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Protein

F-box only protein 38

Gene

Fbxo38

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. May coactivate KLF7, but does not seem to promote KLF7 ubiquitination.1 Publication

GO - Biological processi

  • positive regulation of neuron projection development Source: MGI

Keywordsi

Biological processUbl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 38
Alternative name(s):
Modulator of KLF7 activity
Short name:
MoKA
Gene namesi
Name:Fbxo38
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:2444639. Fbxo38.

Subcellular locationi

  • Cytoplasm 1 Publication
  • Nucleus 1 Publication

GO - Cellular componenti

  • cytoplasm Source: MGI
  • nucleus Source: MGI

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001199341 – 1194F-box only protein 38Add BLAST1194

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei592PhosphothreonineCombined sources1
Modified residuei599PhosphoserineCombined sources1
Modified residuei601PhosphoserineCombined sources1
Modified residuei607PhosphoserineCombined sources1
Modified residuei742PhosphoserineBy similarity1
Modified residuei746PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8BMI0.
MaxQBiQ8BMI0.
PaxDbiQ8BMI0.
PeptideAtlasiQ8BMI0.
PRIDEiQ8BMI0.

PTM databases

iPTMnetiQ8BMI0.
PhosphoSitePlusiQ8BMI0.

Expressioni

Tissue specificityi

Expressed at high levels in embryo (developing brain, spinal chord, branchial arms and limbs). Widely expressed at low levels in adult tissues, with highest expression in testis. Expressed in postmeiotic spermatids.1 Publication

Developmental stagei

In embryo expressed at E11, E15 and E17.1 Publication

Gene expression databases

BgeeiENSMUSG00000042211.
CleanExiMM_FBXO38.
GenevisibleiQ8BMI0. MM.

Interactioni

Subunit structurei

Interacts with KLF7. Part of a SCF (SKP1-cullin-F-box) protein ligase complex (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047541.

Structurei

3D structure databases

ProteinModelPortaliQ8BMI0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 75F-boxAdd BLAST46

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni59 – 119Interaction with KLF71 PublicationAdd BLAST61

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi705 – 712Poly-Ser8

Domaini

The N-terminal region aa 1-349 seems to be involved in cytoplasmic localization.
The C-terminal region aa 473-1194 seems to be involved in nuclear localization.

Phylogenomic databases

eggNOGiENOG410IFU5. Eukaryota.
ENOG410XS1U. LUCA.
GeneTreeiENSGT00390000013163.
HOGENOMiHOG000112545.
HOVERGENiHBG051579.
InParanoidiQ8BMI0.
KOiK10313.
OMAiTRCRVLK.
OrthoDBiEOG091G00W1.
PhylomeDBiQ8BMI0.
TreeFamiTF331125.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiView protein in InterPro
IPR001810. F-box_dom.
IPR032675. L_dom-like.
PfamiView protein in Pfam
PF00646. F-box. 1 hit.
SUPFAMiSSF81383. SSF81383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8BMI0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPRKKSAKV CVMDSEVAEE MTADEEKDYM NQLSHEVLCH IFRYLPLQDI
60 70 80 90 100
MCMECLSRKL KEAVTLYLRV VRVVDLCAGR WWEYMPSGFT DSSFLTLLKK
110 120 130 140 150
MPDVEQLYGL HPRYLERRRV RGQEAFSIPG VLEALQACPN LVGVETSHLE
160 170 180 190 200
LVESIWTYMP HVHILGKFRN RNGAFPIPPE NKLKIPIGAK IQTLHLVGVN
210 220 230 240 250
VPEIPCIPML RHLYMKWVRL TKPQPFKDFL CISLRTFVMR NCAGPTNSLK
260 270 280 290 300
YVPLVTGLAS ARNLEHLEMV RVPFLGGLIQ HVVEDSWRSG GFRNLHTIVL
310 320 330 340 350
GACKNALEVD LGYLIITAAR RLHEVRIQPS LTKDGVFSAL KMAELEFPQF
360 370 380 390 400
ETLHLGYVDE FLLQSRMANA DLVKYGLADV VENPGIITDI GMKAVNEVFS
410 420 430 440 450
CIKYLAIYNC PHLHNPYNWI SDHSRWMRLV DINLVRCHAL KLDSFGQFVE
460 470 480 490 500
LLPSLEFISL DQMFREPPKG CARVGLSAGT GIGVSSALVS NQNSNNDNDN
510 520 530 540 550
NAPNNNANLH DNNHHHPDDS DDDNDFRPDL QAGEAQFAAD ALNEMEDMVQ
560 570 580 590 600
EDGELVAESG NGMPAHNREV LPVDADEEQA GPSGLQRVVK PTPIADHDSE
610 620 630 640 650
SDDEEDSLEL QEVWAPKNGT RRYSEREEKT GDSGQSRETA VSGKGKTPLR
660 670 680 690 700
KRCNNSHQTG QAKPFPLEES SCEKGCQVTS EQIKADMKAA RDVSEKKKSK
710 720 730 740 750
DVYPSCSSSS SSTAASTAGN ASSPSTASQS PDFARTVTSS GSSEPSPPEV
760 770 780 790 800
DVSRQCVCSP GGSEDSEAME EGDAESSVCP RCCCLRPQES QRRTGRCSDE
810 820 830 840 850
ERPSTSRACV VNGADGTRSA FSFRTLPQGG SSGPAHDERT NGSGCGATGE
860 870 880 890 900
DRRGSSQPES CDVQSNEDYP RRPLTRARSR LSHVPLISES EVAKTKPCHA
910 920 930 940 950
MKRKRTADKS TSTSDPVIED DHVQVLVLKS KNLVGVTMTN CGITDLVLKD
960 970 980 990 1000
CPKMMFIHAT RCRVLKHLKV ENAPIVNRFD YAQCKKLNMD QVLDQILRMP
1010 1020 1030 1040 1050
PERNRIIYLR PMQQVDTLTL EQKLFSGPYP YHICIIHEFS NPPNVRNKVR
1060 1070 1080 1090 1100
IRNWMDTIAN INQELIKYEF FLEATRTEED LKKYPKYPWG REIYTLEGVV
1110 1120 1130 1140 1150
DGAPYSMISD FPWLRSLRTA EPNSFARYDF EDDEESTIYA PRRKGQLSAD
1160 1170 1180 1190
ICMETIGEEI SEMRQMKRGI FQRVVAIFIH YCDVNGEPVE DDYI
Length:1,194
Mass (Da):133,928
Last modified:March 1, 2003 - v1
Checksum:i40F973C9638824A8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti659T → M in BAC40718 (PubMed:16141072).Curated1
Sequence conflicti712Missing in AAP31028 (PubMed:14729953).Curated1
Sequence conflicti712Missing in BAC40718 (PubMed:16141072).Curated1
Sequence conflicti715A → T in BAC40718 (PubMed:16141072).Curated1
Sequence conflicti1163M → K in BAC27358 (PubMed:16141072).Curated1
Sequence conflicti1185N → H in BAC27358 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY267463 mRNA. Translation: AAP31028.1.
AK089046 mRNA. Translation: BAC40718.1.
AK031096 mRNA. Translation: BAC27250.1.
AK031347 mRNA. Translation: BAC27358.1.
BC056348 mRNA. Translation: AAH56348.1.
CCDSiCCDS37841.1.
RefSeqiNP_598897.2. NM_134136.3.
UniGeneiMm.21295.

Genome annotation databases

EnsembliENSMUST00000048688; ENSMUSP00000047541; ENSMUSG00000042211.
GeneIDi107035.
KEGGimmu:107035.
UCSCiuc012bdv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY267463 mRNA. Translation: AAP31028.1.
AK089046 mRNA. Translation: BAC40718.1.
AK031096 mRNA. Translation: BAC27250.1.
AK031347 mRNA. Translation: BAC27358.1.
BC056348 mRNA. Translation: AAH56348.1.
CCDSiCCDS37841.1.
RefSeqiNP_598897.2. NM_134136.3.
UniGeneiMm.21295.

3D structure databases

ProteinModelPortaliQ8BMI0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047541.

PTM databases

iPTMnetiQ8BMI0.
PhosphoSitePlusiQ8BMI0.

Proteomic databases

EPDiQ8BMI0.
MaxQBiQ8BMI0.
PaxDbiQ8BMI0.
PeptideAtlasiQ8BMI0.
PRIDEiQ8BMI0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000048688; ENSMUSP00000047541; ENSMUSG00000042211.
GeneIDi107035.
KEGGimmu:107035.
UCSCiuc012bdv.1. mouse.

Organism-specific databases

CTDi81545.
MGIiMGI:2444639. Fbxo38.

Phylogenomic databases

eggNOGiENOG410IFU5. Eukaryota.
ENOG410XS1U. LUCA.
GeneTreeiENSGT00390000013163.
HOGENOMiHOG000112545.
HOVERGENiHBG051579.
InParanoidiQ8BMI0.
KOiK10313.
OMAiTRCRVLK.
OrthoDBiEOG091G00W1.
PhylomeDBiQ8BMI0.
TreeFamiTF331125.

Miscellaneous databases

ChiTaRSiFbxo38. mouse.
PROiPR:Q8BMI0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042211.
CleanExiMM_FBXO38.
GenevisibleiQ8BMI0. MM.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiView protein in InterPro
IPR001810. F-box_dom.
IPR032675. L_dom-like.
PfamiView protein in Pfam
PF00646. F-box. 1 hit.
SUPFAMiSSF81383. SSF81383. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFBX38_MOUSE
AccessioniPrimary (citable) accession number: Q8BMI0
Secondary accession number(s): Q8BTQ4, Q8C0H4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: March 1, 2003
Last modified: May 10, 2017
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.