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Protein

Methyltransferase-like protein 2

Gene

Mettl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probable S-adenosyl-L-methionine-dependent methyltransferase that mediates 3-methylcytidine modification of some tRNAs.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Methyltransferase-like protein 2 (EC:2.1.1.-)
Gene namesi
Name:Mettl2
Synonyms:D11Ertd768e
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1289171 Mettl2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002044532 – 389Methyltransferase-like protein 2Add BLAST388

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei4PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8BMK1
PaxDbiQ8BMK1
PeptideAtlasiQ8BMK1
PRIDEiQ8BMK1

PTM databases

iPTMnetiQ8BMK1
PhosphoSitePlusiQ8BMK1

Expressioni

Gene expression databases

BgeeiENSMUSG00000020691
CleanExiMM_METTL2
GenevisibleiQ8BMK1 MM

Interactioni

Protein-protein interaction databases

IntActiQ8BMK1 2 interactors.
MINTiQ8BMK1
STRINGi10090.ENSMUSP00000021030

Structurei

3D structure databases

ProteinModelPortaliQ8BMK1
SMRiQ8BMK1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2361 Eukaryota
ENOG410YAN4 LUCA
GeneTreeiENSGT00520000055554
HOGENOMiHOG000182278
HOVERGENiHBG075344
InParanoidiQ8BMK1
OMAiAWDHVET
OrthoDBiEOG091G1235
PhylomeDBiQ8BMK1
TreeFamiTF323232

Family and domain databases

InterProiView protein in InterPro
IPR013217 Methyltransf_12
IPR026113 MeTrfase
IPR029063 SAM-dependent_MTases
PANTHERiPTHR22809 PTHR22809, 1 hit
PfamiView protein in Pfam
PF08242 Methyltransf_12, 1 hit
PIRSFiPIRSF037755 Mettl2_prd, 1 hit
SUPFAMiSSF53335 SSF53335, 2 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BMK1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAASFPEGVP ETEDGKRPQF GHRFLSDPAR VFHHNAWDNV KWSEEQAAAA
60 70 80 90 100
ERKVQENSSP LVCPEKQVDY EVNAHKYWDD FYRIHENGFF KDRHWLFTEF
110 120 130 140 150
PELAPSHSHL TGVPLEKQRS DVCEDGPGLT AEQHKCSCAS PGCETQVPPL
160 170 180 190 200
EEPVTQKLGH LEISGEEFPG SSATYRILEV GCGVGNTVFP ILQTNNNPNL
210 220 230 240 250
FVYCCDFSAT AIELLKTNSQ YDPSRCYAFV HDLCDEDQSY PVPEDSLDVI
260 270 280 290 300
VLIFVLSAIV PDKMQKAISK LSRLLKPGGV MLLRDYGRYD MAQLRFKKGQ
310 320 330 340 350
CLSGNFYVRG DGTRVYFFTQ GELDTLFTAA GLEKVQNLVD RRLQVNRGKQ
360 370 380
LTMYRVWIQC KYSKPLALRS SQHVPIPHAT ESSSHSGLL
Length:389
Mass (Da):43,912
Last modified:October 3, 2003 - v2
Checksum:i19FCFB657386B455
GO
Isoform 2 (identifier: Q8BMK1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-263: Missing.

Show »
Length:126
Mass (Da):14,368
Checksum:i2DECA181BA996FE0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti134H → R in BAE31989 (PubMed:16141072).Curated1
Sequence conflicti200L → P in AAH89591 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0084791 – 263Missing in isoform 2. 2 PublicationsAdd BLAST263

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030739 mRNA Translation: BAC27107.1
AK048040 mRNA Translation: BAC33219.1
AK153431 mRNA Translation: BAE31989.1
BC089591 mRNA Translation: AAH89591.1
CCDSiCCDS25538.1 [Q8BMK1-1]
RefSeqiNP_766155.3, NM_172567.3 [Q8BMK1-1]
UniGeneiMm.270091

Genome annotation databases

EnsembliENSMUST00000021030; ENSMUSP00000021030; ENSMUSG00000020691 [Q8BMK1-1]
GeneIDi52686
KEGGimmu:52686
UCSCiuc007lxa.2 mouse [Q8BMK1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiMETL2_MOUSE
AccessioniPrimary (citable) accession number: Q8BMK1
Secondary accession number(s): Q3U5T7, Q5EBH8, Q8BXC2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: October 3, 2003
Last modified: March 28, 2018
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome