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Protein

Cadherin-7

Gene

Cdh7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-418990. Adherens junctions interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-7
Gene namesi
Name:Cdh7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2442792. Cdh7.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini28 – 607ExtracellularSequence analysisAdd BLAST580
Transmembranei608 – 628HelicalSequence analysisAdd BLAST21
Topological domaini629 – 785CytoplasmicSequence analysisAdd BLAST157

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
PropeptideiPRO_000032009028 – 47Sequence analysisAdd BLAST20
ChainiPRO_000032009148 – 785Cadherin-7Add BLAST738

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi449N-linked (GlcNAc...)Sequence analysis1
Glycosylationi530N-linked (GlcNAc...)Sequence analysis1
Modified residuei785PhosphoserineBy similarity1

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ8BM92.
PRIDEiQ8BM92.

PTM databases

iPTMnetiQ8BM92.
PhosphoSitePlusiQ8BM92.

Expressioni

Gene expression databases

BgeeiENSMUSG00000026312.
CleanExiMM_CDH7.
ExpressionAtlasiQ8BM92. baseline and differential.
GenevisibleiQ8BM92. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027542.

Structurei

3D structure databases

ProteinModelPortaliQ8BM92.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini49 – 153Cadherin 1PROSITE-ProRule annotationAdd BLAST105
Domaini154 – 262Cadherin 2PROSITE-ProRule annotationAdd BLAST109
Domaini263 – 377Cadherin 3PROSITE-ProRule annotationAdd BLAST115
Domaini378 – 482Cadherin 4PROSITE-ProRule annotationAdd BLAST105
Domaini482 – 599Cadherin 5PROSITE-ProRule annotationAdd BLAST118

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Sequence similaritiesi

Contains 5 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00760000118954.
HOGENOMiHOG000231252.
HOVERGENiHBG005217.
InParanoidiQ8BM92.
KOiK06799.
OMAiITIQKDL.
OrthoDBiEOG091G01U9.
PhylomeDBiQ8BM92.
TreeFamiTF329887.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BM92-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLGKVELCH FLQLIALFLC FSGMSQAELP RSRSKPYFQS GRSRTKRSWV
60 70 80 90 100
WNQFFVLEEY MGSDPLYVGK LHSDVDKGDG SIKYILSGEG ASSIFIIDEN
110 120 130 140 150
TGDIHATKRL DREEQAYYTL RAQALDRLTN KPVEPESEFV IKIQDINDNE
160 170 180 190 200
PKFLDGPYTA GVPEMSPVGT SVVQVTATDA DDPTYGNSAR VVYSILQGQP
210 220 230 240 250
YFSVEPKTGV IKTALPNMDR EAKDQYLLVI QAKDMVGQNG GLSGTTSVTV
260 270 280 290 300
TLTDVNDNPP RFPRRSYQYN VPESLPVASV VARIKAADAD IGVNAEMEYK
310 320 330 340 350
IVDGDGLGIF KISADKDTQE GIITIQKELD FEAKTSYTLR IEAANRDADP
360 370 380 390 400
RFLSLGPFSD TTTVKIIVED VDEPPVFSSP LYPMEVSEAT QVGHIIGTVA
410 420 430 440 450
AHDPDSSNSP VRYSIDRNTD LERYFNIDAN SGVITTAKSL DRETNAVHNI
460 470 480 490 500
TVLAMESQNP SQVGRGYVAI TILDINDNAP EFAMDYETTV CENAQPGQVI
510 520 530 540 550
QKISAVDKDE PSNGHQFYFS LTTDMTNNHN FSLKDNKDNT ASILTRRNGF
560 570 580 590 600
RRQEQSVYYL PIFIVDSGSP SLSSTNTLTI RVCDCDADGI AQTCNAEAYV
610 620 630 640 650
LPAGLSTGAL IAILACVLTL LVLILLIVTM RRRKKEPLIF DEERDIRENI
660 670 680 690 700
VRYDDEGGGE EDTEAFDMAA LRNLNAIRDS KTRRDVTPEI QFLSRPTFKN
710 720 730 740 750
IPDNVIFREF IWERLKEADV DPGAPPYDSL QTYAFEGNGS VAESLSSLDS
760 770 780
ISSNSDQNYD YLSDWGPRFK RLAEMYGNGQ ESLYS
Length:785
Mass (Da):87,202
Last modified:March 1, 2003 - v1
Checksum:i112A1F409BF85CED
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti307L → V in AAP94032 (PubMed:15273735).Curated1
Sequence conflicti580I → V in BAE23328 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY267034 mRNA. Translation: AAP94032.1.
AK034096 mRNA. Translation: BAC28586.1.
AK137369 mRNA. Translation: BAE23328.1.
CCDSiCCDS15221.1.
RefSeqiNP_001303672.1. NM_001316743.1.
NP_766441.1. NM_172853.3.
XP_006529663.1. XM_006529600.3.
XP_006529664.1. XM_006529601.3.
XP_006529671.1. XM_006529608.3.
XP_006529672.1. XM_006529609.3.
XP_006529673.1. XM_006529610.3.
XP_006529674.1. XM_006529611.3.
XP_011246308.1. XM_011248006.2.
XP_017176182.1. XM_017320693.1.
XP_017176187.1. XM_017320698.1.
XP_017176188.1. XM_017320699.1.
XP_017176190.1. XM_017320701.1.
XP_017176192.1. XM_017320703.1.
UniGeneiMm.213407.
Mm.487119.

Genome annotation databases

EnsembliENSMUST00000027542; ENSMUSP00000027542; ENSMUSG00000026312.
ENSMUST00000112701; ENSMUSP00000108321; ENSMUSG00000026312.
ENSMUST00000172005; ENSMUSP00000129715; ENSMUSG00000026312.
GeneIDi241201.
KEGGimmu:241201.
UCSCiuc007chw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY267034 mRNA. Translation: AAP94032.1.
AK034096 mRNA. Translation: BAC28586.1.
AK137369 mRNA. Translation: BAE23328.1.
CCDSiCCDS15221.1.
RefSeqiNP_001303672.1. NM_001316743.1.
NP_766441.1. NM_172853.3.
XP_006529663.1. XM_006529600.3.
XP_006529664.1. XM_006529601.3.
XP_006529671.1. XM_006529608.3.
XP_006529672.1. XM_006529609.3.
XP_006529673.1. XM_006529610.3.
XP_006529674.1. XM_006529611.3.
XP_011246308.1. XM_011248006.2.
XP_017176182.1. XM_017320693.1.
XP_017176187.1. XM_017320698.1.
XP_017176188.1. XM_017320699.1.
XP_017176190.1. XM_017320701.1.
XP_017176192.1. XM_017320703.1.
UniGeneiMm.213407.
Mm.487119.

3D structure databases

ProteinModelPortaliQ8BM92.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027542.

PTM databases

iPTMnetiQ8BM92.
PhosphoSitePlusiQ8BM92.

Proteomic databases

PaxDbiQ8BM92.
PRIDEiQ8BM92.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027542; ENSMUSP00000027542; ENSMUSG00000026312.
ENSMUST00000112701; ENSMUSP00000108321; ENSMUSG00000026312.
ENSMUST00000172005; ENSMUSP00000129715; ENSMUSG00000026312.
GeneIDi241201.
KEGGimmu:241201.
UCSCiuc007chw.1. mouse.

Organism-specific databases

CTDi1005.
MGIiMGI:2442792. Cdh7.

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00760000118954.
HOGENOMiHOG000231252.
HOVERGENiHBG005217.
InParanoidiQ8BM92.
KOiK06799.
OMAiITIQKDL.
OrthoDBiEOG091G01U9.
PhylomeDBiQ8BM92.
TreeFamiTF329887.

Enzyme and pathway databases

ReactomeiR-MMU-418990. Adherens junctions interactions.

Miscellaneous databases

PROiQ8BM92.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026312.
CleanExiMM_CDH7.
ExpressionAtlasiQ8BM92. baseline and differential.
GenevisibleiQ8BM92. MM.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCADH7_MOUSE
AccessioniPrimary (citable) accession number: Q8BM92
Secondary accession number(s): Q3UVE2, Q67G09
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.