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Q8BMC1

- VATG3_MOUSE

UniProt

Q8BMC1 - VATG3_MOUSE

Protein

V-type proton ATPase subunit G 3

Gene

Atp6v1g3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

    GO - Molecular functioni

    1. hydrogen-exporting ATPase activity, phosphorylative mechanism Source: MGI

    GO - Biological processi

    1. ATP hydrolysis coupled proton transport Source: MGI

    Keywords - Biological processi

    Hydrogen ion transport, Ion transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_198345. Phagosomal maturation (early endosomal stage).
    REACT_198515. Transferrin endocytosis and recycling.

    Protein family/group databases

    TCDBi3.A.2.2.6. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    V-type proton ATPase subunit G 3
    Short name:
    V-ATPase subunit G 3
    Alternative name(s):
    V-ATPase 13 kDa subunit 3
    Vacuolar proton pump subunit G 3
    Gene namesi
    Name:Atp6v1g3
    Synonyms:Atp6g3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:2450548. Atp6v1g3.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: UniProtKB
    2. membrane Source: MGI
    3. plasma membrane Source: UniProtKB
    4. vacuolar proton-transporting V-type ATPase complex Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 118118V-type proton ATPase subunit G 3PRO_0000285921Add
    BLAST

    Proteomic databases

    MaxQBiQ8BMC1.
    PaxDbiQ8BMC1.
    PRIDEiQ8BMC1.

    PTM databases

    PhosphoSiteiQ8BMC1.

    Expressioni

    Tissue specificityi

    Kidney.1 Publication

    Gene expression databases

    BgeeiQ8BMC1.
    CleanExiMM_ATP6V1G3.
    GenevestigatoriQ8BMC1.

    Interactioni

    Subunit structurei

    V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000027643.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BMC1.
    SMRiQ8BMC1. Positions 1-107.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili5 – 5349Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the V-ATPase G subunit family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG235870.
    GeneTreeiENSGT00390000011172.
    HOGENOMiHOG000186416.
    HOVERGENiHBG057827.
    InParanoidiQ8BMC1.
    KOiK02152.
    OMAiHVNYRAT.
    OrthoDBiEOG7MWH0X.
    PhylomeDBiQ8BMC1.
    TreeFamiTF313777.

    Family and domain databases

    InterProiIPR005124. V-ATPase_G.
    [Graphical view]
    PANTHERiPTHR12713. PTHR12713. 1 hit.
    TIGRFAMsiTIGR01147. V_ATP_synt_G. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8BMC1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSQSQGIQQ LLQAEKRAKD KLDEAKKRKG KRLRQAKEEA VAETDQYRMQ    50
    MEKDFRLKQA KIMGSQSHLS DEIEEQTLEK IKELNGSYNK CMESVIKQLL 100
    SMVCDMKPEV HVNYRATN 118
    Length:118
    Mass (Da):13,749
    Last modified:March 1, 2003 - v1
    Checksum:i1D3EF03A5CEB61EE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB088359 mRNA. Translation: BAC57952.1.
    AK032887 mRNA. Translation: BAC28072.1.
    BC107267 mRNA. Translation: AAI07268.1.
    BC107268 mRNA. Translation: AAI07269.1.
    CCDSiCCDS15331.1.
    RefSeqiNP_796371.1. NM_177397.3.
    UniGeneiMm.114424.

    Genome annotation databases

    EnsembliENSMUST00000027643; ENSMUSP00000027643; ENSMUSG00000026394.
    GeneIDi338375.
    KEGGimmu:338375.
    UCSCiuc007cvm.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB088359 mRNA. Translation: BAC57952.1 .
    AK032887 mRNA. Translation: BAC28072.1 .
    BC107267 mRNA. Translation: AAI07268.1 .
    BC107268 mRNA. Translation: AAI07269.1 .
    CCDSi CCDS15331.1.
    RefSeqi NP_796371.1. NM_177397.3.
    UniGenei Mm.114424.

    3D structure databases

    ProteinModelPortali Q8BMC1.
    SMRi Q8BMC1. Positions 1-107.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000027643.

    Protein family/group databases

    TCDBi 3.A.2.2.6. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

    PTM databases

    PhosphoSitei Q8BMC1.

    Proteomic databases

    MaxQBi Q8BMC1.
    PaxDbi Q8BMC1.
    PRIDEi Q8BMC1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000027643 ; ENSMUSP00000027643 ; ENSMUSG00000026394 .
    GeneIDi 338375.
    KEGGi mmu:338375.
    UCSCi uc007cvm.1. mouse.

    Organism-specific databases

    CTDi 127124.
    MGIi MGI:2450548. Atp6v1g3.

    Phylogenomic databases

    eggNOGi NOG235870.
    GeneTreei ENSGT00390000011172.
    HOGENOMi HOG000186416.
    HOVERGENi HBG057827.
    InParanoidi Q8BMC1.
    KOi K02152.
    OMAi HVNYRAT.
    OrthoDBi EOG7MWH0X.
    PhylomeDBi Q8BMC1.
    TreeFami TF313777.

    Enzyme and pathway databases

    Reactomei REACT_198345. Phagosomal maturation (early endosomal stage).
    REACT_198515. Transferrin endocytosis and recycling.

    Miscellaneous databases

    NextBioi 400195.
    PROi Q8BMC1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8BMC1.
    CleanExi MM_ATP6V1G3.
    Genevestigatori Q8BMC1.

    Family and domain databases

    InterProi IPR005124. V-ATPase_G.
    [Graphical view ]
    PANTHERi PTHR12713. PTHR12713. 1 hit.
    TIGRFAMsi TIGR01147. V_ATP_synt_G. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Diversity of mouse proton-translocating ATPase: presence of multiple isoforms of the C, d and G subunits."
      Sun-Wada G.-H., Yoshimizu T., Imai-Senga Y., Wada Y., Futai M.
      Gene 302:147-153(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Wolffian duct.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiVATG3_MOUSE
    AccessioniPrimary (citable) accession number: Q8BMC1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 2007
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3