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Protein

Cell growth regulator with RING finger domain protein 1

Gene

Cgrrf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Able to inhibit growth in several cell lines.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri274 – 309RING-typePROSITE-ProRule annotationAdd BLAST36

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Growth arrest
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Cell growth regulator with RING finger domain protein 1
Alternative name(s):
Cell growth regulatory gene 19 protein
Gene namesi
Name:Cgrrf1
Synonyms:Cgr19
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1916368. Cgrrf1.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000558701 – 332Cell growth regulator with RING finger domain protein 1Add BLAST332

Proteomic databases

MaxQBiQ8BMJ7.
PaxDbiQ8BMJ7.
PRIDEiQ8BMJ7.

PTM databases

iPTMnetiQ8BMJ7.
PhosphoSitePlusiQ8BMJ7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000055128.
CleanExiMM_CGRRF1.
GenevisibleiQ8BMJ7. MM.

Interactioni

Protein-protein interaction databases

BioGridi213033. 1 interactor.
STRINGi10090.ENSMUSP00000070548.

Structurei

3D structure databases

ProteinModelPortaliQ8BMJ7.
SMRiQ8BMJ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri274 – 309RING-typePROSITE-ProRule annotationAdd BLAST36

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410ITZ9. Eukaryota.
ENOG4111F4I. LUCA.
GeneTreeiENSGT00390000004542.
HOGENOMiHOG000111607.
HOVERGENiHBG050932.
InParanoidiQ8BMJ7.
OMAiFYCFRIS.
OrthoDBiEOG091G0G0X.
PhylomeDBiQ8BMJ7.
TreeFamiTF328102.

Family and domain databases

InterProiView protein in InterPro
IPR001841. Znf_RING.
SMARTiView protein in SMART
SM00184. RING. 1 hit.
PROSITEiView protein in PROSITE
PS50089. ZF_RING_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8BMJ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVFLVTLY EYSPLFYIAV VFTCFIVTTG LVLGWFGWDV PVILRNSEET
60 70 80 90 100
QFSTRAFKKQ MRQVKNPFGL EITNSSAASL ATGMALRTDC LEDSRLTCYW
110 120 130 140 150
GCSVQKLYEA LQKHAYCFRI STPQALEEAL YSDYLHREQY FIKKHSKEEI
160 170 180 190 200
YCQLPSDTEI EDFGPVPRSR YPLVALLTLA DEDDREIYDI ISMVSVIHIP
210 220 230 240 250
DKTYKLPCRI LYQYLILAQG QFYDLKQLFM SANNSPPPSN DESPEDRSVE
260 270 280 290 300
QSLLEKVGLA GNDGDPVEES SRDCVVCQNG GVNWVLLPCR HACLCDSCVR
310 320 330
YFKQCPMCRQ FVQESFALCG QKEPDKDLLE TS
Length:332
Mass (Da):37,899
Last modified:March 1, 2003 - v1
Checksum:i5012EE360929ECC1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti82 – 83TG → S in AAH37677 (PubMed:15489334).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030755 mRNA. Translation: BAC27121.1.
AK154797 mRNA. Translation: BAE32835.1.
BC037677 mRNA. Translation: AAH37677.1.
CCDSiCCDS26981.1.
RefSeqiNP_081108.2. NM_026832.3.
XP_006519548.1. XM_006519485.3.
UniGeneiMm.343809.

Genome annotation databases

EnsembliENSMUST00000068532; ENSMUSP00000070548; ENSMUSG00000055128.
GeneIDi68755.
KEGGimmu:68755.
UCSCiuc007thj.1. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCGRF1_MOUSE
AccessioniPrimary (citable) accession number: Q8BMJ7
Secondary accession number(s): Q3U3F1, Q8CI24
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: March 1, 2003
Last modified: July 5, 2017
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot