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Protein

Eukaryotic translation initiation factor 1A, X-chromosomal

Gene

Eif1ax

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits (By similarity).By similarity

GO - Molecular functioni

Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis

Enzyme and pathway databases

ReactomeiR-MMU-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-MMU-72649 Translation initiation complex formation
R-MMU-72689 Formation of a pool of free 40S subunits
R-MMU-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-MMU-72702 Ribosomal scanning and start codon recognition

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 1A, X-chromosomal
Short name:
eIF-1A X isoform
Alternative name(s):
Eukaryotic translation initiation factor 4C
Short name:
eIF-4C
Gene namesi
Name:Eif1ax
Synonyms:Eif1ay
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1913485 Eif1ax

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001451071 – 144Eukaryotic translation initiation factor 1A, X-chromosomalAdd BLAST144

Proteomic databases

EPDiQ8BMJ3
MaxQBiQ8BMJ3
PaxDbiQ8BMJ3
PeptideAtlasiQ8BMJ3
PRIDEiQ8BMJ3

2D gel databases

REPRODUCTION-2DPAGEiQ8BMJ3

PTM databases

iPTMnetiQ8BMJ3
PhosphoSitePlusiQ8BMJ3

Expressioni

Gene expression databases

BgeeiENSMUSG00000067194
GenevisibleiQ8BMJ3 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000084387

Structurei

3D structure databases

ProteinModelPortaliQ8BMJ3
SMRiQ8BMJ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 96S1-likeAdd BLAST75

Sequence similaritiesi

Belongs to the eIF-1A family.Curated

Phylogenomic databases

eggNOGiKOG3403 Eukaryota
COG0361 LUCA
GeneTreeiENSGT00390000008256
HOGENOMiHOG000223675
HOVERGENiHBG001131
InParanoidiQ8BMJ3
KOiK03236
OMAiDADIVHK
OrthoDBiEOG091G195V
PhylomeDBiQ8BMJ3
TreeFamiTF350394

Family and domain databases

CDDicd05793 S1_IF1A, 1 hit
HAMAPiMF_00216 aIF_1A, 1 hit
InterProiView protein in InterPro
IPR012340 NA-bd_OB-fold
IPR006196 RNA-binding_domain_S1_IF1
IPR001253 TIF_eIF-1A
IPR018104 TIF_eIF-1A_CS
PANTHERiPTHR21668 PTHR21668, 1 hit
PfamiView protein in Pfam
PF01176 eIF-1a, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005579 TIF_eIF-1A, 1 hit
SMARTiView protein in SMART
SM00652 eIF1a, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00523 eIF-1A, 1 hit
PROSITEiView protein in PROSITE
PS01262 IF1A, 1 hit
PS50832 S1_IF1_TYPE, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BMJ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKNKGKGGK NRRRGKNENE SEKRELVFKE DGQEYAQVIK MLGNGRLEAM
60 70 80 90 100
CFDGVKRLCH IRGKLRKKVW INTSDIILVG LRDYQDNKAD VILKYNADEA
110 120 130 140
RSLKAYGELP EHAKINETDT FGPGDDDEIQ FDDIGDDDED IDDI
Length:144
Mass (Da):16,460
Last modified:January 23, 2007 - v3
Checksum:i1C4209855B21BFD4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti46R → G in BAC36971 (PubMed:16141072).Curated1
Sequence conflicti63G → R in BAB23869 (PubMed:16141072).Curated1
Sequence conflicti95Y → N in BAC27259 (PubMed:16141072).Curated1
Sequence conflicti136D → E in BAC27130 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005185 mRNA Translation: BAB23869.1
AK007301 mRNA Translation: BAB24942.1
AK012233 mRNA Translation: BAB28110.1
AK012464 mRNA Translation: BAB28259.3
AK012714 mRNA Translation: BAB28428.1
AK021283 mRNA Translation: BAB32361.1
AK030774 mRNA Translation: BAC27130.1
AK031113 mRNA Translation: BAC27259.1
AK077710 mRNA Translation: BAC36971.1
AK090053 mRNA Translation: BAC41069.1
AK134827 mRNA Translation: BAE22301.1
AK134969 mRNA Translation: BAE22363.1
AK165574 mRNA Translation: BAE38266.1
AK166629 mRNA Translation: BAE38904.1
AK166852 mRNA Translation: BAE39071.1
BC027284 mRNA Translation: AAH27284.1
CCDSiCCDS41192.1
RefSeqiNP_079713.2, NM_025437.4
UniGeneiMm.294623

Genome annotation databases

EnsembliENSMUST00000087143; ENSMUSP00000084387; ENSMUSG00000067194
GeneIDi66235
KEGGimmu:66235
UCSCiuc009usl.1 mouse

Entry informationi

Entry nameiIF1AX_MOUSE
AccessioniPrimary (citable) accession number: Q8BMJ3
Secondary accession number(s): Q3UY50
, Q6ZWL8, Q8BJZ2, Q8BMH8, Q9CSL9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 119 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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