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Q8BMP6

- GCP60_MOUSE

UniProt

Q8BMP6 - GCP60_MOUSE

Protein

Golgi resident protein GCP60

Gene

Acbd3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Involved in the maintenance of Golgi structure by interacting with giantin, affecting protein transport between the endoplasmic reticulum and Golgi By similarity. Involved in hormone-induced steroid biosynthesis in testicular Leydig cells.By similarity1 Publication

    GO - Molecular functioni

    1. fatty-acyl-CoA binding Source: InterPro

    GO - Biological processi

    1. steroid biosynthetic process Source: UniProtKB-KW
    2. transport Source: InterPro

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Golgi resident protein GCP60
    Alternative name(s):
    Acyl-CoA-binding domain-containing protein 3
    Golgi complex-associated protein 1
    Short name:
    GOCAP1
    Golgi phosphoprotein 1
    Short name:
    GOLPH1
    PBR- and PKA-associated protein 7
    Peripheral benzodiazepine receptor-associated protein PAP7
    Gene namesi
    Name:Acbd3
    Synonyms:Gcp60, Pap7
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:2181074. Acbd3.

    Subcellular locationi

    Golgi apparatus membrane 1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication. Mitochondrion 1 Publication
    Note: Also mitochondrial (via its interaction with PBR).

    GO - Cellular componenti

    1. Golgi membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: InterPro
    3. mitochondrion Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Golgi apparatus, Membrane, Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 525524Golgi resident protein GCP60PRO_0000214030Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei13 – 131PhosphoserineBy similarity
    Modified residuei20 – 201PhosphoserineBy similarity
    Modified residuei40 – 401PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ8BMP6.
    PaxDbiQ8BMP6.
    PRIDEiQ8BMP6.

    PTM databases

    PhosphoSiteiQ8BMP6.

    Expressioni

    Tissue specificityi

    Expressed in brain (hippocampus, olfactory bulb, neuronal and glial cells of the cortex), eye, submaxillary gland, testis (interstitial and tubular compartments), ovary (granulosa cells, theca cells at late stages and primary follicles), adrenal gland (fasciculata and glomerulosa cells), heart, liver, and steroidogenic cell lines.1 Publication

    Developmental stagei

    Present in embryo. Decreases before birth.1 Publication

    Gene expression databases

    BgeeiQ8BMP6.
    CleanExiMM_ACBD3.
    GenevestigatoriQ8BMP6.

    Interactioni

    Subunit structurei

    Interacts with the C-terminal cytoplasmic domain of giantin/GOLGB1 By similarity. Interacts with PBR and PKA regulatory subunit RI-alpha. Does not interact with PKA regulatory subunit RI-beta nor PKA regulatory subunit RII-alpha.By similarity1 Publication

    Protein-protein interaction databases

    MINTiMINT-1858691.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BMP6.
    SMRiQ8BMP6. Positions 98-159.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini80 – 17192ACBPROSITE-ProRule annotationAdd
    BLAST
    Domaini381 – 523143GOLDPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili169 – 25486Sequence AnalysisAdd
    BLAST
    Coiled coili448 – 47023Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi179 – 1846Poly-Glu
    Compositional biasi186 – 23550Arg-richAdd
    BLAST
    Compositional biasi238 – 30568Gln-richAdd
    BLAST

    Domaini

    The GOLD domain is essential for giantin binding.By similarity

    Sequence similaritiesi

    Contains 1 ACB (acyl-CoA-binding) domain.PROSITE-ProRule annotation
    Contains 1 GOLD domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG287879.
    GeneTreeiENSGT00530000063651.
    HOGENOMiHOG000247039.
    HOVERGENiHBG051712.
    InParanoidiQ8BMP6.
    OrthoDBiEOG7KDFB4.
    PhylomeDBiQ8BMP6.
    TreeFamiTF321667.

    Family and domain databases

    Gene3Di1.20.80.10. 1 hit.
    InterProiIPR022408. Acyl-CoA-binding_prot_CS.
    IPR000582. Acyl-CoA-binding_protein.
    IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
    IPR009038. GOLD.
    [Graphical view]
    PfamiPF00887. ACBP. 1 hit.
    PF13897. GOLD_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF101576. SSF101576. 2 hits.
    SSF47027. SSF47027. 1 hit.
    PROSITEiPS00880. ACB_1. 1 hit.
    PS51228. ACB_2. 1 hit.
    PS50866. GOLD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8BMP6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAQLNVEQL EVSLDGLTLS PDSEERPGAE GAPPQTPPSS APGNGLGSGA    50
    SGQQREPGEA AAEGAAEEAR RMEQHWGFGL EELYGLALRF YKIKDGKAFH 100
    PTYEEKLKFV ALHKQVLLGP YNPDTSPEVG FFDVLGNDRR REWAALGNMS 150
    KEDAMVEFVK LLNKCCPLLS AYVASHRIEK EEEEKRRKAE EERRQREEEE 200
    RERLQKEEEK RKREKEDRLR REEEERRRIE EERLRLEQQK QQIMAALNSQ 250
    TAVQFQQYAA QQYPGNYEQQ QILIRQLQEQ HYQQYMQQLY QVQLAQQQAA 300
    LQKQQEVVMA GASLPASSKV NTAGASDTLS VNGQAKTHTE NSEKVLEPEA 350
    AEEALENGPK DSLPVIAAPS MWTRPQIKDF KEKIRQDADS VITVRRGEVV 400
    TVRVPTHEEG SYLFWEFATD SYDIGFGVYF EWTDSPNAAV SVHVSESSDE 450
    EEEEEENVTC EEKAKKNANK PLLDEIVPVY RRDCHEEVYA GSHQYPGRGV 500
    YLLKFDNSYS LWRSKSVYYR VYYTR 525
    Length:525
    Mass (Da):60,181
    Last modified:January 23, 2007 - v3
    Checksum:iC043CEBF56FCE702
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF022770 mRNA. Translation: AAB71197.3.
    AF501319 Genomic DNA. Translation: AAM22185.1.
    AK030371 mRNA. Translation: BAC26928.1.
    CCDSiCCDS15572.1.
    RefSeqiNP_573488.2. NM_133225.3.
    UniGeneiMm.272981.

    Genome annotation databases

    EnsembliENSMUST00000027780; ENSMUSP00000027780; ENSMUSG00000026499.
    GeneIDi170760.
    KEGGimmu:170760.
    UCSCiuc007dwq.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF022770 mRNA. Translation: AAB71197.3 .
    AF501319 Genomic DNA. Translation: AAM22185.1 .
    AK030371 mRNA. Translation: BAC26928.1 .
    CCDSi CCDS15572.1.
    RefSeqi NP_573488.2. NM_133225.3.
    UniGenei Mm.272981.

    3D structure databases

    ProteinModelPortali Q8BMP6.
    SMRi Q8BMP6. Positions 98-159.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-1858691.

    PTM databases

    PhosphoSitei Q8BMP6.

    Proteomic databases

    MaxQBi Q8BMP6.
    PaxDbi Q8BMP6.
    PRIDEi Q8BMP6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000027780 ; ENSMUSP00000027780 ; ENSMUSG00000026499 .
    GeneIDi 170760.
    KEGGi mmu:170760.
    UCSCi uc007dwq.2. mouse.

    Organism-specific databases

    CTDi 64746.
    MGIi MGI:2181074. Acbd3.

    Phylogenomic databases

    eggNOGi NOG287879.
    GeneTreei ENSGT00530000063651.
    HOGENOMi HOG000247039.
    HOVERGENi HBG051712.
    InParanoidi Q8BMP6.
    OrthoDBi EOG7KDFB4.
    PhylomeDBi Q8BMP6.
    TreeFami TF321667.

    Miscellaneous databases

    ChiTaRSi ACBD3. mouse.
    NextBioi 370362.
    PROi Q8BMP6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8BMP6.
    CleanExi MM_ACBD3.
    Genevestigatori Q8BMP6.

    Family and domain databases

    Gene3Di 1.20.80.10. 1 hit.
    InterProi IPR022408. Acyl-CoA-binding_prot_CS.
    IPR000582. Acyl-CoA-binding_protein.
    IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
    IPR009038. GOLD.
    [Graphical view ]
    Pfami PF00887. ACBP. 1 hit.
    PF13897. GOLD_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF101576. SSF101576. 2 hits.
    SSF47027. SSF47027. 1 hit.
    PROSITEi PS00880. ACB_1. 1 hit.
    PS51228. ACB_2. 1 hit.
    PS50866. GOLD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification, localization, and function in steroidogenesis of PAP7: a peripheral-type benzodiazepine receptor- and PKA (RIalpha)-associated protein."
      Li H., Degenhardt B., Tobin D., Yao Z.-X., Tasken K., Papadopoulos V.
      Mol. Endocrinol. 15:2211-2228(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH PBR AND PKA, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
      Strain: BALB/c.
      Tissue: Testis.
    2. "Molecular cloning, genomic organization, chromosomal mapping and subcellular localization of mouse PAP7: a PBR and PKA-RIalpha associated protein."
      Liu J., Cavalli L.R., Haddad B.R., Papadopoulos V.
      Gene 308:1-10(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Pituitary.

    Entry informationi

    Entry nameiGCP60_MOUSE
    AccessioniPrimary (citable) accession number: Q8BMP6
    Secondary accession number(s): O35371
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2004
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 104 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3