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Protein

Calcium-transporting ATPase

Gene

Atp2c1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.UniRule annotation

Catalytic activityi

ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation

Keywords - Biological processi

Calcium transportUniRule annotation, Ion transport, Transport

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Calcium, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-transporting ATPaseUniRule annotation (EC:3.6.3.8UniRule annotation)
Gene namesi
Name:Atp2c1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1889008. Atp2c1.

Subcellular locationi

  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei63 – 8119HelicalUniRule annotationAdd
BLAST
Transmembranei87 – 10317HelicalUniRule annotationAdd
BLAST
Transmembranei252 – 27120HelicalUniRule annotationAdd
BLAST
Transmembranei277 – 30630HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000082220.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 8375Cation_ATPase_NInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0202. Eukaryota.
COG0474. LUCA.
GeneTreeiENSGT00840000129745.
HOVERGENiHBG106478.

Family and domain databases

Gene3Di1.20.1110.10. 3 hits.
InterProiIPR030336. ATP2C1.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006413. P-type_ATPase_IIA_PMR1.
IPR001757. P_typ_ATPase.
[Graphical view]
PANTHERiPTHR24093:SF214. PTHR24093:SF214. 1 hit.
PfamiPF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
PRINTSiPR00120. HATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01522. ATPase-IIA2_Ca. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BMS7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIPVLTSKRA SELAVSEVAG LLQADLQNGL NKSEVSHRRA FHGWNEFDIS
60 70 80 90 100
EDEPLWKKYI SQFKNPLIML LLASAVISIL MRQFDDAVSI TVAIVIVVTV
110 120 130 140 150
AFVQEYRSEK SLEELSKLVP PECHCVREGK LEHTLARDLV PGDTVCLSVG
160 170 180 190 200
DRVPADLRLF EAVDLSVDES SLTGETAPCS KVTAPQPAAN GDLASRSNIA
210 220 230 240 250
FMGTLVRCGK AKGIVIGTGE NSEFGEVFKM MQAEEAPKTP LQKSMDLLGK
260 270 280 290 300
QLSFYSFGII GIIMLVGWLL GKDILEMFTI SVSLAVAAIP EGLPIVVTVT
310 320 330 340 350
LALGVMRMVK KRAIVKKLPI VETLGCCNVI CSDKTGTLTK NEMTVTHILT
360 370 380 390 400
SDGLHAEVTG VGYNQFGEVI VDGDVVHGFY NPAVSRIVEA GCVCNDAVIR
410 420 430 440 450
NNTLMGKPTE GALIALAMKM GLDGLQQDYI RKAEYPFSSE QKWMAVKCVH
460 470 480 490 500
RTQQDRPEIC FMKGAYEQVI KYCTTYNSKG QTLALTQQQR DLYQQEKARM
510 520 530 540 550
GSAGLRVLAL ASGPELGQLT FLGLVGIIDP PRTGVKEAVT TLIASGVSIK
560 570 580 590 600
MITGDSQETA IAIASRLGLY SKTSQSVSGE EVDTMEVQHL SQIVPKVAVF
610 620 630 640 650
YRASPRHKMK IIKSLQKNGA VVAMTGDGVN DAVALKAADI GVAMGQTGTD
660
VCKEAADMIL VDDDFQTIM
Length:669
Mass (Da):72,330
Last modified:March 1, 2003 - v1
Checksum:iA82803462644DF50
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC113016 Genomic DNA. No translation available.
AC117679 Genomic DNA. No translation available.
AK028393 mRNA. Translation: BAC25929.1.
RefSeqiNP_001240765.1. NM_001253836.1.
UniGeneiMm.326247.
Mm.489853.

Genome annotation databases

EnsembliENSMUST00000163879; ENSMUSP00000129617; ENSMUSG00000032570.
GeneIDi235574.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC113016 Genomic DNA. No translation available.
AC117679 Genomic DNA. No translation available.
AK028393 mRNA. Translation: BAC25929.1.
RefSeqiNP_001240765.1. NM_001253836.1.
UniGeneiMm.326247.
Mm.489853.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000082220.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000163879; ENSMUSP00000129617; ENSMUSG00000032570.
GeneIDi235574.

Organism-specific databases

CTDi27032.
MGIiMGI:1889008. Atp2c1.

Phylogenomic databases

eggNOGiKOG0202. Eukaryota.
COG0474. LUCA.
GeneTreeiENSGT00840000129745.
HOVERGENiHBG106478.

Miscellaneous databases

ChiTaRSiAtp2c1. mouse.
NextBioi382755.
SOURCEiSearch...

Family and domain databases

Gene3Di1.20.1110.10. 3 hits.
InterProiIPR030336. ATP2C1.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006413. P-type_ATPase_IIA_PMR1.
IPR001757. P_typ_ATPase.
[Graphical view]
PANTHERiPTHR24093:SF214. PTHR24093:SF214. 1 hit.
PfamiPF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
PRINTSiPR00120. HATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01522. ATPase-IIA2_Ca. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Placenta and extra embryonic tissueImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Placenta and extra embryonic tissueImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Placenta and extra embryonic tissueImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Placenta and extra embryonic tissueImported.
  5. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Placenta and extra embryonic tissueImported.
  6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Placenta and extra embryonic tissueImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Placenta and extra embryonic tissueImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Placenta and extra embryonic tissueImported.
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ8BMS7_MOUSE
AccessioniPrimary (citable) accession number: Q8BMS7
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: May 11, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.