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Q8BMP4

- GPER1_MOUSE

UniProt

Q8BMP4 - GPER1_MOUSE

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Protein

G-protein coupled estrogen receptor 1

Gene
Gper1, Cmkrl2, Gper, Gpr30
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

G-protein coupled estrogen receptor that binds to 17-beta-estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Stimulates cAMP production, calcium mobilization and tyrosine kinase Src inducing the release of heparin-bound epidermal growth factor (HB-EGF) and subsequent transactivation of the epidermal growth factor receptor (EGFR), activating downstream signaling pathways such as PI3K/Akt and ERK/MAPK. Mediates pleiotropic functions among others in the cardiovascular, endocrine, reproductive, immune and central nervous systems. Has a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a RAMP3-dependent manner. Regulates arterial blood pressure by stimulating vasodilation and reducing vascular smooth muscle and microvascular endothelial cell proliferation. Plays a role in blood glucose homeostasis contributing to the insulin secretion response by pancreatic beta cells. Triggers mitochondrial apoptosis during pachytene spermatocyte differentiation. Stimulates uterine epithelial cell proliferation. Enhances uterine contractility in response to oxytocin. Contributes to thymic atrophy by inducing apoptosis. Attenuates TNF-mediated endothelial expression of leukocyte adhesion molecules. Promotes neuritogenesis in developing hippocampal neurons. Plays a role in acute neuroprotection against NMDA-induced excitotoxic neuronal death. Increases firing activity and intracellular calcium oscillations in luteinizing hormone-releasing hormone (LHRH) neurons. Inhibits early osteoblast proliferation at growth plate during skeletal development. Inhibits mature adipocyte differentiation and lipid accumulation. Involved in the recruitment of beta-arrestin 2 ARRB2 at the plasma membrane in epithelial cells. Functions also as a receptor for aldosterone mediating rapid regulation of vascular contractibility through the PI3K/ERK signaling pathway. Involved in cancer progression regulation. Stimulates cancer-associated fibroblast (CAF) proliferation by a rapid genomic response through the EGFR/ERK transduction pathway. Associated with EGFR, may act as a transcription factor activating growth regulatory genes (c-fos, cyclin D1). Promotes integrin alpha-5/beta-1 and fibronectin (FN) matrix assembly in breast cancer cells.11 Publications

GO - Molecular functioni

  1. chromatin binding Source: Ensembl
  2. estrogen receptor activity Source: UniProtKB
  3. G-protein coupled receptor activity Source: UniProtKB-KW
  4. mineralocorticoid receptor activity Source: UniProtKB
  5. steroid binding Source: UniProtKB

GO - Biological processi

  1. apoptotic chromosome condensation Source: UniProtKB
  2. cell cycle Source: UniProtKB-KW
  3. cellular response to estradiol stimulus Source: UniProtKB
  4. cellular response to glucose stimulus Source: UniProtKB
  5. cellular response to mineralocorticoid stimulus Source: UniProtKB
  6. cellular response to peptide hormone stimulus Source: UniProtKB
  7. cellular response to tumor necrosis factor Source: UniProtKB
  8. cytosolic calcium ion homeostasis Source: UniProtKB
  9. inflammatory response Source: UniProtKB-KW
  10. innate immune response Source: UniProtKB-KW
  11. intracellular steroid hormone receptor signaling pathway Source: UniProtKB
  12. mineralocorticoid receptor signaling pathway Source: GOC
  13. negative regulation of cell cycle arrest Source: UniProtKB
  14. negative regulation of cell proliferation Source: UniProtKB
  15. negative regulation of DNA metabolic process Source: UniProtKB
  16. negative regulation of fat cell differentiation Source: UniProtKB
  17. negative regulation of gene expression Source: UniProtKB
  18. negative regulation of inflammatory response Source: UniProtKB
  19. negative regulation of leukocyte activation Source: UniProtKB
  20. negative regulation of lipid biosynthetic process Source: UniProtKB
  21. neuronal action potential Source: UniProtKB
  22. nuclear fragmentation involved in apoptotic nuclear change Source: UniProtKB
  23. positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway Source: UniProtKB
  24. positive regulation of apoptotic process Source: UniProtKB
  25. positive regulation of cAMP biosynthetic process Source: UniProtKB
  26. positive regulation of cell migration Source: UniProtKB
  27. positive regulation of cell proliferation Source: UniProtKB
  28. positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
  29. positive regulation of cytosolic calcium ion concentration Source: UniProtKB
  30. positive regulation of endothelial cell apoptotic process Source: UniProtKB
  31. positive regulation of epidermal growth factor receptor signaling pathway Source: UniProtKB
  32. positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
  33. positive regulation of establishment of protein localization to plasma membrane Source: UniProtKB
  34. positive regulation of extrinsic apoptotic signaling pathway Source: UniProtKB
  35. positive regulation of gene expression Source: UniProtKB
  36. positive regulation of G-protein coupled receptor protein signaling pathway Source: UniProtKB
  37. positive regulation of inositol trisphosphate biosynthetic process Source: UniProtKB
  38. positive regulation of insulin secretion Source: UniProtKB
  39. positive regulation of MAPK cascade Source: UniProtKB
  40. positive regulation of neurogenesis Source: UniProtKB
  41. positive regulation of neurotransmitter secretion Source: UniProtKB
  42. positive regulation of phosphatidylinositol 3-kinase signaling Source: UniProtKB
  43. positive regulation of protein phosphorylation Source: UniProtKB
  44. positive regulation of release of cytochrome c from mitochondria Source: UniProtKB
  45. positive regulation of release of sequestered calcium ion into cytosol Source: UniProtKB
  46. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  47. positive regulation of uterine smooth muscle contraction Source: UniProtKB
  48. positive regulation of vasodilation Source: UniProtKB
  49. steroid hormone mediated signaling pathway Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Apoptosis, Cell cycle, Differentiation, Immunity, Inflammatory response, Innate immunity, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled estrogen receptor 1
Alternative name(s):
Chemoattractant receptor-like 2
G protein-coupled estrogen receptor 1
G-protein coupled receptor 30
Membrane estrogen receptor
Short name:
mER
Gene namesi
Name:Gper1
Synonyms:Cmkrl2, Gper, Gpr30
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:1924104. Gper1.

Subcellular locationi

Nucleus By similarity. Cytoplasm. Cytoplasmperinuclear region By similarity. Cytoplasm By similarity. Cytoplasmcytoskeleton By similarity. Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity. Golgi apparatus membrane; Multi-pass membrane protein By similarity. Cell projectiondendrite By similarity. Cytoplasmic vesicle membrane; Multi-pass membrane protein By similarity. Early endosome By similarity. Recycling endosome By similarity. Golgi apparatustrans-Golgi network By similarity. Cell projectiondendritic spine membrane; Multi-pass membrane protein By similarity. Cell projectionaxon By similarity. Cell junctionsynapsepostsynaptic cell membranepostsynaptic density By similarity. Mitochondrion membrane; Multi-pass membrane protein By similarity
Note: Colocalized with BSN to the active zone of presynaptic density. Colocalized with DLG4/PSD95 and neurabin-2 PPP1R9B in neuronal synaptosomes. Endocytosed in a agonist- and arrestin-independent manner. Colocalized with RAMP3 and clathrin-coated pits at the plasma membrane. Colocalized with transferrin receptor at the plasma membrane and perinuclear region. Accumulated and colocalized with RAB11 proteins in recycling endosomes and trans-Golgi network (TGN), but does neither recycle back to the cell surface nor traffics to late endosome or lysosome. Colocalized with calnexin in the endoplasmic reticulum. Traffics to intracellular sites via cytokeratin intermediate filaments like KRT7 and KRT8 after constitutive endocytosis in epithelial cells. Colocalized with EGFR in the nucleus of agonist-induced cancer-associated fibroblasts (CAF) By similarity.5 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6262Extracellular Reviewed predictionAdd
BLAST
Transmembranei63 – 8422Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini85 – 9612Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei97 – 12024Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini121 – 13212Extracellular Reviewed predictionAdd
BLAST
Transmembranei133 – 15321Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini154 – 17522Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei176 – 19419Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini195 – 22026Extracellular Reviewed predictionAdd
BLAST
Transmembranei221 – 23616Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini237 – 25923Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei260 – 28021Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini281 – 30626Extracellular Reviewed predictionAdd
BLAST
Transmembranei307 – 32721Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini328 – 37548Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. axon Source: UniProtKB
  2. axon terminus Source: UniProtKB
  3. cell junction Source: UniProtKB-KW
  4. cytoplasm Source: UniProtKB
  5. cytoplasmic vesicle membrane Source: UniProtKB
  6. dendrite Source: UniProtKB
  7. dendritic shaft Source: UniProtKB
  8. dendritic spine head Source: UniProtKB
  9. dendritic spine membrane Source: UniProtKB
  10. early endosome Source: UniProtKB
  11. endoplasmic reticulum Source: UniProtKB
  12. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  13. Golgi apparatus Source: UniProtKB
  14. Golgi membrane Source: UniProtKB-SubCell
  15. integral component of membrane Source: UniProtKB-KW
  16. intracellular Source: UniProtKB
  17. keratin filament Source: UniProtKB
  18. mitochondrial membrane Source: UniProtKB
  19. neuronal postsynaptic density Source: UniProtKB
  20. nuclear envelope Source: UniProtKB
  21. nucleus Source: UniProtKB
  22. perinuclear region of cytoplasm Source: UniProtKB
  23. plasma membrane Source: UniProtKB
  24. postsynaptic density Source: UniProtKB
  25. postsynaptic membrane Source: UniProtKB-KW
  26. presynaptic active zone Source: UniProtKB
  27. presynaptic membrane Source: UniProtKB
  28. recycling endosome Source: UniProtKB
  29. trans-Golgi network Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Endoplasmic reticulum, Endosome, Golgi apparatus, Membrane, Mitochondrion, Nucleus, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Disruption phenotypei

Strong variations in phenotypes, probably depending on the distinct targeting strategies, genetic background and experimental conditions used in the different experiments. According to 1 Publication, mice are viable and fertile and do not display any gross physical, immunological, reproductive and neurological abnormalities, but show 17-beta-estradiol (E2)-induced alleviated thymic atrophy. According to 1 Publication, male mice display increased body size, femur length, bone mass and cell proliferative activity within the growth plate. According to 1 Publication, female mice, but not male, show reduced body weight and skeletal growth, hyperglycemia, impaired glucose tolerance with reduced glucose-stimulated insulin release and increased blood pressure. According to 1 Publication mice show increased body weight, visceral adiposity, vascular tone and blood pressure. No visible phenotype according to 1 Publication.5 Publications

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi375 – 3751V → A: Loss of interaction with DLG4. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 375375G-protein coupled estrogen receptor 1PRO_0000069311Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine By similarity
Glycosylationi32 – 321N-linked (GlcNAc...) Reviewed prediction
Glycosylationi44 – 441N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi130 ↔ 207 Reviewed prediction

Post-translational modificationi

Ubiquitinated; ubiquitination occurs at the plasma membrane and leads to proteasome-mediated degradation By similarity.
N-glycosylated.1 Publication

Keywords - PTMi

Acetylation, Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

PRIDEiQ8BMP4.

Expressioni

Tissue specificityi

Expressed in brain, heart, spleen, preadipocytes, mature adipocytes and primary hippocampal neurons. Expressed in neurons of the hippocampus, hypothalamic paraventricular nucleus (PVH), supraoptic nucleus (SON) and the median eminence. Expressed in the nucleus ambiguous (at protein level). Expressed in brain, pituitary gland, adrenal medulla, renal pelvis, ovary, endothelial cells, visceral fat tissues and islets of Langerhans.6 Publications

Inductioni

Up-regulated during adipogenesis.1 Publication

Gene expression databases

BgeeiQ8BMP4.
CleanExiMM_GPER.
GenevestigatoriQ8BMP4.

Interactioni

Subunit structurei

Interacts with RAMP3. Interacts with KRT7 and KRT8. Interacts with EGFR; the interaction increases after agonist-induced stimulation in cancer-associated fibroblasts (CAF). Interacts with EGFR and ESR1. Interacts (via C-terminus tail motif) with DLG4 (via N-terminus tandem pair of PDZ domains); the interaction is direct and induces the increase of GPER1 protein levels residing at the plasma membrane surface in a estradiol-independent manner By similarity. Homodimer Inferred. Heterodimer; heterodimerizes with other G-protein-coupled receptor (GPCRs) like CRHR1, HTR1A and PAQR8.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ8BMP4.
SMRiQ8BMP4. Positions 57-336.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG151076.
GeneTreeiENSGT00530000063910.
HOGENOMiHOG000013114.
HOVERGENiHBG005351.
InParanoidiB2RRW0.
KOiK04246.
OMAiQHARLSC.
OrthoDBiEOG7WX08J.
TreeFamiTF333506.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BMP4-1 [UniParc]FASTAAdd to Basket

« Hide

MDATTPAQTV GVEIYLGPVW PAPSNSTPLA LNLSLALRED APGNLTGDLS    50
EHQQYVIALF LSCLYTIFLF PIGFVGNILI LVVNISFREK MTIPDLYFIN 100
LAAADLILVA DSLIEVFNLD EQYYDIAVLC TFMSLFLQIN MYSSVFFLTW 150
MSFDRYLALA KAMRCGLFRT KHHARLSCGL IWMASVSATL VPFTAVHLRH 200
TEEACFCFAD VREVQWLEVT LGFIMPFAII GLCYSLIVRA LIRAHRHRGL 250
RPRRQKALRM IFAVVLVFFI CWLPENVFIS VHLLQWTQPG DTPCKQSFRH 300
AYPLTGHIVN LAAFSNSCLN PLIYSFLGET FRDKLRLYVE QKTSLPALNR 350
FCHATLKAVI PDSTEQSEVR FSSAV 375
Length:375
Mass (Da):42,479
Last modified:July 27, 2011 - v2
Checksum:iAF7E4795C3A9A405
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti314 – 3141F → I in BAC26930. 1 Publication
Sequence conflicti369 – 3691V → I in BAB31118. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK018203 mRNA. Translation: BAB31118.1.
AK030375 mRNA. Translation: BAC26930.1.
CH466529 Genomic DNA. Translation: EDL19153.1.
BC138598 mRNA. Translation: AAI38599.1.
BC138616 mRNA. Translation: AAI38617.1.
CCDSiCCDS19811.1.
RefSeqiNP_084047.2. NM_029771.3.
XP_006504820.1. XM_006504757.1.
UniGeneiMm.389706.

Genome annotation databases

EnsembliENSMUST00000066211; ENSMUSP00000080370; ENSMUSG00000053647.
GeneIDi76854.
KEGGimmu:76854.
UCSCiuc009agr.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK018203 mRNA. Translation: BAB31118.1 .
AK030375 mRNA. Translation: BAC26930.1 .
CH466529 Genomic DNA. Translation: EDL19153.1 .
BC138598 mRNA. Translation: AAI38599.1 .
BC138616 mRNA. Translation: AAI38617.1 .
CCDSi CCDS19811.1.
RefSeqi NP_084047.2. NM_029771.3.
XP_006504820.1. XM_006504757.1.
UniGenei Mm.389706.

3D structure databases

ProteinModelPortali Q8BMP4.
SMRi Q8BMP4. Positions 57-336.
ModBasei Search...
MobiDBi Search...

Chemistry

GuidetoPHARMACOLOGYi 221.

Protein family/group databases

GPCRDBi Search...

Proteomic databases

PRIDEi Q8BMP4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000066211 ; ENSMUSP00000080370 ; ENSMUSG00000053647 .
GeneIDi 76854.
KEGGi mmu:76854.
UCSCi uc009agr.2. mouse.

Organism-specific databases

CTDi 2852.
MGIi MGI:1924104. Gper1.

Phylogenomic databases

eggNOGi NOG151076.
GeneTreei ENSGT00530000063910.
HOGENOMi HOG000013114.
HOVERGENi HBG005351.
InParanoidi B2RRW0.
KOi K04246.
OMAi QHARLSC.
OrthoDBi EOG7WX08J.
TreeFami TF333506.

Miscellaneous databases

NextBioi 345931.
PROi Q8BMP4.
SOURCEi Search...

Gene expression databases

Bgeei Q8BMP4.
CleanExi MM_GPER.
Genevestigatori Q8BMP4.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Medulla oblongata and Pituitary.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  4. Cited for: ABSENCE OF ESTROGEN-BINDING, DISRUPTION PHENOTYPE.
  5. Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  6. "Deletion of the G protein-coupled receptor 30 impairs glucose tolerance, reduces bone growth, increases blood pressure, and eliminates estradiol-stimulated insulin release in female mice."
    Martensson U.E., Salehi S.A., Windahl S., Gomez M.F., Sward K., Daszkiewicz-Nilsson J., Wendt A., Andersson N., Hellstrand P., Grande P.O., Owman C., Rosen C.J., Adamo M.L., Lundquist I., Rorsman P., Nilsson B.O., Ohlsson C., Olde B., Leeb-Lundberg L.M.
    Endocrinology 150:687-698(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  7. "Localisation of GPR30, a novel G protein-coupled oestrogen receptor, suggests multiple functions in rodent brain and peripheral tissues."
    Hazell G.G., Yao S.T., Roper J.A., Prossnitz E.R., O'Carroll A.M., Lolait S.J.
    J. Endocrinol. 202:223-236(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  8. Cited for: FUNCTION.
  9. "Mechanisms of estradiol-induced insulin secretion by the G protein-coupled estrogen receptor GPR30/GPER in pancreatic beta-cells."
    Sharma G., Prossnitz E.R.
    Endocrinology 152:3030-3039(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  10. "GPR30 deficiency causes increased bone mass, mineralization, and growth plate proliferative activity in male mice."
    Ford J., Hajibeigi A., Long M., Hahner L., Gore C., Hsieh J.T., Clegg D., Zerwekh J., Oz O.K.
    J. Bone Miner. Res. 26:298-307(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  11. "The GPER1 agonist G-1 attenuates endothelial cell proliferation by inhibiting DNA synthesis and accumulating cells in the S and G2 phases of the cell cycle."
    Holm A., Baldetorp B., Olde B., Leeb-Lundberg L.M., Nilsson B.O.
    J. Vasc. Res. 48:327-335(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  12. "G protein-coupled estrogen receptor 1/G protein-coupled receptor 30 localizes in the plasma membrane and traffics intracellularly on cytokeratin intermediate filaments."
    Sanden C., Broselid S., Cornmark L., Andersson K., Daszkiewicz-Nilsson J., Martensson U.E., Olde B., Leeb-Lundberg L.M.
    Mol. Pharmacol. 79:400-410(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION, SUBCELLULAR LOCATION.
  13. "G-protein-coupled receptor 30 mediates rapid neuroprotective effects of estrogen via depression of NR2B-containing NMDA receptors."
    Liu S.B., Zhang N., Guo Y.Y., Zhao R., Shi T.Y., Feng S.F., Wang S.Q., Yang Q., Li X.Q., Wu Y.M., Ma L., Hou Y., Xiong L.Z., Zhang W., Zhao M.G.
    J. Neurosci. 32:4887-4900(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  14. "Role of ERbeta and GPR30 in the endocrine pancreas: A matter of estrogen dose."
    Ropero A.B., Pang Y., Alonso-Magdalena P., Thomas P., Nadal A.
    Steroids 77:951-958(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  15. "GPER mediates the inhibitory actions of estrogen on adipogenesis in 3T3-L1 cells through perturbation of mitotic clonal expansion."
    Zhu P., Yuen J.M., Sham K.W., Cheng C.H.
    Gen. Comp. Endocrinol. 193:19-26(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION.
  16. "Post-synaptic density-95 (PSD-95) binding capacity of G-protein-coupled receptor 30 (GPR30), an estrogen receptor that can be identified in hippocampal dendritic spines."
    Akama K.T., Thompson L.I., Milner T.A., McEwen B.S.
    J. Biol. Chem. 288:6438-6450(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT, MUTAGENESIS OF VAL-375.
  17. "G-protein-coupled receptor 30 interacts with receptor activity-modifying protein 3 and confers sex-dependent cardioprotection."
    Lenhart P.M., Broselid S., Barrick C.J., Leeb-Lundberg L.M., Caron K.M.
    J. Mol. Endocrinol. 51:191-202(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  18. "G protein-coupled estrogen receptor is required for the neuritogenic mechanism of 17beta-estradiol in developing hippocampal neurons."
    Ruiz-Palmero I., Hernando M., Garcia-Segura L.M., Arevalo M.A.
    Mol. Cell. Endocrinol. 372:105-115(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  19. "A critical review of fundamental controversies in the field of GPR30 research."
    Langer G., Bader B., Meoli L., Isensee J., Delbeck M., Noppinger P.R., Otto C.
    Steroids 75:603-610(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiGPER1_MOUSE
AccessioniPrimary (citable) accession number: Q8BMP4
Secondary accession number(s): B2RRW0, Q9D392
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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