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Q8BMN3

- ACHB3_MOUSE

UniProt

Q8BMN3 - ACHB3_MOUSE

Protein

Neuronal acetylcholine receptor subunit beta-3

Gene

Chrnb3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.By similarity

    GO - Molecular functioni

    1. acetylcholine-activated cation-selective channel activity Source: InterPro
    2. acetylcholine binding Source: Ensembl
    3. drug binding Source: Ensembl

    GO - Biological processi

    1. protein heterooligomerization Source: Ensembl

    Keywords - Molecular functioni

    Ion channel, Ligand-gated ion channel, Receptor

    Keywords - Biological processi

    Ion transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_198583. Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.
    REACT_198585. Highly calcium permeable nicotinic acetylcholine receptors.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neuronal acetylcholine receptor subunit beta-3
    Gene namesi
    Name:Chrnb3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:106212. Chrnb3.

    Subcellular locationi

    GO - Cellular componenti

    1. acetylcholine-gated channel complex Source: Ensembl
    2. cell junction Source: UniProtKB-KW
    3. neuron projection Source: Ensembl
    4. postsynaptic membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3030Sequence AnalysisAdd
    BLAST
    Chaini31 – 464434Neuronal acetylcholine receptor subunit beta-3PRO_0000000384Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi55 – 551N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi159 ↔ 173By similarity
    Glycosylationi172 – 1721N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8BMN3.
    PRIDEiQ8BMN3.

    PTM databases

    PhosphoSiteiQ8BMN3.

    Expressioni

    Gene expression databases

    BgeeiQ8BMN3.
    GenevestigatoriQ8BMN3.

    Interactioni

    Subunit structurei

    Neuronal AChR seems to be composed of two different types of subunits: alpha and beta.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BMN3.
    SMRiQ8BMN3. Positions 32-346, 401-452.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini31 – 238208ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini327 – 434108CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei239 – 26325HelicalSequence AnalysisAdd
    BLAST
    Transmembranei271 – 28818HelicalSequence AnalysisAdd
    BLAST
    Transmembranei305 – 32622HelicalSequence AnalysisAdd
    BLAST
    Transmembranei435 – 45319HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG252943.
    GeneTreeiENSGT00750000117712.
    HOGENOMiHOG000006756.
    HOVERGENiHBG003756.
    InParanoidiQ8BMN3.
    KOiK04814.
    OMAiDRYSFPD.
    OrthoDBiEOG72JWGV.
    PhylomeDBiQ8BMN3.
    TreeFamiTF315605.

    Family and domain databases

    Gene3Di1.20.120.370. 2 hits.
    2.70.170.10. 1 hit.
    InterProiIPR027361. Acetylcholine_rcpt_TM.
    IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    IPR018000. Neurotransmitter_ion_chnl_CS.
    IPR002394. Nicotinic_acetylcholine_rcpt.
    [Graphical view]
    PANTHERiPTHR18945. PTHR18945. 1 hit.
    PfamiPF02931. Neur_chan_LBD. 1 hit.
    PF02932. Neur_chan_memb. 2 hits.
    [Graphical view]
    PRINTSiPR00254. NICOTINICR.
    PR00252. NRIONCHANNEL.
    SUPFAMiSSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 1 hit.
    TIGRFAMsiTIGR00860. LIC. 1 hit.
    PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8BMN3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTGFLRVFLA LSATLSGSWV TLTATAGLSS VAEHEDALLR HLFQGYQKCV    50
    RPVLNSSDII KVYFGLKISQ LVDVDEKNQL MTTNVWLKQE WTDQKLRWNP 100
    EDYGGINSIK VPSESLWLPD IVLFENADGR FEGSLMTKAI VKSSGTVSWT 150
    PPASYKSSCT MDVTFFPFDK QNCSMKFGSW TYDGTMVDLI LINENVDRKD 200
    FFDNGEWEIL NAKGMKGNRR EGFYSYPFVT YSFVLRRLPL FYTLFLIIPC 250
    LGLSFLTVLV FYLPSDEGEK LSLSTSVLVS LTVFLLVIEE IIPSSSKVIP 300
    LIGEYLLFIM IFVTLSIIVT VFVINVHHRS SSTYHPMAPW VKRLFLEKLP 350
    RWLCMKDPRD RFSFPDGTES KGTVRGKFPG KKKQTPTSDG ERVLVAFLEK 400
    ASESIRYISR HVKKEHFISQ VVQDWKFVAQ VLDRIFLWLF LTASVLGSVL 450
    IFIPALKMWI HRFH 464
    Length:464
    Mass (Da):53,112
    Last modified:March 1, 2003 - v1
    Checksum:i2ECEA3E0DAF2D5EB
    GO
    Isoform 2 (identifier: Q8BMN3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         75-89: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:449
    Mass (Da):51,282
    Checksum:iFF54824C5DAAC8E7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti170 – 1701K → R in AAL75573. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei75 – 8915Missing in isoform 2. 1 PublicationVSP_013775Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF467896 mRNA. Translation: AAL75573.1.
    AY574268 mRNA. Translation: AAS90364.1.
    AK017571 mRNA. Translation: BAB30812.1.
    AK030464 mRNA. Translation: BAC26973.1.
    BC058193 mRNA. Translation: AAH58193.1.
    CCDSiCCDS22216.1. [Q8BMN3-2]
    CCDS22217.1. [Q8BMN3-1]
    RefSeqiNP_081730.1. NM_027454.4. [Q8BMN3-2]
    NP_775304.1. NM_173212.4. [Q8BMN3-1]
    UniGeneiMm.110444.

    Genome annotation databases

    EnsembliENSMUST00000060943; ENSMUSP00000052297; ENSMUSG00000031492. [Q8BMN3-1]
    ENSMUST00000079463; ENSMUSP00000078428; ENSMUSG00000031492. [Q8BMN3-2]
    GeneIDi108043.
    KEGGimmu:108043.
    UCSCiuc009lit.2. mouse. [Q8BMN3-1]
    uc009liu.2. mouse. [Q8BMN3-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF467896 mRNA. Translation: AAL75573.1 .
    AY574268 mRNA. Translation: AAS90364.1 .
    AK017571 mRNA. Translation: BAB30812.1 .
    AK030464 mRNA. Translation: BAC26973.1 .
    BC058193 mRNA. Translation: AAH58193.1 .
    CCDSi CCDS22216.1. [Q8BMN3-2 ]
    CCDS22217.1. [Q8BMN3-1 ]
    RefSeqi NP_081730.1. NM_027454.4. [Q8BMN3-2 ]
    NP_775304.1. NM_173212.4. [Q8BMN3-1 ]
    UniGenei Mm.110444.

    3D structure databases

    ProteinModelPortali Q8BMN3.
    SMRi Q8BMN3. Positions 32-346, 401-452.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi Q8BMN3.
    GuidetoPHARMACOLOGYi 473.

    PTM databases

    PhosphoSitei Q8BMN3.

    Proteomic databases

    PaxDbi Q8BMN3.
    PRIDEi Q8BMN3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000060943 ; ENSMUSP00000052297 ; ENSMUSG00000031492 . [Q8BMN3-1 ]
    ENSMUST00000079463 ; ENSMUSP00000078428 ; ENSMUSG00000031492 . [Q8BMN3-2 ]
    GeneIDi 108043.
    KEGGi mmu:108043.
    UCSCi uc009lit.2. mouse. [Q8BMN3-1 ]
    uc009liu.2. mouse. [Q8BMN3-2 ]

    Organism-specific databases

    CTDi 1142.
    MGIi MGI:106212. Chrnb3.

    Phylogenomic databases

    eggNOGi NOG252943.
    GeneTreei ENSGT00750000117712.
    HOGENOMi HOG000006756.
    HOVERGENi HBG003756.
    InParanoidi Q8BMN3.
    KOi K04814.
    OMAi DRYSFPD.
    OrthoDBi EOG72JWGV.
    PhylomeDBi Q8BMN3.
    TreeFami TF315605.

    Enzyme and pathway databases

    Reactomei REACT_198583. Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.
    REACT_198585. Highly calcium permeable nicotinic acetylcholine receptors.

    Miscellaneous databases

    ChiTaRSi CHRNB3. mouse.
    NextBioi 359931.
    PROi Q8BMN3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8BMN3.
    Genevestigatori Q8BMN3.

    Family and domain databases

    Gene3Di 1.20.120.370. 2 hits.
    2.70.170.10. 1 hit.
    InterProi IPR027361. Acetylcholine_rcpt_TM.
    IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    IPR018000. Neurotransmitter_ion_chnl_CS.
    IPR002394. Nicotinic_acetylcholine_rcpt.
    [Graphical view ]
    PANTHERi PTHR18945. PTHR18945. 1 hit.
    Pfami PF02931. Neur_chan_LBD. 1 hit.
    PF02932. Neur_chan_memb. 2 hits.
    [Graphical view ]
    PRINTSi PR00254. NICOTINICR.
    PR00252. NRIONCHANNEL.
    SUPFAMi SSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 1 hit.
    TIGRFAMsi TIGR00860. LIC. 1 hit.
    PROSITEi PS00236. NEUROTR_ION_CHANNEL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Stitzel J.A., Lautner M.A., Jimenez M., Bhandarkar S.J., Curtis C.D., Remias J.
      Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. Groot-Kormelink P.J.
      Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Strain: BALB/c.
      Tissue: Brain.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6J.
      Tissue: Pituitary.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Eye.

    Entry informationi

    Entry nameiACHB3_MOUSE
    AccessioniPrimary (citable) accession number: Q8BMN3
    Secondary accession number(s): Q8R5H3, Q9CYK8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 24, 2005
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3