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Q8BM88

- CATO_MOUSE

UniProt

Q8BM88 - CATO_MOUSE

Protein

Cathepsin O

Gene

Ctso

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Proteolytic enzyme possibly involved in normal cellular protein degradation and turnover.By similarity

    Catalytic activityi

    The recombinant human enzyme hydrolyzes synthetic endopeptidase substrates including Z-Phe-Arg-NHMec and Z-Arg-Arg-NHMec.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei123 – 1231By similarity
    Active sitei260 – 2601By similarity
    Active sitei280 – 2801By similarity

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Protein family/group databases

    MEROPSiC01.035.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cathepsin O (EC:3.4.22.42)
    Gene namesi
    Name:Ctso
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:2139628. Ctso.

    Subcellular locationi

    Lysosome By similarity

    GO - Cellular componenti

    1. lysosome Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Lysosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Propeptidei24 – 9875Activation peptidePRO_0000026323Add
    BLAST
    Chaini99 – 312214Cathepsin OPRO_0000026324Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi53 – 531N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi96 – 961N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi120 ↔ 161By similarity
    Disulfide bondi154 ↔ 195By similarity
    Disulfide bondi253 ↔ 301By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Proteomic databases

    PRIDEiQ8BM88.

    PTM databases

    PhosphoSiteiQ8BM88.

    Expressioni

    Gene expression databases

    BgeeiQ8BM88.
    CleanExiMM_CTSO.
    GenevestigatoriQ8BM88.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BM88.
    SMRiQ8BM88. Positions 59-308.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase C1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG4870.
    GeneTreeiENSGT00750000117440.
    HOGENOMiHOG000230774.
    HOVERGENiHBG105050.
    InParanoidiQ8BM88.
    KOiK01374.
    OMAiHVKMGSN.
    OrthoDBiEOG72NRQS.
    PhylomeDBiQ8BM88.
    TreeFamiTF331594.

    Family and domain databases

    InterProiIPR000169. Pept_cys_AS.
    IPR025660. Pept_his_AS.
    IPR013128. Peptidase_C1A.
    IPR000668. Peptidase_C1A_C.
    [Graphical view]
    PANTHERiPTHR12411. PTHR12411. 1 hit.
    PfamiPF00112. Peptidase_C1. 1 hit.
    [Graphical view]
    PRINTSiPR00705. PAPAIN.
    SMARTiSM00645. Pept_C1. 1 hit.
    [Graphical view]
    PROSITEiPS00139. THIOL_PROTEASE_CYS. 1 hit.
    PS00639. THIOL_PROTEASE_HIS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8BM88-1 [UniParc]FASTAAdd to Basket

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    MKPQLVNLLL LCCCCLGRHG VAGTWSWSHQ REAAALRESL HRHRYLNSFP    50
    HENSTAFYGV NQFSYLFPEE FKALYLGSKY AWAPRYPAEG QRPIPNVSLP 100
    LRFDWRDKHV VNPVRNQEMC GGCWAFSVVS AIESARAIQG KSLDYLSVQQ 150
    VIDCSFNNSG CLGGSPLCAL RWLNETQLKL VADSQYPFKA VNGQCRHFPQ 200
    SQAGVSVKDF SAYNFRGQED EMARALLSFG PLVVIVDAMS WQDYLGGIIQ 250
    HHCSSGEANH AVLITGFDRT GNTPYWMVRN SWGSSWGVEG YAHVKMGGNV 300
    CGIADSVAAV FV 312
    Length:312
    Mass (Da):34,723
    Last modified:March 1, 2003 - v1
    Checksum:i4C7C056D0771807C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti63 – 631F → L in BAC33765. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK034490 mRNA. Translation: BAC28728.1.
    AK049470 mRNA. Translation: BAC33765.1.
    AK165930 mRNA. Translation: BAE38466.1.
    AK166103 mRNA. Translation: BAE38573.1.
    BC044664 mRNA. Translation: AAH44664.1.
    CCDSiCCDS17426.1.
    RefSeqiNP_808330.1. NM_177662.2.
    UniGeneiMm.254642.

    Genome annotation databases

    EnsembliENSMUST00000029649; ENSMUSP00000029649; ENSMUSG00000028015.
    GeneIDi229445.
    KEGGimmu:229445.
    UCSCiuc008pon.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK034490 mRNA. Translation: BAC28728.1 .
    AK049470 mRNA. Translation: BAC33765.1 .
    AK165930 mRNA. Translation: BAE38466.1 .
    AK166103 mRNA. Translation: BAE38573.1 .
    BC044664 mRNA. Translation: AAH44664.1 .
    CCDSi CCDS17426.1.
    RefSeqi NP_808330.1. NM_177662.2.
    UniGenei Mm.254642.

    3D structure databases

    ProteinModelPortali Q8BM88.
    SMRi Q8BM88. Positions 59-308.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi C01.035.

    PTM databases

    PhosphoSitei Q8BM88.

    Proteomic databases

    PRIDEi Q8BM88.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000029649 ; ENSMUSP00000029649 ; ENSMUSG00000028015 .
    GeneIDi 229445.
    KEGGi mmu:229445.
    UCSCi uc008pon.1. mouse.

    Organism-specific databases

    CTDi 1519.
    MGIi MGI:2139628. Ctso.

    Phylogenomic databases

    eggNOGi COG4870.
    GeneTreei ENSGT00750000117440.
    HOGENOMi HOG000230774.
    HOVERGENi HBG105050.
    InParanoidi Q8BM88.
    KOi K01374.
    OMAi HVKMGSN.
    OrthoDBi EOG72NRQS.
    PhylomeDBi Q8BM88.
    TreeFami TF331594.

    Miscellaneous databases

    NextBioi 379433.
    PROi Q8BM88.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8BM88.
    CleanExi MM_CTSO.
    Genevestigatori Q8BM88.

    Family and domain databases

    InterProi IPR000169. Pept_cys_AS.
    IPR025660. Pept_his_AS.
    IPR013128. Peptidase_C1A.
    IPR000668. Peptidase_C1A_C.
    [Graphical view ]
    PANTHERi PTHR12411. PTHR12411. 1 hit.
    Pfami PF00112. Peptidase_C1. 1 hit.
    [Graphical view ]
    PRINTSi PR00705. PAPAIN.
    SMARTi SM00645. Pept_C1. 1 hit.
    [Graphical view ]
    PROSITEi PS00139. THIOL_PROTEASE_CYS. 1 hit.
    PS00639. THIOL_PROTEASE_HIS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Diencephalon, Embryo and Lung.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 21-312.
      Strain: FVB/N.
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiCATO_MOUSE
    AccessioniPrimary (citable) accession number: Q8BM88
    Secondary accession number(s): Q3TM69, Q80V35, Q8BKX0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2005
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3