycle Source: UniProtKB-KW
  • epidermal growth factor receptor signaling pathway via I-kappaB kinase/NF-kappaB cascade Source: MGI
  • homeostasis of number of cells Source: MGI
  • negative regulation of NIK/NF-kappaB signaling Source: MGI
  • negative regulation of peptidyl-serine phosphorylation Source: MGI
  • ossification Source: MGI
  • positive regulation of apoptotic process Source: MGI
  • positive regulation of JNK cascade Source: MGI
  • positive regulation of protein autophosphorylation Source: MGI
  • positive regulation of protein kinase activity Source: MGI
  • protein stabilization Source: MGI
  • regulation of NIK/NF-kappaB signaling Source: MGI
  • regulation of osteoblast differentiation Source: MGI
  • regulation of osteoclast differentiation Source: MGI
  • skeletal system development Source: MGI

Keywordsi

Biological processCell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Ras association domain-containing protein 2
Gene namesi
Name:Rassf2
Synonyms:Kiaa0168
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2442060 Rassf2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Kinetochore, Nucleus

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002330381 – 326Ras association domain-containing protein 2Add BLAST326

Post-translational modificationi

Phosphorylated by STK3/MST2 and STK4/MST1.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8BMS9
MaxQBiQ8BMS9
PaxDbiQ8BMS9
PeptideAtlasiQ8BMS9
PRIDEiQ8BMS9

PTM databases

iPTMnetiQ8BMS9
PhosphoSitePlusiQ8BMS9

Expressioni

Gene expression databases

BgeeiENSMUSG00000027339
ExpressionAtlasiQ8BMS9 baseline and differential
GenevisibleiQ8BMS9 MM

Interactioni

Subunit structurei

Interacts directly with activated KRAS in a GTP-dependent manner. Interacts (via SARAH domain) with STK3/MST2 AND STK4/MST1.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028814

Structurei

3D structure databases

ProteinModelPortaliQ8BMS9
SMRiQ8BMS9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini176 – 264Ras-associatingPROSITE-ProRule annotationAdd BLAST89
Domaini272 – 319SARAHPROSITE-ProRule annotationAdd BLAST48

Phylogenomic databases

eggNOGiKOG4239 Eukaryota
ENOG410Y2N1 LUCA
GeneTreeiENSGT00510000046426
HOGENOMiHOG000231738
HOVERGENiHBG054302
InParanoidiQ8BMS9
KOiK09851
OMAiTVLRLMI
OrthoDBiEOG091G0BOA
PhylomeDBiQ8BMS9
TreeFamiTF319243

Family and domain databases

InterProiView protein in InterPro
IPR033614 C-RASSF
IPR000159 RA_dom
IPR033618 RASSF2
IPR011524 SARAH_dom
IPR029071 Ubiquitin-like_domsf
PANTHERiPTHR22738 PTHR22738, 1 hit
PTHR22738:SF14 PTHR22738:SF14, 1 hit
PfamiView protein in Pfam
PF16517 Nore1-SARAH, 1 hit
PF00788 RA, 1 hit
SMARTiView protein in SMART
SM00314 RA, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50200 RA, 1 hit
PS50951 SARAH, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BMS9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDYTHQPALI PCGQDKYMPK SELLLHLKTY NLYYEGQNLQ LRHREEEDEF
60 70 80 90 100
IVEGLLNISW GLRRPIRLQM QDDHERIRPP PSSSSWHSGC NLGAQGTTLK
110 120 130 140 150
PLTMPTVQIS EVDMPVEGLE THSPTDSRGL KPVQEDTPQL MRTRSDVGVR
160 170 180 190 200
RRGNVRTSSD QRRIRRHRFS INGHFYNHKT SVFTPAYGSV TNVRINSTMT
210 220 230 240 250
TPQVLKLLLN KFKIENSAEE FALYVVHTSG EKQRLKSSDY PLIARILQGP
260 270 280 290 300
CEQISKVFLM EKDQVEEVTY DVAQYIKFEM PVLKSFIQKL QEEEDREVEK
310 320
LMRKYTVLRL MIRQRLEEIA ETPETI
Length:326
Mass (Da):37,973
Last modified:March 1, 2003 - v1
Checksum:i5CEFDFC1BEA0F473
GO

Sequence cautioni

The sequence BAD32184 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK172906 mRNA Translation: BAD32184.1 Different initiation.
AK028384 mRNA Translation: BAC25921.1
BC057402 mRNA Translation: AAH57402.1
CCDSiCCDS16768.1
RefSeqiNP_780654.1, NM_175445.4
XP_006499202.1, XM_006499139.3
XP_006499203.1, XM_006499140.3
XP_006499204.1, XM_006499141.2
XP_006499205.1, XM_006499142.2
XP_006499206.1, XM_006499143.3
XP_006499207.1, XM_006499144.3
UniGeneiMm.204737

Genome annotation databases

EnsembliENSMUST00000028814; ENSMUSP00000028814; ENSMUSG00000027339
ENSMUST00000103182; ENSMUSP00000099471; ENSMUSG00000027339
GeneIDi215653
KEGGimmu:215653
UCSCiuc008mmf.2 mouse

Similar proteinsi

Entry informationi

Entry nameiRASF2_MOUSE
AccessioniPrimary (citable) accession number: Q8BMS9
Secondary accession number(s): Q6A0B2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health