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Q8BMQ2 (TF3C4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
General transcription factor 3C polypeptide 4

EC=2.3.1.48
Alternative name(s):
TF3C-delta
Transcription factor IIIC 90 kDa subunit
Short name=TFIIIC 90 kDa subunit
Short name=TFIIIC90
Transcription factor IIIC subunit delta
Gene names
Name:Gtf3c4
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length817 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA, tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin. Has histone acetyltransferase activity (HAT) with unique specificity for free and nucleosomal H3. May cooperate with GTF3C5 in facilitating the recruitment of TFIIIB and RNA polymerase through direct interactions with BRF1, POLR3C and POLR3F. May be localized close to the A box By similarity.

Catalytic activity

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

Subunit structure

Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and GTF3C6. Interacts with BRF1, GTF3C1, GTF3C2, GTF3C5, GTF3C6, POLR3C and POLR3F By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the TFIIIC subunit 4 family.

Ontologies

Keywords
   Biological processTranscription
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
   LigandDNA-binding
   Molecular functionAcyltransferase
Transferase
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtranscription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componenttranscription factor TFIIIC complex

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

histone acetyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8BMQ2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8BMQ2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-323: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q8BMQ2-3)

The sequence of this isoform differs from the canonical sequence as follows:
     270-817: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 817817General transcription factor 3C polypeptide 4
PRO_0000209714

Amino acid modifications

Modified residue11N-acetylmethionine By similarity
Modified residue6071Phosphoserine By similarity

Natural variations

Alternative sequence1 – 323323Missing in isoform 2.
VSP_010577
Alternative sequence270 – 817548Missing in isoform 3.
VSP_010578

Experimental info

Sequence conflict211E → Q in BAC26916. Ref.1
Sequence conflict7031P → H in BAC26916. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 895ED56D1B7B1F05

FASTA81791,613
        10         20         30         40         50         60 
MSEADQALVG PKADEPSPPA EEKDEGGGKE AAADAAPGPS ASFRLMVTRR EPAVKLQYAV 

        70         80         90        100        110        120 
SGLEPLSWSE DHRVSVSTAR SVAVLELICD VHNPGQDLVI HRTSVPAPLN SCLLKVGSKT 

       130        140        150        160        170        180 
EVAECKEKFA SSKDPTISQT FMLDRMFNPE GKALPPMRGF KYTSWSPMGC DANGRCLLAA 

       190        200        210        220        230        240 
LTMDNRLTVQ VNLNRLQWVQ LVDLTEIYGD RLYETSYRLS KNEAPEGNLG DFAEFQRRHS 

       250        260        270        280        290        300 
MQTPVRMEWS SICTTQQVKH NNECRDVSSV LLAVLFENGN IAVWQFQLPF VGKESISSCN 

       310        320        330        340        350        360 
TIESGISSPS VLFWWEYEHN NRKMSGLIVG SAFGPVKILP VNLKAVKGYF TLRQPVVLWK 

       370        380        390        400        410        420 
EMDKLPVHSI KCVPLYHPYQ KCSCSLVVAA RGSYVFWCLL LISKAGLNVH NSHVTGLHSL 

       430        440        450        460        470        480 
PIVSITADKQ NGTVYTCSSD GKVRQLIPIF TDVALKFEHQ LIKLSDVFGS VRTHGIAVSP 

       490        500        510        520        530        540 
CGAYLAIITT EGMMNGLHPV NKNYQVQFVT LKTFEEAAAQ LLESSVQNLF KQVDLIDLVR 

       550        560        570        580        590        600 
WKILKDKHIP QFLHEALEKK IESSGVTYFW RFKLFLLRIL YQSMQKSPSE ALWKPTHEDS 

       610        620        630        640        650        660 
KILLVDSPGM GDGEDEQQEE GTSKQGTKAG LQEKSKEGDT EETPEDSLTA GGDTGGREPV 

       670        680        690        700        710        720 
EEKLLEIQGK IEAVEMHLTR EHMKRVLGEV YLHTWITENT SIPTRGLCNF LMSDEDYDDR 

       730        740        750        760        770        780 
TAQVLIGHIS KKMNKQTFPE RCSLCKEILP FTDRKQAVCS NGHIWLRCFL TYQSCQSLIY 

       790        800        810 
RRCLLHDSIA RHPVPEDPDW IKRLLQSPCP FCDSPVF 

« Hide

Isoform 2 [UniParc].

Checksum: 0B4138780B192F23
Show »

FASTA49455,746
Isoform 3 [UniParc].

Checksum: 687FB95613A1607E
Show »

FASTA26929,717

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Strain: C57BL/6J.
Tissue: Corpus striatum and Pituitary.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
Tissue: Limb.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK030351 mRNA. Translation: BAC26916.1.
AK047698 mRNA. Translation: BAC33130.1.
AL732526 Genomic DNA. Translation: CAM21459.1.
CH466542 Genomic DNA. Translation: EDL08398.1.
BC061476 mRNA. Translation: AAH61476.1.
BC117919 mRNA. Translation: AAI17920.1.
BC117920 mRNA. Translation: AAI17921.1.
CCDSCCDS15847.1. [Q8BMQ2-1]
RefSeqNP_001159505.1. NM_001166033.1.
NP_766565.2. NM_172977.3. [Q8BMQ2-1]
UniGeneMm.26043.

3D structure databases

ProteinModelPortalQ8BMQ2.
SMRQ8BMQ2. Positions 270-341.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ8BMQ2. 1 interaction.
MINTMINT-4137550.
STRING10090.ENSMUSP00000042265.

PTM databases

PhosphoSiteQ8BMQ2.

Proteomic databases

MaxQBQ8BMQ2.
PaxDbQ8BMQ2.
PRIDEQ8BMQ2.

Protocols and materials databases

DNASU269252.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000037117; ENSMUSP00000042265; ENSMUSG00000035666. [Q8BMQ2-1]
GeneID269252.
KEGGmmu:269252.
UCSCuc008ize.2. mouse. [Q8BMQ2-1]

Organism-specific databases

CTD9329.
MGIMGI:2138937. Gtf3c4.

Phylogenomic databases

eggNOGNOG79304.
GeneTreeENSGT00390000011873.
HOGENOMHOG000121774.
HOVERGENHBG059337.
InParanoidQ148Y1.
KOK11310.
OMAWQFQLPF.
OrthoDBEOG7WQ7RS.
TreeFamTF328412.

Gene expression databases

ArrayExpressQ8BMQ2.
BgeeQ8BMQ2.
CleanExMM_GTF3C4.
GenevestigatorQ8BMQ2.

Family and domain databases

InterProIPR024761. TFIIIC_delta_N.
IPR024764. TFIIIC_Znf.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamPF12657. TFIIIC_delta. 1 hit.
PF12660. zf-TFIIIC. 1 hit.
[Graphical view]
SUPFAMSSF50978. SSF50978. 2 hits.
ProtoNetSearch...

Other

NextBio392756.
PROQ8BMQ2.
SOURCESearch...

Entry information

Entry nameTF3C4_MOUSE
AccessionPrimary (citable) accession number: Q8BMQ2
Secondary accession number(s): Q148Y1, Q8BKZ4
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot