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Q8BMG7

- RBGPR_MOUSE

UniProt

Q8BMG7 - RBGPR_MOUSE

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Protein
Rab3 GTPase-activating protein non-catalytic subunit
Gene
Rab3gap2, Kiaa0839
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Regulatory subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab3 GTPase-activating complex specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters By similarity.

GO - Molecular functioni

  1. GTPase activator activity Source: UniProtKB-KW
  2. enzyme regulator activity Source: UniProtKB
  3. protein heterodimerization activity Source: UniProtKB

GO - Biological processi

  1. regulation of GTPase activity Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Names & Taxonomyi

Protein namesi
Recommended name:
Rab3 GTPase-activating protein non-catalytic subunit
Alternative name(s):
Rab3 GTPase-activating protein 150 kDa subunit
Rab3-GAP p150
Short name:
Rab3-GAP150
Rab3-GAP regulatory subunit
Gene namesi
Name:Rab3gap2
Synonyms:Kiaa0839
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1916043. Rab3gap2.

Subcellular locationi

Cytoplasm By similarity
Note: In neurons, it is enriched in the synaptic soluble fraction By similarity.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13661366Rab3 GTPase-activating protein non-catalytic subunit
PRO_0000191663Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei448 – 4481Phosphoserine By similarity
Modified residuei899 – 8991Phosphothreonine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8BMG7.
PaxDbiQ8BMG7.
PRIDEiQ8BMG7.

PTM databases

PhosphoSiteiQ8BMG7.

Expressioni

Gene expression databases

CleanExiMM_RAB3GAP2.
GenevestigatoriQ8BMG7.

Interactioni

Subunit structurei

The Rab3 GTPase-activating complex is a heterodimer composed of RAB3GAP and RAB3-GAP150. The Rab3 GTPase-activating complex interacts with DMXL2 By similarity.

Protein-protein interaction databases

BioGridi221114. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ8BMG7.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG317114.
HOGENOMiHOG000290717.
HOVERGENiHBG067039.
InParanoidiQ8BMG7.
PhylomeDBiQ8BMG7.

Family and domain databases

InterProiIPR026059. Rab3-gap_reg.
IPR029257. RAB3GAP2_C.
[Graphical view]
PANTHERiPTHR12472. PTHR12472. 1 hit.
PfamiPF14656. RAB3GAP2_C. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8BMG7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MACSIVQFCS FQDLQSARDF LFPHLREETP GALKRDPSKT SSWEDDSWGA     50
WEETEPREPE EEGNTSKTQK NSWLQECVLS LSPTSDLMVI AREQKAAFLV 100
RKWKHGDKGK EEMQFAVGWS GSVSAEEGEY VTSALCIPLA SQKRSSTGRP 150
DWTCIVVGFT SGYVRFYTEG VLLLAQLLNE DKVLQLKCRT YEIPRHPGVT 200
EQNEELSILY PAAIVTIDGF SLFQSLRACR NQVAKAAASG NENIQPPPLA 250
YKKWGLQDID TIIDHASVGI MTLSPFDQMK TASNIGGFNA AIKNSPPAMS 300
QYITVGSSPF TGFFYALEGS TQPLLSHVAL AVASKLTSAL FSAASGWLGW 350
KSKHEEDTVQ KQKPKMEPAT PLAVRFGLPD SRRHGESICL SPCNTLAAVT 400
DDFGRVILLD VARGIAIRMW KGYRDAQVGW IQIVEDLHER VPEKGGFSPF 450
GNTQGPSRVA QFLVIYAPRR GILEVWNTQQ GPRVGAFNVG KHCRLLYPGY 500
KIMGLNNVTS QSWQPQTYQI CLVDPVSASV KAVNVPFHLA LSDKKSERAK 550
DLHLVKKLSA LLRAKSPRPD SFETEIKELI LDIKYPATKK QALESILASD 600
RLSFSCLRNV TQTLMDTLKN QELESVDEGL LQFCASKLKL LHLYESVSQL 650
NTLDFHSDTP FSDNDLAVLL RLDDKELLKL RALLEKYKQE NTKATVRFSE 700
DADRVLPVKT FLEYLEYEKD ALSIRKIGEE ECVALGSFFF WKCLHGKSST 750
EEMCHSLESA GLSPQQLLSL LLSVWLSKEK DILDKPQSVC CLHTMLSLLS 800
KMKVAIDETW DSQSVSPWWQ QMRMACIQSE NSGAALLSAH VGHSVAAQMS 850
SGATDKKFSQ MELDADAEAL TDSWEALSLD TEYWKLLLRQ LEDCLILQTL 900
LHSKLSPPAA KAPSLQSEPL PRLSVKKLLE GGKGGIADSV AKWIFKQDLS 950
PELLKCANKE RDVENPDEPR EDLLHLAYEQ FPCSLELDVL HAHCCWEYVV 1000
QWNKDPEEAR FLVRSIEHLK QILNPHVQNG IALMMWNTFL VKRFSAATYL 1050
MDKVGKSPKD RLCRRDVGMS DTALTSFLGS CLELLQTSLE ADISRDEVQV 1100
PVLDTEDAWL SVEGPISIVE LALEQKPIHY PLVEHHSVLC SILYASMRFS 1150
LKSVKPLALF DSKGKNAFFK DLTSIQLLPS GEMDPNFISV RQQFLLKVVS 1200
AAVQAQHSKD KDPSAEAANT HWKDLNWPGL AVDLAHHLQV SDDVIRRHYV 1250
GELYSHGADL LGEEAIFQVQ DKEVLASQLL VLTGQRLAHA LFHTQTKEGM 1300
ELLARLPPTL CTWLKAMNPQ DLQNTGVPIA ATAKLVHKVM ELLPEKHGQY 1350
SLALHLIDAV EAMATL 1366
Length:1,366
Mass (Da):152,535
Last modified:April 12, 2005 - v2
Checksum:iA84C2C1416F673BA
GO
Isoform 2 (identifier: Q8BMG7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1068: Missing.

Note: No experimental confirmation available.

Show »
Length:298
Mass (Da):32,950
Checksum:i1BC695910AC3D832
GO

Sequence cautioni

The sequence BAC65667.2 differs from that shown. Reason: The sequence differs from that shown because it seems to be derived from a pre-mRNA.
The sequence AAH57872.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAC27296.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 10681068Missing in isoform 2.
VSP_013313Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti727 – 7271I → V in BAC27296. 1 Publication
Sequence conflicti747 – 7471K → E in BAC27296. 1 Publication
Sequence conflicti747 – 7471K → E1 Publication
Sequence conflicti862 – 8621E → V in BAC27296. 1 Publication
Sequence conflicti862 – 8621E → V1 Publication
Sequence conflicti906 – 9061S → T in AAH57872. 1 Publication
Sequence conflicti1021 – 10211Q → H in AAH57872. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK031191 mRNA. Translation: BAC27296.1. Different initiation.
AK048759 mRNA. Translation: BAC33447.1.
AC129195 Genomic DNA. No translation available.
AC131084 Genomic DNA. No translation available.
AC158963 Genomic DNA. No translation available.
BC057872 mRNA. Translation: AAH57872.1. Different initiation.
AK122385 Transcribed RNA. Translation: BAC65667.2. Sequence problems.
RefSeqiNP_001157226.1. NM_001163754.1.
UniGeneiMm.275841.

Genome annotation databases

GeneIDi98732.
KEGGimmu:98732.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK031191 mRNA. Translation: BAC27296.1 . Different initiation.
AK048759 mRNA. Translation: BAC33447.1 .
AC129195 Genomic DNA. No translation available.
AC131084 Genomic DNA. No translation available.
AC158963 Genomic DNA. No translation available.
BC057872 mRNA. Translation: AAH57872.1 . Different initiation.
AK122385 Transcribed RNA. Translation: BAC65667.2 . Sequence problems.
RefSeqi NP_001157226.1. NM_001163754.1.
UniGenei Mm.275841.

3D structure databases

ProteinModelPortali Q8BMG7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 221114. 1 interaction.

PTM databases

PhosphoSitei Q8BMG7.

Proteomic databases

MaxQBi Q8BMG7.
PaxDbi Q8BMG7.
PRIDEi Q8BMG7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 98732.
KEGGi mmu:98732.

Organism-specific databases

CTDi 25782.
MGIi MGI:1916043. Rab3gap2.
Rougei Search...

Phylogenomic databases

eggNOGi NOG317114.
HOGENOMi HOG000290717.
HOVERGENi HBG067039.
InParanoidi Q8BMG7.
PhylomeDBi Q8BMG7.

Miscellaneous databases

ChiTaRSi RAB3GAP2. mouse.
NextBioi 353601.
PROi Q8BMG7.
SOURCEi Search...

Gene expression databases

CleanExi MM_RAB3GAP2.
Genevestigatori Q8BMG7.

Family and domain databases

InterProi IPR026059. Rab3-gap_reg.
IPR029257. RAB3GAP2_C.
[Graphical view ]
PANTHERi PTHR12472. PTHR12472. 1 hit.
Pfami PF14656. RAB3GAP2_C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 319-1366 (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Cerebellum and Forelimb.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 283-1366 (ISOFORM 1).
    Strain: NMRI.
    Tissue: Mammary tumor.
  4. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
    DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 432-1364 (ISOFORM 1).
    Tissue: Brain.
  5. Okazaki N., Kikuno R., Nagase T., Ohara O., Koga H.
    Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  6. "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
    Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
    Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain cortex.

Entry informationi

Entry nameiRBGPR_MOUSE
AccessioniPrimary (citable) accession number: Q8BMG7
Secondary accession number(s): Q6PEU0, Q80TQ6, Q8BX72
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: April 12, 2005
Last modified: June 11, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi