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Protein

Cell growth regulator with RING finger domain protein 1

Gene

Cgrrf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Able to inhibit growth in several cell lines.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri274 – 30936RING-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Growth arrest

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Cell growth regulator with RING finger domain protein 1
Alternative name(s):
Cell growth regulatory gene 19 protein
Gene namesi
Name:Cgrrf1
Synonyms:Cgr19
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1916368. Cgrrf1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 332332Cell growth regulator with RING finger domain protein 1PRO_0000055870Add
BLAST

Proteomic databases

MaxQBiQ8BMJ7.
PaxDbiQ8BMJ7.
PRIDEiQ8BMJ7.

PTM databases

iPTMnetiQ8BMJ7.
PhosphoSiteiQ8BMJ7.

Expressioni

Gene expression databases

BgeeiQ8BMJ7.
CleanExiMM_CGRRF1.
GenevisibleiQ8BMJ7. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000070548.

Structurei

3D structure databases

ProteinModelPortaliQ8BMJ7.
SMRiQ8BMJ7. Positions 258-320.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri274 – 30936RING-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410ITZ9. Eukaryota.
ENOG4111F4I. LUCA.
GeneTreeiENSGT00390000004542.
HOGENOMiHOG000111607.
HOVERGENiHBG050932.
InParanoidiQ8BMJ7.
OMAiVIHIPDK.
OrthoDBiEOG71CFN5.
PhylomeDBiQ8BMJ7.
TreeFamiTF328102.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BMJ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVFLVTLY EYSPLFYIAV VFTCFIVTTG LVLGWFGWDV PVILRNSEET
60 70 80 90 100
QFSTRAFKKQ MRQVKNPFGL EITNSSAASL ATGMALRTDC LEDSRLTCYW
110 120 130 140 150
GCSVQKLYEA LQKHAYCFRI STPQALEEAL YSDYLHREQY FIKKHSKEEI
160 170 180 190 200
YCQLPSDTEI EDFGPVPRSR YPLVALLTLA DEDDREIYDI ISMVSVIHIP
210 220 230 240 250
DKTYKLPCRI LYQYLILAQG QFYDLKQLFM SANNSPPPSN DESPEDRSVE
260 270 280 290 300
QSLLEKVGLA GNDGDPVEES SRDCVVCQNG GVNWVLLPCR HACLCDSCVR
310 320 330
YFKQCPMCRQ FVQESFALCG QKEPDKDLLE TS
Length:332
Mass (Da):37,899
Last modified:March 1, 2003 - v1
Checksum:i5012EE360929ECC1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti82 – 832TG → S in AAH37677 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030755 mRNA. Translation: BAC27121.1.
AK154797 mRNA. Translation: BAE32835.1.
BC037677 mRNA. Translation: AAH37677.1.
CCDSiCCDS26981.1.
RefSeqiNP_081108.2. NM_026832.3.
XP_006519548.1. XM_006519485.2.
UniGeneiMm.343809.

Genome annotation databases

EnsembliENSMUST00000068532; ENSMUSP00000070548; ENSMUSG00000055128.
GeneIDi68755.
KEGGimmu:68755.
UCSCiuc007thj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030755 mRNA. Translation: BAC27121.1.
AK154797 mRNA. Translation: BAE32835.1.
BC037677 mRNA. Translation: AAH37677.1.
CCDSiCCDS26981.1.
RefSeqiNP_081108.2. NM_026832.3.
XP_006519548.1. XM_006519485.2.
UniGeneiMm.343809.

3D structure databases

ProteinModelPortaliQ8BMJ7.
SMRiQ8BMJ7. Positions 258-320.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000070548.

PTM databases

iPTMnetiQ8BMJ7.
PhosphoSiteiQ8BMJ7.

Proteomic databases

MaxQBiQ8BMJ7.
PaxDbiQ8BMJ7.
PRIDEiQ8BMJ7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000068532; ENSMUSP00000070548; ENSMUSG00000055128.
GeneIDi68755.
KEGGimmu:68755.
UCSCiuc007thj.1. mouse.

Organism-specific databases

CTDi10668.
MGIiMGI:1916368. Cgrrf1.

Phylogenomic databases

eggNOGiENOG410ITZ9. Eukaryota.
ENOG4111F4I. LUCA.
GeneTreeiENSGT00390000004542.
HOGENOMiHOG000111607.
HOVERGENiHBG050932.
InParanoidiQ8BMJ7.
OMAiVIHIPDK.
OrthoDBiEOG71CFN5.
PhylomeDBiQ8BMJ7.
TreeFamiTF328102.

Miscellaneous databases

NextBioi327854.
PROiQ8BMJ7.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BMJ7.
CleanExiMM_CGRRF1.
GenevisibleiQ8BMJ7. MM.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.

Entry informationi

Entry nameiCGRF1_MOUSE
AccessioniPrimary (citable) accession number: Q8BMJ7
Secondary accession number(s): Q3U3F1, Q8CI24
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: March 1, 2003
Last modified: January 20, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.