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Q8BMC0

- LPAR6_MOUSE

UniProt

Q8BMC0 - LPAR6_MOUSE

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Protein
Lysophosphatidic acid receptor 6
Gene
Lpar6, P2ry5, P2y5
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in the receptor activation. Important for the maintenance of hair growth and texture By similarity.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_207651. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysophosphatidic acid receptor 6
    Short name:
    LPA receptor 6
    Short name:
    LPA-6
    Alternative name(s):
    Oleoyl-L-alpha-lysophosphatidic acid receptor
    P2Y purinoceptor 5
    Short name:
    P2Y5
    Purinergic receptor 5
    Gene namesi
    Name:Lpar6
    Synonyms:P2ry5, P2y5
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:1914418. Lpar6.

    Subcellular locationi

    Topology

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2525Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei26 – 4621Helical; Name=1; Reviewed prediction
    Add
    BLAST
    Topological domaini47 – 5610Cytoplasmic Reviewed prediction
    Transmembranei57 – 7721Helical; Name=2; Reviewed prediction
    Add
    BLAST
    Topological domaini78 – 9013Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei91 – 11121Helical; Name=3; Reviewed prediction
    Add
    BLAST
    Topological domaini112 – 13423Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei135 – 15521Helical; Name=4; Reviewed prediction
    Add
    BLAST
    Topological domaini156 – 18328Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei184 – 20421Helical; Name=5; Reviewed prediction
    Add
    BLAST
    Topological domaini205 – 23026Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei231 – 25121Helical; Name=6; Reviewed prediction
    Add
    BLAST
    Topological domaini252 – 27221Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei273 – 29321Helical; Name=7; Reviewed prediction
    Add
    BLAST
    Topological domaini294 – 34451Cytoplasmic Reviewed prediction
    Add
    BLAST

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 344344Lysophosphatidic acid receptor 6
    PRO_0000070026Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...) Reviewed prediction
    Disulfide bondi89 ↔ 168 Reviewed prediction
    Glycosylationi162 – 1621N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi163 – 1631N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi262 – 2621N-linked (GlcNAc...) Reviewed prediction
    Lipidationi284 – 2841S-palmitoyl cysteine By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PRIDEiQ8BMC0.

    PTM databases

    PhosphoSiteiQ8BMC0.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed. Detected in the hair follicles and skin (at protein level).2 Publications

    Gene expression databases

    BgeeiQ8BMC0.
    CleanExiMM_P2RY5.
    GenevestigatoriQ8BMC0.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BMC0.
    SMRiQ8BMC0. Positions 23-300.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG289230.
    GeneTreeiENSGT00750000117402.
    HOGENOMiHOG000231307.
    HOVERGENiHBG101917.
    InParanoidiQ8BMC0.
    KOiK04273.
    OMAiFRIFYFA.
    OrthoDBiEOG71VSSZ.
    PhylomeDBiQ8BMC0.
    TreeFamiTF350009.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8BMC0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVSSNGSQCP YDDSFKYTLY GCMFSMVFVL GLISNCVAIY IFICALKVRN    50
    ETTTYMINLA MSDLLFVFTL PFRIFYFATR NWPFGDLLCK ISVMLFYTNM 100
    YGSILFLTCI SVDRFLAIVY PFKSKTLRTK RNAKIVCIAV WFTVMGGSAP 150
    AVFFQSTHSQ GNNTSEACFE NFPAATWKTY LSRIVIFIEI VGFFIPLILN 200
    VTCSSMVLRT LNKPVTLSRS KMNKTKVLKM IFVHLVIFCF CFVPYNINLI 250
    LYSLMRTQTF VNCSVVAAVR TMYPITLCIA VSNCCFDPIV YYFTSDTIQN 300
    SIKMKNWSVR RSDSRFSEVQ GTENFIQHNL QTLKNKIFDN ESAI 344
    Length:344
    Mass (Da):39,439
    Last modified:March 1, 2003 - v1
    Checksum:i50270D1D14AEDAB2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK032901 mRNA. Translation: BAC28077.1.
    AK169602 mRNA. Translation: BAE41252.1.
    BC145940 mRNA. Translation: AAI45941.1.
    BC145942 mRNA. Translation: AAI45943.1.
    BC069991 mRNA. Translation: AAH69991.1.
    BC047931 mRNA. Translation: AAH47931.1.
    CCDSiCCDS27268.1.
    RefSeqiNP_780325.1. NM_175116.4.
    UniGeneiMm.390681.

    Genome annotation databases

    EnsembliENSMUST00000044405; ENSMUSP00000042327; ENSMUSG00000033446.
    GeneIDi67168.
    KEGGimmu:67168.
    UCSCiuc007upq.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK032901 mRNA. Translation: BAC28077.1 .
    AK169602 mRNA. Translation: BAE41252.1 .
    BC145940 mRNA. Translation: AAI45941.1 .
    BC145942 mRNA. Translation: AAI45943.1 .
    BC069991 mRNA. Translation: AAH69991.1 .
    BC047931 mRNA. Translation: AAH47931.1 .
    CCDSi CCDS27268.1.
    RefSeqi NP_780325.1. NM_175116.4.
    UniGenei Mm.390681.

    3D structure databases

    ProteinModelPortali Q8BMC0.
    SMRi Q8BMC0. Positions 23-300.
    ModBasei Search...

    Chemistry

    GuidetoPHARMACOLOGYi 163.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q8BMC0.

    Proteomic databases

    PRIDEi Q8BMC0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000044405 ; ENSMUSP00000042327 ; ENSMUSG00000033446 .
    GeneIDi 67168.
    KEGGi mmu:67168.
    UCSCi uc007upq.2. mouse.

    Organism-specific databases

    CTDi 10161.
    MGIi MGI:1914418. Lpar6.

    Phylogenomic databases

    eggNOGi NOG289230.
    GeneTreei ENSGT00750000117402.
    HOGENOMi HOG000231307.
    HOVERGENi HBG101917.
    InParanoidi Q8BMC0.
    KOi K04273.
    OMAi FRIFYFA.
    OrthoDBi EOG71VSSZ.
    PhylomeDBi Q8BMC0.
    TreeFami TF350009.

    Enzyme and pathway databases

    Reactomei REACT_207651. G alpha (q) signalling events.

    Miscellaneous databases

    NextBioi 323782.
    PROi Q8BMC0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8BMC0.
    CleanExi MM_P2RY5.
    Genevestigatori Q8BMC0.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Mesonephros and Thymus.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Bone, Brain and Mammary gland.
    3. "G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth."
      Pasternack S.M., von Kuegelgen I., Aboud K.A., Lee Y.-A., Rueschendorf F., Voss K., Hillmer A.M., Molderings G.J., Franz T., Ramirez A., Nuernberg P., Noethen M.M., Betz R.C.
      Nat. Genet. 40:329-334(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    4. "Disruption of P2RY5, an orphan G protein-coupled receptor, underlies autosomal recessive woolly hair."
      Shimomura Y., Wajid M., Ishii Y., Shapiro L., Petukhova L., Gordon D., Christiano A.M.
      Nat. Genet. 40:335-339(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiLPAR6_MOUSE
    AccessioniPrimary (citable) accession number: Q8BMC0
    Secondary accession number(s): A6H6N5, Q3TEJ6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: March 1, 2003
    Last modified: September 3, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

    Similar proteinsi