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Protein

Calcium-binding mitochondrial carrier protein SCaMC-1

Gene

Slc25a24

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Calcium-dependent mitochondrial solute carrier. Mediates the reversible, electroneutral exchange of Mg-ATP or Mg-ADP against phosphate ions, catalyzing the net uptake or efflux of adenine nucleotides across the mitochondrial inner membrane. Nucleotide transport is inactive when cytosolic calcium levels are low, and is activated by an increase in cytosolic calcium levels. May play a role in protecting cells against oxidative stress-induced cell death, probably by promoting the formation of calcium-phosphate precipitates in the mitochondrial matrix, and thereby buffering calcium levels in the mitochondrial matrix (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi32 – 43121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi68 – 79122PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi99 – 110123PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi135 – 146124PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-binding mitochondrial carrier protein SCaMC-1
Alternative name(s):
Small calcium-binding mitochondrial carrier protein 1
Solute carrier family 25 member 24
Gene namesi
Name:Slc25a24
Synonyms:Scamc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1917160. Slc25a24.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 197197Mitochondrial intermembraneSequence analysisAdd
BLAST
Transmembranei198 – 21518Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini216 – 25035Mitochondrial matrixSequence analysisAdd
BLAST
Transmembranei251 – 27020Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini271 – 29323Mitochondrial intermembraneSequence analysisAdd
BLAST
Transmembranei294 – 30714Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini308 – 34336Mitochondrial matrixSequence analysisAdd
BLAST
Transmembranei344 – 36320Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini364 – 38623Mitochondrial intermembraneSequence analysisAdd
BLAST
Transmembranei387 – 40418Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini405 – 44339Mitochondrial matrixSequence analysisAdd
BLAST
Transmembranei444 – 46320Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini464 – 47512Mitochondrial intermembraneSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 475475Calcium-binding mitochondrial carrier protein SCaMC-1PRO_0000317595Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei318 – 3181N6-acetyllysine; alternateCombined sources
Modified residuei318 – 3181N6-succinyllysine; alternateCombined sources
Modified residuei334 – 3341N6-acetyllysineBy similarity
Modified residuei435 – 4351N6-acetyllysine; alternateCombined sources
Modified residuei435 – 4351N6-succinyllysine; alternateCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8BMD8.
MaxQBiQ8BMD8.
PaxDbiQ8BMD8.
PeptideAtlasiQ8BMD8.
PRIDEiQ8BMD8.

PTM databases

iPTMnetiQ8BMD8.
PhosphoSiteiQ8BMD8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000040322.
ExpressionAtlasiQ8BMD8. baseline and differential.
GenevisibleiQ8BMD8. MM.

Interactioni

Protein-protein interaction databases

BioGridi230896. 1 interaction.
MINTiMINT-1868197.
STRINGi10090.ENSMUSP00000029477.

Structurei

3D structure databases

ProteinModelPortaliQ8BMD8.
SMRiQ8BMD8. Positions 22-462.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 5436EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini55 – 8834EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini86 – 12136EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Domaini122 – 15736EF-hand 4PROSITE-ProRule annotationAdd
BLAST
Repeati192 – 27685Solcar 1Add
BLAST
Repeati284 – 36986Solcar 2Add
BLAST
Repeati381 – 46989Solcar 3Add
BLAST

Domaini

The N-terminal domain can bind calcium and regulates the ATP carrier activity of the transmembrane domain. The apo form of the N-terminal domain is intrinsically disordered and binds to the transmembrane domain, leading to inhibition of the ATP carrier activity. Calcium binding leads to a major conformation change and abolishes the interaction with the transmembrane domain and the inhibition of the ATP carrier activity (By similarity).By similarity

Sequence similaritiesi

Contains 4 EF-hand domains.PROSITE-ProRule annotation
Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0036. Eukaryota.
ENOG410XQ4P. LUCA.
GeneTreeiENSGT00760000119245.
HOGENOMiHOG000165728.
HOVERGENiHBG108464.
InParanoidiQ8BMD8.
KOiK14684.
OMAiTTWLEHY.
OrthoDBiEOG091G0C8S.
PhylomeDBiQ8BMD8.
TreeFamiTF313492.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.50.40.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR002167. Graves_DC.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 2 hits.
PF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00928. GRAVESDC.
PR00926. MITOCARRIER.
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
SSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 4 hits.
PS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BMD8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRWLRAFVL PTAACHDAEP PTRYETLFRA LDRNGDGVVD IGELQQGLQS
60 70 80 90 100
LGIPLGQDAE EKIFTTGDVN KDGKLDFEEF MKYLKDHEKK MKLAFKSLDK
110 120 130 140 150
NNDGKIEPSE IVQSLQMLGL HISEKQAELI LQSIDSDGTM TVDWNEWRDY
160 170 180 190 200
FLFNPVTDIE EIIRFWKHST GIDIGDSLTI PDEFTEDEKK SGQWWRQLLA
210 220 230 240 250
GGVAGAVSRT STAPLDRLKV MMQVHGSKSM NIFGGFRQMV KEGGIRSLWR
260 270 280 290 300
GNGTNVIKIA PETAVKFWAY EQYKKLLTEE GQKLGTFERF ISGSMAGATA
310 320 330 340 350
QTFIYPMEVL KTRLAVAKTG QYSGIYGCAK KILKHEGFGA FYKGYIPNLL
360 370 380 390 400
GIIPYAGIDL AVYELLKSYW LDNFAKDSVN PGVMVLLSCG ALSSTCGQLA
410 420 430 440 450
SYPLALVRTR MQAQATVEGA PQLSMVGLFQ RIVSKEGVSG LYRGITPNFM
460 470
KVLPAVGISY VVYENMKQTL GVAQK
Length:475
Mass (Da):52,902
Last modified:March 1, 2003 - v1
Checksum:iDB9BEE1C3D16AF41
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti27 – 271L → F in BAE40063 (PubMed:16141072).Curated
Sequence conflicti27 – 271L → F in BAE39810 (PubMed:16141072).Curated
Sequence conflicti133 – 1331S → G in AAH55369 (PubMed:15489334).Curated
Sequence conflicti475 – 4751K → E in BAE41903 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK032806 mRNA. Translation: BAC28031.1.
AK146034 mRNA. Translation: BAE26847.1.
AK167778 mRNA. Translation: BAE39810.1.
AK168090 mRNA. Translation: BAE40063.1.
AK170598 mRNA. Translation: BAE41903.1.
AL671921, AL845310 Genomic DNA. Translation: CAM19805.1.
AL845310, AL671921 Genomic DNA. Translation: CAM26535.1.
CT010461 Genomic DNA. Translation: CAM28161.1.
BC055369 mRNA. Translation: AAH55369.1.
CCDSiCCDS17772.1.
RefSeqiNP_766273.1. NM_172685.3.
UniGeneiMm.33574.

Genome annotation databases

EnsembliENSMUST00000029477; ENSMUSP00000029477; ENSMUSG00000040322.
GeneIDi229731.
KEGGimmu:229731.
UCSCiuc008rae.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK032806 mRNA. Translation: BAC28031.1.
AK146034 mRNA. Translation: BAE26847.1.
AK167778 mRNA. Translation: BAE39810.1.
AK168090 mRNA. Translation: BAE40063.1.
AK170598 mRNA. Translation: BAE41903.1.
AL671921, AL845310 Genomic DNA. Translation: CAM19805.1.
AL845310, AL671921 Genomic DNA. Translation: CAM26535.1.
CT010461 Genomic DNA. Translation: CAM28161.1.
BC055369 mRNA. Translation: AAH55369.1.
CCDSiCCDS17772.1.
RefSeqiNP_766273.1. NM_172685.3.
UniGeneiMm.33574.

3D structure databases

ProteinModelPortaliQ8BMD8.
SMRiQ8BMD8. Positions 22-462.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230896. 1 interaction.
MINTiMINT-1868197.
STRINGi10090.ENSMUSP00000029477.

PTM databases

iPTMnetiQ8BMD8.
PhosphoSiteiQ8BMD8.

Proteomic databases

EPDiQ8BMD8.
MaxQBiQ8BMD8.
PaxDbiQ8BMD8.
PeptideAtlasiQ8BMD8.
PRIDEiQ8BMD8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029477; ENSMUSP00000029477; ENSMUSG00000040322.
GeneIDi229731.
KEGGimmu:229731.
UCSCiuc008rae.1. mouse.

Organism-specific databases

CTDi29957.
MGIiMGI:1917160. Slc25a24.

Phylogenomic databases

eggNOGiKOG0036. Eukaryota.
ENOG410XQ4P. LUCA.
GeneTreeiENSGT00760000119245.
HOGENOMiHOG000165728.
HOVERGENiHBG108464.
InParanoidiQ8BMD8.
KOiK14684.
OMAiTTWLEHY.
OrthoDBiEOG091G0C8S.
PhylomeDBiQ8BMD8.
TreeFamiTF313492.

Miscellaneous databases

PROiQ8BMD8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040322.
ExpressionAtlasiQ8BMD8. baseline and differential.
GenevisibleiQ8BMD8. MM.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.50.40.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR002167. Graves_DC.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 2 hits.
PF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00928. GRAVESDC.
PR00926. MITOCARRIER.
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
SSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 4 hits.
PS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSCMC1_MOUSE
AccessioniPrimary (citable) accession number: Q8BMD8
Secondary accession number(s): Q3TCQ2, Q3THY3, Q7TPC2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.