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Protein

Signal recognition particle subunit SRP68

Gene

Srp68

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP68 binds the 7S RNA, SRP72 binds to this complex subsequently. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-1799339. SRP-dependent cotranslational protein targeting to membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal recognition particle subunit SRP68
Short name:
SRP68
Alternative name(s):
Signal recognition particle 68 kDa protein
Gene namesi
Name:Srp68
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1917447. Srp68.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Signal recognition particle

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001352281 – 625Signal recognition particle subunit SRP68Add BLAST625

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei47PhosphoserineBy similarity1
Modified residuei240PhosphoserineBy similarity1
Modified residuei451N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8BMA6.
MaxQBiQ8BMA6.
PaxDbiQ8BMA6.
PeptideAtlasiQ8BMA6.
PRIDEiQ8BMA6.

PTM databases

iPTMnetiQ8BMA6.
PhosphoSitePlusiQ8BMA6.
SwissPalmiQ8BMA6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000020780.
CleanExiMM_SRP68.
ExpressionAtlasiQ8BMA6. baseline and differential.
GenevisibleiQ8BMA6. MM.

Interactioni

Subunit structurei

Signal recognition particle consists of a 7S RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.

Protein-protein interaction databases

BioGridi229892. 4 interactors.
STRINGi10090.ENSMUSP00000021133.

Structurei

3D structure databases

ProteinModelPortaliQ8BMA6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi9 – 29Poly-GlyAdd BLAST21

Domaini

The RNA-binding domain is located near the N-terminus.By similarity

Sequence similaritiesi

Belongs to the SRP68 family.Curated

Phylogenomic databases

eggNOGiKOG2460. Eukaryota.
ENOG410XPW1. LUCA.
GeneTreeiENSGT00390000011856.
HOGENOMiHOG000231195.
HOVERGENiHBG059793.
InParanoidiQ8BMA6.
KOiK03107.
OMAiIGDQSAM.
OrthoDBiEOG091G0ARE.
TreeFamiTF105779.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR026258. SRP68.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PfamiPF16969. SRP68. 1 hit.
[Graphical view]
PIRSFiPIRSF038995. SRP68. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8BMA6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAEKQIPGG GSGGGGSGSG GGGGGSGGGR SAGGDENKEN ERPSAGSKAN
60 70 80 90 100
KEFGDSLSLE ILQIIKESQQ QHGLRHGDFQ RYRGYCSRRQ RRLRKTLNFK
110 120 130 140 150
MGNRHKFTGK KVTEELLTDN RYLLLVLMDA ERAWSYAMQL KQEANTEPRK
160 170 180 190 200
RFHLLSRLRK AVKHAEELER LCESNRVDAK TKLEAQAYTA YLSGMLRFEH
210 220 230 240 250
QEWKSAIEAF NKCKTIYEKL ASAFTEEQAV LYNQRVEEIS PNIRYCAYNI
260 270 280 290 300
GDQSAINELM QMRLRSGGTE GLLAEKLEAL ITQTRAKQAA TMSEVEWRGR
310 320 330 340 350
TVPVKIDKVR IFLLGLADNE AAIVQAESEE TKERLFESML SECRDALQAV
360 370 380 390 400
REELKPDQKQ RDYALDGESG KVSNLQYLHS YLTYIKLSTA IRRNENMAKG
410 420 430 440 450
LHRALLQQQP EDDSKRSPRP QDLIRLYDII LQNLVELLQL PGLEEDRTFQ
460 470 480 490 500
KEISLKTLVF KAYRCFFIAQ SYVLVKKWSE ALVLYDRVLK YANEVSSHGG
510 520 530 540 550
ASKNSLKDLP DVQELITQVR SEKCSLQAAA ILDANDSHQT DTSSQVKDNT
560 570 580 590 600
PLVERFESFC LDPSLVTKQA NLVHFPPGFQ PIPCKPLFFD LALNHVAFPP
610 620
LEDKLEQKTK SGLTGYIKGI FGFRS
Length:625
Mass (Da):70,574
Last modified:July 27, 2011 - v2
Checksum:i0CC69D6CB102CEF5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti176R → Q in BAC28124 (PubMed:16141072).Curated1
Sequence conflicti544S → Y in BAC28124 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK033010 mRNA. Translation: BAC28124.1.
AL669925, AL645861 Genomic DNA. Translation: CAM16383.1.
AL645861, AL669925 Genomic DNA. Translation: CAM16795.1.
CH466558 Genomic DNA. Translation: EDL34568.1.
BC070422 mRNA. Translation: AAH70422.1.
CCDSiCCDS25662.1.
RefSeqiNP_666144.3. NM_146032.3.
UniGeneiMm.29655.

Genome annotation databases

EnsembliENSMUST00000021133; ENSMUSP00000021133; ENSMUSG00000020780.
GeneIDi217337.
KEGGimmu:217337.
UCSCiuc007mkq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK033010 mRNA. Translation: BAC28124.1.
AL669925, AL645861 Genomic DNA. Translation: CAM16383.1.
AL645861, AL669925 Genomic DNA. Translation: CAM16795.1.
CH466558 Genomic DNA. Translation: EDL34568.1.
BC070422 mRNA. Translation: AAH70422.1.
CCDSiCCDS25662.1.
RefSeqiNP_666144.3. NM_146032.3.
UniGeneiMm.29655.

3D structure databases

ProteinModelPortaliQ8BMA6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi229892. 4 interactors.
STRINGi10090.ENSMUSP00000021133.

PTM databases

iPTMnetiQ8BMA6.
PhosphoSitePlusiQ8BMA6.
SwissPalmiQ8BMA6.

Proteomic databases

EPDiQ8BMA6.
MaxQBiQ8BMA6.
PaxDbiQ8BMA6.
PeptideAtlasiQ8BMA6.
PRIDEiQ8BMA6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021133; ENSMUSP00000021133; ENSMUSG00000020780.
GeneIDi217337.
KEGGimmu:217337.
UCSCiuc007mkq.1. mouse.

Organism-specific databases

CTDi6730.
MGIiMGI:1917447. Srp68.

Phylogenomic databases

eggNOGiKOG2460. Eukaryota.
ENOG410XPW1. LUCA.
GeneTreeiENSGT00390000011856.
HOGENOMiHOG000231195.
HOVERGENiHBG059793.
InParanoidiQ8BMA6.
KOiK03107.
OMAiIGDQSAM.
OrthoDBiEOG091G0ARE.
TreeFamiTF105779.

Enzyme and pathway databases

ReactomeiR-MMU-1799339. SRP-dependent cotranslational protein targeting to membrane.

Miscellaneous databases

PROiQ8BMA6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020780.
CleanExiMM_SRP68.
ExpressionAtlasiQ8BMA6. baseline and differential.
GenevisibleiQ8BMA6. MM.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR026258. SRP68.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PfamiPF16969. SRP68. 1 hit.
[Graphical view]
PIRSFiPIRSF038995. SRP68. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSRP68_MOUSE
AccessioniPrimary (citable) accession number: Q8BMA6
Secondary accession number(s): A2AAN1, Q6NS76
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: July 27, 2011
Last modified: November 30, 2016
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.