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Protein

Arylsulfatase J

Gene

Arsj

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Cofactori

Ca2+By similarityNote: Binds 1 Ca2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi82 – 821CalciumBy similarity
Metal bindingi83 – 831CalciumBy similarity
Metal bindingi120 – 1201Calcium; via 3-oxoalanineBy similarity
Binding sitei174 – 1741SubstrateBy similarity
Active sitei176 – 1761By similarity
Binding sitei267 – 2671SubstrateBy similarity
Metal bindingi325 – 3251CalciumBy similarity
Metal bindingi326 – 3261CalciumBy similarity
Binding sitei343 – 3431SubstrateBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-1660662. Glycosphingolipid metabolism.
R-MMU-1663150. The activation of arylsulfatases.

Names & Taxonomyi

Protein namesi
Recommended name:
Arylsulfatase J (EC:3.1.6.-)
Short name:
ASJ
Gene namesi
Name:Arsj
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:2443513. Arsj.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4747Sequence analysisAdd
BLAST
Chaini48 – 598551Arylsulfatase JPRO_0000042218Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei120 – 12013-oxoalanine (Cys)By similarity
Glycosylationi155 – 1551N-linked (GlcNAc...)Sequence analysis
Glycosylationi304 – 3041N-linked (GlcNAc...)Sequence analysis
Glycosylationi316 – 3161N-linked (GlcNAc...)Sequence analysis
Glycosylationi429 – 4291N-linked (GlcNAc...)Sequence analysis
Glycosylationi495 – 4951N-linked (GlcNAc...)Sequence analysis
Glycosylationi525 – 5251N-linked (GlcNAc...)Sequence analysis
Glycosylationi563 – 5631N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8BM89.
PRIDEiQ8BM89.

PTM databases

PhosphoSiteiQ8BM89.

Expressioni

Gene expression databases

BgeeiQ8BM89.
CleanExiMM_ARSJ.
ExpressionAtlasiQ8BM89. baseline and differential.
GenevisibleiQ8BM89. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000091511.

Structurei

3D structure databases

ProteinModelPortaliQ8BM89.
SMRiQ8BM89. Positions 74-552.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the sulfatase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3867. Eukaryota.
COG3119. LUCA.
GeneTreeiENSGT00760000119062.
HOVERGENiHBG004282.
InParanoidiQ8BM89.
KOiK12375.
OMAiAIRVQHW.
OrthoDBiEOG7MKW5Q.
TreeFamiTF314186.

Family and domain databases

Gene3Di3.40.720.10. 1 hit.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR024607. Sulfatase_CS.
IPR000917. Sulfatase_N.
[Graphical view]
PfamiPF00884. Sulfatase. 1 hit.
[Graphical view]
SUPFAMiSSF53649. SSF53649. 1 hit.
PROSITEiPS00523. SULFATASE_1. 1 hit.
PS00149. SULFATASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BM89-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPRDSAEPL PPLSPQAWAW SGKFLAMGAL AGFSVLSLLT YGYLCWGQDL
60 70 80 90 100
EEEGSLKAQV DERPEAGTAG TSQPHLIFIL ADDQGFRDVG YHGSEIKTPT
110 120 130 140 150
LDKLAAEGVK LENYYVQPIC TPSRSQFITG KYQIHTGLQH SIIRPTQPNC
160 170 180 190 200
LPLDNATLPQ KLKEVGYSTH MVGKWHLGFY RKDCMPTKRG FDTFFGSLLG
210 220 230 240 250
SGDYYTHYKC DSPGVCGYDL YENDNAAWDY DNGIYSTQMY TQRVQQILAT
260 270 280 290 300
HDPTKPLFLY VAYQAVHSPL QAPGRYFEHY RSIININRRR YAAMLSCLDE
310 320 330 340 350
AIHNVTLALK RYGFYNNSII IYSSDNGGQP TAGGSNWPLR GSKGTYWEGG
360 370 380 390 400
IRAVGFVHSP LLKNKGTVCK ELVHITDWYP TLISLAEGQI DEDIQLDGYD
410 420 430 440 450
IWETISEGLR SPRVDILHNI DPIYTKAKNG SWAAGYGIWN TAIQSAIRVQ
460 470 480 490 500
HWKLLTGNPG YSDWVPPQAF SNLGPNRWHN ERITLSTGKS IWLFNITADP
510 520 530 540 550
YERVDLSSRY PGIVKKLLRR LSQFNKTAVP VRYPPKDPRS NPRLNGGVWG
560 570 580 590
PWYKEENKKK KSNKTKAKKM QKKKSKARMR KQLAAHSSIK CHPSVATG
Length:598
Mass (Da):67,354
Last modified:March 1, 2003 - v1
Checksum:i34E85DAC88FDD4CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK034454 mRNA. Translation: BAC28715.1.
AK046410 mRNA. Translation: BAC32714.1.
AK052931 mRNA. Translation: BAC35208.1.
CCDSiCCDS17822.1.
RefSeqiNP_775627.1. NM_173451.3.
XP_011238439.1. XM_011240137.1.
UniGeneiMm.317021.

Genome annotation databases

EnsembliENSMUST00000093976; ENSMUSP00000091511; ENSMUSG00000046561.
GeneIDi271970.
KEGGimmu:271970.
UCSCiuc008rgc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK034454 mRNA. Translation: BAC28715.1.
AK046410 mRNA. Translation: BAC32714.1.
AK052931 mRNA. Translation: BAC35208.1.
CCDSiCCDS17822.1.
RefSeqiNP_775627.1. NM_173451.3.
XP_011238439.1. XM_011240137.1.
UniGeneiMm.317021.

3D structure databases

ProteinModelPortaliQ8BM89.
SMRiQ8BM89. Positions 74-552.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000091511.

PTM databases

PhosphoSiteiQ8BM89.

Proteomic databases

PaxDbiQ8BM89.
PRIDEiQ8BM89.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000093976; ENSMUSP00000091511; ENSMUSG00000046561.
GeneIDi271970.
KEGGimmu:271970.
UCSCiuc008rgc.1. mouse.

Organism-specific databases

CTDi79642.
MGIiMGI:2443513. Arsj.

Phylogenomic databases

eggNOGiKOG3867. Eukaryota.
COG3119. LUCA.
GeneTreeiENSGT00760000119062.
HOVERGENiHBG004282.
InParanoidiQ8BM89.
KOiK12375.
OMAiAIRVQHW.
OrthoDBiEOG7MKW5Q.
TreeFamiTF314186.

Enzyme and pathway databases

ReactomeiR-MMU-1660662. Glycosphingolipid metabolism.
R-MMU-1663150. The activation of arylsulfatases.

Miscellaneous databases

NextBioi393532.
PROiQ8BM89.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BM89.
CleanExiMM_ARSJ.
ExpressionAtlasiQ8BM89. baseline and differential.
GenevisibleiQ8BM89. MM.

Family and domain databases

Gene3Di3.40.720.10. 1 hit.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR024607. Sulfatase_CS.
IPR000917. Sulfatase_N.
[Graphical view]
PfamiPF00884. Sulfatase. 1 hit.
[Graphical view]
SUPFAMiSSF53649. SSF53649. 1 hit.
PROSITEiPS00523. SULFATASE_1. 1 hit.
PS00149. SULFATASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Corpora quadrigemina, Diencephalon and Heart.

Entry informationi

Entry nameiARSJ_MOUSE
AccessioniPrimary (citable) accession number: Q8BM89
Secondary accession number(s): Q8BKG5, Q8BL46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: March 1, 2003
Last modified: January 20, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.