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Protein

Mitochondrial folate transporter/carrier

Gene

Slc25a32

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Transports folate across the inner membranes of mitochondria.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-MMU-196757. Metabolism of folate and pterines.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial folate transporter/carrier
Alternative name(s):
Solute carrier family 25 member 32
Gene namesi
Name:Slc25a32
Synonyms:Mftc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1917156. Slc25a32.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei26 – 4621Helical; Name=1Sequence analysisAdd
BLAST
Transmembranei89 – 10618Helical; Name=2Sequence analysisAdd
BLAST
Transmembranei123 – 14321Helical; Name=3Sequence analysisAdd
BLAST
Transmembranei185 – 20319Helical; Name=4Sequence analysisAdd
BLAST
Transmembranei227 – 24317Helical; Name=5Sequence analysisAdd
BLAST
Transmembranei281 – 30020Helical; Name=6Sequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: UniProtKB-SubCell
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 316316Mitochondrial folate transporter/carrierPRO_0000090643Add
BLAST

Proteomic databases

EPDiQ8BMG8.
MaxQBiQ8BMG8.
PaxDbiQ8BMG8.
PRIDEiQ8BMG8.

PTM databases

PhosphoSiteiQ8BMG8.

Expressioni

Gene expression databases

BgeeiQ8BMG8.
CleanExiMM_SLC25A32.
GenevisibleiQ8BMG8. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022908.

Structurei

3D structure databases

ProteinModelPortaliQ8BMG8.
SMRiQ8BMG8. Positions 26-288.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati20 – 10990Solcar 1Add
BLAST
Repeati118 – 20992Solcar 2Add
BLAST
Repeati222 – 30685Solcar 3Add
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0764. Eukaryota.
ENOG410XPAJ. LUCA.
GeneTreeiENSGT00770000120566.
HOGENOMiHOG000188210.
HOVERGENiHBG101979.
InParanoidiQ8BMG8.
KOiK15115.
OMAiXSTVEYI.
OrthoDBiEOG70W3DW.
PhylomeDBiQ8BMG8.
TreeFamiTF314217.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BMG8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGQGQSAAG SAAWSAVFRH VRYENLVAGV SGGVLSNLAL HPLDLVKIRF
60 70 80 90 100
AVSDGLEVRP KYKGILHCLA TIWKVDGLRG LYQGVTPNVW GAGLSWGLYF
110 120 130 140 150
FFYNAIKSYK TEGRAEQLEP LEYLVSAAEA GAMTLCITNP LWVTKTRLML
160 170 180 190 200
QYGGVASPSQ RQYKGMFDAL VKIYKYEGVR GLYKGFVPGL FGTSHGALQF
210 220 230 240 250
MAYELLKLKY NKHINRLPEA QLSTAEYISV AALSKIFAVA ATYPYQVVRA
260 270 280 290 300
RLQDQHVSYG GVTDVITKTW RKEGIGGFYK GIAPNLIRVT PACCITFVVY
310
ENVSHFLYDL REKKVS
Length:316
Mass (Da):35,049
Last modified:March 1, 2003 - v1
Checksum:i58D18DFBAC6B169E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK031187 mRNA. Translation: BAC27295.1.
AK167501 mRNA. Translation: BAE39577.1.
AK170643 mRNA. Translation: BAE41931.1.
AK172029 mRNA. Translation: BAE42785.1.
CCDSiCCDS27443.1.
RefSeqiNP_765990.2. NM_172402.3.
UniGeneiMm.17875.

Genome annotation databases

EnsembliENSMUST00000022908; ENSMUSP00000022908; ENSMUSG00000022299.
ENSMUST00000202369; ENSMUSP00000144490; ENSMUSG00000107007.
GeneIDi69906.
KEGGimmu:69906.
UCSCiuc007vob.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK031187 mRNA. Translation: BAC27295.1.
AK167501 mRNA. Translation: BAE39577.1.
AK170643 mRNA. Translation: BAE41931.1.
AK172029 mRNA. Translation: BAE42785.1.
CCDSiCCDS27443.1.
RefSeqiNP_765990.2. NM_172402.3.
UniGeneiMm.17875.

3D structure databases

ProteinModelPortaliQ8BMG8.
SMRiQ8BMG8. Positions 26-288.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022908.

PTM databases

PhosphoSiteiQ8BMG8.

Proteomic databases

EPDiQ8BMG8.
MaxQBiQ8BMG8.
PaxDbiQ8BMG8.
PRIDEiQ8BMG8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022908; ENSMUSP00000022908; ENSMUSG00000022299.
ENSMUST00000202369; ENSMUSP00000144490; ENSMUSG00000107007.
GeneIDi69906.
KEGGimmu:69906.
UCSCiuc007vob.2. mouse.

Organism-specific databases

CTDi81034.
MGIiMGI:1917156. Slc25a32.

Phylogenomic databases

eggNOGiKOG0764. Eukaryota.
ENOG410XPAJ. LUCA.
GeneTreeiENSGT00770000120566.
HOGENOMiHOG000188210.
HOVERGENiHBG101979.
InParanoidiQ8BMG8.
KOiK15115.
OMAiXSTVEYI.
OrthoDBiEOG70W3DW.
PhylomeDBiQ8BMG8.
TreeFamiTF314217.

Enzyme and pathway databases

ReactomeiR-MMU-196757. Metabolism of folate and pterines.

Miscellaneous databases

NextBioi330583.
PROiQ8BMG8.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BMG8.
CleanExiMM_SLC25A32.
GenevisibleiQ8BMG8. MM.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Forelimb, Placenta and Spleen.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brown adipose tissue, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiMFTC_MOUSE
AccessioniPrimary (citable) accession number: Q8BMG8
Secondary accession number(s): Q3TCM5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: March 1, 2003
Last modified: May 11, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.