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Protein

Methyltransferase-like protein 2

Gene

Mettl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Probable S-adenosyl-L-methionine-dependent methyltransferase that mediates 3-methylcytidine modification of some tRNAs.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Methyltransferase-like protein 2 (EC:2.1.1.-)
Gene namesi
Name:Mettl2
Synonyms:D11Ertd768e
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1289171. Mettl2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 389389Methyltransferase-like protein 2PRO_0000204453Add
BLAST

Proteomic databases

EPDiQ8BMK1.
MaxQBiQ8BMK1.
PaxDbiQ8BMK1.
PRIDEiQ8BMK1.

PTM databases

iPTMnetiQ8BMK1.
PhosphoSiteiQ8BMK1.

Expressioni

Gene expression databases

BgeeiQ8BMK1.
CleanExiMM_METTL2.
GenevisibleiQ8BMK1. MM.

Interactioni

Protein-protein interaction databases

IntActiQ8BMK1. 2 interactions.
MINTiMINT-4101795.
STRINGi10090.ENSMUSP00000021030.

Structurei

3D structure databases

ProteinModelPortaliQ8BMK1.
SMRiQ8BMK1. Positions 169-281.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2361. Eukaryota.
ENOG410YAN4. LUCA.
GeneTreeiENSGT00520000055554.
HOGENOMiHOG000182278.
HOVERGENiHBG075344.
InParanoidiQ8BMK1.
OMAiDIIVMIF.
OrthoDBiEOG7VX8ZJ.
PhylomeDBiQ8BMK1.
TreeFamiTF323232.

Family and domain databases

Gene3Di3.40.50.150. 2 hits.
InterProiIPR026113. MeTrfase.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR22809. PTHR22809. 2 hits.
SUPFAMiSSF53335. SSF53335. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BMK1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAASFPEGVP ETEDGKRPQF GHRFLSDPAR VFHHNAWDNV KWSEEQAAAA
60 70 80 90 100
ERKVQENSSP LVCPEKQVDY EVNAHKYWDD FYRIHENGFF KDRHWLFTEF
110 120 130 140 150
PELAPSHSHL TGVPLEKQRS DVCEDGPGLT AEQHKCSCAS PGCETQVPPL
160 170 180 190 200
EEPVTQKLGH LEISGEEFPG SSATYRILEV GCGVGNTVFP ILQTNNNPNL
210 220 230 240 250
FVYCCDFSAT AIELLKTNSQ YDPSRCYAFV HDLCDEDQSY PVPEDSLDVI
260 270 280 290 300
VLIFVLSAIV PDKMQKAISK LSRLLKPGGV MLLRDYGRYD MAQLRFKKGQ
310 320 330 340 350
CLSGNFYVRG DGTRVYFFTQ GELDTLFTAA GLEKVQNLVD RRLQVNRGKQ
360 370 380
LTMYRVWIQC KYSKPLALRS SQHVPIPHAT ESSSHSGLL
Length:389
Mass (Da):43,912
Last modified:October 3, 2003 - v2
Checksum:i19FCFB657386B455
GO
Isoform 2 (identifier: Q8BMK1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-263: Missing.

Show »
Length:126
Mass (Da):14,368
Checksum:i2DECA181BA996FE0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti134 – 1341H → R in BAE31989 (PubMed:16141072).Curated
Sequence conflicti200 – 2001L → P in AAH89591 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 263263Missing in isoform 2. 2 PublicationsVSP_008479Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030739 mRNA. Translation: BAC27107.1.
AK048040 mRNA. Translation: BAC33219.1.
AK153431 mRNA. Translation: BAE31989.1.
BC089591 mRNA. Translation: AAH89591.1.
CCDSiCCDS25538.1. [Q8BMK1-1]
RefSeqiNP_766155.3. NM_172567.3. [Q8BMK1-1]
UniGeneiMm.270091.

Genome annotation databases

EnsembliENSMUST00000021030; ENSMUSP00000021030; ENSMUSG00000020691. [Q8BMK1-1]
GeneIDi52686.
KEGGimmu:52686.
UCSCiuc007lxa.2. mouse. [Q8BMK1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030739 mRNA. Translation: BAC27107.1.
AK048040 mRNA. Translation: BAC33219.1.
AK153431 mRNA. Translation: BAE31989.1.
BC089591 mRNA. Translation: AAH89591.1.
CCDSiCCDS25538.1. [Q8BMK1-1]
RefSeqiNP_766155.3. NM_172567.3. [Q8BMK1-1]
UniGeneiMm.270091.

3D structure databases

ProteinModelPortaliQ8BMK1.
SMRiQ8BMK1. Positions 169-281.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8BMK1. 2 interactions.
MINTiMINT-4101795.
STRINGi10090.ENSMUSP00000021030.

PTM databases

iPTMnetiQ8BMK1.
PhosphoSiteiQ8BMK1.

Proteomic databases

EPDiQ8BMK1.
MaxQBiQ8BMK1.
PaxDbiQ8BMK1.
PRIDEiQ8BMK1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021030; ENSMUSP00000021030; ENSMUSG00000020691. [Q8BMK1-1]
GeneIDi52686.
KEGGimmu:52686.
UCSCiuc007lxa.2. mouse. [Q8BMK1-1]

Organism-specific databases

CTDi52686.
MGIiMGI:1289171. Mettl2.

Phylogenomic databases

eggNOGiKOG2361. Eukaryota.
ENOG410YAN4. LUCA.
GeneTreeiENSGT00520000055554.
HOGENOMiHOG000182278.
HOVERGENiHBG075344.
InParanoidiQ8BMK1.
OMAiDIIVMIF.
OrthoDBiEOG7VX8ZJ.
PhylomeDBiQ8BMK1.
TreeFamiTF323232.

Miscellaneous databases

PROiQ8BMK1.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BMK1.
CleanExiMM_METTL2.
GenevisibleiQ8BMK1. MM.

Family and domain databases

Gene3Di3.40.50.150. 2 hits.
InterProiIPR026113. MeTrfase.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR22809. PTHR22809. 2 hits.
SUPFAMiSSF53335. SSF53335. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Bone marrow and Head.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Heart.

Entry informationi

Entry nameiMETL2_MOUSE
AccessioniPrimary (citable) accession number: Q8BMK1
Secondary accession number(s): Q3U5T7, Q5EBH8, Q8BXC2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: October 3, 2003
Last modified: June 8, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.