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Protein

Cytidine and dCMP deaminase domain-containing protein 1

Gene

Cdadc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play an important role in testicular development and spermatogenesis.By similarity

Cofactori

Zn2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi399 – 3991Zinc; catalyticBy similarity
Active sitei401 – 4011Proton donorBy similarity
Metal bindingi427 – 4271Zinc; catalyticBy similarity
Metal bindingi430 – 4301Zinc; catalyticBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Cytidine and dCMP deaminase domain-containing protein 1
Gene namesi
Name:Cdadc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1919141. Cdadc1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 523523Cytidine and dCMP deaminase domain-containing protein 1PRO_0000300493Add
BLAST

Proteomic databases

EPDiQ8BMD5.
MaxQBiQ8BMD5.
PaxDbiQ8BMD5.
PRIDEiQ8BMD5.

PTM databases

iPTMnetiQ8BMD5.
PhosphoSiteiQ8BMD5.

Expressioni

Gene expression databases

BgeeiQ8BMD5.
CleanExiMM_CDADC1.
ExpressionAtlasiQ8BMD5. baseline and differential.
GenevisibleiQ8BMD5. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000128022.

Structurei

3D structure databases

ProteinModelPortaliQ8BMD5.
SMRiQ8BMD5. Positions 88-158, 321-462.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini71 – 16999CMP/dCMP-type deaminase 1PROSITE-ProRule annotationAdd
BLAST
Domaini318 – 483166CMP/dCMP-type deaminase 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 CMP/dCMP-type deaminase domains.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3127. Eukaryota.
COG2131. LUCA.
GeneTreeiENSGT00390000001951.
HOVERGENiHBG057359.
InParanoidiQ8BMD5.
PhylomeDBiQ8BMD5.

Family and domain databases

InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR016193. Cytidine_deaminase-like.
IPR015517. dCMP_deaminase-rel.
[Graphical view]
PANTHERiPTHR11086. PTHR11086. 3 hits.
PfamiPF00383. dCMP_cyt_deam_1. 2 hits.
[Graphical view]
SUPFAMiSSF53927. SSF53927. 2 hits.
PROSITEiPS00903. CYT_DCMP_DEAMINASES_1. 1 hit.
PS51747. CYT_DCMP_DEAMINASES_2. 2 hits.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BMD5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKETDQMQSL EGSGAERSVG TQTGSMTGQI PRLSKVNLFT LLSLWMELFP
60 70 80 90 100
GVEAQGQKSQ KTEEESRGPL GDNEELTRVS TEKKQVKKTG LVVVKNMKII
110 120 130 140 150
GLHCSSEDLH TGQIALIKHG SRLKNCDLYF SRKPCSACLK MIVNAGVNRI
160 170 180 190 200
SYWPSDPEIS LLTEASSSED AKLDAKAAER LKSNSRAHVC VLLQPLVCYM
210 220 230 240 250
VQFVEETSYK CDFIQKTAKA LPGADTDFYS ECKQERIKEY EMLFLVSNEE
260 270 280 290 300
RHKQILMTIG LESLCEDPYF SNLRQNMKDL ILLLATVASS VPNLKHFGFY
310 320 330 340 350
CSSPEQINEI HNQSLPQEVA RHCMVQARLL AYRTEDHKTG VGAVIWAEAK
360 370 380 390 400
SRSCDGTGAM YFIGCGYNAF PVGSEYADFP HMDDKHKDRE IRKFRYIIHA
410 420 430 440 450
EQNALTFRCQ DIKPEERSMI FVTKCPCDEC VPLIKGAGIK QIYAGDVDVG
460 470 480 490 500
KKKADISYMK FGELEGVRKF TWQLNPSEAY SLDPNEPERR ENGVLRRRSA
510 520
KDEQRSSKRP RLETRSAGRA TLQ
Length:523
Mass (Da):59,062
Last modified:March 1, 2003 - v1
Checksum:i49E525840EE7B274
GO
Isoform 2 (identifier: Q8BMD5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     492-499: NGVLRRRS → RSATTACF
     500-523: Missing.

Show »
Length:499
Mass (Da):56,237
Checksum:iE0D75761F95B2C7A
GO
Isoform 3 (identifier: Q8BMD5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     492-497: NGVLRR → SFFFMP
     498-523: Missing.

Show »
Length:497
Mass (Da):56,156
Checksum:iFDC6D13F200B5C62
GO
Isoform 4 (identifier: Q8BMD5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     492-500: NGVLRRRSA → KHLSIKRSH
     501-523: Missing.

Show »
Length:500
Mass (Da):56,487
Checksum:i46A1BDE9900D41C8
GO
Isoform 6 (identifier: Q8BMD5-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-96: Missing.
     480-523: Missing.

Show »
Length:383
Mass (Da):43,376
Checksum:i1147071F4A65BC08
GO

Sequence cautioni

The sequence BAB26191.1 differs from that shown. Reason: Frameshift at position 82. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti252 – 2521H → R in BAC30171 (PubMed:16141072).Curated
Sequence conflicti310 – 3123IHN → VHS in AAH04588 (PubMed:15489334).Curated
Sequence conflicti417 – 4171R → H in BAC30171 (PubMed:16141072).Curated
Sequence conflicti417 – 4171R → H in AAH04588 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9696Missing in isoform 6. 1 PublicationVSP_027817Add
BLAST
Alternative sequencei480 – 52344Missing in isoform 6. 1 PublicationVSP_027818Add
BLAST
Alternative sequencei492 – 5009NGVLRRRSA → KHLSIKRSH in isoform 4. 2 PublicationsVSP_027819
Alternative sequencei492 – 4998NGVLRRRS → RSATTACF in isoform 2. 1 PublicationVSP_027820
Alternative sequencei492 – 4976NGVLRR → SFFFMP in isoform 3. 1 PublicationVSP_027821
Alternative sequencei498 – 52326Missing in isoform 3. 1 PublicationVSP_027822Add
BLAST
Alternative sequencei500 – 52324Missing in isoform 2. 1 PublicationVSP_027823Add
BLAST
Alternative sequencei501 – 52323Missing in isoform 4. 2 PublicationsVSP_027824Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009280 mRNA. Translation: BAB26191.1. Frameshift.
AK032600 mRNA. Translation: BAC27943.1.
AK032813 mRNA. Translation: BAC28036.1.
AK038926 mRNA. Translation: BAC30171.1.
AK039148 mRNA. Translation: BAC30255.1.
BC004588 mRNA. Translation: AAH04588.1.
BC006901 mRNA. Translation: AAH06901.1.
CCDSiCCDS36940.1. [Q8BMD5-1]
CCDS49513.1. [Q8BMD5-2]
CCDS49515.1. [Q8BMD5-4]
RefSeqiNP_001162007.1. NM_001168535.1.
NP_001162008.1. NM_001168536.1. [Q8BMD5-4]
NP_001162009.1. NM_001168537.1. [Q8BMD5-2]
NP_001162010.1. NM_001168538.1. [Q8BMD5-3]
NP_082262.1. NM_027986.3. [Q8BMD5-1]
UniGeneiMm.439850.

Genome annotation databases

EnsembliENSMUST00000022555; ENSMUSP00000022555; ENSMUSG00000021982. [Q8BMD5-2]
ENSMUST00000056997; ENSMUSP00000052233; ENSMUSG00000021982. [Q8BMD5-1]
ENSMUST00000171683; ENSMUSP00000128064; ENSMUSG00000021982. [Q8BMD5-4]
GeneIDi71891.
KEGGimmu:71891.
UCSCiuc007ueo.2. mouse. [Q8BMD5-1]
uc007uep.2. mouse. [Q8BMD5-4]
uc011zmw.1. mouse. [Q8BMD5-3]
uc011zmx.1. mouse. [Q8BMD5-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009280 mRNA. Translation: BAB26191.1. Frameshift.
AK032600 mRNA. Translation: BAC27943.1.
AK032813 mRNA. Translation: BAC28036.1.
AK038926 mRNA. Translation: BAC30171.1.
AK039148 mRNA. Translation: BAC30255.1.
BC004588 mRNA. Translation: AAH04588.1.
BC006901 mRNA. Translation: AAH06901.1.
CCDSiCCDS36940.1. [Q8BMD5-1]
CCDS49513.1. [Q8BMD5-2]
CCDS49515.1. [Q8BMD5-4]
RefSeqiNP_001162007.1. NM_001168535.1.
NP_001162008.1. NM_001168536.1. [Q8BMD5-4]
NP_001162009.1. NM_001168537.1. [Q8BMD5-2]
NP_001162010.1. NM_001168538.1. [Q8BMD5-3]
NP_082262.1. NM_027986.3. [Q8BMD5-1]
UniGeneiMm.439850.

3D structure databases

ProteinModelPortaliQ8BMD5.
SMRiQ8BMD5. Positions 88-158, 321-462.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000128022.

PTM databases

iPTMnetiQ8BMD5.
PhosphoSiteiQ8BMD5.

Proteomic databases

EPDiQ8BMD5.
MaxQBiQ8BMD5.
PaxDbiQ8BMD5.
PRIDEiQ8BMD5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022555; ENSMUSP00000022555; ENSMUSG00000021982. [Q8BMD5-2]
ENSMUST00000056997; ENSMUSP00000052233; ENSMUSG00000021982. [Q8BMD5-1]
ENSMUST00000171683; ENSMUSP00000128064; ENSMUSG00000021982. [Q8BMD5-4]
GeneIDi71891.
KEGGimmu:71891.
UCSCiuc007ueo.2. mouse. [Q8BMD5-1]
uc007uep.2. mouse. [Q8BMD5-4]
uc011zmw.1. mouse. [Q8BMD5-3]
uc011zmx.1. mouse. [Q8BMD5-2]

Organism-specific databases

CTDi81602.
MGIiMGI:1919141. Cdadc1.

Phylogenomic databases

eggNOGiKOG3127. Eukaryota.
COG2131. LUCA.
GeneTreeiENSGT00390000001951.
HOVERGENiHBG057359.
InParanoidiQ8BMD5.
PhylomeDBiQ8BMD5.

Miscellaneous databases

ChiTaRSiCdadc1. mouse.
PROiQ8BMD5.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BMD5.
CleanExiMM_CDADC1.
ExpressionAtlasiQ8BMD5. baseline and differential.
GenevisibleiQ8BMD5. MM.

Family and domain databases

InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR016193. Cytidine_deaminase-like.
IPR015517. dCMP_deaminase-rel.
[Graphical view]
PANTHERiPTHR11086. PTHR11086. 3 hits.
PfamiPF00383. dCMP_cyt_deam_1. 2 hits.
[Graphical view]
SUPFAMiSSF53927. SSF53927. 2 hits.
PROSITEiPS00903. CYT_DCMP_DEAMINASES_1. 1 hit.
PS51747. CYT_DCMP_DEAMINASES_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3; 4 AND 6).
    Strain: C57BL/6J.
    Tissue: Hypothalamus, Olfactory bulb, Tongue and Wolffian duct.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 289-523 (ISOFORM 4).
    Strain: Czech II and FVB/N.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiCDAC1_MOUSE
AccessioniPrimary (citable) accession number: Q8BMD5
Secondary accession number(s): Q8BYL2
, Q8BYN1, Q8C014, Q922P4, Q99KL2, Q9D7F3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 1, 2003
Last modified: June 8, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.