Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8BMJ3

- IF1AX_MOUSE

UniProt

Q8BMJ3 - IF1AX_MOUSE

Protein

Eukaryotic translation initiation factor 1A, X-chromosomal

Gene

Eif1ax

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits By similarity.By similarity

    GO - Molecular functioni

    1. translation initiation factor activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Initiation factor

    Keywords - Biological processi

    Protein biosynthesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Eukaryotic translation initiation factor 1A, X-chromosomal
    Short name:
    eIF-1A X isoform
    Alternative name(s):
    Eukaryotic translation initiation factor 4C
    Short name:
    eIF-4C
    Gene namesi
    Name:Eif1ax
    Synonyms:Eif1ay
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:1913485. Eif1ax.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 144144Eukaryotic translation initiation factor 1A, X-chromosomalPRO_0000145107Add
    BLAST

    Proteomic databases

    MaxQBiQ8BMJ3.
    PaxDbiQ8BMJ3.
    PRIDEiQ8BMJ3.

    2D gel databases

    REPRODUCTION-2DPAGEQ8BMJ3.

    PTM databases

    PhosphoSiteiQ8BMJ3.

    Expressioni

    Gene expression databases

    BgeeiQ8BMJ3.
    GenevestigatoriQ8BMJ3.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BMJ3.
    SMRiQ8BMJ3. Positions 2-131.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini22 – 9675S1-likeAdd
    BLAST

    Sequence similaritiesi

    Belongs to the eIF-1A family.Curated
    Contains 1 S1-like domain.Curated

    Phylogenomic databases

    eggNOGiCOG0361.
    GeneTreeiENSGT00390000008256.
    HOGENOMiHOG000223675.
    HOVERGENiHBG001131.
    InParanoidiQ8BMJ3.
    KOiK03236.
    OMAiWNEYATI.
    OrthoDBiEOG7VHT0G.
    PhylomeDBiQ8BMJ3.
    TreeFamiTF350394.

    Family and domain databases

    Gene3Di2.40.50.140. 1 hit.
    HAMAPiMF_00216. aIF_1A.
    InterProiIPR012340. NA-bd_OB-fold.
    IPR006196. RNA-binding_domain_S1_IF1.
    IPR001253. TIF_eIF-1A.
    IPR018104. TIF_eIF-1A_CS.
    [Graphical view]
    PANTHERiPTHR21668. PTHR21668. 1 hit.
    PfamiPF01176. eIF-1a. 1 hit.
    [Graphical view]
    ProDomiPD005579. TIF_eIF-1A. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00652. eIF1a. 1 hit.
    [Graphical view]
    SUPFAMiSSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00523. eIF-1A. 1 hit.
    PROSITEiPS01262. IF1A. 1 hit.
    PS50832. S1_IF1_TYPE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8BMJ3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPKNKGKGGK NRRRGKNENE SEKRELVFKE DGQEYAQVIK MLGNGRLEAM    50
    CFDGVKRLCH IRGKLRKKVW INTSDIILVG LRDYQDNKAD VILKYNADEA 100
    RSLKAYGELP EHAKINETDT FGPGDDDEIQ FDDIGDDDED IDDI 144
    Length:144
    Mass (Da):16,460
    Last modified:January 23, 2007 - v3
    Checksum:i1C4209855B21BFD4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti46 – 461R → G in BAC36971. (PubMed:16141072)Curated
    Sequence conflicti63 – 631G → R in BAB23869. (PubMed:16141072)Curated
    Sequence conflicti95 – 951Y → N in BAC27259. (PubMed:16141072)Curated
    Sequence conflicti136 – 1361D → E in BAC27130. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK005185 mRNA. Translation: BAB23869.1.
    AK007301 mRNA. Translation: BAB24942.1.
    AK012233 mRNA. Translation: BAB28110.1.
    AK012464 mRNA. Translation: BAB28259.3.
    AK012714 mRNA. Translation: BAB28428.1.
    AK021283 mRNA. Translation: BAB32361.1.
    AK030774 mRNA. Translation: BAC27130.1.
    AK031113 mRNA. Translation: BAC27259.1.
    AK077710 mRNA. Translation: BAC36971.1.
    AK090053 mRNA. Translation: BAC41069.1.
    AK134827 mRNA. Translation: BAE22301.1.
    AK134969 mRNA. Translation: BAE22363.1.
    AK165574 mRNA. Translation: BAE38266.1.
    AK166629 mRNA. Translation: BAE38904.1.
    AK166852 mRNA. Translation: BAE39071.1.
    BC027284 mRNA. Translation: AAH27284.1.
    CCDSiCCDS41192.1.
    RefSeqiNP_079713.2. NM_025437.4.
    UniGeneiMm.294623.

    Genome annotation databases

    EnsembliENSMUST00000087143; ENSMUSP00000084387; ENSMUSG00000067194.
    GeneIDi66235.
    KEGGimmu:66235.
    UCSCiuc009usl.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK005185 mRNA. Translation: BAB23869.1 .
    AK007301 mRNA. Translation: BAB24942.1 .
    AK012233 mRNA. Translation: BAB28110.1 .
    AK012464 mRNA. Translation: BAB28259.3 .
    AK012714 mRNA. Translation: BAB28428.1 .
    AK021283 mRNA. Translation: BAB32361.1 .
    AK030774 mRNA. Translation: BAC27130.1 .
    AK031113 mRNA. Translation: BAC27259.1 .
    AK077710 mRNA. Translation: BAC36971.1 .
    AK090053 mRNA. Translation: BAC41069.1 .
    AK134827 mRNA. Translation: BAE22301.1 .
    AK134969 mRNA. Translation: BAE22363.1 .
    AK165574 mRNA. Translation: BAE38266.1 .
    AK166629 mRNA. Translation: BAE38904.1 .
    AK166852 mRNA. Translation: BAE39071.1 .
    BC027284 mRNA. Translation: AAH27284.1 .
    CCDSi CCDS41192.1.
    RefSeqi NP_079713.2. NM_025437.4.
    UniGenei Mm.294623.

    3D structure databases

    ProteinModelPortali Q8BMJ3.
    SMRi Q8BMJ3. Positions 2-131.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8BMJ3.

    2D gel databases

    REPRODUCTION-2DPAGE Q8BMJ3.

    Proteomic databases

    MaxQBi Q8BMJ3.
    PaxDbi Q8BMJ3.
    PRIDEi Q8BMJ3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000087143 ; ENSMUSP00000084387 ; ENSMUSG00000067194 .
    GeneIDi 66235.
    KEGGi mmu:66235.
    UCSCi uc009usl.1. mouse.

    Organism-specific databases

    CTDi 1964.
    MGIi MGI:1913485. Eif1ax.

    Phylogenomic databases

    eggNOGi COG0361.
    GeneTreei ENSGT00390000008256.
    HOGENOMi HOG000223675.
    HOVERGENi HBG001131.
    InParanoidi Q8BMJ3.
    KOi K03236.
    OMAi WNEYATI.
    OrthoDBi EOG7VHT0G.
    PhylomeDBi Q8BMJ3.
    TreeFami TF350394.

    Miscellaneous databases

    NextBioi 321045.
    PROi Q8BMJ3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8BMJ3.
    Genevestigatori Q8BMJ3.

    Family and domain databases

    Gene3Di 2.40.50.140. 1 hit.
    HAMAPi MF_00216. aIF_1A.
    InterProi IPR012340. NA-bd_OB-fold.
    IPR006196. RNA-binding_domain_S1_IF1.
    IPR001253. TIF_eIF-1A.
    IPR018104. TIF_eIF-1A_CS.
    [Graphical view ]
    PANTHERi PTHR21668. PTHR21668. 1 hit.
    Pfami PF01176. eIF-1a. 1 hit.
    [Graphical view ]
    ProDomi PD005579. TIF_eIF-1A. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00652. eIF1a. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00523. eIF-1A. 1 hit.
    PROSITEi PS01262. IF1A. 1 hit.
    PS50832. S1_IF1_TYPE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Blastocyst, Cerebellum, Embryo, Embryonic eye, Embryonic stem cell, Forelimb, Medulla oblongata, Olfactory bulb and Testis.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiIF1AX_MOUSE
    AccessioniPrimary (citable) accession number: Q8BMJ3
    Secondary accession number(s): Q3UY50
    , Q6ZWL8, Q8BJZ2, Q8BMH8, Q9CSL9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 12, 2005
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 95 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Translation initiation factors
      List of translation initiation factor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3