Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

SHC-transforming protein 2

Gene

Shc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-167044. Signalling to RAS.
R-MMU-4420097. VEGFA-VEGFR2 Pathway.
R-MMU-5673001. RAF/MAP kinase cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
SHC-transforming protein 2
Alternative name(s):
Protein Sck
Protein Sli
SHC-transforming protein B
Src homology 2 domain-containing-transforming protein C2
Short name:
SH2 domain protein C2
Gene namesi
Name:Shc2
Synonyms:Sck, ShcB
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:106180. Shc2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000977331 – 573SHC-transforming protein 2Add BLAST573

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei316Phosphotyrosine1 Publication1
Modified residuei317Phosphotyrosine1 Publication1
Modified residuei395Phosphotyrosine1 Publication1

Post-translational modificationi

Phosphorylated on tyrosine by the Trk receptors.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8BMC3.
PaxDbiQ8BMC3.
PRIDEiQ8BMC3.

PTM databases

iPTMnetiQ8BMC3.
PhosphoSitePlusiQ8BMC3.

Expressioni

Tissue specificityi

Expressed in brain. Expressed at high level in the hypothalamus and at low level in the caudate nucleus.

Gene expression databases

BgeeiENSMUSG00000020312.
ExpressionAtlasiQ8BMC3. baseline and differential.
GenevisibleiQ8BMC3. MM.

Interactioni

Subunit structurei

Interacts with the Trk receptors in a phosphotyrosine-dependent manner and MEGF12. Once activated, binds to GRB2 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi229705. 2 interactors.
IntActiQ8BMC3. 1 interactor.
STRINGi10090.ENSMUSP00000129491.

Structurei

3D structure databases

ProteinModelPortaliQ8BMC3.
SMRiQ8BMC3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini125 – 309PIDPROSITE-ProRule annotationAdd BLAST185
Domaini478 – 569SH2PROSITE-ProRule annotationAdd BLAST92

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni310 – 477CH1Add BLAST168

Domaini

The PID domain mediates binding to the TrkA receptor.By similarity

Sequence similaritiesi

Contains 1 PID domain.PROSITE-ProRule annotation
Contains 1 SH2 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiKOG3697. Eukaryota.
ENOG410XTJN. LUCA.
GeneTreeiENSGT00390000018860.
HOGENOMiHOG000231974.
HOVERGENiHBG050121.
InParanoidiQ8BMC3.
KOiK17447.
OMAiPRMPQWK.
OrthoDBiEOG091G04DC.
PhylomeDBiQ8BMC3.
TreeFamiTF315807.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR006019. PID_Shc-like.
IPR006020. PTB/PI_dom.
IPR000980. SH2.
IPR029591. SHC2.
[Graphical view]
PANTHERiPTHR10337:SF5. PTHR10337:SF5. 2 hits.
PfamiPF00640. PID. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00629. SHCPIDOMAIN.
SMARTiSM00462. PTB. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS01179. PID. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BMC3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQGPGGRAA PEPEAPTTFC ALLPRMPQWK FAAPGSFLGR GPAATRVAGV
60 70 80 90 100
AEAQPEPGVP ALAAVLGACE PRCAAPCPLP ALGRCRGSGT RGARVTPDVA
110 120 130 140 150
DEWVRKGGFI HKPAHGWLHP DARVLGPGVS YIVRYMGCIE VLRSMRSLDF
160 170 180 190 200
NTRTQVTREA INRLHEAVPG VRGSWKKKAP NKALASILGK SNLRFAGMSI
210 220 230 240 250
SVNISVDGLN LSVPATRQII ANHHMQSISF ASGGDTDMTD YVAYVAKDPI
260 270 280 290 300
NQRACHILEC CEGLAQSVIS TVGQAFELRF KQYLHSPPKA VVPPERLTGL
310 320 330 340 350
EELAWGDDDA AADHNYYNSI PGKEPPLGGL VDSRLAVTQP CALATLGGLG
360 370 380 390 400
QGMTPVWRDA RGLPWDMGPS GAAPPGDGYV QADARGPHDY EEHLYVNTQG
410 420 430 440 450
LDAVELEDTA EAPLQFEDSP KKDLFDMRPF EDALKLHACS VAAGITAASP
460 470 480 490 500
PLEDQWPSPP TRRAPIAPTE EQLRQEPWYH GRMSRRAAEK LLRADGDFLV
510 520 530 540 550
RDSVTNPGQY VLTGMHAGQP KHLLLVDPEG VVRTKDVLFE SISHLIDYHL
560 570
KNGLPIVAAE SELHLRGVVS REP
Length:573
Mass (Da):61,771
Last modified:July 1, 2008 - v3
Checksum:i7663705836A902C8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti84 – 93RCRGSGTRGA → PGSAGAPRRP in BAC28066 (PubMed:16141072).Curated10

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC132265 Genomic DNA. No translation available.
AK032878 mRNA. Translation: BAC28066.1.
CCDSiCCDS48620.1.
RefSeqiNP_001019710.1. NM_001024539.1.
UniGeneiMm.39424.

Genome annotation databases

EnsembliENSMUST00000163867; ENSMUSP00000129491; ENSMUSG00000020312.
GeneIDi216148.
KEGGimmu:216148.
UCSCiuc007fzd.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC132265 Genomic DNA. No translation available.
AK032878 mRNA. Translation: BAC28066.1.
CCDSiCCDS48620.1.
RefSeqiNP_001019710.1. NM_001024539.1.
UniGeneiMm.39424.

3D structure databases

ProteinModelPortaliQ8BMC3.
SMRiQ8BMC3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi229705. 2 interactors.
IntActiQ8BMC3. 1 interactor.
STRINGi10090.ENSMUSP00000129491.

PTM databases

iPTMnetiQ8BMC3.
PhosphoSitePlusiQ8BMC3.

Proteomic databases

MaxQBiQ8BMC3.
PaxDbiQ8BMC3.
PRIDEiQ8BMC3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000163867; ENSMUSP00000129491; ENSMUSG00000020312.
GeneIDi216148.
KEGGimmu:216148.
UCSCiuc007fzd.2. mouse.

Organism-specific databases

CTDi25759.
MGIiMGI:106180. Shc2.

Phylogenomic databases

eggNOGiKOG3697. Eukaryota.
ENOG410XTJN. LUCA.
GeneTreeiENSGT00390000018860.
HOGENOMiHOG000231974.
HOVERGENiHBG050121.
InParanoidiQ8BMC3.
KOiK17447.
OMAiPRMPQWK.
OrthoDBiEOG091G04DC.
PhylomeDBiQ8BMC3.
TreeFamiTF315807.

Enzyme and pathway databases

ReactomeiR-MMU-167044. Signalling to RAS.
R-MMU-4420097. VEGFA-VEGFR2 Pathway.
R-MMU-5673001. RAF/MAP kinase cascade.

Miscellaneous databases

PROiQ8BMC3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020312.
ExpressionAtlasiQ8BMC3. baseline and differential.
GenevisibleiQ8BMC3. MM.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR006019. PID_Shc-like.
IPR006020. PTB/PI_dom.
IPR000980. SH2.
IPR029591. SHC2.
[Graphical view]
PANTHERiPTHR10337:SF5. PTHR10337:SF5. 2 hits.
PfamiPF00640. PID. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00629. SHCPIDOMAIN.
SMARTiSM00462. PTB. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS01179. PID. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSHC2_MOUSE
AccessioniPrimary (citable) accession number: Q8BMC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: July 1, 2008
Last modified: November 2, 2016
This is version 106 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.