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Q8BMG7

- RBGPR_MOUSE

UniProt

Q8BMG7 - RBGPR_MOUSE

Protein

Rab3 GTPase-activating protein non-catalytic subunit

Gene

Rab3gap2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 2 (12 Apr 2005)
      Previous versions | rss
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    Functioni

    Regulatory subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab3 GTPase-activating complex specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters By similarity.By similarity

    GO - Molecular functioni

    1. enzyme regulator activity Source: UniProtKB
    2. GTPase activator activity Source: UniProtKB-KW
    3. protein heterodimerization activity Source: UniProtKB

    GO - Biological processi

    1. regulation of GTPase activity Source: UniProtKB

    Keywords - Molecular functioni

    GTPase activation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Rab3 GTPase-activating protein non-catalytic subunit
    Alternative name(s):
    Rab3 GTPase-activating protein 150 kDa subunit
    Rab3-GAP p150
    Short name:
    Rab3-GAP150
    Rab3-GAP regulatory subunit
    Gene namesi
    Name:Rab3gap2
    Synonyms:Kiaa0839
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:1916043. Rab3gap2.

    Subcellular locationi

    Cytoplasm By similarity
    Note: In neurons, it is enriched in the synaptic soluble fraction.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13661366Rab3 GTPase-activating protein non-catalytic subunitPRO_0000191663Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei448 – 4481PhosphoserineBy similarity
    Modified residuei899 – 8991PhosphothreonineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8BMG7.
    PaxDbiQ8BMG7.
    PRIDEiQ8BMG7.

    PTM databases

    PhosphoSiteiQ8BMG7.

    Expressioni

    Gene expression databases

    CleanExiMM_RAB3GAP2.
    GenevestigatoriQ8BMG7.

    Interactioni

    Subunit structurei

    The Rab3 GTPase-activating complex is a heterodimer composed of RAB3GAP and RAB3-GAP150. The Rab3 GTPase-activating complex interacts with DMXL2 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi221114. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BMG7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Rab3-GAP regulatory subunit family.Curated

    Phylogenomic databases

    eggNOGiNOG317114.
    HOGENOMiHOG000290717.
    HOVERGENiHBG067039.
    InParanoidiQ8BMG7.
    PhylomeDBiQ8BMG7.

    Family and domain databases

    InterProiIPR026059. Rab3-gap_reg.
    IPR029257. RAB3GAP2_C.
    [Graphical view]
    PANTHERiPTHR12472. PTHR12472. 1 hit.
    PfamiPF14656. RAB3GAP2_C. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8BMG7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MACSIVQFCS FQDLQSARDF LFPHLREETP GALKRDPSKT SSWEDDSWGA     50
    WEETEPREPE EEGNTSKTQK NSWLQECVLS LSPTSDLMVI AREQKAAFLV 100
    RKWKHGDKGK EEMQFAVGWS GSVSAEEGEY VTSALCIPLA SQKRSSTGRP 150
    DWTCIVVGFT SGYVRFYTEG VLLLAQLLNE DKVLQLKCRT YEIPRHPGVT 200
    EQNEELSILY PAAIVTIDGF SLFQSLRACR NQVAKAAASG NENIQPPPLA 250
    YKKWGLQDID TIIDHASVGI MTLSPFDQMK TASNIGGFNA AIKNSPPAMS 300
    QYITVGSSPF TGFFYALEGS TQPLLSHVAL AVASKLTSAL FSAASGWLGW 350
    KSKHEEDTVQ KQKPKMEPAT PLAVRFGLPD SRRHGESICL SPCNTLAAVT 400
    DDFGRVILLD VARGIAIRMW KGYRDAQVGW IQIVEDLHER VPEKGGFSPF 450
    GNTQGPSRVA QFLVIYAPRR GILEVWNTQQ GPRVGAFNVG KHCRLLYPGY 500
    KIMGLNNVTS QSWQPQTYQI CLVDPVSASV KAVNVPFHLA LSDKKSERAK 550
    DLHLVKKLSA LLRAKSPRPD SFETEIKELI LDIKYPATKK QALESILASD 600
    RLSFSCLRNV TQTLMDTLKN QELESVDEGL LQFCASKLKL LHLYESVSQL 650
    NTLDFHSDTP FSDNDLAVLL RLDDKELLKL RALLEKYKQE NTKATVRFSE 700
    DADRVLPVKT FLEYLEYEKD ALSIRKIGEE ECVALGSFFF WKCLHGKSST 750
    EEMCHSLESA GLSPQQLLSL LLSVWLSKEK DILDKPQSVC CLHTMLSLLS 800
    KMKVAIDETW DSQSVSPWWQ QMRMACIQSE NSGAALLSAH VGHSVAAQMS 850
    SGATDKKFSQ MELDADAEAL TDSWEALSLD TEYWKLLLRQ LEDCLILQTL 900
    LHSKLSPPAA KAPSLQSEPL PRLSVKKLLE GGKGGIADSV AKWIFKQDLS 950
    PELLKCANKE RDVENPDEPR EDLLHLAYEQ FPCSLELDVL HAHCCWEYVV 1000
    QWNKDPEEAR FLVRSIEHLK QILNPHVQNG IALMMWNTFL VKRFSAATYL 1050
    MDKVGKSPKD RLCRRDVGMS DTALTSFLGS CLELLQTSLE ADISRDEVQV 1100
    PVLDTEDAWL SVEGPISIVE LALEQKPIHY PLVEHHSVLC SILYASMRFS 1150
    LKSVKPLALF DSKGKNAFFK DLTSIQLLPS GEMDPNFISV RQQFLLKVVS 1200
    AAVQAQHSKD KDPSAEAANT HWKDLNWPGL AVDLAHHLQV SDDVIRRHYV 1250
    GELYSHGADL LGEEAIFQVQ DKEVLASQLL VLTGQRLAHA LFHTQTKEGM 1300
    ELLARLPPTL CTWLKAMNPQ DLQNTGVPIA ATAKLVHKVM ELLPEKHGQY 1350
    SLALHLIDAV EAMATL 1366
    Length:1,366
    Mass (Da):152,535
    Last modified:April 12, 2005 - v2
    Checksum:iA84C2C1416F673BA
    GO
    Isoform 2 (identifier: Q8BMG7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1068: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:298
    Mass (Da):32,950
    Checksum:i1BC695910AC3D832
    GO

    Sequence cautioni

    The sequence BAC65667.2 differs from that shown. Reason: The sequence differs from that shown because it seems to be derived from a pre-mRNA.
    The sequence AAH57872.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAC27296.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti727 – 7271I → V in BAC27296. (PubMed:16141072)Curated
    Sequence conflicti747 – 7471K → E in BAC27296. (PubMed:16141072)Curated
    Sequence conflicti747 – 7471K → E(PubMed:19468303)Curated
    Sequence conflicti862 – 8621E → V in BAC27296. (PubMed:16141072)Curated
    Sequence conflicti862 – 8621E → V(PubMed:19468303)Curated
    Sequence conflicti906 – 9061S → T in AAH57872. (PubMed:15489334)Curated
    Sequence conflicti1021 – 10211Q → H in AAH57872. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 10681068Missing in isoform 2. 1 PublicationVSP_013313Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK031191 mRNA. Translation: BAC27296.1. Different initiation.
    AK048759 mRNA. Translation: BAC33447.1.
    AC129195 Genomic DNA. No translation available.
    AC131084 Genomic DNA. No translation available.
    AC158963 Genomic DNA. No translation available.
    BC057872 mRNA. Translation: AAH57872.1. Different initiation.
    AK122385 Transcribed RNA. Translation: BAC65667.2. Sequence problems.
    RefSeqiNP_001157226.1. NM_001163754.1.
    UniGeneiMm.275841.

    Genome annotation databases

    GeneIDi98732.
    KEGGimmu:98732.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK031191 mRNA. Translation: BAC27296.1 . Different initiation.
    AK048759 mRNA. Translation: BAC33447.1 .
    AC129195 Genomic DNA. No translation available.
    AC131084 Genomic DNA. No translation available.
    AC158963 Genomic DNA. No translation available.
    BC057872 mRNA. Translation: AAH57872.1 . Different initiation.
    AK122385 Transcribed RNA. Translation: BAC65667.2 . Sequence problems.
    RefSeqi NP_001157226.1. NM_001163754.1.
    UniGenei Mm.275841.

    3D structure databases

    ProteinModelPortali Q8BMG7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 221114. 1 interaction.

    PTM databases

    PhosphoSitei Q8BMG7.

    Proteomic databases

    MaxQBi Q8BMG7.
    PaxDbi Q8BMG7.
    PRIDEi Q8BMG7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 98732.
    KEGGi mmu:98732.

    Organism-specific databases

    CTDi 25782.
    MGIi MGI:1916043. Rab3gap2.
    Rougei Search...

    Phylogenomic databases

    eggNOGi NOG317114.
    HOGENOMi HOG000290717.
    HOVERGENi HBG067039.
    InParanoidi Q8BMG7.
    PhylomeDBi Q8BMG7.

    Miscellaneous databases

    ChiTaRSi RAB3GAP2. mouse.
    NextBioi 353601.
    PROi Q8BMG7.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_RAB3GAP2.
    Genevestigatori Q8BMG7.

    Family and domain databases

    InterProi IPR026059. Rab3-gap_reg.
    IPR029257. RAB3GAP2_C.
    [Graphical view ]
    PANTHERi PTHR12472. PTHR12472. 1 hit.
    Pfami PF14656. RAB3GAP2_C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 319-1366 (ISOFORM 1).
      Strain: C57BL/6J.
      Tissue: Cerebellum and Forelimb.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 283-1366 (ISOFORM 1).
      Strain: NMRI.
      Tissue: Mammary tumor.
    4. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
      DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 432-1364 (ISOFORM 1).
      Tissue: Brain.
    5. Okazaki N., Kikuno R., Nagase T., Ohara O., Koga H.
      Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    6. "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
      Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
      Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain cortex.

    Entry informationi

    Entry nameiRBGPR_MOUSE
    AccessioniPrimary (citable) accession number: Q8BMG7
    Secondary accession number(s): Q6PEU0, Q80TQ6, Q8BX72
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 12, 2005
    Last sequence update: April 12, 2005
    Last modified: October 1, 2014
    This is version 89 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3