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Protein

Probable G-protein coupled receptor 128

Gene

Gpr128

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Orphan receptor.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Protein family/group databases

MEROPSiS63.034.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 128
Gene namesi
Name:Gpr128
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:2441732. Gpr128.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 435409ExtracellularSequence AnalysisAdd
BLAST
Transmembranei436 – 45621Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini457 – 4659CytoplasmicSequence Analysis
Transmembranei466 – 48621Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini487 – 52337ExtracellularSequence AnalysisAdd
BLAST
Transmembranei524 – 54421Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini545 – 56117CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei562 – 58221Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini583 – 62341ExtracellularSequence AnalysisAdd
BLAST
Transmembranei624 – 64421Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini645 – 66824CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei669 – 68921Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini690 – 6945ExtracellularSequence Analysis
Transmembranei695 – 71521Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini716 – 78570CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Chaini27 – 785759Probable G-protein coupled receptor 128PRO_0000012904Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi82 – 821N-linked (GlcNAc...)Sequence Analysis
Glycosylationi122 – 1221N-linked (GlcNAc...)Sequence Analysis
Glycosylationi133 – 1331N-linked (GlcNAc...)Sequence Analysis
Glycosylationi152 – 1521N-linked (GlcNAc...)Sequence Analysis
Glycosylationi159 – 1591N-linked (GlcNAc...)Sequence Analysis
Glycosylationi178 – 1781N-linked (GlcNAc...)Sequence Analysis
Glycosylationi195 – 1951N-linked (GlcNAc...)Sequence Analysis
Glycosylationi239 – 2391N-linked (GlcNAc...)Sequence Analysis
Glycosylationi289 – 2891N-linked (GlcNAc...)Sequence Analysis
Glycosylationi348 – 3481N-linked (GlcNAc...)Sequence Analysis
Glycosylationi400 – 4001N-linked (GlcNAc...)Sequence Analysis
Glycosylationi408 – 4081N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ8BM96.

PTM databases

PhosphoSiteiQ8BM96.

Expressioni

Gene expression databases

BgeeiQ8BM96.
CleanExiMM_GPR128.
GenevestigatoriQ8BM96.

Structurei

3D structure databases

ProteinModelPortaliQ8BM96.
SMRiQ8BM96. Positions 522-710.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini377 – 42448GPSPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 GPS domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG271406.
GeneTreeiENSGT00780000121893.
HOGENOMiHOG000236310.
HOVERGENiHBG063831.
InParanoidiQ8BM96.
KOiK08464.
OMAiCICTEEW.
OrthoDBiEOG7NW68G.
TreeFamiTF351485.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR000203. GPS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
SMARTiSM00303. GPS. 1 hit.
[Graphical view]
PROSITEiPS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BM96-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSCRSCNVR VLVAIVCGLL TGIVLGLGIW RMVIRINRGI FVPVPSIPVQ
60 70 80 90 100
FCRNGGTWQN GRCICTEEWK GLRCTIANFC ENSTDGEFTF GSIPVGRYGP
110 120 130 140 150
SLQTCEPGTL NAGSPKATRL CNVSEFGNIE LQNVTKGSCN INLQTLEIQI
160 170 180 190 200
NNQTASAENI SREAQVLTAD ASKLTAQNIT SATTVVGQIF GKANNESQAK
210 220 230 240 250
KTAIATVSQI LDASEDVFQK AAEMDNSKSF SNLIKQMENY SYSQGDQTVV
260 270 280 290 300
EPNIAIQSVT RDDNSGPSVL FSVQKGSSNS LVSGRILINK TANGLNPDGQ
310 320 330 340 350
TELQILLNTG ENRKSCGFMV YQNHKLFQSK TFTATSDFSQ KIISSKINES
360 370 380 390 400
EQQRQNKVSV EMVFNPTYDK RELRLHSYAC VYWNFLINDW DTQGCQKTGN
410 420 430 440 450
TTEFLRCNCS HTTNFAVLMS FKKDYKYPKS LDILSNIGCA LSIAGLALTI
460 470 480 490 500
LFQILTRKIR KTSVTWVLVS LCSSMLIFNL LFVFGIENSN KNLKTSDSDI
510 520 530 540 550
NVKPENNKIP ESDTIETPNP SCTAIAALLH YFLLVTFTWN GLSATQLYFL
560 570 580 590 600
LIRTMKPLPR HFIIFISLVG WGVPAIIVGV TIGSIYALSG NKRYWELDYR
610 620 630 640 650
QEEICWLAVP KDNDYARSPL LWSFIIPVTI ILITNITIFV IITVKVLWKN
660 670 680 690 700
NQNLTSTKKV SSLKKVFSTL SIAVVFGVTW ILAYAMLISN DDIRIVFSYI
710 720 730 740 750
FCLFNTTQGL QIFILYTVRT KVFQSEASKI LKSLSSSFDR TKPMPSITPL
760 770 780
KLRVRMYNML RSLPSLNERF RLLEPSGMTE ETSLS
Length:785
Mass (Da):87,684
Last modified:July 27, 2011 - v2
Checksum:i9CC84D14747704A7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti295 – 2951L → F in BAC28377 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK033593 mRNA. Translation: BAC28377.1.
CT025158 Genomic DNA. Translation: CAO78102.1.
CH466521 Genomic DNA. Translation: EDK98164.1.
BC132302 mRNA. Translation: AAI32303.1.
BC137963 mRNA. Translation: AAI37964.1.
AY255604 mRNA. Translation: AAO85116.1.
CCDSiCCDS28225.1.
RefSeqiNP_766413.2. NM_172825.3.
UniGeneiMm.258979.

Genome annotation databases

EnsembliENSMUST00000023437; ENSMUSP00000023437; ENSMUSG00000022755.
GeneIDi239853.
KEGGimmu:239853.
UCSCiuc007zmw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK033593 mRNA. Translation: BAC28377.1.
CT025158 Genomic DNA. Translation: CAO78102.1.
CH466521 Genomic DNA. Translation: EDK98164.1.
BC132302 mRNA. Translation: AAI32303.1.
BC137963 mRNA. Translation: AAI37964.1.
AY255604 mRNA. Translation: AAO85116.1.
CCDSiCCDS28225.1.
RefSeqiNP_766413.2. NM_172825.3.
UniGeneiMm.258979.

3D structure databases

ProteinModelPortaliQ8BM96.
SMRiQ8BM96. Positions 522-710.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiS63.034.
GPCRDBiSearch...

PTM databases

PhosphoSiteiQ8BM96.

Proteomic databases

PRIDEiQ8BM96.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023437; ENSMUSP00000023437; ENSMUSG00000022755.
GeneIDi239853.
KEGGimmu:239853.
UCSCiuc007zmw.1. mouse.

Organism-specific databases

CTDi84873.
MGIiMGI:2441732. Gpr128.

Phylogenomic databases

eggNOGiNOG271406.
GeneTreeiENSGT00780000121893.
HOGENOMiHOG000236310.
HOVERGENiHBG063831.
InParanoidiQ8BM96.
KOiK08464.
OMAiCICTEEW.
OrthoDBiEOG7NW68G.
TreeFamiTF351485.

Miscellaneous databases

NextBioi384319.
PROiQ8BM96.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BM96.
CleanExiMM_GPR128.
GenevestigatoriQ8BM96.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR000203. GPS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
SMARTiSM00303. GPS. 1 hit.
[Graphical view]
PROSITEiPS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cecum.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 8-116.
  6. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 39-53, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.

Entry informationi

Entry nameiGP128_MOUSE
AccessioniPrimary (citable) accession number: Q8BM96
Secondary accession number(s): A2RSY9, Q80T42
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: July 27, 2011
Last modified: March 4, 2015
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.