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Protein

General transcription factor 3C polypeptide 4

Gene

Gtf3c4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA, tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin. Has histone acetyltransferase activity (HAT) with unique specificity for free and nucleosomal H3. May cooperate with GTF3C5 in facilitating the recruitment of TFIIIB and RNA polymerase through direct interactions with BRF1, POLR3C and POLR3F. May be localized close to the A box (By similarity).By similarity

Catalytic activityi

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. histone acetyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Transcription

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_250309. RNA Polymerase III Transcription Initiation From Type 1 Promoter.
REACT_251592. RNA Polymerase III Transcription Initiation From Type 2 Promoter.
REACT_261233. RNA Polymerase III Abortive And Retractive Initiation.

Names & Taxonomyi

Protein namesi
Recommended name:
General transcription factor 3C polypeptide 4 (EC:2.3.1.48)
Alternative name(s):
TF3C-delta
Transcription factor IIIC 90 kDa subunit
Short name:
TFIIIC 90 kDa subunit
Short name:
TFIIIC90
Transcription factor IIIC subunit delta
Gene namesi
Name:Gtf3c4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:2138937. Gtf3c4.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. transcription factor TFIIIC complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 817817General transcription factor 3C polypeptide 4PRO_0000209714Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei607 – 6071PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ8BMQ2.
PaxDbiQ8BMQ2.
PRIDEiQ8BMQ2.

PTM databases

PhosphoSiteiQ8BMQ2.

Expressioni

Gene expression databases

BgeeiQ8BMQ2.
CleanExiMM_GTF3C4.
ExpressionAtlasiQ8BMQ2. baseline and differential.
GenevestigatoriQ8BMQ2.

Interactioni

Subunit structurei

Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and GTF3C6. Interacts with BRF1, GTF3C1, GTF3C2, GTF3C5, GTF3C6, POLR3C and POLR3F (By similarity).By similarity

Protein-protein interaction databases

IntActiQ8BMQ2. 1 interaction.
MINTiMINT-4137550.
STRINGi10090.ENSMUSP00000042265.

Structurei

3D structure databases

ProteinModelPortaliQ8BMQ2.
SMRiQ8BMQ2. Positions 271-341.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TFIIIC subunit 4 family.Curated

Phylogenomic databases

eggNOGiNOG79304.
GeneTreeiENSGT00390000011873.
HOGENOMiHOG000121774.
HOVERGENiHBG059337.
InParanoidiQ8BMQ2.
KOiK11310.
OMAiWQFQLPF.
OrthoDBiEOG7WQ7RS.
TreeFamiTF328412.

Family and domain databases

InterProiIPR024761. TFIIIC_delta_N.
IPR024764. TFIIIC_Znf.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF12657. TFIIIC_delta. 1 hit.
PF12660. zf-TFIIIC. 1 hit.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BMQ2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSEADQALVG PKADEPSPPA EEKDEGGGKE AAADAAPGPS ASFRLMVTRR
60 70 80 90 100
EPAVKLQYAV SGLEPLSWSE DHRVSVSTAR SVAVLELICD VHNPGQDLVI
110 120 130 140 150
HRTSVPAPLN SCLLKVGSKT EVAECKEKFA SSKDPTISQT FMLDRMFNPE
160 170 180 190 200
GKALPPMRGF KYTSWSPMGC DANGRCLLAA LTMDNRLTVQ VNLNRLQWVQ
210 220 230 240 250
LVDLTEIYGD RLYETSYRLS KNEAPEGNLG DFAEFQRRHS MQTPVRMEWS
260 270 280 290 300
SICTTQQVKH NNECRDVSSV LLAVLFENGN IAVWQFQLPF VGKESISSCN
310 320 330 340 350
TIESGISSPS VLFWWEYEHN NRKMSGLIVG SAFGPVKILP VNLKAVKGYF
360 370 380 390 400
TLRQPVVLWK EMDKLPVHSI KCVPLYHPYQ KCSCSLVVAA RGSYVFWCLL
410 420 430 440 450
LISKAGLNVH NSHVTGLHSL PIVSITADKQ NGTVYTCSSD GKVRQLIPIF
460 470 480 490 500
TDVALKFEHQ LIKLSDVFGS VRTHGIAVSP CGAYLAIITT EGMMNGLHPV
510 520 530 540 550
NKNYQVQFVT LKTFEEAAAQ LLESSVQNLF KQVDLIDLVR WKILKDKHIP
560 570 580 590 600
QFLHEALEKK IESSGVTYFW RFKLFLLRIL YQSMQKSPSE ALWKPTHEDS
610 620 630 640 650
KILLVDSPGM GDGEDEQQEE GTSKQGTKAG LQEKSKEGDT EETPEDSLTA
660 670 680 690 700
GGDTGGREPV EEKLLEIQGK IEAVEMHLTR EHMKRVLGEV YLHTWITENT
710 720 730 740 750
SIPTRGLCNF LMSDEDYDDR TAQVLIGHIS KKMNKQTFPE RCSLCKEILP
760 770 780 790 800
FTDRKQAVCS NGHIWLRCFL TYQSCQSLIY RRCLLHDSIA RHPVPEDPDW
810
IKRLLQSPCP FCDSPVF
Length:817
Mass (Da):91,613
Last modified:July 27, 2011 - v2
Checksum:i895ED56D1B7B1F05
GO
Isoform 2 (identifier: Q8BMQ2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-323: Missing.

Note: No experimental confirmation available.

Show »
Length:494
Mass (Da):55,746
Checksum:i0B4138780B192F23
GO
Isoform 3 (identifier: Q8BMQ2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     270-817: Missing.

Note: No experimental confirmation available.

Show »
Length:269
Mass (Da):29,717
Checksum:i687FB95613A1607E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti21 – 211E → Q in BAC26916 (PubMed:16141072).Curated
Sequence conflicti703 – 7031P → H in BAC26916 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 323323Missing in isoform 2. 1 PublicationVSP_010577Add
BLAST
Alternative sequencei270 – 817548Missing in isoform 3. 1 PublicationVSP_010578Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030351 mRNA. Translation: BAC26916.1.
AK047698 mRNA. Translation: BAC33130.1.
AL732526 Genomic DNA. Translation: CAM21459.1.
CH466542 Genomic DNA. Translation: EDL08398.1.
BC061476 mRNA. Translation: AAH61476.1.
BC117919 mRNA. Translation: AAI17920.1.
BC117920 mRNA. Translation: AAI17921.1.
CCDSiCCDS15847.1. [Q8BMQ2-1]
RefSeqiNP_001159505.1. NM_001166033.1.
NP_766565.2. NM_172977.3. [Q8BMQ2-1]
UniGeneiMm.26043.

Genome annotation databases

EnsembliENSMUST00000037117; ENSMUSP00000042265; ENSMUSG00000035666. [Q8BMQ2-1]
GeneIDi269252.
KEGGimmu:269252.
UCSCiuc008ize.2. mouse. [Q8BMQ2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030351 mRNA. Translation: BAC26916.1.
AK047698 mRNA. Translation: BAC33130.1.
AL732526 Genomic DNA. Translation: CAM21459.1.
CH466542 Genomic DNA. Translation: EDL08398.1.
BC061476 mRNA. Translation: AAH61476.1.
BC117919 mRNA. Translation: AAI17920.1.
BC117920 mRNA. Translation: AAI17921.1.
CCDSiCCDS15847.1. [Q8BMQ2-1]
RefSeqiNP_001159505.1. NM_001166033.1.
NP_766565.2. NM_172977.3. [Q8BMQ2-1]
UniGeneiMm.26043.

3D structure databases

ProteinModelPortaliQ8BMQ2.
SMRiQ8BMQ2. Positions 271-341.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8BMQ2. 1 interaction.
MINTiMINT-4137550.
STRINGi10090.ENSMUSP00000042265.

PTM databases

PhosphoSiteiQ8BMQ2.

Proteomic databases

MaxQBiQ8BMQ2.
PaxDbiQ8BMQ2.
PRIDEiQ8BMQ2.

Protocols and materials databases

DNASUi269252.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037117; ENSMUSP00000042265; ENSMUSG00000035666. [Q8BMQ2-1]
GeneIDi269252.
KEGGimmu:269252.
UCSCiuc008ize.2. mouse. [Q8BMQ2-1]

Organism-specific databases

CTDi9329.
MGIiMGI:2138937. Gtf3c4.

Phylogenomic databases

eggNOGiNOG79304.
GeneTreeiENSGT00390000011873.
HOGENOMiHOG000121774.
HOVERGENiHBG059337.
InParanoidiQ8BMQ2.
KOiK11310.
OMAiWQFQLPF.
OrthoDBiEOG7WQ7RS.
TreeFamiTF328412.

Enzyme and pathway databases

ReactomeiREACT_250309. RNA Polymerase III Transcription Initiation From Type 1 Promoter.
REACT_251592. RNA Polymerase III Transcription Initiation From Type 2 Promoter.
REACT_261233. RNA Polymerase III Abortive And Retractive Initiation.

Miscellaneous databases

NextBioi392756.
PROiQ8BMQ2.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BMQ2.
CleanExiMM_GTF3C4.
ExpressionAtlasiQ8BMQ2. baseline and differential.
GenevestigatoriQ8BMQ2.

Family and domain databases

InterProiIPR024761. TFIIIC_delta_N.
IPR024764. TFIIIC_Znf.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF12657. TFIIIC_delta. 1 hit.
PF12660. zf-TFIIIC. 1 hit.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Corpus striatum and Pituitary.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Limb.

Entry informationi

Entry nameiTF3C4_MOUSE
AccessioniPrimary (citable) accession number: Q8BMQ2
Secondary accession number(s): Q148Y1, Q8BKZ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: July 27, 2011
Last modified: March 4, 2015
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.