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Protein

V-type proton ATPase subunit G 3

Gene

Atp6v1g3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

GO - Molecular functioni

GO - Biological processi

  • ATP hydrolysis coupled proton transport Source: MGI

Keywordsi

Biological processHydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-1222556 ROS, RNS production in phagocytes
R-MMU-77387 Insulin receptor recycling
R-MMU-917977 Transferrin endocytosis and recycling
R-MMU-983712 Ion channel transport

Protein family/group databases

TCDBi3.A.2.2.6 the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit G 3
Short name:
V-ATPase subunit G 3
Alternative name(s):
V-ATPase 13 kDa subunit 3
Vacuolar proton pump subunit G 3
Gene namesi
Name:Atp6v1g3
Synonyms:Atp6g3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2450548 Atp6v1g3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002859211 – 118V-type proton ATPase subunit G 3Add BLAST118

Proteomic databases

MaxQBiQ8BMC1
PaxDbiQ8BMC1
PeptideAtlasiQ8BMC1
PRIDEiQ8BMC1

PTM databases

iPTMnetiQ8BMC1
PhosphoSitePlusiQ8BMC1

Expressioni

Tissue specificityi

Kidney.1 Publication

Gene expression databases

BgeeiENSMUSG00000026394
CleanExiMM_ATP6V1G3

Interactioni

Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027643

Structurei

3D structure databases

ProteinModelPortaliQ8BMC1
SMRiQ8BMC1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili5 – 53Sequence analysisAdd BLAST49

Sequence similaritiesi

Belongs to the V-ATPase G subunit family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1772 Eukaryota
ENOG4111XX0 LUCA
GeneTreeiENSGT00390000011172
HOGENOMiHOG000186416
HOVERGENiHBG057827
InParanoidiQ8BMC1
KOiK02152
OMAiYNKYMES
OrthoDBiEOG091G0XIZ
PhylomeDBiQ8BMC1
TreeFamiTF313777

Family and domain databases

InterProiView protein in InterPro
IPR005124 V-ATPase_G
PANTHERiPTHR12713 PTHR12713, 1 hit
PfamiView protein in Pfam
PF03179 V-ATPase_G, 1 hit
TIGRFAMsiTIGR01147 V_ATP_synt_G, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BMC1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSQSQGIQQ LLQAEKRAKD KLDEAKKRKG KRLRQAKEEA VAETDQYRMQ
60 70 80 90 100
MEKDFRLKQA KIMGSQSHLS DEIEEQTLEK IKELNGSYNK CMESVIKQLL
110
SMVCDMKPEV HVNYRATN
Length:118
Mass (Da):13,749
Last modified:March 1, 2003 - v1
Checksum:i1D3EF03A5CEB61EE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB088359 mRNA Translation: BAC57952.1
AK032887 mRNA Translation: BAC28072.1
BC107267 mRNA Translation: AAI07268.1
BC107268 mRNA Translation: AAI07269.1
CCDSiCCDS15331.1
RefSeqiNP_796371.1, NM_177397.3
UniGeneiMm.114424

Genome annotation databases

EnsembliENSMUST00000027643; ENSMUSP00000027643; ENSMUSG00000026394
GeneIDi338375
KEGGimmu:338375
UCSCiuc007cvm.1 mouse

Similar proteinsi

Entry informationi

Entry nameiVATG3_MOUSE
AccessioniPrimary (citable) accession number: Q8BMC1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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