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Q8BMJ3 (IF1AX_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Eukaryotic translation initiation factor 1A, X-chromosomal

Short name=eIF-1A X isoform
Alternative name(s):
Eukaryotic translation initiation factor 4C
Short name=eIF-4C
Gene names
Name:Eif1ax
Synonyms:Eif1ay
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length144 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits By similarity. HAMAP-Rule MF_00216

Sequence similarities

Belongs to the eIF-1A family.

Contains 1 S1-like domain.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Molecular functionInitiation factor
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functiontranslation initiation factor activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 144144Eukaryotic translation initiation factor 1A, X-chromosomal HAMAP-Rule MF_00216
PRO_0000145107

Regions

Domain22 – 9675S1-like

Experimental info

Sequence conflict461R → G in BAC36971. Ref.1
Sequence conflict631G → R in BAB23869. Ref.1
Sequence conflict951Y → N in BAC27259. Ref.1
Sequence conflict1361D → E in BAC27130. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8BMJ3 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 1C4209855B21BFD4

FASTA14416,460
        10         20         30         40         50         60 
MPKNKGKGGK NRRRGKNENE SEKRELVFKE DGQEYAQVIK MLGNGRLEAM CFDGVKRLCH 

        70         80         90        100        110        120 
IRGKLRKKVW INTSDIILVG LRDYQDNKAD VILKYNADEA RSLKAYGELP EHAKINETDT 

       130        140 
FGPGDDDEIQ FDDIGDDDED IDDI 

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Blastocyst, Cerebellum, Embryo, Embryonic eye, Embryonic stem cell, Forelimb, Medulla oblongata, Olfactory bulb and Testis.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Mammary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK005185 mRNA. Translation: BAB23869.1.
AK007301 mRNA. Translation: BAB24942.1.
AK012233 mRNA. Translation: BAB28110.1.
AK012464 mRNA. Translation: BAB28259.3.
AK012714 mRNA. Translation: BAB28428.1.
AK021283 mRNA. Translation: BAB32361.1.
AK030774 mRNA. Translation: BAC27130.1.
AK031113 mRNA. Translation: BAC27259.1.
AK077710 mRNA. Translation: BAC36971.1.
AK090053 mRNA. Translation: BAC41069.1.
AK134827 mRNA. Translation: BAE22301.1.
AK134969 mRNA. Translation: BAE22363.1.
AK165574 mRNA. Translation: BAE38266.1.
AK166629 mRNA. Translation: BAE38904.1.
AK166852 mRNA. Translation: BAE39071.1.
BC027284 mRNA. Translation: AAH27284.1.
CCDSCCDS41192.1.
RefSeqNP_079713.2. NM_025437.4.
UniGeneMm.294623.

3D structure databases

ProteinModelPortalQ8BMJ3.
SMRQ8BMJ3. Positions 2-131.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ8BMJ3.

2D gel databases

REPRODUCTION-2DPAGEQ8BMJ3.

Proteomic databases

MaxQBQ8BMJ3.
PaxDbQ8BMJ3.
PRIDEQ8BMJ3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000087143; ENSMUSP00000084387; ENSMUSG00000067194.
GeneID66235.
KEGGmmu:66235.
UCSCuc009usl.1. mouse.

Organism-specific databases

CTD1964.
MGIMGI:1913485. Eif1ax.

Phylogenomic databases

eggNOGCOG0361.
GeneTreeENSGT00390000008256.
HOGENOMHOG000223675.
HOVERGENHBG001131.
InParanoidQ8BMJ3.
KOK03236.
OMAWNEYATI.
OrthoDBEOG7VHT0G.
PhylomeDBQ8BMJ3.
TreeFamTF350394.

Gene expression databases

BgeeQ8BMJ3.
GenevestigatorQ8BMJ3.

Family and domain databases

Gene3D2.40.50.140. 1 hit.
HAMAPMF_00216. aIF_1A.
InterProIPR012340. NA-bd_OB-fold.
IPR006196. RNA-binding_domain_S1_IF1.
IPR001253. TIF_eIF-1A.
IPR018104. TIF_eIF-1A_CS.
[Graphical view]
PANTHERPTHR21668. PTHR21668. 1 hit.
PfamPF01176. eIF-1a. 1 hit.
[Graphical view]
ProDomPD005579. TIF_eIF-1A. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00652. eIF1a. 1 hit.
[Graphical view]
SUPFAMSSF50249. SSF50249. 1 hit.
TIGRFAMsTIGR00523. eIF-1A. 1 hit.
PROSITEPS01262. IF1A. 1 hit.
PS50832. S1_IF1_TYPE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio321045.
PROQ8BMJ3.
SOURCESearch...

Entry information

Entry nameIF1AX_MOUSE
AccessionPrimary (citable) accession number: Q8BMJ3
Secondary accession number(s): Q3UY50 expand/collapse secondary AC list , Q6ZWL8, Q8BJZ2, Q8BMH8, Q9CSL9
Entry history
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 94 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Translation initiation factors

List of translation initiation factor entries