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Q8BMP6

- GCP60_MOUSE

UniProt

Q8BMP6 - GCP60_MOUSE

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Protein
Golgi resident protein GCP60
Gene
Acbd3, Gcp60, Pap7
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in the maintenance of Golgi structure by interacting with giantin, affecting protein transport between the endoplasmic reticulum and Golgi By similarity. Involved in hormone-induced steroid biosynthesis in testicular Leydig cells.1 Publication

GO - Molecular functioni

  1. fatty-acyl-CoA binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. steroid biosynthetic process Source: UniProtKB-KW
  2. transport Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Golgi resident protein GCP60
Alternative name(s):
Acyl-CoA-binding domain-containing protein 3
Golgi complex-associated protein 1
Short name:
GOCAP1
Golgi phosphoprotein 1
Short name:
GOLPH1
PBR- and PKA-associated protein 7
Peripheral benzodiazepine receptor-associated protein PAP7
Gene namesi
Name:Acbd3
Synonyms:Gcp60, Pap7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:2181074. Acbd3.

Subcellular locationi

Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Mitochondrion
Note: Also mitochondrial (via its interaction with PBR).1 Publication

GO - Cellular componenti

  1. Golgi membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: InterPro
  3. mitochondrion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 525524Golgi resident protein GCP60
PRO_0000214030Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity
Modified residuei13 – 131Phosphoserine By similarity
Modified residuei20 – 201Phosphoserine By similarity
Modified residuei40 – 401Phosphoserine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ8BMP6.
PaxDbiQ8BMP6.
PRIDEiQ8BMP6.

PTM databases

PhosphoSiteiQ8BMP6.

Expressioni

Tissue specificityi

Expressed in brain (hippocampus, olfactory bulb, neuronal and glial cells of the cortex), eye, submaxillary gland, testis (interstitial and tubular compartments), ovary (granulosa cells, theca cells at late stages and primary follicles), adrenal gland (fasciculata and glomerulosa cells), heart, liver, and steroidogenic cell lines.1 Publication

Developmental stagei

Present in embryo. Decreases before birth.1 Publication

Gene expression databases

BgeeiQ8BMP6.
CleanExiMM_ACBD3.
GenevestigatoriQ8BMP6.

Interactioni

Subunit structurei

Interacts with the C-terminal cytoplasmic domain of giantin/GOLGB1 By similarity. Interacts with PBR and PKA regulatory subunit RI-alpha. Does not interact with PKA regulatory subunit RI-beta nor PKA regulatory subunit RII-alpha.1 Publication

Protein-protein interaction databases

MINTiMINT-1858691.

Structurei

3D structure databases

ProteinModelPortaliQ8BMP6.
SMRiQ8BMP6. Positions 98-159.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini80 – 17192ACB
Add
BLAST
Domaini381 – 523143GOLD
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili169 – 25486 Reviewed prediction
Add
BLAST
Coiled coili448 – 47023 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi179 – 1846Poly-Glu
Compositional biasi186 – 23550Arg-rich
Add
BLAST
Compositional biasi238 – 30568Gln-rich
Add
BLAST

Domaini

The GOLD domain is essential for giantin binding By similarity.

Sequence similaritiesi

Contains 1 GOLD domain.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG287879.
GeneTreeiENSGT00530000063651.
HOGENOMiHOG000247039.
HOVERGENiHBG051712.
InParanoidiQ8BMP6.
OrthoDBiEOG7KDFB4.
PhylomeDBiQ8BMP6.
TreeFamiTF321667.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
InterProiIPR022408. Acyl-CoA-binding_prot_CS.
IPR000582. Acyl-CoA-binding_protein.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR009038. GOLD.
[Graphical view]
PfamiPF00887. ACBP. 1 hit.
PF13897. GOLD_2. 1 hit.
[Graphical view]
SUPFAMiSSF101576. SSF101576. 2 hits.
SSF47027. SSF47027. 1 hit.
PROSITEiPS00880. ACB_1. 1 hit.
PS51228. ACB_2. 1 hit.
PS50866. GOLD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BMP6-1 [UniParc]FASTAAdd to Basket

« Hide

MAAQLNVEQL EVSLDGLTLS PDSEERPGAE GAPPQTPPSS APGNGLGSGA    50
SGQQREPGEA AAEGAAEEAR RMEQHWGFGL EELYGLALRF YKIKDGKAFH 100
PTYEEKLKFV ALHKQVLLGP YNPDTSPEVG FFDVLGNDRR REWAALGNMS 150
KEDAMVEFVK LLNKCCPLLS AYVASHRIEK EEEEKRRKAE EERRQREEEE 200
RERLQKEEEK RKREKEDRLR REEEERRRIE EERLRLEQQK QQIMAALNSQ 250
TAVQFQQYAA QQYPGNYEQQ QILIRQLQEQ HYQQYMQQLY QVQLAQQQAA 300
LQKQQEVVMA GASLPASSKV NTAGASDTLS VNGQAKTHTE NSEKVLEPEA 350
AEEALENGPK DSLPVIAAPS MWTRPQIKDF KEKIRQDADS VITVRRGEVV 400
TVRVPTHEEG SYLFWEFATD SYDIGFGVYF EWTDSPNAAV SVHVSESSDE 450
EEEEEENVTC EEKAKKNANK PLLDEIVPVY RRDCHEEVYA GSHQYPGRGV 500
YLLKFDNSYS LWRSKSVYYR VYYTR 525
Length:525
Mass (Da):60,181
Last modified:January 23, 2007 - v3
Checksum:iC043CEBF56FCE702
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF022770 mRNA. Translation: AAB71197.3.
AF501319 Genomic DNA. Translation: AAM22185.1.
AK030371 mRNA. Translation: BAC26928.1.
CCDSiCCDS15572.1.
RefSeqiNP_573488.2. NM_133225.3.
UniGeneiMm.272981.

Genome annotation databases

EnsembliENSMUST00000027780; ENSMUSP00000027780; ENSMUSG00000026499.
GeneIDi170760.
KEGGimmu:170760.
UCSCiuc007dwq.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF022770 mRNA. Translation: AAB71197.3 .
AF501319 Genomic DNA. Translation: AAM22185.1 .
AK030371 mRNA. Translation: BAC26928.1 .
CCDSi CCDS15572.1.
RefSeqi NP_573488.2. NM_133225.3.
UniGenei Mm.272981.

3D structure databases

ProteinModelPortali Q8BMP6.
SMRi Q8BMP6. Positions 98-159.
ModBasei Search...

Protein-protein interaction databases

MINTi MINT-1858691.

PTM databases

PhosphoSitei Q8BMP6.

Proteomic databases

MaxQBi Q8BMP6.
PaxDbi Q8BMP6.
PRIDEi Q8BMP6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000027780 ; ENSMUSP00000027780 ; ENSMUSG00000026499 .
GeneIDi 170760.
KEGGi mmu:170760.
UCSCi uc007dwq.2. mouse.

Organism-specific databases

CTDi 64746.
MGIi MGI:2181074. Acbd3.

Phylogenomic databases

eggNOGi NOG287879.
GeneTreei ENSGT00530000063651.
HOGENOMi HOG000247039.
HOVERGENi HBG051712.
InParanoidi Q8BMP6.
OrthoDBi EOG7KDFB4.
PhylomeDBi Q8BMP6.
TreeFami TF321667.

Miscellaneous databases

ChiTaRSi ACBD3. mouse.
NextBioi 370362.
PROi Q8BMP6.
SOURCEi Search...

Gene expression databases

Bgeei Q8BMP6.
CleanExi MM_ACBD3.
Genevestigatori Q8BMP6.

Family and domain databases

Gene3Di 1.20.80.10. 1 hit.
InterProi IPR022408. Acyl-CoA-binding_prot_CS.
IPR000582. Acyl-CoA-binding_protein.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR009038. GOLD.
[Graphical view ]
Pfami PF00887. ACBP. 1 hit.
PF13897. GOLD_2. 1 hit.
[Graphical view ]
SUPFAMi SSF101576. SSF101576. 2 hits.
SSF47027. SSF47027. 1 hit.
PROSITEi PS00880. ACB_1. 1 hit.
PS51228. ACB_2. 1 hit.
PS50866. GOLD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification, localization, and function in steroidogenesis of PAP7: a peripheral-type benzodiazepine receptor- and PKA (RIalpha)-associated protein."
    Li H., Degenhardt B., Tobin D., Yao Z.-X., Tasken K., Papadopoulos V.
    Mol. Endocrinol. 15:2211-2228(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH PBR AND PKA, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: BALB/c.
    Tissue: Testis.
  2. "Molecular cloning, genomic organization, chromosomal mapping and subcellular localization of mouse PAP7: a PBR and PKA-RIalpha associated protein."
    Liu J., Cavalli L.R., Haddad B.R., Papadopoulos V.
    Gene 308:1-10(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Pituitary.

Entry informationi

Entry nameiGCP60_MOUSE
AccessioniPrimary (citable) accession number: Q8BMP6
Secondary accession number(s): O35371
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 103 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi