Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8BMQ2

- TF3C4_MOUSE

UniProt

Q8BMQ2 - TF3C4_MOUSE

Protein

General transcription factor 3C polypeptide 4

Gene

Gtf3c4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA, tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin. Has histone acetyltransferase activity (HAT) with unique specificity for free and nucleosomal H3. May cooperate with GTF3C5 in facilitating the recruitment of TFIIIB and RNA polymerase through direct interactions with BRF1, POLR3C and POLR3F. May be localized close to the A box By similarity.By similarity

    Catalytic activityi

    Acetyl-CoA + [histone] = CoA + acetyl-[histone].

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. histone acetyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Transcription

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    General transcription factor 3C polypeptide 4 (EC:2.3.1.48)
    Alternative name(s):
    TF3C-delta
    Transcription factor IIIC 90 kDa subunit
    Short name:
    TFIIIC 90 kDa subunit
    Short name:
    TFIIIC90
    Transcription factor IIIC subunit delta
    Gene namesi
    Name:Gtf3c4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:2138937. Gtf3c4.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. transcription factor TFIIIC complex Source: Ensembl

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 817817General transcription factor 3C polypeptide 4PRO_0000209714Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity
    Modified residuei607 – 6071PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ8BMQ2.
    PaxDbiQ8BMQ2.
    PRIDEiQ8BMQ2.

    PTM databases

    PhosphoSiteiQ8BMQ2.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8BMQ2.
    BgeeiQ8BMQ2.
    CleanExiMM_GTF3C4.
    GenevestigatoriQ8BMQ2.

    Interactioni

    Subunit structurei

    Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and GTF3C6. Interacts with BRF1, GTF3C1, GTF3C2, GTF3C5, GTF3C6, POLR3C and POLR3F By similarity.By similarity

    Protein-protein interaction databases

    IntActiQ8BMQ2. 1 interaction.
    MINTiMINT-4137550.
    STRINGi10090.ENSMUSP00000042265.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BMQ2.
    SMRiQ8BMQ2. Positions 270-341.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TFIIIC subunit 4 family.Curated

    Phylogenomic databases

    eggNOGiNOG79304.
    GeneTreeiENSGT00390000011873.
    HOGENOMiHOG000121774.
    HOVERGENiHBG059337.
    InParanoidiQ148Y1.
    KOiK11310.
    OMAiWQFQLPF.
    OrthoDBiEOG7WQ7RS.
    TreeFamiTF328412.

    Family and domain databases

    InterProiIPR024761. TFIIIC_delta_N.
    IPR024764. TFIIIC_Znf.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF12657. TFIIIC_delta. 1 hit.
    PF12660. zf-TFIIIC. 1 hit.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 2 hits.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8BMQ2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSEADQALVG PKADEPSPPA EEKDEGGGKE AAADAAPGPS ASFRLMVTRR    50
    EPAVKLQYAV SGLEPLSWSE DHRVSVSTAR SVAVLELICD VHNPGQDLVI 100
    HRTSVPAPLN SCLLKVGSKT EVAECKEKFA SSKDPTISQT FMLDRMFNPE 150
    GKALPPMRGF KYTSWSPMGC DANGRCLLAA LTMDNRLTVQ VNLNRLQWVQ 200
    LVDLTEIYGD RLYETSYRLS KNEAPEGNLG DFAEFQRRHS MQTPVRMEWS 250
    SICTTQQVKH NNECRDVSSV LLAVLFENGN IAVWQFQLPF VGKESISSCN 300
    TIESGISSPS VLFWWEYEHN NRKMSGLIVG SAFGPVKILP VNLKAVKGYF 350
    TLRQPVVLWK EMDKLPVHSI KCVPLYHPYQ KCSCSLVVAA RGSYVFWCLL 400
    LISKAGLNVH NSHVTGLHSL PIVSITADKQ NGTVYTCSSD GKVRQLIPIF 450
    TDVALKFEHQ LIKLSDVFGS VRTHGIAVSP CGAYLAIITT EGMMNGLHPV 500
    NKNYQVQFVT LKTFEEAAAQ LLESSVQNLF KQVDLIDLVR WKILKDKHIP 550
    QFLHEALEKK IESSGVTYFW RFKLFLLRIL YQSMQKSPSE ALWKPTHEDS 600
    KILLVDSPGM GDGEDEQQEE GTSKQGTKAG LQEKSKEGDT EETPEDSLTA 650
    GGDTGGREPV EEKLLEIQGK IEAVEMHLTR EHMKRVLGEV YLHTWITENT 700
    SIPTRGLCNF LMSDEDYDDR TAQVLIGHIS KKMNKQTFPE RCSLCKEILP 750
    FTDRKQAVCS NGHIWLRCFL TYQSCQSLIY RRCLLHDSIA RHPVPEDPDW 800
    IKRLLQSPCP FCDSPVF 817
    Length:817
    Mass (Da):91,613
    Last modified:July 27, 2011 - v2
    Checksum:i895ED56D1B7B1F05
    GO
    Isoform 2 (identifier: Q8BMQ2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-323: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:494
    Mass (Da):55,746
    Checksum:i0B4138780B192F23
    GO
    Isoform 3 (identifier: Q8BMQ2-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         270-817: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:269
    Mass (Da):29,717
    Checksum:i687FB95613A1607E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti21 – 211E → Q in BAC26916. (PubMed:16141072)Curated
    Sequence conflicti703 – 7031P → H in BAC26916. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 323323Missing in isoform 2. 1 PublicationVSP_010577Add
    BLAST
    Alternative sequencei270 – 817548Missing in isoform 3. 1 PublicationVSP_010578Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK030351 mRNA. Translation: BAC26916.1.
    AK047698 mRNA. Translation: BAC33130.1.
    AL732526 Genomic DNA. Translation: CAM21459.1.
    CH466542 Genomic DNA. Translation: EDL08398.1.
    BC061476 mRNA. Translation: AAH61476.1.
    BC117919 mRNA. Translation: AAI17920.1.
    BC117920 mRNA. Translation: AAI17921.1.
    CCDSiCCDS15847.1. [Q8BMQ2-1]
    RefSeqiNP_001159505.1. NM_001166033.1.
    NP_766565.2. NM_172977.3. [Q8BMQ2-1]
    UniGeneiMm.26043.

    Genome annotation databases

    EnsembliENSMUST00000037117; ENSMUSP00000042265; ENSMUSG00000035666. [Q8BMQ2-1]
    GeneIDi269252.
    KEGGimmu:269252.
    UCSCiuc008ize.2. mouse. [Q8BMQ2-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK030351 mRNA. Translation: BAC26916.1 .
    AK047698 mRNA. Translation: BAC33130.1 .
    AL732526 Genomic DNA. Translation: CAM21459.1 .
    CH466542 Genomic DNA. Translation: EDL08398.1 .
    BC061476 mRNA. Translation: AAH61476.1 .
    BC117919 mRNA. Translation: AAI17920.1 .
    BC117920 mRNA. Translation: AAI17921.1 .
    CCDSi CCDS15847.1. [Q8BMQ2-1 ]
    RefSeqi NP_001159505.1. NM_001166033.1.
    NP_766565.2. NM_172977.3. [Q8BMQ2-1 ]
    UniGenei Mm.26043.

    3D structure databases

    ProteinModelPortali Q8BMQ2.
    SMRi Q8BMQ2. Positions 270-341.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8BMQ2. 1 interaction.
    MINTi MINT-4137550.
    STRINGi 10090.ENSMUSP00000042265.

    PTM databases

    PhosphoSitei Q8BMQ2.

    Proteomic databases

    MaxQBi Q8BMQ2.
    PaxDbi Q8BMQ2.
    PRIDEi Q8BMQ2.

    Protocols and materials databases

    DNASUi 269252.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000037117 ; ENSMUSP00000042265 ; ENSMUSG00000035666 . [Q8BMQ2-1 ]
    GeneIDi 269252.
    KEGGi mmu:269252.
    UCSCi uc008ize.2. mouse. [Q8BMQ2-1 ]

    Organism-specific databases

    CTDi 9329.
    MGIi MGI:2138937. Gtf3c4.

    Phylogenomic databases

    eggNOGi NOG79304.
    GeneTreei ENSGT00390000011873.
    HOGENOMi HOG000121774.
    HOVERGENi HBG059337.
    InParanoidi Q148Y1.
    KOi K11310.
    OMAi WQFQLPF.
    OrthoDBi EOG7WQ7RS.
    TreeFami TF328412.

    Miscellaneous databases

    NextBioi 392756.
    PROi Q8BMQ2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8BMQ2.
    Bgeei Q8BMQ2.
    CleanExi MM_GTF3C4.
    Genevestigatori Q8BMQ2.

    Family and domain databases

    InterProi IPR024761. TFIIIC_delta_N.
    IPR024764. TFIIIC_Znf.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF12657. TFIIIC_delta. 1 hit.
    PF12660. zf-TFIIIC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6J.
      Tissue: Corpus striatum and Pituitary.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
      Tissue: Limb.

    Entry informationi

    Entry nameiTF3C4_MOUSE
    AccessioniPrimary (citable) accession number: Q8BMQ2
    Secondary accession number(s): Q148Y1, Q8BKZ4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2004
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 94 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3