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Protein

Signal recognition particle subunit SRP68

Gene

Srp68

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP68 binds the 7S RNA, SRP72 binds to this complex subsequently. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-1799339 SRP-dependent cotranslational protein targeting to membrane

Names & Taxonomyi

Protein namesi
Recommended name:
Signal recognition particle subunit SRP68
Short name:
SRP68
Alternative name(s):
Signal recognition particle 68 kDa protein
Gene namesi
Name:Srp68
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1917447 Srp68

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Signal recognition particle

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001352281 – 625Signal recognition particle subunit SRP68Add BLAST625

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei47PhosphoserineBy similarity1
Modified residuei240PhosphoserineBy similarity1
Modified residuei451N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8BMA6
MaxQBiQ8BMA6
PaxDbiQ8BMA6
PeptideAtlasiQ8BMA6
PRIDEiQ8BMA6

PTM databases

iPTMnetiQ8BMA6
PhosphoSitePlusiQ8BMA6
SwissPalmiQ8BMA6

Expressioni

Gene expression databases

BgeeiENSMUSG00000020780
CleanExiMM_SRP68
ExpressionAtlasiQ8BMA6 baseline and differential
GenevisibleiQ8BMA6 MM

Interactioni

Subunit structurei

Signal recognition particle consists of a 7S RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi229892, 4 interactors
STRINGi10090.ENSMUSP00000021133

Structurei

3D structure databases

ProteinModelPortaliQ8BMA6
SMRiQ8BMA6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi9 – 29Poly-GlyAdd BLAST21

Domaini

The RNA-binding domain is located near the N-terminus.By similarity

Sequence similaritiesi

Belongs to the SRP68 family.Curated

Phylogenomic databases

eggNOGiKOG2460 Eukaryota
ENOG410XPW1 LUCA
GeneTreeiENSGT00390000011856
HOGENOMiHOG000231195
HOVERGENiHBG059793
InParanoidiQ8BMA6
KOiK03107
OMAiFRCYYIA
OrthoDBiEOG091G0ARE
TreeFamiTF105779

Family and domain databases

CDDicd15481 SRP68-RBD, 1 hit
Gene3Di1.10.3450.40, 1 hit
InterProiView protein in InterPro
IPR026258 SRP68
IPR034652 SRP68-RBD
IPR038253 SRP68_N_sf
PANTHERiPTHR12860 PTHR12860, 1 hit
PfamiView protein in Pfam
PF16969 SRP68, 1 hit
PIRSFiPIRSF038995 SRP68, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BMA6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAEKQIPGG GSGGGGSGSG GGGGGSGGGR SAGGDENKEN ERPSAGSKAN
60 70 80 90 100
KEFGDSLSLE ILQIIKESQQ QHGLRHGDFQ RYRGYCSRRQ RRLRKTLNFK
110 120 130 140 150
MGNRHKFTGK KVTEELLTDN RYLLLVLMDA ERAWSYAMQL KQEANTEPRK
160 170 180 190 200
RFHLLSRLRK AVKHAEELER LCESNRVDAK TKLEAQAYTA YLSGMLRFEH
210 220 230 240 250
QEWKSAIEAF NKCKTIYEKL ASAFTEEQAV LYNQRVEEIS PNIRYCAYNI
260 270 280 290 300
GDQSAINELM QMRLRSGGTE GLLAEKLEAL ITQTRAKQAA TMSEVEWRGR
310 320 330 340 350
TVPVKIDKVR IFLLGLADNE AAIVQAESEE TKERLFESML SECRDALQAV
360 370 380 390 400
REELKPDQKQ RDYALDGESG KVSNLQYLHS YLTYIKLSTA IRRNENMAKG
410 420 430 440 450
LHRALLQQQP EDDSKRSPRP QDLIRLYDII LQNLVELLQL PGLEEDRTFQ
460 470 480 490 500
KEISLKTLVF KAYRCFFIAQ SYVLVKKWSE ALVLYDRVLK YANEVSSHGG
510 520 530 540 550
ASKNSLKDLP DVQELITQVR SEKCSLQAAA ILDANDSHQT DTSSQVKDNT
560 570 580 590 600
PLVERFESFC LDPSLVTKQA NLVHFPPGFQ PIPCKPLFFD LALNHVAFPP
610 620
LEDKLEQKTK SGLTGYIKGI FGFRS
Length:625
Mass (Da):70,574
Last modified:July 27, 2011 - v2
Checksum:i0CC69D6CB102CEF5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti176R → Q in BAC28124 (PubMed:16141072).Curated1
Sequence conflicti544S → Y in BAC28124 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK033010 mRNA Translation: BAC28124.1
AL669925, AL645861 Genomic DNA Translation: CAM16383.1
AL645861, AL669925 Genomic DNA Translation: CAM16795.1
CH466558 Genomic DNA Translation: EDL34568.1
BC070422 mRNA Translation: AAH70422.1
CCDSiCCDS25662.1
RefSeqiNP_666144.3, NM_146032.3
UniGeneiMm.29655

Genome annotation databases

EnsembliENSMUST00000021133; ENSMUSP00000021133; ENSMUSG00000020780
GeneIDi217337
KEGGimmu:217337
UCSCiuc007mkq.1 mouse

Similar proteinsi

Entry informationi

Entry nameiSRP68_MOUSE
AccessioniPrimary (citable) accession number: Q8BMA6
Secondary accession number(s): A2AAN1, Q6NS76
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: July 27, 2011
Last modified: March 28, 2018
This is version 112 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health