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Q8BM96

- GP128_MOUSE

UniProt

Q8BM96 - GP128_MOUSE

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Protein
Probable G-protein coupled receptor 128
Gene
Gpr128
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Orphan receptor.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW

GO - Biological processi

  1. neuropeptide signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Protein family/group databases

MEROPSiS63.034.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 128
Gene namesi
Name:Gpr128
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:2441732. Gpr128.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 435409Extracellular Reviewed prediction
Add
BLAST
Transmembranei436 – 45621Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini457 – 4659Cytoplasmic Reviewed prediction
Transmembranei466 – 48621Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini487 – 52337Extracellular Reviewed prediction
Add
BLAST
Transmembranei524 – 54421Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini545 – 56117Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei562 – 58221Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini583 – 62341Extracellular Reviewed prediction
Add
BLAST
Transmembranei624 – 64421Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini645 – 66824Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei669 – 68921Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini690 – 6945Extracellular Reviewed prediction
Transmembranei695 – 71521Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini716 – 78570Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626 Reviewed prediction
Add
BLAST
Chaini27 – 785759Probable G-protein coupled receptor 128
PRO_0000012904Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi82 – 821N-linked (GlcNAc...) Reviewed prediction
Glycosylationi122 – 1221N-linked (GlcNAc...) Reviewed prediction
Glycosylationi133 – 1331N-linked (GlcNAc...) Reviewed prediction
Glycosylationi152 – 1521N-linked (GlcNAc...) Reviewed prediction
Glycosylationi159 – 1591N-linked (GlcNAc...) Reviewed prediction
Glycosylationi178 – 1781N-linked (GlcNAc...) Reviewed prediction
Glycosylationi195 – 1951N-linked (GlcNAc...) Reviewed prediction
Glycosylationi239 – 2391N-linked (GlcNAc...) Reviewed prediction
Glycosylationi289 – 2891N-linked (GlcNAc...) Reviewed prediction
Glycosylationi348 – 3481N-linked (GlcNAc...) Reviewed prediction
Glycosylationi400 – 4001N-linked (GlcNAc...) Reviewed prediction
Glycosylationi408 – 4081N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ8BM96.

PTM databases

PhosphoSiteiQ8BM96.

Expressioni

Gene expression databases

BgeeiQ8BM96.
CleanExiMM_GPR128.
GenevestigatoriQ8BM96.

Structurei

3D structure databases

ProteinModelPortaliQ8BM96.
SMRiQ8BM96. Positions 50-77, 522-710.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini377 – 42448GPS
Add
BLAST

Sequence similaritiesi

Contains 1 GPS domain.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG271406.
GeneTreeiENSGT00610000085899.
HOGENOMiHOG000236310.
HOVERGENiHBG063831.
InParanoidiA2RSY9.
KOiK08464.
OMAiCICTEEW.
OrthoDBiEOG7NW68G.
TreeFamiTF351485.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR000203. GPS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
SMARTiSM00303. GPS. 1 hit.
[Graphical view]
PROSITEiPS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BM96-1 [UniParc]FASTAAdd to Basket

« Hide

MRSCRSCNVR VLVAIVCGLL TGIVLGLGIW RMVIRINRGI FVPVPSIPVQ    50
FCRNGGTWQN GRCICTEEWK GLRCTIANFC ENSTDGEFTF GSIPVGRYGP 100
SLQTCEPGTL NAGSPKATRL CNVSEFGNIE LQNVTKGSCN INLQTLEIQI 150
NNQTASAENI SREAQVLTAD ASKLTAQNIT SATTVVGQIF GKANNESQAK 200
KTAIATVSQI LDASEDVFQK AAEMDNSKSF SNLIKQMENY SYSQGDQTVV 250
EPNIAIQSVT RDDNSGPSVL FSVQKGSSNS LVSGRILINK TANGLNPDGQ 300
TELQILLNTG ENRKSCGFMV YQNHKLFQSK TFTATSDFSQ KIISSKINES 350
EQQRQNKVSV EMVFNPTYDK RELRLHSYAC VYWNFLINDW DTQGCQKTGN 400
TTEFLRCNCS HTTNFAVLMS FKKDYKYPKS LDILSNIGCA LSIAGLALTI 450
LFQILTRKIR KTSVTWVLVS LCSSMLIFNL LFVFGIENSN KNLKTSDSDI 500
NVKPENNKIP ESDTIETPNP SCTAIAALLH YFLLVTFTWN GLSATQLYFL 550
LIRTMKPLPR HFIIFISLVG WGVPAIIVGV TIGSIYALSG NKRYWELDYR 600
QEEICWLAVP KDNDYARSPL LWSFIIPVTI ILITNITIFV IITVKVLWKN 650
NQNLTSTKKV SSLKKVFSTL SIAVVFGVTW ILAYAMLISN DDIRIVFSYI 700
FCLFNTTQGL QIFILYTVRT KVFQSEASKI LKSLSSSFDR TKPMPSITPL 750
KLRVRMYNML RSLPSLNERF RLLEPSGMTE ETSLS 785
Length:785
Mass (Da):87,684
Last modified:July 27, 2011 - v2
Checksum:i9CC84D14747704A7
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti295 – 2951L → F in BAC28377. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK033593 mRNA. Translation: BAC28377.1.
CT025158 Genomic DNA. Translation: CAO78102.1.
CH466521 Genomic DNA. Translation: EDK98164.1.
BC132302 mRNA. Translation: AAI32303.1.
BC137963 mRNA. Translation: AAI37964.1.
AY255604 mRNA. Translation: AAO85116.1.
CCDSiCCDS28225.1.
RefSeqiNP_766413.2. NM_172825.3.
UniGeneiMm.258979.

Genome annotation databases

EnsembliENSMUST00000023437; ENSMUSP00000023437; ENSMUSG00000022755.
GeneIDi239853.
KEGGimmu:239853.
UCSCiuc007zmw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK033593 mRNA. Translation: BAC28377.1 .
CT025158 Genomic DNA. Translation: CAO78102.1 .
CH466521 Genomic DNA. Translation: EDK98164.1 .
BC132302 mRNA. Translation: AAI32303.1 .
BC137963 mRNA. Translation: AAI37964.1 .
AY255604 mRNA. Translation: AAO85116.1 .
CCDSi CCDS28225.1.
RefSeqi NP_766413.2. NM_172825.3.
UniGenei Mm.258979.

3D structure databases

ProteinModelPortali Q8BM96.
SMRi Q8BM96. Positions 50-77, 522-710.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S63.034.
GPCRDBi Search...

PTM databases

PhosphoSitei Q8BM96.

Proteomic databases

PRIDEi Q8BM96.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000023437 ; ENSMUSP00000023437 ; ENSMUSG00000022755 .
GeneIDi 239853.
KEGGi mmu:239853.
UCSCi uc007zmw.1. mouse.

Organism-specific databases

CTDi 84873.
MGIi MGI:2441732. Gpr128.

Phylogenomic databases

eggNOGi NOG271406.
GeneTreei ENSGT00610000085899.
HOGENOMi HOG000236310.
HOVERGENi HBG063831.
InParanoidi A2RSY9.
KOi K08464.
OMAi CICTEEW.
OrthoDBi EOG7NW68G.
TreeFami TF351485.

Miscellaneous databases

NextBioi 384319.
PROi Q8BM96.
SOURCEi Search...

Gene expression databases

Bgeei Q8BM96.
CleanExi MM_GPR128.
Genevestigatori Q8BM96.

Family and domain databases

InterProi IPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR000203. GPS.
[Graphical view ]
Pfami PF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
[Graphical view ]
PRINTSi PR00249. GPCRSECRETIN.
SMARTi SM00303. GPS. 1 hit.
[Graphical view ]
PROSITEi PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cecum.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 8-116.
  6. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 39-53, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.

Entry informationi

Entry nameiGP128_MOUSE
AccessioniPrimary (citable) accession number: Q8BM96
Secondary accession number(s): A2RSY9, Q80T42
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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