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Protein

Eukaryotic translation initiation factor 1A, X-chromosomal

Gene

Eif1ax

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits (By similarity).By similarity

GO - Molecular functioni

Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis

Enzyme and pathway databases

ReactomeiR-MMU-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-MMU-72649. Translation initiation complex formation.
R-MMU-72689. Formation of a pool of free 40S subunits.
R-MMU-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-MMU-72702. Ribosomal scanning and start codon recognition.
R-MMU-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 1A, X-chromosomal
Short name:
eIF-1A X isoform
Alternative name(s):
Eukaryotic translation initiation factor 4C
Short name:
eIF-4C
Gene namesi
Name:Eif1ax
Synonyms:Eif1ay
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1913485. Eif1ax.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001451071 – 144Eukaryotic translation initiation factor 1A, X-chromosomalAdd BLAST144

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki88Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ8BMJ3.
MaxQBiQ8BMJ3.
PaxDbiQ8BMJ3.
PeptideAtlasiQ8BMJ3.
PRIDEiQ8BMJ3.

2D gel databases

REPRODUCTION-2DPAGEiQ8BMJ3.

PTM databases

iPTMnetiQ8BMJ3.
PhosphoSitePlusiQ8BMJ3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000067194.
GenevisibleiQ8BMJ3. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000084387.

Structurei

3D structure databases

ProteinModelPortaliQ8BMJ3.
SMRiQ8BMJ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 96S1-likeAdd BLAST75

Sequence similaritiesi

Belongs to the eIF-1A family.Curated

Phylogenomic databases

eggNOGiKOG3403. Eukaryota.
COG0361. LUCA.
GeneTreeiENSGT00390000008256.
HOGENOMiHOG000223675.
HOVERGENiHBG001131.
InParanoidiQ8BMJ3.
KOiK03236.
OMAiDADIVHK.
OrthoDBiEOG091G195V.
PhylomeDBiQ8BMJ3.
TreeFamiTF350394.

Family and domain databases

CDDicd05793. S1_IF1A. 1 hit.
HAMAPiMF_00216. aIF_1A. 1 hit.
InterProiView protein in InterPro
IPR012340. NA-bd_OB-fold.
IPR006196. RNA-binding_domain_S1_IF1.
IPR001253. TIF_eIF-1A.
IPR018104. TIF_eIF-1A_CS.
PANTHERiPTHR21668. PTHR21668. 1 hit.
PfamiView protein in Pfam
PF01176. eIF-1a. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005579. TIF_eIF-1A. 1 hit.
SMARTiView protein in SMART
SM00652. eIF1a. 1 hit.
SUPFAMiSSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00523. eIF-1A. 1 hit.
PROSITEiView protein in PROSITE
PS01262. IF1A. 1 hit.
PS50832. S1_IF1_TYPE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8BMJ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKNKGKGGK NRRRGKNENE SEKRELVFKE DGQEYAQVIK MLGNGRLEAM
60 70 80 90 100
CFDGVKRLCH IRGKLRKKVW INTSDIILVG LRDYQDNKAD VILKYNADEA
110 120 130 140
RSLKAYGELP EHAKINETDT FGPGDDDEIQ FDDIGDDDED IDDI
Length:144
Mass (Da):16,460
Last modified:January 23, 2007 - v3
Checksum:i1C4209855B21BFD4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti46R → G in BAC36971 (PubMed:16141072).Curated1
Sequence conflicti63G → R in BAB23869 (PubMed:16141072).Curated1
Sequence conflicti95Y → N in BAC27259 (PubMed:16141072).Curated1
Sequence conflicti136D → E in BAC27130 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005185 mRNA. Translation: BAB23869.1.
AK007301 mRNA. Translation: BAB24942.1.
AK012233 mRNA. Translation: BAB28110.1.
AK012464 mRNA. Translation: BAB28259.3.
AK012714 mRNA. Translation: BAB28428.1.
AK021283 mRNA. Translation: BAB32361.1.
AK030774 mRNA. Translation: BAC27130.1.
AK031113 mRNA. Translation: BAC27259.1.
AK077710 mRNA. Translation: BAC36971.1.
AK090053 mRNA. Translation: BAC41069.1.
AK134827 mRNA. Translation: BAE22301.1.
AK134969 mRNA. Translation: BAE22363.1.
AK165574 mRNA. Translation: BAE38266.1.
AK166629 mRNA. Translation: BAE38904.1.
AK166852 mRNA. Translation: BAE39071.1.
BC027284 mRNA. Translation: AAH27284.1.
CCDSiCCDS41192.1.
RefSeqiNP_079713.2. NM_025437.4.
UniGeneiMm.294623.

Genome annotation databases

EnsembliENSMUST00000087143; ENSMUSP00000084387; ENSMUSG00000067194.
GeneIDi66235.
KEGGimmu:66235.
UCSCiuc009usl.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiIF1AX_MOUSE
AccessioniPrimary (citable) accession number: Q8BMJ3
Secondary accession number(s): Q3UY50
, Q6ZWL8, Q8BJZ2, Q8BMH8, Q9CSL9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: January 23, 2007
Last modified: September 27, 2017
This is version 117 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families