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Protein

SHC-transforming protein 2

Gene

Shc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-167044 Signalling to RAS
R-MMU-4420097 VEGFA-VEGFR2 Pathway
R-MMU-5673001 RAF/MAP kinase cascade

Names & Taxonomyi

Protein namesi
Recommended name:
SHC-transforming protein 2
Alternative name(s):
Protein Sck
Protein Sli
SHC-transforming protein B
Src homology 2 domain-containing-transforming protein C2
Short name:
SH2 domain protein C2
Gene namesi
Name:Shc2
Synonyms:Sck, ShcB
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:106180 Shc2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000977331 – 573SHC-transforming protein 2Add BLAST573

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei316Phosphotyrosine1 Publication1
Modified residuei317Phosphotyrosine1 Publication1
Modified residuei395Phosphotyrosine1 Publication1

Post-translational modificationi

Phosphorylated on tyrosine by the Trk receptors.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8BMC3
PaxDbiQ8BMC3
PRIDEiQ8BMC3

PTM databases

iPTMnetiQ8BMC3
PhosphoSitePlusiQ8BMC3

Expressioni

Tissue specificityi

Expressed in brain. Expressed at high level in the hypothalamus and at low level in the caudate nucleus.

Gene expression databases

BgeeiENSMUSG00000020312
ExpressionAtlasiQ8BMC3 baseline and differential
GenevisibleiQ8BMC3 MM

Interactioni

Subunit structurei

Interacts with the Trk receptors in a phosphotyrosine-dependent manner and MEGF12. Once activated, binds to GRB2 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi229705, 2 interactors
IntActiQ8BMC3, 1 interactor
MINTiQ8BMC3
STRINGi10090.ENSMUSP00000129491

Structurei

3D structure databases

ProteinModelPortaliQ8BMC3
SMRiQ8BMC3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini125 – 309PIDPROSITE-ProRule annotationAdd BLAST185
Domaini478 – 569SH2PROSITE-ProRule annotationAdd BLAST92

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni310 – 477CH1Add BLAST168

Domaini

The PID domain mediates binding to the TrkA receptor.By similarity

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiKOG3697 Eukaryota
ENOG410XTJN LUCA
GeneTreeiENSGT00390000018860
HOGENOMiHOG000231974
HOVERGENiHBG050121
InParanoidiQ8BMC3
KOiK17447
OMAiPRMPQWK
OrthoDBiEOG091G04DC
PhylomeDBiQ8BMC3
TreeFamiTF315807

Family and domain databases

CDDicd01209 PTB_Shc, 1 hit
cd09925 SH2_SHC, 1 hit
Gene3Di2.30.29.30, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR006019 PID_Shc-like
IPR006020 PTB/PI_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR029591 SHC2
IPR035676 SHC_SH2
PANTHERiPTHR10337:SF5 PTHR10337:SF5, 1 hit
PfamiView protein in Pfam
PF00640 PID, 1 hit
PF00017 SH2, 1 hit
PRINTSiPR00401 SH2DOMAIN
PR00629 SHCPIDOMAIN
SMARTiView protein in SMART
SM00462 PTB, 1 hit
SM00252 SH2, 1 hit
SUPFAMiSSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS01179 PID, 1 hit
PS50001 SH2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BMC3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQGPGGRAA PEPEAPTTFC ALLPRMPQWK FAAPGSFLGR GPAATRVAGV
60 70 80 90 100
AEAQPEPGVP ALAAVLGACE PRCAAPCPLP ALGRCRGSGT RGARVTPDVA
110 120 130 140 150
DEWVRKGGFI HKPAHGWLHP DARVLGPGVS YIVRYMGCIE VLRSMRSLDF
160 170 180 190 200
NTRTQVTREA INRLHEAVPG VRGSWKKKAP NKALASILGK SNLRFAGMSI
210 220 230 240 250
SVNISVDGLN LSVPATRQII ANHHMQSISF ASGGDTDMTD YVAYVAKDPI
260 270 280 290 300
NQRACHILEC CEGLAQSVIS TVGQAFELRF KQYLHSPPKA VVPPERLTGL
310 320 330 340 350
EELAWGDDDA AADHNYYNSI PGKEPPLGGL VDSRLAVTQP CALATLGGLG
360 370 380 390 400
QGMTPVWRDA RGLPWDMGPS GAAPPGDGYV QADARGPHDY EEHLYVNTQG
410 420 430 440 450
LDAVELEDTA EAPLQFEDSP KKDLFDMRPF EDALKLHACS VAAGITAASP
460 470 480 490 500
PLEDQWPSPP TRRAPIAPTE EQLRQEPWYH GRMSRRAAEK LLRADGDFLV
510 520 530 540 550
RDSVTNPGQY VLTGMHAGQP KHLLLVDPEG VVRTKDVLFE SISHLIDYHL
560 570
KNGLPIVAAE SELHLRGVVS REP
Length:573
Mass (Da):61,771
Last modified:July 1, 2008 - v3
Checksum:i7663705836A902C8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti84 – 93RCRGSGTRGA → PGSAGAPRRP in BAC28066 (PubMed:16141072).Curated10

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC132265 Genomic DNA No translation available.
AK032878 mRNA Translation: BAC28066.1
CCDSiCCDS48620.1
RefSeqiNP_001019710.1, NM_001024539.1
UniGeneiMm.39424

Genome annotation databases

EnsembliENSMUST00000020564; ENSMUSP00000020564; ENSMUSG00000020312
GeneIDi216148
KEGGimmu:216148
UCSCiuc007fzd.2 mouse

Similar proteinsi

Entry informationi

Entry nameiSHC2_MOUSE
AccessioniPrimary (citable) accession number: Q8BMC3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: July 1, 2008
Last modified: March 28, 2018
This is version 117 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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