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Q8BMG7

- RBGPR_MOUSE

UniProt

Q8BMG7 - RBGPR_MOUSE

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Protein

Rab3 GTPase-activating protein non-catalytic subunit

Gene

Rab3gap2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Regulatory subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab3 GTPase-activating complex specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters (By similarity).By similarity

GO - Molecular functioni

  1. enzyme regulator activity Source: UniProtKB
  2. GTPase activator activity Source: UniProtKB-KW
  3. protein heterodimerization activity Source: UniProtKB

GO - Biological processi

  1. regulation of GTPase activity Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Names & Taxonomyi

Protein namesi
Recommended name:
Rab3 GTPase-activating protein non-catalytic subunit
Alternative name(s):
Rab3 GTPase-activating protein 150 kDa subunit
Rab3-GAP p150
Short name:
Rab3-GAP150
Rab3-GAP regulatory subunit
Gene namesi
Name:Rab3gap2
Synonyms:Kiaa0839
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1916043. Rab3gap2.

Subcellular locationi

Cytoplasm By similarity
Note: In neurons, it is enriched in the synaptic soluble fraction.By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13661366Rab3 GTPase-activating protein non-catalytic subunitPRO_0000191663Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei448 – 4481PhosphoserineBy similarity
Modified residuei899 – 8991PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8BMG7.
PaxDbiQ8BMG7.
PRIDEiQ8BMG7.

PTM databases

PhosphoSiteiQ8BMG7.

Expressioni

Gene expression databases

CleanExiMM_RAB3GAP2.
GenevestigatoriQ8BMG7.

Interactioni

Subunit structurei

The Rab3 GTPase-activating complex is a heterodimer composed of RAB3GAP and RAB3-GAP150. The Rab3 GTPase-activating complex interacts with DMXL2 (By similarity).By similarity

Protein-protein interaction databases

BioGridi221114. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ8BMG7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Rab3-GAP regulatory subunit family.Curated

Phylogenomic databases

eggNOGiNOG317114.
HOGENOMiHOG000290717.
HOVERGENiHBG067039.
InParanoidiQ8BMG7.
PhylomeDBiQ8BMG7.

Family and domain databases

InterProiIPR026059. Rab3-gap_reg.
IPR029257. RAB3GAP2_C.
[Graphical view]
PANTHERiPTHR12472. PTHR12472. 1 hit.
PfamiPF14656. RAB3GAP2_C. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8BMG7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MACSIVQFCS FQDLQSARDF LFPHLREETP GALKRDPSKT SSWEDDSWGA
60 70 80 90 100
WEETEPREPE EEGNTSKTQK NSWLQECVLS LSPTSDLMVI AREQKAAFLV
110 120 130 140 150
RKWKHGDKGK EEMQFAVGWS GSVSAEEGEY VTSALCIPLA SQKRSSTGRP
160 170 180 190 200
DWTCIVVGFT SGYVRFYTEG VLLLAQLLNE DKVLQLKCRT YEIPRHPGVT
210 220 230 240 250
EQNEELSILY PAAIVTIDGF SLFQSLRACR NQVAKAAASG NENIQPPPLA
260 270 280 290 300
YKKWGLQDID TIIDHASVGI MTLSPFDQMK TASNIGGFNA AIKNSPPAMS
310 320 330 340 350
QYITVGSSPF TGFFYALEGS TQPLLSHVAL AVASKLTSAL FSAASGWLGW
360 370 380 390 400
KSKHEEDTVQ KQKPKMEPAT PLAVRFGLPD SRRHGESICL SPCNTLAAVT
410 420 430 440 450
DDFGRVILLD VARGIAIRMW KGYRDAQVGW IQIVEDLHER VPEKGGFSPF
460 470 480 490 500
GNTQGPSRVA QFLVIYAPRR GILEVWNTQQ GPRVGAFNVG KHCRLLYPGY
510 520 530 540 550
KIMGLNNVTS QSWQPQTYQI CLVDPVSASV KAVNVPFHLA LSDKKSERAK
560 570 580 590 600
DLHLVKKLSA LLRAKSPRPD SFETEIKELI LDIKYPATKK QALESILASD
610 620 630 640 650
RLSFSCLRNV TQTLMDTLKN QELESVDEGL LQFCASKLKL LHLYESVSQL
660 670 680 690 700
NTLDFHSDTP FSDNDLAVLL RLDDKELLKL RALLEKYKQE NTKATVRFSE
710 720 730 740 750
DADRVLPVKT FLEYLEYEKD ALSIRKIGEE ECVALGSFFF WKCLHGKSST
760 770 780 790 800
EEMCHSLESA GLSPQQLLSL LLSVWLSKEK DILDKPQSVC CLHTMLSLLS
810 820 830 840 850
KMKVAIDETW DSQSVSPWWQ QMRMACIQSE NSGAALLSAH VGHSVAAQMS
860 870 880 890 900
SGATDKKFSQ MELDADAEAL TDSWEALSLD TEYWKLLLRQ LEDCLILQTL
910 920 930 940 950
LHSKLSPPAA KAPSLQSEPL PRLSVKKLLE GGKGGIADSV AKWIFKQDLS
960 970 980 990 1000
PELLKCANKE RDVENPDEPR EDLLHLAYEQ FPCSLELDVL HAHCCWEYVV
1010 1020 1030 1040 1050
QWNKDPEEAR FLVRSIEHLK QILNPHVQNG IALMMWNTFL VKRFSAATYL
1060 1070 1080 1090 1100
MDKVGKSPKD RLCRRDVGMS DTALTSFLGS CLELLQTSLE ADISRDEVQV
1110 1120 1130 1140 1150
PVLDTEDAWL SVEGPISIVE LALEQKPIHY PLVEHHSVLC SILYASMRFS
1160 1170 1180 1190 1200
LKSVKPLALF DSKGKNAFFK DLTSIQLLPS GEMDPNFISV RQQFLLKVVS
1210 1220 1230 1240 1250
AAVQAQHSKD KDPSAEAANT HWKDLNWPGL AVDLAHHLQV SDDVIRRHYV
1260 1270 1280 1290 1300
GELYSHGADL LGEEAIFQVQ DKEVLASQLL VLTGQRLAHA LFHTQTKEGM
1310 1320 1330 1340 1350
ELLARLPPTL CTWLKAMNPQ DLQNTGVPIA ATAKLVHKVM ELLPEKHGQY
1360
SLALHLIDAV EAMATL
Length:1,366
Mass (Da):152,535
Last modified:April 12, 2005 - v2
Checksum:iA84C2C1416F673BA
GO
Isoform 2 (identifier: Q8BMG7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1068: Missing.

Note: No experimental confirmation available.

Show »
Length:298
Mass (Da):32,950
Checksum:i1BC695910AC3D832
GO

Sequence cautioni

The sequence BAC65667.2 differs from that shown. Reason: The sequence differs from that shown because it seems to be derived from a pre-mRNA.
The sequence AAH57872.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAC27296.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti727 – 7271I → V in BAC27296. (PubMed:16141072)Curated
Sequence conflicti747 – 7471K → E in BAC27296. (PubMed:16141072)Curated
Sequence conflicti747 – 7471K → E(PubMed:19468303)Curated
Sequence conflicti862 – 8621E → V in BAC27296. (PubMed:16141072)Curated
Sequence conflicti862 – 8621E → V(PubMed:19468303)Curated
Sequence conflicti906 – 9061S → T in AAH57872. (PubMed:15489334)Curated
Sequence conflicti1021 – 10211Q → H in AAH57872. (PubMed:15489334)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 10681068Missing in isoform 2. 1 PublicationVSP_013313Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK031191 mRNA. Translation: BAC27296.1. Different initiation.
AK048759 mRNA. Translation: BAC33447.1.
AC129195 Genomic DNA. No translation available.
AC131084 Genomic DNA. No translation available.
AC158963 Genomic DNA. No translation available.
BC057872 mRNA. Translation: AAH57872.1. Different initiation.
AK122385 Transcribed RNA. Translation: BAC65667.2. Sequence problems.
RefSeqiNP_001157226.1. NM_001163754.1.
UniGeneiMm.275841.

Genome annotation databases

GeneIDi98732.
KEGGimmu:98732.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK031191 mRNA. Translation: BAC27296.1 . Different initiation.
AK048759 mRNA. Translation: BAC33447.1 .
AC129195 Genomic DNA. No translation available.
AC131084 Genomic DNA. No translation available.
AC158963 Genomic DNA. No translation available.
BC057872 mRNA. Translation: AAH57872.1 . Different initiation.
AK122385 Transcribed RNA. Translation: BAC65667.2 . Sequence problems.
RefSeqi NP_001157226.1. NM_001163754.1.
UniGenei Mm.275841.

3D structure databases

ProteinModelPortali Q8BMG7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 221114. 1 interaction.

PTM databases

PhosphoSitei Q8BMG7.

Proteomic databases

MaxQBi Q8BMG7.
PaxDbi Q8BMG7.
PRIDEi Q8BMG7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 98732.
KEGGi mmu:98732.

Organism-specific databases

CTDi 25782.
MGIi MGI:1916043. Rab3gap2.
Rougei Search...

Phylogenomic databases

eggNOGi NOG317114.
HOGENOMi HOG000290717.
HOVERGENi HBG067039.
InParanoidi Q8BMG7.
PhylomeDBi Q8BMG7.

Miscellaneous databases

ChiTaRSi RAB3GAP2. mouse.
NextBioi 353601.
PROi Q8BMG7.
SOURCEi Search...

Gene expression databases

CleanExi MM_RAB3GAP2.
Genevestigatori Q8BMG7.

Family and domain databases

InterProi IPR026059. Rab3-gap_reg.
IPR029257. RAB3GAP2_C.
[Graphical view ]
PANTHERi PTHR12472. PTHR12472. 1 hit.
Pfami PF14656. RAB3GAP2_C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 319-1366 (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Cerebellum and Forelimb.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 283-1366 (ISOFORM 1).
    Strain: NMRI.
    Tissue: Mammary tumor.
  4. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
    DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 432-1364 (ISOFORM 1).
    Tissue: Brain.
  5. Okazaki N., Kikuno R., Nagase T., Ohara O., Koga H.
    Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  6. "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
    Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
    Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain cortex.

Entry informationi

Entry nameiRBGPR_MOUSE
AccessioniPrimary (citable) accession number: Q8BMG7
Secondary accession number(s): Q6PEU0, Q80TQ6, Q8BX72
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: April 12, 2005
Last modified: October 29, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3