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Protein

Ubiquinone biosynthesis O-methyltransferase, mitochondrial

Gene

Coq3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + 3,4-dihydroxy-5-all-trans-polyprenylbenzoate = S-adenosyl-L-homocysteine + 3-methoxy-4-hydroxy-5-all-trans-polyprenylbenzoate.UniRule annotation
S-adenosyl-L-methionine + 3-demethylubiquinone-n = S-adenosyl-L-homocysteine + ubiquinone-n.UniRule annotation

Pathwayi: ubiquinone biosynthesis

This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei125 – 1251S-adenosyl-L-methionineUniRule annotation
Binding sitei155 – 1551S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation
Binding sitei176 – 1761S-adenosyl-L-methionineUniRule annotation
Binding sitei223 – 2231S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Ubiquinone biosynthesis

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

ReactomeiR-MMU-2142789. Ubiquinol biosynthesis.
UniPathwayiUPA00232.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquinone biosynthesis O-methyltransferase, mitochondrialUniRule annotation
Alternative name(s):
3-demethylubiquinol 3-O-methyltransferaseUniRule annotation (EC:2.1.1.64UniRule annotation)
Polyprenyldihydroxybenzoate methyltransferaseUniRule annotation (EC:2.1.1.114UniRule annotation)
Gene namesi
Name:Coq3UniRule annotation
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:101813. Coq3.

Subcellular locationi

  • Mitochondrion inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Matrix side UniRule annotation

GO - Cellular componenti

  • extrinsic component of mitochondrial inner membrane Source: UniProtKB-HAMAP
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 8686MitochondrionSequence analysisAdd
BLAST
Chaini87 – 370284Ubiquinone biosynthesis O-methyltransferase, mitochondrialPRO_0000035927Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei144 – 1441N6-acetyllysineCombined sources
Modified residuei150 – 1501N6-acetyllysineCombined sources
Modified residuei197 – 1971N6-acetyllysineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8BMS4.
MaxQBiQ8BMS4.
PaxDbiQ8BMS4.
PeptideAtlasiQ8BMS4.
PRIDEiQ8BMS4.

PTM databases

iPTMnetiQ8BMS4.
PhosphoSiteiQ8BMS4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028247.
CleanExiMM_COQ3.
GenevisibleiQ8BMS4. MM.

Interactioni

Subunit structurei

Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.UniRule annotation

Protein-protein interaction databases

IntActiQ8BMS4. 1 interaction.
MINTiMINT-4091555.
STRINGi10090.ENSMUSP00000029909.

Structurei

3D structure databases

ProteinModelPortaliQ8BMS4.
SMRiQ8BMS4. Positions 143-312.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.UniRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1270. Eukaryota.
COG2227. LUCA.
GeneTreeiENSGT00390000007284.
HOGENOMiHOG000278064.
HOVERGENiHBG051078.
InParanoidiQ8BMS4.
KOiK00591.
OMAiWRWINST.
OrthoDBiEOG091G0ICD.
PhylomeDBiQ8BMS4.
TreeFamiTF314553.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_00472. UbiG. 1 hit.
InterProiIPR029063. SAM-dependent_MTases.
IPR010233. UbiG_MeTrfase.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR01983. UbiG. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BMS4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWRGGRLGSR GVRLLETLGF GCPSAVAQPP RLTSRSAYSG TQLTRNLQIK
60 70 80 90 100
PWELGEHGTM CFRSYRMALS CLSRVKTYRT PWKRLYSTSQ TTVDSREVKN
110 120 130 140 150
FQALAHTWWD EYGKFAPLHS MNDLRVPFIR DNLLKTSASH HPGKPLSGMK
160 170 180 190 200
ILDVGCGGGL LTEPLGRLGA SVVGIDPVAE NIKIAQHHKS FDPVLDKRIQ
210 220 230 240 250
YKVCSLEEAV DESAECFDAV VASEVVEHVS HLEMFIQCCY QVLKPGGSLF
260 270 280 290 300
ITTVNKTQLS YALGIVFAEQ IAGIVPKGTH TWEKFVSPEK LESILEPNGL
310 320 330 340 350
SVETVAGLVY NPFSGYWHWS ENTSLNYAAH AVRSRAQEHQ EPAESALKGE
360 370
TGALHANTSG SPSVREEQRT
Length:370
Mass (Da):40,957
Last modified:March 1, 2003 - v1
Checksum:i5023BC29E2DB3E45
GO

Sequence cautioni

The sequence BAC29030 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti298 – 2981N → Y in AAH60960 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028680 mRNA. Translation: BAC26063.1.
AK035318 mRNA. Translation: BAC29030.1. Different initiation.
AK170488 mRNA. Translation: BAE41830.1.
BC060960 mRNA. Translation: AAH60960.1.
CCDSiCCDS18003.1.
RefSeqiNP_766275.1. NM_172687.1.
XP_006537871.1. XM_006537808.2.
UniGeneiMm.5662.

Genome annotation databases

EnsembliENSMUST00000029909; ENSMUSP00000029909; ENSMUSG00000028247.
GeneIDi230027.
KEGGimmu:230027.
UCSCiuc008sdj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028680 mRNA. Translation: BAC26063.1.
AK035318 mRNA. Translation: BAC29030.1. Different initiation.
AK170488 mRNA. Translation: BAE41830.1.
BC060960 mRNA. Translation: AAH60960.1.
CCDSiCCDS18003.1.
RefSeqiNP_766275.1. NM_172687.1.
XP_006537871.1. XM_006537808.2.
UniGeneiMm.5662.

3D structure databases

ProteinModelPortaliQ8BMS4.
SMRiQ8BMS4. Positions 143-312.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8BMS4. 1 interaction.
MINTiMINT-4091555.
STRINGi10090.ENSMUSP00000029909.

PTM databases

iPTMnetiQ8BMS4.
PhosphoSiteiQ8BMS4.

Proteomic databases

EPDiQ8BMS4.
MaxQBiQ8BMS4.
PaxDbiQ8BMS4.
PeptideAtlasiQ8BMS4.
PRIDEiQ8BMS4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029909; ENSMUSP00000029909; ENSMUSG00000028247.
GeneIDi230027.
KEGGimmu:230027.
UCSCiuc008sdj.1. mouse.

Organism-specific databases

CTDi51805.
MGIiMGI:101813. Coq3.

Phylogenomic databases

eggNOGiKOG1270. Eukaryota.
COG2227. LUCA.
GeneTreeiENSGT00390000007284.
HOGENOMiHOG000278064.
HOVERGENiHBG051078.
InParanoidiQ8BMS4.
KOiK00591.
OMAiWRWINST.
OrthoDBiEOG091G0ICD.
PhylomeDBiQ8BMS4.
TreeFamiTF314553.

Enzyme and pathway databases

UniPathwayiUPA00232.
ReactomeiR-MMU-2142789. Ubiquinol biosynthesis.

Miscellaneous databases

PROiQ8BMS4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028247.
CleanExiMM_COQ3.
GenevisibleiQ8BMS4. MM.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_00472. UbiG. 1 hit.
InterProiIPR029063. SAM-dependent_MTases.
IPR010233. UbiG_MeTrfase.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR01983. UbiG. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCOQ3_MOUSE
AccessioniPrimary (citable) accession number: Q8BMS4
Secondary accession number(s): Q3TCX5, Q6P918, Q8BM28
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.