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Protein

Cytidine and dCMP deaminase domain-containing protein 1

Gene

Cdadc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play an important role in testicular development and spermatogenesis.By similarity

Cofactori

Zn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi399Zinc; catalyticBy similarity1
Active sitei401Proton donorBy similarity1
Metal bindingi427Zinc; catalyticBy similarity1
Metal bindingi430Zinc; catalyticBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Cytidine and dCMP deaminase domain-containing protein 1
Gene namesi
Name:Cdadc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1919141. Cdadc1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003004931 – 523Cytidine and dCMP deaminase domain-containing protein 1Add BLAST523

Proteomic databases

PaxDbiQ8BMD5.
PRIDEiQ8BMD5.

PTM databases

iPTMnetiQ8BMD5.
PhosphoSitePlusiQ8BMD5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000021982.
CleanExiMM_CDADC1.
ExpressionAtlasiQ8BMD5. baseline and differential.
GenevisibleiQ8BMD5. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000128022.

Structurei

3D structure databases

ProteinModelPortaliQ8BMD5.
SMRiQ8BMD5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini71 – 169CMP/dCMP-type deaminase 1PROSITE-ProRule annotationAdd BLAST99
Domaini318 – 483CMP/dCMP-type deaminase 2PROSITE-ProRule annotationAdd BLAST166

Sequence similaritiesi

Contains 2 CMP/dCMP-type deaminase domains.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3127. Eukaryota.
COG2131. LUCA.
GeneTreeiENSGT00390000001951.
HOVERGENiHBG057359.
InParanoidiQ8BMD5.
PhylomeDBiQ8BMD5.

Family and domain databases

CDDicd01286. deoxycytidylate_deaminase. 1 hit.
InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR016193. Cytidine_deaminase-like.
IPR015517. dCMP_deaminase-rel.
[Graphical view]
PANTHERiPTHR11086. PTHR11086. 3 hits.
PfamiPF00383. dCMP_cyt_deam_1. 2 hits.
[Graphical view]
SUPFAMiSSF53927. SSF53927. 2 hits.
PROSITEiPS00903. CYT_DCMP_DEAMINASES_1. 1 hit.
PS51747. CYT_DCMP_DEAMINASES_2. 2 hits.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BMD5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKETDQMQSL EGSGAERSVG TQTGSMTGQI PRLSKVNLFT LLSLWMELFP
60 70 80 90 100
GVEAQGQKSQ KTEEESRGPL GDNEELTRVS TEKKQVKKTG LVVVKNMKII
110 120 130 140 150
GLHCSSEDLH TGQIALIKHG SRLKNCDLYF SRKPCSACLK MIVNAGVNRI
160 170 180 190 200
SYWPSDPEIS LLTEASSSED AKLDAKAAER LKSNSRAHVC VLLQPLVCYM
210 220 230 240 250
VQFVEETSYK CDFIQKTAKA LPGADTDFYS ECKQERIKEY EMLFLVSNEE
260 270 280 290 300
RHKQILMTIG LESLCEDPYF SNLRQNMKDL ILLLATVASS VPNLKHFGFY
310 320 330 340 350
CSSPEQINEI HNQSLPQEVA RHCMVQARLL AYRTEDHKTG VGAVIWAEAK
360 370 380 390 400
SRSCDGTGAM YFIGCGYNAF PVGSEYADFP HMDDKHKDRE IRKFRYIIHA
410 420 430 440 450
EQNALTFRCQ DIKPEERSMI FVTKCPCDEC VPLIKGAGIK QIYAGDVDVG
460 470 480 490 500
KKKADISYMK FGELEGVRKF TWQLNPSEAY SLDPNEPERR ENGVLRRRSA
510 520
KDEQRSSKRP RLETRSAGRA TLQ
Length:523
Mass (Da):59,062
Last modified:March 1, 2003 - v1
Checksum:i49E525840EE7B274
GO
Isoform 2 (identifier: Q8BMD5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     492-499: NGVLRRRS → RSATTACF
     500-523: Missing.

Show »
Length:499
Mass (Da):56,237
Checksum:iE0D75761F95B2C7A
GO
Isoform 3 (identifier: Q8BMD5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     492-497: NGVLRR → SFFFMP
     498-523: Missing.

Show »
Length:497
Mass (Da):56,156
Checksum:iFDC6D13F200B5C62
GO
Isoform 4 (identifier: Q8BMD5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     492-500: NGVLRRRSA → KHLSIKRSH
     501-523: Missing.

Show »
Length:500
Mass (Da):56,487
Checksum:i46A1BDE9900D41C8
GO
Isoform 6 (identifier: Q8BMD5-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-96: Missing.
     480-523: Missing.

Show »
Length:383
Mass (Da):43,376
Checksum:i1147071F4A65BC08
GO

Sequence cautioni

The sequence BAB26191 differs from that shown. Reason: Frameshift at position 82.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti252H → R in BAC30171 (PubMed:16141072).Curated1
Sequence conflicti310 – 312IHN → VHS in AAH04588 (PubMed:15489334).Curated3
Sequence conflicti417R → H in BAC30171 (PubMed:16141072).Curated1
Sequence conflicti417R → H in AAH04588 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0278171 – 96Missing in isoform 6. 1 PublicationAdd BLAST96
Alternative sequenceiVSP_027818480 – 523Missing in isoform 6. 1 PublicationAdd BLAST44
Alternative sequenceiVSP_027819492 – 500NGVLRRRSA → KHLSIKRSH in isoform 4. 2 Publications9
Alternative sequenceiVSP_027820492 – 499NGVLRRRS → RSATTACF in isoform 2. 1 Publication8
Alternative sequenceiVSP_027821492 – 497NGVLRR → SFFFMP in isoform 3. 1 Publication6
Alternative sequenceiVSP_027822498 – 523Missing in isoform 3. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_027823500 – 523Missing in isoform 2. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_027824501 – 523Missing in isoform 4. 2 PublicationsAdd BLAST23

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009280 mRNA. Translation: BAB26191.1. Frameshift.
AK032600 mRNA. Translation: BAC27943.1.
AK032813 mRNA. Translation: BAC28036.1.
AK038926 mRNA. Translation: BAC30171.1.
AK039148 mRNA. Translation: BAC30255.1.
BC004588 mRNA. Translation: AAH04588.1.
BC006901 mRNA. Translation: AAH06901.1.
CCDSiCCDS36940.1. [Q8BMD5-1]
CCDS49513.1. [Q8BMD5-2]
CCDS49515.1. [Q8BMD5-4]
RefSeqiNP_001162007.1. NM_001168535.1.
NP_001162008.1. NM_001168536.1. [Q8BMD5-4]
NP_001162009.1. NM_001168537.1. [Q8BMD5-2]
NP_001162010.1. NM_001168538.1. [Q8BMD5-3]
NP_082262.1. NM_027986.3. [Q8BMD5-1]
XP_017171695.1. XM_017316206.1.
UniGeneiMm.439850.

Genome annotation databases

EnsembliENSMUST00000022555; ENSMUSP00000022555; ENSMUSG00000021982. [Q8BMD5-2]
ENSMUST00000056997; ENSMUSP00000052233; ENSMUSG00000021982. [Q8BMD5-1]
ENSMUST00000171683; ENSMUSP00000128064; ENSMUSG00000021982. [Q8BMD5-4]
GeneIDi71891.
KEGGimmu:71891.
UCSCiuc007ueo.2. mouse. [Q8BMD5-1]
uc007uep.2. mouse. [Q8BMD5-4]
uc011zmw.1. mouse. [Q8BMD5-3]
uc011zmx.1. mouse. [Q8BMD5-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009280 mRNA. Translation: BAB26191.1. Frameshift.
AK032600 mRNA. Translation: BAC27943.1.
AK032813 mRNA. Translation: BAC28036.1.
AK038926 mRNA. Translation: BAC30171.1.
AK039148 mRNA. Translation: BAC30255.1.
BC004588 mRNA. Translation: AAH04588.1.
BC006901 mRNA. Translation: AAH06901.1.
CCDSiCCDS36940.1. [Q8BMD5-1]
CCDS49513.1. [Q8BMD5-2]
CCDS49515.1. [Q8BMD5-4]
RefSeqiNP_001162007.1. NM_001168535.1.
NP_001162008.1. NM_001168536.1. [Q8BMD5-4]
NP_001162009.1. NM_001168537.1. [Q8BMD5-2]
NP_001162010.1. NM_001168538.1. [Q8BMD5-3]
NP_082262.1. NM_027986.3. [Q8BMD5-1]
XP_017171695.1. XM_017316206.1.
UniGeneiMm.439850.

3D structure databases

ProteinModelPortaliQ8BMD5.
SMRiQ8BMD5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000128022.

PTM databases

iPTMnetiQ8BMD5.
PhosphoSitePlusiQ8BMD5.

Proteomic databases

PaxDbiQ8BMD5.
PRIDEiQ8BMD5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022555; ENSMUSP00000022555; ENSMUSG00000021982. [Q8BMD5-2]
ENSMUST00000056997; ENSMUSP00000052233; ENSMUSG00000021982. [Q8BMD5-1]
ENSMUST00000171683; ENSMUSP00000128064; ENSMUSG00000021982. [Q8BMD5-4]
GeneIDi71891.
KEGGimmu:71891.
UCSCiuc007ueo.2. mouse. [Q8BMD5-1]
uc007uep.2. mouse. [Q8BMD5-4]
uc011zmw.1. mouse. [Q8BMD5-3]
uc011zmx.1. mouse. [Q8BMD5-2]

Organism-specific databases

CTDi81602.
MGIiMGI:1919141. Cdadc1.

Phylogenomic databases

eggNOGiKOG3127. Eukaryota.
COG2131. LUCA.
GeneTreeiENSGT00390000001951.
HOVERGENiHBG057359.
InParanoidiQ8BMD5.
PhylomeDBiQ8BMD5.

Miscellaneous databases

ChiTaRSiCdadc1. mouse.
PROiQ8BMD5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021982.
CleanExiMM_CDADC1.
ExpressionAtlasiQ8BMD5. baseline and differential.
GenevisibleiQ8BMD5. MM.

Family and domain databases

CDDicd01286. deoxycytidylate_deaminase. 1 hit.
InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR016193. Cytidine_deaminase-like.
IPR015517. dCMP_deaminase-rel.
[Graphical view]
PANTHERiPTHR11086. PTHR11086. 3 hits.
PfamiPF00383. dCMP_cyt_deam_1. 2 hits.
[Graphical view]
SUPFAMiSSF53927. SSF53927. 2 hits.
PROSITEiPS00903. CYT_DCMP_DEAMINASES_1. 1 hit.
PS51747. CYT_DCMP_DEAMINASES_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCDAC1_MOUSE
AccessioniPrimary (citable) accession number: Q8BMD5
Secondary accession number(s): Q8BYL2
, Q8BYN1, Q8C014, Q922P4, Q99KL2, Q9D7F3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.