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Protein

Adhesion G-protein coupled receptor G7

Gene

Adgrg7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Orphan receptor.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Protein family/group databases

MEROPSiP02.031.

Names & Taxonomyi

Protein namesi
Recommended name:
Adhesion G-protein coupled receptor G7
Alternative name(s):
G-protein coupled receptor 128
Gene namesi
Name:Adgrg7
Synonyms:Gpr128
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:2441732. Adgrg7.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 435ExtracellularCuratedAdd BLAST409
Transmembranei436 – 456Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini457 – 465CytoplasmicCurated9
Transmembranei466 – 486Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini487 – 523ExtracellularCuratedAdd BLAST37
Transmembranei524 – 544Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini545 – 561CytoplasmicCuratedAdd BLAST17
Transmembranei562 – 582Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini583 – 623ExtracellularCuratedAdd BLAST41
Transmembranei624 – 644Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini645 – 668CytoplasmicCuratedAdd BLAST24
Transmembranei669 – 689Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini690 – 694ExtracellularCurated5
Transmembranei695 – 715Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini716 – 785CytoplasmicCuratedAdd BLAST70

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

Deficient mice exhibit less body weight gain and an increase in intestinal contraction frequency.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000001290427 – 785Adhesion G-protein coupled receptor G7Add BLAST759

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi82N-linked (GlcNAc...)Sequence analysis1
Glycosylationi122N-linked (GlcNAc...)Sequence analysis1
Glycosylationi133N-linked (GlcNAc...)Sequence analysis1
Glycosylationi152N-linked (GlcNAc...)Sequence analysis1
Glycosylationi159N-linked (GlcNAc...)Sequence analysis1
Glycosylationi178N-linked (GlcNAc...)Sequence analysis1
Glycosylationi195N-linked (GlcNAc...)Sequence analysis1
Glycosylationi239N-linked (GlcNAc...)Sequence analysis1
Glycosylationi289N-linked (GlcNAc...)Sequence analysis1
Glycosylationi348N-linked (GlcNAc...)Sequence analysis1
Glycosylationi400N-linked (GlcNAc...)Sequence analysis1
Glycosylationi408N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8BM96.
PeptideAtlasiQ8BM96.
PRIDEiQ8BM96.

PTM databases

iPTMnetiQ8BM96.
PhosphoSitePlusiQ8BM96.

Expressioni

Tissue specificityi

Selectively expressed in the intestinal tissues.1 Publication

Gene expression databases

BgeeiENSMUSG00000022755.
CleanExiMM_GPR128.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023437.

Structurei

3D structure databases

ProteinModelPortaliQ8BM96.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini377 – 424GPSPROSITE-ProRule annotationAdd BLAST48

Sequence similaritiesi

Contains 1 GPS domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4193. Eukaryota.
ENOG410XSD2. LUCA.
GeneTreeiENSGT00830000128272.
HOGENOMiHOG000236310.
HOVERGENiHBG063831.
InParanoidiQ8BM96.
KOiK08464.
OMAiCICTEEW.
OrthoDBiEOG091G03DK.
TreeFamiTF351485.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR000203. GPS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
SMARTiSM00303. GPS. 1 hit.
[Graphical view]
PROSITEiPS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BM96-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSCRSCNVR VLVAIVCGLL TGIVLGLGIW RMVIRINRGI FVPVPSIPVQ
60 70 80 90 100
FCRNGGTWQN GRCICTEEWK GLRCTIANFC ENSTDGEFTF GSIPVGRYGP
110 120 130 140 150
SLQTCEPGTL NAGSPKATRL CNVSEFGNIE LQNVTKGSCN INLQTLEIQI
160 170 180 190 200
NNQTASAENI SREAQVLTAD ASKLTAQNIT SATTVVGQIF GKANNESQAK
210 220 230 240 250
KTAIATVSQI LDASEDVFQK AAEMDNSKSF SNLIKQMENY SYSQGDQTVV
260 270 280 290 300
EPNIAIQSVT RDDNSGPSVL FSVQKGSSNS LVSGRILINK TANGLNPDGQ
310 320 330 340 350
TELQILLNTG ENRKSCGFMV YQNHKLFQSK TFTATSDFSQ KIISSKINES
360 370 380 390 400
EQQRQNKVSV EMVFNPTYDK RELRLHSYAC VYWNFLINDW DTQGCQKTGN
410 420 430 440 450
TTEFLRCNCS HTTNFAVLMS FKKDYKYPKS LDILSNIGCA LSIAGLALTI
460 470 480 490 500
LFQILTRKIR KTSVTWVLVS LCSSMLIFNL LFVFGIENSN KNLKTSDSDI
510 520 530 540 550
NVKPENNKIP ESDTIETPNP SCTAIAALLH YFLLVTFTWN GLSATQLYFL
560 570 580 590 600
LIRTMKPLPR HFIIFISLVG WGVPAIIVGV TIGSIYALSG NKRYWELDYR
610 620 630 640 650
QEEICWLAVP KDNDYARSPL LWSFIIPVTI ILITNITIFV IITVKVLWKN
660 670 680 690 700
NQNLTSTKKV SSLKKVFSTL SIAVVFGVTW ILAYAMLISN DDIRIVFSYI
710 720 730 740 750
FCLFNTTQGL QIFILYTVRT KVFQSEASKI LKSLSSSFDR TKPMPSITPL
760 770 780
KLRVRMYNML RSLPSLNERF RLLEPSGMTE ETSLS
Length:785
Mass (Da):87,684
Last modified:July 27, 2011 - v2
Checksum:i9CC84D14747704A7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti295L → F in BAC28377 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK033593 mRNA. Translation: BAC28377.1.
CT025158 Genomic DNA. Translation: CAO78102.1.
CH466521 Genomic DNA. Translation: EDK98164.1.
BC132302 mRNA. Translation: AAI32303.1.
BC137963 mRNA. Translation: AAI37964.1.
AY255604 mRNA. Translation: AAO85116.1.
CCDSiCCDS28225.1.
RefSeqiNP_766413.2. NM_172825.3.
UniGeneiMm.258979.

Genome annotation databases

EnsembliENSMUST00000023437; ENSMUSP00000023437; ENSMUSG00000022755.
GeneIDi239853.
KEGGimmu:239853.
UCSCiuc007zmw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK033593 mRNA. Translation: BAC28377.1.
CT025158 Genomic DNA. Translation: CAO78102.1.
CH466521 Genomic DNA. Translation: EDK98164.1.
BC132302 mRNA. Translation: AAI32303.1.
BC137963 mRNA. Translation: AAI37964.1.
AY255604 mRNA. Translation: AAO85116.1.
CCDSiCCDS28225.1.
RefSeqiNP_766413.2. NM_172825.3.
UniGeneiMm.258979.

3D structure databases

ProteinModelPortaliQ8BM96.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023437.

Protein family/group databases

MEROPSiP02.031.
GPCRDBiSearch...

PTM databases

iPTMnetiQ8BM96.
PhosphoSitePlusiQ8BM96.

Proteomic databases

PaxDbiQ8BM96.
PeptideAtlasiQ8BM96.
PRIDEiQ8BM96.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023437; ENSMUSP00000023437; ENSMUSG00000022755.
GeneIDi239853.
KEGGimmu:239853.
UCSCiuc007zmw.1. mouse.

Organism-specific databases

CTDi84873.
MGIiMGI:2441732. Adgrg7.

Phylogenomic databases

eggNOGiKOG4193. Eukaryota.
ENOG410XSD2. LUCA.
GeneTreeiENSGT00830000128272.
HOGENOMiHOG000236310.
HOVERGENiHBG063831.
InParanoidiQ8BM96.
KOiK08464.
OMAiCICTEEW.
OrthoDBiEOG091G03DK.
TreeFamiTF351485.

Miscellaneous databases

PROiQ8BM96.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022755.
CleanExiMM_GPR128.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR000203. GPS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
SMARTiSM00303. GPS. 1 hit.
[Graphical view]
PROSITEiPS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAGRG7_MOUSE
AccessioniPrimary (citable) accession number: Q8BM96
Secondary accession number(s): A2RSY9, Q80T42
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.