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Protein

Cytoskeleton-associated protein 4

Gene

Ckap4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

High-affinity epithelial cell surface receptor for APF.By similarity
Mediates the anchoring of the endoplasmic reticulum to microtubules.By similarity

Enzyme and pathway databases

ReactomeiR-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-5683826 Surfactant metabolism
R-MMU-6798695 Neutrophil degranulation
R-MMU-8957275 Post-translational protein phosphorylation

Names & Taxonomyi

Protein namesi
Recommended name:
Cytoskeleton-associated protein 4
Alternative name(s):
63-kDa cytoskeleton-linking membrane protein
Short name:
Climp-63
Short name:
p63
Gene namesi
Name:Ckap4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:2444926 Ckap4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 85CytoplasmicSequence analysisAdd BLAST85
Transmembranei86 – 108HelicalSequence analysisAdd BLAST23
Topological domaini109 – 575ExtracellularSequence analysisAdd BLAST467

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002524181 – 575Cytoskeleton-associated protein 4Add BLAST575

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei3PhosphoserineBy similarity1
Modified residuei17PhosphoserineBy similarity1
Modified residuei19PhosphoserineBy similarity1
Modified residuei21N6-acetyllysineCombined sources1
Lipidationi79S-palmitoyl cysteine; by ZDHHC2By similarity1
Modified residuei211PhosphoserineBy similarity1
Modified residuei292PhosphoserineBy similarity1
Modified residuei367PhosphoserineCombined sources1

Post-translational modificationi

Reversibly palmitoylated. Palmitoylation at Cys-79 by DHHC2 is required for its trafficking from the ER to the plasma membrane and for its perinuclear localization (By similarity).By similarity
Increased phosphorylation during mitosis prevents binding to microtubules.By similarity

Keywords - PTMi

Acetylation, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

EPDiQ8BMK4
MaxQBiQ8BMK4
PaxDbiQ8BMK4
PeptideAtlasiQ8BMK4
PRIDEiQ8BMK4

PTM databases

iPTMnetiQ8BMK4
PhosphoSitePlusiQ8BMK4
SwissPalmiQ8BMK4

Expressioni

Gene expression databases

BgeeiENSMUSG00000046841
CleanExiMM_CKAP4
GenevisibleiQ8BMK4 MM

Interactioni

Protein-protein interaction databases

BioGridi229721, 3 interactors
IntActiQ8BMK4, 3 interactors
MINTiQ8BMK4
STRINGi10090.ENSMUSP00000050336

Structurei

3D structure databases

ProteinModelPortaliQ8BMK4
SMRiQ8BMK4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili125 – 193Sequence analysisAdd BLAST69
Coiled coili236 – 438Sequence analysisAdd BLAST203
Coiled coili507 – 575Sequence analysisAdd BLAST69

Keywords - Domaini

Coiled coil, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIRS Eukaryota
ENOG4111Q54 LUCA
GeneTreeiENSGT00390000015968
HOGENOMiHOG000060146
HOVERGENiHBG101940
InParanoidiQ8BMK4
KOiK13999
OMAiFSGWCVH
OrthoDBiEOG091G067G
PhylomeDBiQ8BMK4
TreeFamiTF332395

Family and domain databases

InterProiView protein in InterPro
IPR028428 Ckap4
PANTHERiPTHR45161 PTHR45161, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BMK4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSAKQRGSK GGHGAASPSD KGAHPSGGAD DVAKKPPAAP QQPQPPAPHP
60 70 80 90 100
PQHPQNQAHR GGHRGRSSAA TANASSASCS RRLGRVLNFL FYLSLVAAAA
110 120 130 140 150
FSGWYVHHVL EEVQQVRRGH QDFSRQRDEL GQGLQGVEQK VQSLQATFGT
160 170 180 190 200
FESLLRNSQH KQDLTEKAVK EGESELNRIS EVLQKLQNEI LKDLSDGIHV
210 220 230 240 250
VKDARERDFT SLENTVEERL TELTKSINDN IAIFTDVQKR SQKEINEVKM
260 270 280 290 300
KVASLEESKG DRSQDVKTLK DAVKEVQASM MSRERDIEAL KSSLQTMESD
310 320 330 340 350
VYTEVRELVS LKQEQQAFKQ AADSERLALQ ALTEKLLRSE ESSSRLPEDI
360 370 380 390 400
RRLEEELQQL KVGAHGSEEG AVFKDSKALE ELQRQIEGLG ARLQYVEDGV
410 420 430 440 450
YSMQVASARH TESLESLLSK SQEYEQRLAM LQEHVGNLGS SSDLASTVRS
460 470 480 490 500
LGETQLALSS DLKELKQSLG ELPGTVESLQ EQVLSLLSQD QAQAEGLPPQ
510 520 530 540 550
DFLDRLSSLD NLKSSVSQVE SDLKMLRTAV DSLVAYSVKI ETNENNLESA
560 570
KGLLDDLRND LDRLFLKVEK IHEKI
Length:575
Mass (Da):63,692
Last modified:October 17, 2006 - v2
Checksum:i6967F47741C7033D
GO

Sequence cautioni

The sequence AAH25522 differs from that shown. Contaminating sequence. Vector contamination at the N-terminus.Curated
The sequence AAH25522 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAC41005 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti243K → M in AAH25522 (PubMed:15489334).Curated1
Sequence conflicti281M → I in BAC41005 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC140333 Genomic DNA No translation available.
AC150314 Genomic DNA No translation available.
BC025522 mRNA Translation: AAH25522.1 Different initiation.
BC138318 mRNA Translation: AAI38319.1
BC138320 mRNA Translation: AAI38321.1
AK030708 mRNA Translation: BAC27092.1
AK089935 mRNA Translation: BAC41005.1 Different initiation.
CCDSiCCDS24080.1
RefSeqiNP_780660.1, NM_175451.1
UniGeneiMm.334999

Genome annotation databases

EnsembliENSMUST00000053871; ENSMUSP00000050336; ENSMUSG00000046841
ENSMUST00000167671; ENSMUSP00000130304; ENSMUSG00000046841
GeneIDi216197
KEGGimmu:216197
UCSCiuc007gkq.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCKAP4_MOUSE
AccessioniPrimary (citable) accession number: Q8BMK4
Secondary accession number(s): B2RRB4, Q8BTK8, Q8R3F2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: October 17, 2006
Last modified: May 23, 2018
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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