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Q8BMP6

- GCP60_MOUSE

UniProt

Q8BMP6 - GCP60_MOUSE

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Protein

Golgi resident protein GCP60

Gene

Acbd3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Involved in the maintenance of Golgi structure by interacting with giantin, affecting protein transport between the endoplasmic reticulum and Golgi (By similarity). Involved in hormone-induced steroid biosynthesis in testicular Leydig cells.By similarity1 Publication

GO - Molecular functioni

  1. fatty-acyl-CoA binding Source: InterPro

GO - Biological processi

  1. steroid biosynthetic process Source: UniProtKB-KW
  2. transport Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Golgi resident protein GCP60
Alternative name(s):
Acyl-CoA-binding domain-containing protein 3
Golgi complex-associated protein 1
Short name:
GOCAP1
Golgi phosphoprotein 1
Short name:
GOLPH1
PBR- and PKA-associated protein 7
Peripheral benzodiazepine receptor-associated protein PAP7
Gene namesi
Name:Acbd3
Synonyms:Gcp60, Pap7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:2181074. Acbd3.

Subcellular locationi

Golgi apparatus membrane 1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication. Mitochondrion 1 Publication
Note: Also mitochondrial (via its interaction with PBR).

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-KW
  2. integral component of membrane Source: InterPro
  3. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 525524Golgi resident protein GCP60PRO_0000214030Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei13 – 131PhosphoserineBy similarity
Modified residuei20 – 201PhosphoserineBy similarity
Modified residuei40 – 401PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ8BMP6.
PaxDbiQ8BMP6.
PRIDEiQ8BMP6.

PTM databases

PhosphoSiteiQ8BMP6.

Expressioni

Tissue specificityi

Expressed in brain (hippocampus, olfactory bulb, neuronal and glial cells of the cortex), eye, submaxillary gland, testis (interstitial and tubular compartments), ovary (granulosa cells, theca cells at late stages and primary follicles), adrenal gland (fasciculata and glomerulosa cells), heart, liver, and steroidogenic cell lines.1 Publication

Developmental stagei

Present in embryo. Decreases before birth.1 Publication

Gene expression databases

BgeeiQ8BMP6.
CleanExiMM_ACBD3.
GenevestigatoriQ8BMP6.

Interactioni

Subunit structurei

Interacts with the C-terminal cytoplasmic domain of giantin/GOLGB1 (By similarity). Interacts with PBR and PKA regulatory subunit RI-alpha. Does not interact with PKA regulatory subunit RI-beta nor PKA regulatory subunit RII-alpha.By similarity1 Publication

Protein-protein interaction databases

MINTiMINT-1858691.

Structurei

3D structure databases

ProteinModelPortaliQ8BMP6.
SMRiQ8BMP6. Positions 98-159, 382-521.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini80 – 17192ACBPROSITE-ProRule annotationAdd
BLAST
Domaini381 – 523143GOLDPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili169 – 25486Sequence AnalysisAdd
BLAST
Coiled coili448 – 47023Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi179 – 1846Poly-Glu
Compositional biasi186 – 23550Arg-richAdd
BLAST
Compositional biasi238 – 30568Gln-richAdd
BLAST

Domaini

The GOLD domain is essential for giantin binding.By similarity

Sequence similaritiesi

Contains 1 ACB (acyl-CoA-binding) domain.PROSITE-ProRule annotation
Contains 1 GOLD domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG287879.
GeneTreeiENSGT00530000063651.
HOGENOMiHOG000247039.
HOVERGENiHBG051712.
InParanoidiQ8BMP6.
OrthoDBiEOG7KDFB4.
PhylomeDBiQ8BMP6.
TreeFamiTF321667.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
InterProiIPR022408. Acyl-CoA-binding_prot_CS.
IPR000582. Acyl-CoA-binding_protein.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR009038. GOLD.
[Graphical view]
PfamiPF00887. ACBP. 1 hit.
PF13897. GOLD_2. 1 hit.
[Graphical view]
SUPFAMiSSF101576. SSF101576. 2 hits.
SSF47027. SSF47027. 1 hit.
PROSITEiPS00880. ACB_1. 1 hit.
PS51228. ACB_2. 1 hit.
PS50866. GOLD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BMP6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAQLNVEQL EVSLDGLTLS PDSEERPGAE GAPPQTPPSS APGNGLGSGA
60 70 80 90 100
SGQQREPGEA AAEGAAEEAR RMEQHWGFGL EELYGLALRF YKIKDGKAFH
110 120 130 140 150
PTYEEKLKFV ALHKQVLLGP YNPDTSPEVG FFDVLGNDRR REWAALGNMS
160 170 180 190 200
KEDAMVEFVK LLNKCCPLLS AYVASHRIEK EEEEKRRKAE EERRQREEEE
210 220 230 240 250
RERLQKEEEK RKREKEDRLR REEEERRRIE EERLRLEQQK QQIMAALNSQ
260 270 280 290 300
TAVQFQQYAA QQYPGNYEQQ QILIRQLQEQ HYQQYMQQLY QVQLAQQQAA
310 320 330 340 350
LQKQQEVVMA GASLPASSKV NTAGASDTLS VNGQAKTHTE NSEKVLEPEA
360 370 380 390 400
AEEALENGPK DSLPVIAAPS MWTRPQIKDF KEKIRQDADS VITVRRGEVV
410 420 430 440 450
TVRVPTHEEG SYLFWEFATD SYDIGFGVYF EWTDSPNAAV SVHVSESSDE
460 470 480 490 500
EEEEEENVTC EEKAKKNANK PLLDEIVPVY RRDCHEEVYA GSHQYPGRGV
510 520
YLLKFDNSYS LWRSKSVYYR VYYTR
Length:525
Mass (Da):60,181
Last modified:January 23, 2007 - v3
Checksum:iC043CEBF56FCE702
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF022770 mRNA. Translation: AAB71197.3.
AF501319 Genomic DNA. Translation: AAM22185.1.
AK030371 mRNA. Translation: BAC26928.1.
CCDSiCCDS15572.1.
RefSeqiNP_573488.2. NM_133225.3.
UniGeneiMm.272981.

Genome annotation databases

EnsembliENSMUST00000027780; ENSMUSP00000027780; ENSMUSG00000026499.
GeneIDi170760.
KEGGimmu:170760.
UCSCiuc007dwq.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF022770 mRNA. Translation: AAB71197.3 .
AF501319 Genomic DNA. Translation: AAM22185.1 .
AK030371 mRNA. Translation: BAC26928.1 .
CCDSi CCDS15572.1.
RefSeqi NP_573488.2. NM_133225.3.
UniGenei Mm.272981.

3D structure databases

ProteinModelPortali Q8BMP6.
SMRi Q8BMP6. Positions 98-159, 382-521.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-1858691.

PTM databases

PhosphoSitei Q8BMP6.

Proteomic databases

MaxQBi Q8BMP6.
PaxDbi Q8BMP6.
PRIDEi Q8BMP6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000027780 ; ENSMUSP00000027780 ; ENSMUSG00000026499 .
GeneIDi 170760.
KEGGi mmu:170760.
UCSCi uc007dwq.2. mouse.

Organism-specific databases

CTDi 64746.
MGIi MGI:2181074. Acbd3.

Phylogenomic databases

eggNOGi NOG287879.
GeneTreei ENSGT00530000063651.
HOGENOMi HOG000247039.
HOVERGENi HBG051712.
InParanoidi Q8BMP6.
OrthoDBi EOG7KDFB4.
PhylomeDBi Q8BMP6.
TreeFami TF321667.

Miscellaneous databases

ChiTaRSi ACBD3. mouse.
NextBioi 370362.
PROi Q8BMP6.
SOURCEi Search...

Gene expression databases

Bgeei Q8BMP6.
CleanExi MM_ACBD3.
Genevestigatori Q8BMP6.

Family and domain databases

Gene3Di 1.20.80.10. 1 hit.
InterProi IPR022408. Acyl-CoA-binding_prot_CS.
IPR000582. Acyl-CoA-binding_protein.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR009038. GOLD.
[Graphical view ]
Pfami PF00887. ACBP. 1 hit.
PF13897. GOLD_2. 1 hit.
[Graphical view ]
SUPFAMi SSF101576. SSF101576. 2 hits.
SSF47027. SSF47027. 1 hit.
PROSITEi PS00880. ACB_1. 1 hit.
PS51228. ACB_2. 1 hit.
PS50866. GOLD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification, localization, and function in steroidogenesis of PAP7: a peripheral-type benzodiazepine receptor- and PKA (RIalpha)-associated protein."
    Li H., Degenhardt B., Tobin D., Yao Z.-X., Tasken K., Papadopoulos V.
    Mol. Endocrinol. 15:2211-2228(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH PBR AND PKA, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: BALB/c.
    Tissue: Testis.
  2. "Molecular cloning, genomic organization, chromosomal mapping and subcellular localization of mouse PAP7: a PBR and PKA-RIalpha associated protein."
    Liu J., Cavalli L.R., Haddad B.R., Papadopoulos V.
    Gene 308:1-10(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Pituitary.

Entry informationi

Entry nameiGCP60_MOUSE
AccessioniPrimary (citable) accession number: Q8BMP6
Secondary accession number(s): O35371
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 105 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3