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Q8BMC1

- VATG3_MOUSE

UniProt

Q8BMC1 - VATG3_MOUSE

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Protein

V-type proton ATPase subunit G 3

Gene

Atp6v1g3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

GO - Molecular functioni

  1. hydrogen-exporting ATPase activity, phosphorylative mechanism Source: MGI

GO - Biological processi

  1. ATP hydrolysis coupled proton transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiREACT_198345. Phagosomal maturation (early endosomal stage).
REACT_198515. Transferrin endocytosis and recycling.

Protein family/group databases

TCDBi3.A.2.2.6. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit G 3
Short name:
V-ATPase subunit G 3
Alternative name(s):
V-ATPase 13 kDa subunit 3
Vacuolar proton pump subunit G 3
Gene namesi
Name:Atp6v1g3
Synonyms:Atp6g3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:2450548. Atp6v1g3.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: UniProtKB
  2. membrane Source: MGI
  3. plasma membrane Source: UniProtKB
  4. vacuolar proton-transporting V-type ATPase complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 118118V-type proton ATPase subunit G 3PRO_0000285921Add
BLAST

Proteomic databases

MaxQBiQ8BMC1.
PaxDbiQ8BMC1.
PRIDEiQ8BMC1.

PTM databases

PhosphoSiteiQ8BMC1.

Expressioni

Tissue specificityi

Kidney.1 Publication

Gene expression databases

BgeeiQ8BMC1.
CleanExiMM_ATP6V1G3.
GenevestigatoriQ8BMC1.

Interactioni

Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027643.

Structurei

3D structure databases

ProteinModelPortaliQ8BMC1.
SMRiQ8BMC1. Positions 1-107.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili5 – 5349Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the V-ATPase G subunit family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG235870.
GeneTreeiENSGT00390000011172.
HOGENOMiHOG000186416.
HOVERGENiHBG057827.
InParanoidiQ8BMC1.
KOiK02152.
OMAiHVNYRAT.
OrthoDBiEOG7MWH0X.
PhylomeDBiQ8BMC1.
TreeFamiTF313777.

Family and domain databases

InterProiIPR005124. V-ATPase_G.
[Graphical view]
PANTHERiPTHR12713. PTHR12713. 1 hit.
TIGRFAMsiTIGR01147. V_ATP_synt_G. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8BMC1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTSQSQGIQQ LLQAEKRAKD KLDEAKKRKG KRLRQAKEEA VAETDQYRMQ
60 70 80 90 100
MEKDFRLKQA KIMGSQSHLS DEIEEQTLEK IKELNGSYNK CMESVIKQLL
110
SMVCDMKPEV HVNYRATN
Length:118
Mass (Da):13,749
Last modified:March 1, 2003 - v1
Checksum:i1D3EF03A5CEB61EE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB088359 mRNA. Translation: BAC57952.1.
AK032887 mRNA. Translation: BAC28072.1.
BC107267 mRNA. Translation: AAI07268.1.
BC107268 mRNA. Translation: AAI07269.1.
CCDSiCCDS15331.1.
RefSeqiNP_796371.1. NM_177397.3.
UniGeneiMm.114424.

Genome annotation databases

EnsembliENSMUST00000027643; ENSMUSP00000027643; ENSMUSG00000026394.
GeneIDi338375.
KEGGimmu:338375.
UCSCiuc007cvm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB088359 mRNA. Translation: BAC57952.1 .
AK032887 mRNA. Translation: BAC28072.1 .
BC107267 mRNA. Translation: AAI07268.1 .
BC107268 mRNA. Translation: AAI07269.1 .
CCDSi CCDS15331.1.
RefSeqi NP_796371.1. NM_177397.3.
UniGenei Mm.114424.

3D structure databases

ProteinModelPortali Q8BMC1.
SMRi Q8BMC1. Positions 1-107.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000027643.

Protein family/group databases

TCDBi 3.A.2.2.6. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

PTM databases

PhosphoSitei Q8BMC1.

Proteomic databases

MaxQBi Q8BMC1.
PaxDbi Q8BMC1.
PRIDEi Q8BMC1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000027643 ; ENSMUSP00000027643 ; ENSMUSG00000026394 .
GeneIDi 338375.
KEGGi mmu:338375.
UCSCi uc007cvm.1. mouse.

Organism-specific databases

CTDi 127124.
MGIi MGI:2450548. Atp6v1g3.

Phylogenomic databases

eggNOGi NOG235870.
GeneTreei ENSGT00390000011172.
HOGENOMi HOG000186416.
HOVERGENi HBG057827.
InParanoidi Q8BMC1.
KOi K02152.
OMAi HVNYRAT.
OrthoDBi EOG7MWH0X.
PhylomeDBi Q8BMC1.
TreeFami TF313777.

Enzyme and pathway databases

Reactomei REACT_198345. Phagosomal maturation (early endosomal stage).
REACT_198515. Transferrin endocytosis and recycling.

Miscellaneous databases

NextBioi 400195.
PROi Q8BMC1.
SOURCEi Search...

Gene expression databases

Bgeei Q8BMC1.
CleanExi MM_ATP6V1G3.
Genevestigatori Q8BMC1.

Family and domain databases

InterProi IPR005124. V-ATPase_G.
[Graphical view ]
PANTHERi PTHR12713. PTHR12713. 1 hit.
TIGRFAMsi TIGR01147. V_ATP_synt_G. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Diversity of mouse proton-translocating ATPase: presence of multiple isoforms of the C, d and G subunits."
    Sun-Wada G.-H., Yoshimizu T., Imai-Senga Y., Wada Y., Futai M.
    Gene 302:147-153(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Wolffian duct.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiVATG3_MOUSE
AccessioniPrimary (citable) accession number: Q8BMC1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: March 1, 2003
Last modified: October 1, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3