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Protein

V-type proton ATPase subunit G 3

Gene

Atp6v1g3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

GO - Molecular functioni

GO - Biological processi

  • ATP hydrolysis coupled proton transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-1222556. ROS, RNS production in response to bacteria.
R-MMU-77387. Insulin receptor recycling.
R-MMU-917977. Transferrin endocytosis and recycling.
R-MMU-983712. Ion channel transport.

Protein family/group databases

TCDBi3.A.2.2.6. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit G 3
Short name:
V-ATPase subunit G 3
Alternative name(s):
V-ATPase 13 kDa subunit 3
Vacuolar proton pump subunit G 3
Gene namesi
Name:Atp6v1g3
Synonyms:Atp6g3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2450548. Atp6v1g3.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: UniProtKB
  • membrane Source: MGI
  • plasma membrane Source: UniProtKB
  • vacuolar proton-transporting V-type ATPase complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 118118V-type proton ATPase subunit G 3PRO_0000285921Add
BLAST

Proteomic databases

MaxQBiQ8BMC1.
PaxDbiQ8BMC1.
PeptideAtlasiQ8BMC1.
PRIDEiQ8BMC1.

PTM databases

iPTMnetiQ8BMC1.
PhosphoSiteiQ8BMC1.

Expressioni

Tissue specificityi

Kidney.1 Publication

Gene expression databases

BgeeiENSMUSG00000026394.
CleanExiMM_ATP6V1G3.

Interactioni

Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027643.

Structurei

3D structure databases

ProteinModelPortaliQ8BMC1.
SMRiQ8BMC1. Positions 1-106.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili5 – 5349Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the V-ATPase G subunit family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1772. Eukaryota.
ENOG4111XX0. LUCA.
GeneTreeiENSGT00390000011172.
HOGENOMiHOG000186416.
HOVERGENiHBG057827.
InParanoidiQ8BMC1.
KOiK02152.
OMAiYNKYMES.
OrthoDBiEOG091G0XIZ.
PhylomeDBiQ8BMC1.
TreeFamiTF313777.

Family and domain databases

InterProiIPR005124. V-ATPase_G.
[Graphical view]
PANTHERiPTHR12713. PTHR12713. 1 hit.
TIGRFAMsiTIGR01147. V_ATP_synt_G. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8BMC1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSQSQGIQQ LLQAEKRAKD KLDEAKKRKG KRLRQAKEEA VAETDQYRMQ
60 70 80 90 100
MEKDFRLKQA KIMGSQSHLS DEIEEQTLEK IKELNGSYNK CMESVIKQLL
110
SMVCDMKPEV HVNYRATN
Length:118
Mass (Da):13,749
Last modified:March 1, 2003 - v1
Checksum:i1D3EF03A5CEB61EE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB088359 mRNA. Translation: BAC57952.1.
AK032887 mRNA. Translation: BAC28072.1.
BC107267 mRNA. Translation: AAI07268.1.
BC107268 mRNA. Translation: AAI07269.1.
CCDSiCCDS15331.1.
RefSeqiNP_796371.1. NM_177397.3.
UniGeneiMm.114424.

Genome annotation databases

EnsembliENSMUST00000027643; ENSMUSP00000027643; ENSMUSG00000026394.
GeneIDi338375.
KEGGimmu:338375.
UCSCiuc007cvm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB088359 mRNA. Translation: BAC57952.1.
AK032887 mRNA. Translation: BAC28072.1.
BC107267 mRNA. Translation: AAI07268.1.
BC107268 mRNA. Translation: AAI07269.1.
CCDSiCCDS15331.1.
RefSeqiNP_796371.1. NM_177397.3.
UniGeneiMm.114424.

3D structure databases

ProteinModelPortaliQ8BMC1.
SMRiQ8BMC1. Positions 1-106.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027643.

Protein family/group databases

TCDBi3.A.2.2.6. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

PTM databases

iPTMnetiQ8BMC1.
PhosphoSiteiQ8BMC1.

Proteomic databases

MaxQBiQ8BMC1.
PaxDbiQ8BMC1.
PeptideAtlasiQ8BMC1.
PRIDEiQ8BMC1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027643; ENSMUSP00000027643; ENSMUSG00000026394.
GeneIDi338375.
KEGGimmu:338375.
UCSCiuc007cvm.1. mouse.

Organism-specific databases

CTDi127124.
MGIiMGI:2450548. Atp6v1g3.

Phylogenomic databases

eggNOGiKOG1772. Eukaryota.
ENOG4111XX0. LUCA.
GeneTreeiENSGT00390000011172.
HOGENOMiHOG000186416.
HOVERGENiHBG057827.
InParanoidiQ8BMC1.
KOiK02152.
OMAiYNKYMES.
OrthoDBiEOG091G0XIZ.
PhylomeDBiQ8BMC1.
TreeFamiTF313777.

Enzyme and pathway databases

ReactomeiR-MMU-1222556. ROS, RNS production in response to bacteria.
R-MMU-77387. Insulin receptor recycling.
R-MMU-917977. Transferrin endocytosis and recycling.
R-MMU-983712. Ion channel transport.

Miscellaneous databases

PROiQ8BMC1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026394.
CleanExiMM_ATP6V1G3.

Family and domain databases

InterProiIPR005124. V-ATPase_G.
[Graphical view]
PANTHERiPTHR12713. PTHR12713. 1 hit.
TIGRFAMsiTIGR01147. V_ATP_synt_G. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiVATG3_MOUSE
AccessioniPrimary (citable) accession number: Q8BMC1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.