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Protein

Calcium-transporting ATPase

Gene

Atp2c1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotation
Biological processCalcium transportUniRule annotation, Ion transport, Transport
LigandATP-bindingUniRule annotationSAAS annotation, Calcium, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-transporting ATPaseUniRule annotation (EC:3.6.3.8UniRule annotation)
Gene namesi
Name:Atp2c1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1889008 Atp2c1

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei63 – 81HelicalUniRule annotationAdd BLAST19
Transmembranei87 – 103HelicalUniRule annotationAdd BLAST17
Transmembranei252 – 271HelicalUniRule annotationAdd BLAST20
Transmembranei277 – 306HelicalUniRule annotationAdd BLAST30

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

MaxQBiQ8BMS7
PeptideAtlasiQ8BMS7

Expressioni

Gene expression databases

BgeeiENSMUSG00000032570

Structurei

3D structure databases

SMRiQ8BMS7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 83Cation_ATPase_NInterPro annotationAdd BLAST75

Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0202 Eukaryota
COG0474 LUCA
GeneTreeiENSGT00890000139334
HOVERGENiHBG106478

Family and domain databases

Gene3Di3.40.1110.101 hit
3.40.50.10001 hit
InterProiView protein in InterPro
IPR030336 ATP2C1
IPR004014 ATPase_P-typ_cation-transptr_N
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006413 P-type_ATPase_IIA_PMR1
IPR001757 P_typ_ATPase
PANTHERiPTHR42861:SF2 PTHR42861:SF2, 1 hit
PfamiView protein in Pfam
PF00690 Cation_ATPase_N, 1 hit
PRINTSiPR00120 HATPASE
SMARTiView protein in SMART
SM00831 Cation_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 2 hits
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 2 hits
TIGRFAMsiTIGR01522 ATPase-IIA2_Ca, 1 hit
TIGR01494 ATPase_P-type, 2 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BMS7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIPVLTSKRA SELAVSEVAG LLQADLQNGL NKSEVSHRRA FHGWNEFDIS
60 70 80 90 100
EDEPLWKKYI SQFKNPLIML LLASAVISIL MRQFDDAVSI TVAIVIVVTV
110 120 130 140 150
AFVQEYRSEK SLEELSKLVP PECHCVREGK LEHTLARDLV PGDTVCLSVG
160 170 180 190 200
DRVPADLRLF EAVDLSVDES SLTGETAPCS KVTAPQPAAN GDLASRSNIA
210 220 230 240 250
FMGTLVRCGK AKGIVIGTGE NSEFGEVFKM MQAEEAPKTP LQKSMDLLGK
260 270 280 290 300
QLSFYSFGII GIIMLVGWLL GKDILEMFTI SVSLAVAAIP EGLPIVVTVT
310 320 330 340 350
LALGVMRMVK KRAIVKKLPI VETLGCCNVI CSDKTGTLTK NEMTVTHILT
360 370 380 390 400
SDGLHAEVTG VGYNQFGEVI VDGDVVHGFY NPAVSRIVEA GCVCNDAVIR
410 420 430 440 450
NNTLMGKPTE GALIALAMKM GLDGLQQDYI RKAEYPFSSE QKWMAVKCVH
460 470 480 490 500
RTQQDRPEIC FMKGAYEQVI KYCTTYNSKG QTLALTQQQR DLYQQEKARM
510 520 530 540 550
GSAGLRVLAL ASGPELGQLT FLGLVGIIDP PRTGVKEAVT TLIASGVSIK
560 570 580 590 600
MITGDSQETA IAIASRLGLY SKTSQSVSGE EVDTMEVQHL SQIVPKVAVF
610 620 630 640 650
YRASPRHKMK IIKSLQKNGA VVAMTGDGVN DAVALKAADI GVAMGQTGTD
660
VCKEAADMIL VDDDFQTIM
Length:669
Mass (Da):72,330
Last modified:March 1, 2003 - v1
Checksum:iA82803462644DF50
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC113016 Genomic DNA No translation available.
AC117679 Genomic DNA No translation available.
AK028393 mRNA Translation: BAC25929.1
RefSeqiNP_001240765.1, NM_001253836.1
UniGeneiMm.326247
Mm.489853

Genome annotation databases

EnsembliENSMUST00000163879; ENSMUSP00000129617; ENSMUSG00000032570
GeneIDi235574

Similar proteinsi

Entry informationi

Entry nameiQ8BMS7_MOUSE
AccessioniPrimary (citable) accession number: Q8BMS7
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: April 25, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported