Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Lysophosphatidic acid receptor 6

Gene

Lpar6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in the receptor activation. Important for the maintenance of hair growth and texture (By similarity).By similarity

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_207651. G alpha (q) signalling events.
REACT_239564. P2Y receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophosphatidic acid receptor 6
Short name:
LPA receptor 6
Short name:
LPA-6
Alternative name(s):
Oleoyl-L-alpha-lysophosphatidic acid receptor
P2Y purinoceptor 5
Short name:
P2Y5
Purinergic receptor 5
Gene namesi
Name:Lpar6
Synonyms:P2ry5, P2y5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:1914418. Lpar6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
BLAST
Transmembranei26 – 4621Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini47 – 5610CytoplasmicSequence Analysis
Transmembranei57 – 7721Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini78 – 9013ExtracellularSequence AnalysisAdd
BLAST
Transmembranei91 – 11121Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini112 – 13423CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei135 – 15521Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini156 – 18328ExtracellularSequence AnalysisAdd
BLAST
Transmembranei184 – 20421Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini205 – 23026CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei231 – 25121Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini252 – 27221ExtracellularSequence AnalysisAdd
BLAST
Transmembranei273 – 29321Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini294 – 34451CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 344344Lysophosphatidic acid receptor 6PRO_0000070026Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi89 ↔ 168PROSITE-ProRule annotation
Glycosylationi162 – 1621N-linked (GlcNAc...)Sequence Analysis
Glycosylationi163 – 1631N-linked (GlcNAc...)Sequence Analysis
Glycosylationi262 – 2621N-linked (GlcNAc...)Sequence Analysis
Lipidationi284 – 2841S-palmitoyl cysteineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

MaxQBiQ8BMC0.
PRIDEiQ8BMC0.

PTM databases

PhosphoSiteiQ8BMC0.

Expressioni

Tissue specificityi

Ubiquitously expressed. Detected in the hair follicles and skin (at protein level).2 Publications

Gene expression databases

BgeeiQ8BMC0.
CleanExiMM_P2RY5.
GenevestigatoriQ8BMC0.

Structurei

3D structure databases

ProteinModelPortaliQ8BMC0.
SMRiQ8BMC0. Positions 23-300.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG289230.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000231307.
HOVERGENiHBG101917.
InParanoidiQ8BMC0.
KOiK04273.
OMAiFRIFYFA.
OrthoDBiEOG71VSSZ.
PhylomeDBiQ8BMC0.
TreeFamiTF350009.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BMC0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSSNGSQCP YDDSFKYTLY GCMFSMVFVL GLISNCVAIY IFICALKVRN
60 70 80 90 100
ETTTYMINLA MSDLLFVFTL PFRIFYFATR NWPFGDLLCK ISVMLFYTNM
110 120 130 140 150
YGSILFLTCI SVDRFLAIVY PFKSKTLRTK RNAKIVCIAV WFTVMGGSAP
160 170 180 190 200
AVFFQSTHSQ GNNTSEACFE NFPAATWKTY LSRIVIFIEI VGFFIPLILN
210 220 230 240 250
VTCSSMVLRT LNKPVTLSRS KMNKTKVLKM IFVHLVIFCF CFVPYNINLI
260 270 280 290 300
LYSLMRTQTF VNCSVVAAVR TMYPITLCIA VSNCCFDPIV YYFTSDTIQN
310 320 330 340
SIKMKNWSVR RSDSRFSEVQ GTENFIQHNL QTLKNKIFDN ESAI
Length:344
Mass (Da):39,439
Last modified:March 1, 2003 - v1
Checksum:i50270D1D14AEDAB2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK032901 mRNA. Translation: BAC28077.1.
AK169602 mRNA. Translation: BAE41252.1.
BC145940 mRNA. Translation: AAI45941.1.
BC145942 mRNA. Translation: AAI45943.1.
BC069991 mRNA. Translation: AAH69991.1.
BC047931 mRNA. Translation: AAH47931.1.
CCDSiCCDS27268.1.
RefSeqiNP_780325.1. NM_175116.4.
UniGeneiMm.390681.

Genome annotation databases

EnsembliENSMUST00000044405; ENSMUSP00000042327; ENSMUSG00000033446.
GeneIDi67168.
KEGGimmu:67168.
UCSCiuc007upq.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK032901 mRNA. Translation: BAC28077.1.
AK169602 mRNA. Translation: BAE41252.1.
BC145940 mRNA. Translation: AAI45941.1.
BC145942 mRNA. Translation: AAI45943.1.
BC069991 mRNA. Translation: AAH69991.1.
BC047931 mRNA. Translation: AAH47931.1.
CCDSiCCDS27268.1.
RefSeqiNP_780325.1. NM_175116.4.
UniGeneiMm.390681.

3D structure databases

ProteinModelPortaliQ8BMC0.
SMRiQ8BMC0. Positions 23-300.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

GuidetoPHARMACOLOGYi163.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ8BMC0.

Proteomic databases

MaxQBiQ8BMC0.
PRIDEiQ8BMC0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044405; ENSMUSP00000042327; ENSMUSG00000033446.
GeneIDi67168.
KEGGimmu:67168.
UCSCiuc007upq.2. mouse.

Organism-specific databases

CTDi10161.
MGIiMGI:1914418. Lpar6.

Phylogenomic databases

eggNOGiNOG289230.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000231307.
HOVERGENiHBG101917.
InParanoidiQ8BMC0.
KOiK04273.
OMAiFRIFYFA.
OrthoDBiEOG71VSSZ.
PhylomeDBiQ8BMC0.
TreeFamiTF350009.

Enzyme and pathway databases

ReactomeiREACT_207651. G alpha (q) signalling events.
REACT_239564. P2Y receptors.

Miscellaneous databases

NextBioi323782.
PROiQ8BMC0.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BMC0.
CleanExiMM_P2RY5.
GenevestigatoriQ8BMC0.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Mesonephros and Thymus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Bone, Brain and Mammary gland.
  3. "G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth."
    Pasternack S.M., von Kuegelgen I., Aboud K.A., Lee Y.-A., Rueschendorf F., Voss K., Hillmer A.M., Molderings G.J., Franz T., Ramirez A., Nuernberg P., Noethen M.M., Betz R.C.
    Nat. Genet. 40:329-334(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  4. "Disruption of P2RY5, an orphan G protein-coupled receptor, underlies autosomal recessive woolly hair."
    Shimomura Y., Wajid M., Ishii Y., Shapiro L., Petukhova L., Gordon D., Christiano A.M.
    Nat. Genet. 40:335-339(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiLPAR6_MOUSE
AccessioniPrimary (citable) accession number: Q8BMC0
Secondary accession number(s): A6H6N5, Q3TEJ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: March 1, 2003
Last modified: February 4, 2015
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.