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Q8BM96

- GP128_MOUSE

UniProt

Q8BM96 - GP128_MOUSE

Protein

Probable G-protein coupled receptor 128

Gene

Gpr128

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Orphan receptor.

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW

    GO - Biological processi

    1. neuropeptide signaling pathway Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Protein family/group databases

    MEROPSiS63.034.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable G-protein coupled receptor 128
    Gene namesi
    Name:Gpr128
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:2441732. Gpr128.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Chaini27 – 785759Probable G-protein coupled receptor 128PRO_0000012904Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi82 – 821N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi122 – 1221N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi133 – 1331N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi152 – 1521N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi159 – 1591N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi178 – 1781N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi195 – 1951N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi239 – 2391N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi289 – 2891N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi348 – 3481N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi400 – 4001N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi408 – 4081N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ8BM96.

    PTM databases

    PhosphoSiteiQ8BM96.

    Expressioni

    Gene expression databases

    BgeeiQ8BM96.
    CleanExiMM_GPR128.
    GenevestigatoriQ8BM96.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BM96.
    SMRiQ8BM96. Positions 50-77, 522-710.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini27 – 435409ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini457 – 4659CytoplasmicSequence Analysis
    Topological domaini487 – 52337ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini545 – 56117CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini583 – 62341ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini645 – 66824CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini690 – 6945ExtracellularSequence Analysis
    Topological domaini716 – 78570CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei436 – 45621Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei466 – 48621Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei524 – 54421Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei562 – 58221Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei624 – 64421Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei669 – 68921Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei695 – 71521Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini377 – 42448GPSPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 GPS domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG271406.
    GeneTreeiENSGT00610000085899.
    HOGENOMiHOG000236310.
    HOVERGENiHBG063831.
    InParanoidiA2RSY9.
    KOiK08464.
    OMAiCICTEEW.
    OrthoDBiEOG7NW68G.
    TreeFamiTF351485.

    Family and domain databases

    InterProiIPR017981. GPCR_2-like.
    IPR000832. GPCR_2_secretin-like.
    IPR000203. GPS.
    [Graphical view]
    PfamiPF00002. 7tm_2. 1 hit.
    PF01825. GPS. 1 hit.
    [Graphical view]
    PRINTSiPR00249. GPCRSECRETIN.
    SMARTiSM00303. GPS. 1 hit.
    [Graphical view]
    PROSITEiPS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    PS50221. GPS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8BM96-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRSCRSCNVR VLVAIVCGLL TGIVLGLGIW RMVIRINRGI FVPVPSIPVQ    50
    FCRNGGTWQN GRCICTEEWK GLRCTIANFC ENSTDGEFTF GSIPVGRYGP 100
    SLQTCEPGTL NAGSPKATRL CNVSEFGNIE LQNVTKGSCN INLQTLEIQI 150
    NNQTASAENI SREAQVLTAD ASKLTAQNIT SATTVVGQIF GKANNESQAK 200
    KTAIATVSQI LDASEDVFQK AAEMDNSKSF SNLIKQMENY SYSQGDQTVV 250
    EPNIAIQSVT RDDNSGPSVL FSVQKGSSNS LVSGRILINK TANGLNPDGQ 300
    TELQILLNTG ENRKSCGFMV YQNHKLFQSK TFTATSDFSQ KIISSKINES 350
    EQQRQNKVSV EMVFNPTYDK RELRLHSYAC VYWNFLINDW DTQGCQKTGN 400
    TTEFLRCNCS HTTNFAVLMS FKKDYKYPKS LDILSNIGCA LSIAGLALTI 450
    LFQILTRKIR KTSVTWVLVS LCSSMLIFNL LFVFGIENSN KNLKTSDSDI 500
    NVKPENNKIP ESDTIETPNP SCTAIAALLH YFLLVTFTWN GLSATQLYFL 550
    LIRTMKPLPR HFIIFISLVG WGVPAIIVGV TIGSIYALSG NKRYWELDYR 600
    QEEICWLAVP KDNDYARSPL LWSFIIPVTI ILITNITIFV IITVKVLWKN 650
    NQNLTSTKKV SSLKKVFSTL SIAVVFGVTW ILAYAMLISN DDIRIVFSYI 700
    FCLFNTTQGL QIFILYTVRT KVFQSEASKI LKSLSSSFDR TKPMPSITPL 750
    KLRVRMYNML RSLPSLNERF RLLEPSGMTE ETSLS 785
    Length:785
    Mass (Da):87,684
    Last modified:July 27, 2011 - v2
    Checksum:i9CC84D14747704A7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti295 – 2951L → F in BAC28377. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK033593 mRNA. Translation: BAC28377.1.
    CT025158 Genomic DNA. Translation: CAO78102.1.
    CH466521 Genomic DNA. Translation: EDK98164.1.
    BC132302 mRNA. Translation: AAI32303.1.
    BC137963 mRNA. Translation: AAI37964.1.
    AY255604 mRNA. Translation: AAO85116.1.
    CCDSiCCDS28225.1.
    RefSeqiNP_766413.2. NM_172825.3.
    UniGeneiMm.258979.

    Genome annotation databases

    EnsembliENSMUST00000023437; ENSMUSP00000023437; ENSMUSG00000022755.
    GeneIDi239853.
    KEGGimmu:239853.
    UCSCiuc007zmw.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK033593 mRNA. Translation: BAC28377.1 .
    CT025158 Genomic DNA. Translation: CAO78102.1 .
    CH466521 Genomic DNA. Translation: EDK98164.1 .
    BC132302 mRNA. Translation: AAI32303.1 .
    BC137963 mRNA. Translation: AAI37964.1 .
    AY255604 mRNA. Translation: AAO85116.1 .
    CCDSi CCDS28225.1.
    RefSeqi NP_766413.2. NM_172825.3.
    UniGenei Mm.258979.

    3D structure databases

    ProteinModelPortali Q8BM96.
    SMRi Q8BM96. Positions 50-77, 522-710.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S63.034.
    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q8BM96.

    Proteomic databases

    PRIDEi Q8BM96.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000023437 ; ENSMUSP00000023437 ; ENSMUSG00000022755 .
    GeneIDi 239853.
    KEGGi mmu:239853.
    UCSCi uc007zmw.1. mouse.

    Organism-specific databases

    CTDi 84873.
    MGIi MGI:2441732. Gpr128.

    Phylogenomic databases

    eggNOGi NOG271406.
    GeneTreei ENSGT00610000085899.
    HOGENOMi HOG000236310.
    HOVERGENi HBG063831.
    InParanoidi A2RSY9.
    KOi K08464.
    OMAi CICTEEW.
    OrthoDBi EOG7NW68G.
    TreeFami TF351485.

    Miscellaneous databases

    NextBioi 384319.
    PROi Q8BM96.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8BM96.
    CleanExi MM_GPR128.
    Genevestigatori Q8BM96.

    Family and domain databases

    InterProi IPR017981. GPCR_2-like.
    IPR000832. GPCR_2_secretin-like.
    IPR000203. GPS.
    [Graphical view ]
    Pfami PF00002. 7tm_2. 1 hit.
    PF01825. GPS. 1 hit.
    [Graphical view ]
    PRINTSi PR00249. GPCRSECRETIN.
    SMARTi SM00303. GPS. 1 hit.
    [Graphical view ]
    PROSITEi PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    PS50221. GPS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Cecum.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 8-116.
    6. Lubec G., Sunyer B., Chen W.-Q.
      Submitted (JAN-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 39-53, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: OF1.
      Tissue: Hippocampus.

    Entry informationi

    Entry nameiGP128_MOUSE
    AccessioniPrimary (citable) accession number: Q8BM96
    Secondary accession number(s): A2RSY9, Q80T42
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 29, 2004
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 90 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3