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Protein

Ras association domain-containing protein 2

Gene

Rassf2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • bone remodeling Source: MGI
  • cell cycle Source: UniProtKB-KW
  • epidermal growth factor receptor signaling pathway via I-kappaB kinase/NF-kappaB cascade Source: MGI
  • homeostasis of number of cells Source: MGI
  • negative regulation of NIK/NF-kappaB signaling Source: MGI
  • negative regulation of peptidyl-serine phosphorylation Source: MGI
  • ossification Source: MGI
  • positive regulation of apoptotic process Source: MGI
  • positive regulation of JNK cascade Source: MGI
  • positive regulation of protein autophosphorylation Source: MGI
  • positive regulation of protein kinase activity Source: MGI
  • protein phosphorylation Source: MGI
  • protein stabilization Source: MGI
  • regulation of NIK/NF-kappaB signaling Source: MGI
  • regulation of osteoblast differentiation Source: MGI
  • regulation of osteoclast differentiation Source: MGI
  • skeletal system development Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Ras association domain-containing protein 2
Gene namesi
Name:Rassf2
Synonyms:Kiaa0168
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2442060. Rassf2.

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasm By similarity

  • Note: Translocates to the cytoplasm in the presence of STK3/MST2 AND STK4/MST1.By similarity

GO - Cellular componenti

  • cytoplasm Source: MGI
  • nucleus Source: MGI
  • protein complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 326326Ras association domain-containing protein 2PRO_0000233038Add
BLAST

Post-translational modificationi

Phosphorylated by STK3/MST2 and STK4/MST1.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8BMS9.
MaxQBiQ8BMS9.
PaxDbiQ8BMS9.
PRIDEiQ8BMS9.

PTM databases

iPTMnetiQ8BMS9.
PhosphoSiteiQ8BMS9.

Expressioni

Gene expression databases

BgeeiQ8BMS9.
ExpressionAtlasiQ8BMS9. baseline and differential.
GenevisibleiQ8BMS9. MM.

Interactioni

Subunit structurei

Interacts directly with activated KRAS in a GTP-dependent manner. Interacts (via SARAH domain) with STK3/MST2 AND STK4/MST1.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028814.

Structurei

3D structure databases

ProteinModelPortaliQ8BMS9.
SMRiQ8BMS9. Positions 189-261.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini176 – 26489Ras-associatingPROSITE-ProRule annotationAdd
BLAST
Domaini272 – 31948SARAHPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Ras-associating domain.PROSITE-ProRule annotation
Contains 1 SARAH domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4239. Eukaryota.
ENOG410Y2N1. LUCA.
GeneTreeiENSGT00510000046426.
HOGENOMiHOG000231738.
HOVERGENiHBG054302.
InParanoidiQ8BMS9.
KOiK09851.
OMAiNTDYPLV.
OrthoDBiEOG7DVDBF.
PhylomeDBiQ8BMS9.
TreeFamiTF319243.

Family and domain databases

InterProiIPR000159. RA_dom.
IPR011524. SARAH_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF16517. Nore1-SARAH. 1 hit.
PF00788. RA. 1 hit.
[Graphical view]
SMARTiSM00314. RA. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50200. RA. 1 hit.
PS50951. SARAH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BMS9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDYTHQPALI PCGQDKYMPK SELLLHLKTY NLYYEGQNLQ LRHREEEDEF
60 70 80 90 100
IVEGLLNISW GLRRPIRLQM QDDHERIRPP PSSSSWHSGC NLGAQGTTLK
110 120 130 140 150
PLTMPTVQIS EVDMPVEGLE THSPTDSRGL KPVQEDTPQL MRTRSDVGVR
160 170 180 190 200
RRGNVRTSSD QRRIRRHRFS INGHFYNHKT SVFTPAYGSV TNVRINSTMT
210 220 230 240 250
TPQVLKLLLN KFKIENSAEE FALYVVHTSG EKQRLKSSDY PLIARILQGP
260 270 280 290 300
CEQISKVFLM EKDQVEEVTY DVAQYIKFEM PVLKSFIQKL QEEEDREVEK
310 320
LMRKYTVLRL MIRQRLEEIA ETPETI
Length:326
Mass (Da):37,973
Last modified:March 1, 2003 - v1
Checksum:i5CEFDFC1BEA0F473
GO

Sequence cautioni

The sequence BAD32184.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK172906 mRNA. Translation: BAD32184.1. Different initiation.
AK028384 mRNA. Translation: BAC25921.1.
BC057402 mRNA. Translation: AAH57402.1.
CCDSiCCDS16768.1.
RefSeqiNP_780654.1. NM_175445.4.
XP_006499202.1. XM_006499139.2.
XP_006499203.1. XM_006499140.2.
XP_006499204.1. XM_006499141.2.
XP_006499205.1. XM_006499142.2.
XP_006499206.1. XM_006499143.2.
XP_006499207.1. XM_006499144.2.
UniGeneiMm.204737.

Genome annotation databases

EnsembliENSMUST00000028814; ENSMUSP00000028814; ENSMUSG00000027339.
ENSMUST00000103182; ENSMUSP00000099471; ENSMUSG00000027339.
GeneIDi215653.
KEGGimmu:215653.
UCSCiuc008mmf.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK172906 mRNA. Translation: BAD32184.1. Different initiation.
AK028384 mRNA. Translation: BAC25921.1.
BC057402 mRNA. Translation: AAH57402.1.
CCDSiCCDS16768.1.
RefSeqiNP_780654.1. NM_175445.4.
XP_006499202.1. XM_006499139.2.
XP_006499203.1. XM_006499140.2.
XP_006499204.1. XM_006499141.2.
XP_006499205.1. XM_006499142.2.
XP_006499206.1. XM_006499143.2.
XP_006499207.1. XM_006499144.2.
UniGeneiMm.204737.

3D structure databases

ProteinModelPortaliQ8BMS9.
SMRiQ8BMS9. Positions 189-261.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028814.

PTM databases

iPTMnetiQ8BMS9.
PhosphoSiteiQ8BMS9.

Proteomic databases

EPDiQ8BMS9.
MaxQBiQ8BMS9.
PaxDbiQ8BMS9.
PRIDEiQ8BMS9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028814; ENSMUSP00000028814; ENSMUSG00000027339.
ENSMUST00000103182; ENSMUSP00000099471; ENSMUSG00000027339.
GeneIDi215653.
KEGGimmu:215653.
UCSCiuc008mmf.2. mouse.

Organism-specific databases

CTDi9770.
MGIiMGI:2442060. Rassf2.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG4239. Eukaryota.
ENOG410Y2N1. LUCA.
GeneTreeiENSGT00510000046426.
HOGENOMiHOG000231738.
HOVERGENiHBG054302.
InParanoidiQ8BMS9.
KOiK09851.
OMAiNTDYPLV.
OrthoDBiEOG7DVDBF.
PhylomeDBiQ8BMS9.
TreeFamiTF319243.

Miscellaneous databases

ChiTaRSiRassf2. mouse.
PROiQ8BMS9.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BMS9.
ExpressionAtlasiQ8BMS9. baseline and differential.
GenevisibleiQ8BMS9. MM.

Family and domain databases

InterProiIPR000159. RA_dom.
IPR011524. SARAH_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF16517. Nore1-SARAH. 1 hit.
PF00788. RA. 1 hit.
[Graphical view]
SMARTiSM00314. RA. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50200. RA. 1 hit.
PS50951. SARAH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
    DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Placenta.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Lung, Spleen and Testis.

Entry informationi

Entry nameiRASF2_MOUSE
AccessioniPrimary (citable) accession number: Q8BMS9
Secondary accession number(s): Q6A0B2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: March 1, 2003
Last modified: June 8, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.