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Q8BM88

- CATO_MOUSE

UniProt

Q8BM88 - CATO_MOUSE

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Protein

Cathepsin O

Gene
Ctso
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Proteolytic enzyme possibly involved in normal cellular protein degradation and turnover By similarity.

Catalytic activityi

The recombinant human enzyme hydrolyzes synthetic endopeptidase substrates including Z-Phe-Arg-NHMec and Z-Arg-Arg-NHMec.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei123 – 1231 By similarity
Active sitei260 – 2601 By similarity
Active sitei280 – 2801 By similarity

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Protein family/group databases

MEROPSiC01.035.

Names & Taxonomyi

Protein namesi
Recommended name:
Cathepsin O (EC:3.4.22.42)
Gene namesi
Name:Ctso
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:2139628. Ctso.

Subcellular locationi

Lysosome By similarity

GO - Cellular componenti

  1. lysosome Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed predictionAdd
BLAST
Propeptidei24 – 9875Activation peptidePRO_0000026323Add
BLAST
Chaini99 – 312214Cathepsin OPRO_0000026324Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi53 – 531N-linked (GlcNAc...) Reviewed prediction
Glycosylationi96 – 961N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi120 ↔ 161 By similarity
Disulfide bondi154 ↔ 195 By similarity
Disulfide bondi253 ↔ 301 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PRIDEiQ8BM88.

PTM databases

PhosphoSiteiQ8BM88.

Expressioni

Gene expression databases

BgeeiQ8BM88.
CleanExiMM_CTSO.
GenevestigatoriQ8BM88.

Structurei

3D structure databases

ProteinModelPortaliQ8BM88.
SMRiQ8BM88. Positions 59-308.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C1 family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG4870.
GeneTreeiENSGT00750000117440.
HOGENOMiHOG000230774.
HOVERGENiHBG105050.
InParanoidiQ8BM88.
KOiK01374.
OMAiHVKMGSN.
OrthoDBiEOG72NRQS.
PhylomeDBiQ8BM88.
TreeFamiTF331594.

Family and domain databases

InterProiIPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiPF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BM88-1 [UniParc]FASTAAdd to Basket

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MKPQLVNLLL LCCCCLGRHG VAGTWSWSHQ REAAALRESL HRHRYLNSFP    50
HENSTAFYGV NQFSYLFPEE FKALYLGSKY AWAPRYPAEG QRPIPNVSLP 100
LRFDWRDKHV VNPVRNQEMC GGCWAFSVVS AIESARAIQG KSLDYLSVQQ 150
VIDCSFNNSG CLGGSPLCAL RWLNETQLKL VADSQYPFKA VNGQCRHFPQ 200
SQAGVSVKDF SAYNFRGQED EMARALLSFG PLVVIVDAMS WQDYLGGIIQ 250
HHCSSGEANH AVLITGFDRT GNTPYWMVRN SWGSSWGVEG YAHVKMGGNV 300
CGIADSVAAV FV 312
Length:312
Mass (Da):34,723
Last modified:March 1, 2003 - v1
Checksum:i4C7C056D0771807C
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti63 – 631F → L in BAC33765. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK034490 mRNA. Translation: BAC28728.1.
AK049470 mRNA. Translation: BAC33765.1.
AK165930 mRNA. Translation: BAE38466.1.
AK166103 mRNA. Translation: BAE38573.1.
BC044664 mRNA. Translation: AAH44664.1.
CCDSiCCDS17426.1.
RefSeqiNP_808330.1. NM_177662.2.
UniGeneiMm.254642.

Genome annotation databases

EnsembliENSMUST00000029649; ENSMUSP00000029649; ENSMUSG00000028015.
GeneIDi229445.
KEGGimmu:229445.
UCSCiuc008pon.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK034490 mRNA. Translation: BAC28728.1 .
AK049470 mRNA. Translation: BAC33765.1 .
AK165930 mRNA. Translation: BAE38466.1 .
AK166103 mRNA. Translation: BAE38573.1 .
BC044664 mRNA. Translation: AAH44664.1 .
CCDSi CCDS17426.1.
RefSeqi NP_808330.1. NM_177662.2.
UniGenei Mm.254642.

3D structure databases

ProteinModelPortali Q8BM88.
SMRi Q8BM88. Positions 59-308.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi C01.035.

PTM databases

PhosphoSitei Q8BM88.

Proteomic databases

PRIDEi Q8BM88.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000029649 ; ENSMUSP00000029649 ; ENSMUSG00000028015 .
GeneIDi 229445.
KEGGi mmu:229445.
UCSCi uc008pon.1. mouse.

Organism-specific databases

CTDi 1519.
MGIi MGI:2139628. Ctso.

Phylogenomic databases

eggNOGi COG4870.
GeneTreei ENSGT00750000117440.
HOGENOMi HOG000230774.
HOVERGENi HBG105050.
InParanoidi Q8BM88.
KOi K01374.
OMAi HVKMGSN.
OrthoDBi EOG72NRQS.
PhylomeDBi Q8BM88.
TreeFami TF331594.

Miscellaneous databases

NextBioi 379433.
PROi Q8BM88.
SOURCEi Search...

Gene expression databases

Bgeei Q8BM88.
CleanExi MM_CTSO.
Genevestigatori Q8BM88.

Family and domain databases

InterProi IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
[Graphical view ]
PANTHERi PTHR12411. PTHR12411. 1 hit.
Pfami PF00112. Peptidase_C1. 1 hit.
[Graphical view ]
PRINTSi PR00705. PAPAIN.
SMARTi SM00645. Pept_C1. 1 hit.
[Graphical view ]
PROSITEi PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Diencephalon, Embryo and Lung.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 21-312.
    Strain: FVB/N.
    Tissue: Mammary gland.

Entry informationi

Entry nameiCATO_MOUSE
AccessioniPrimary (citable) accession number: Q8BM88
Secondary accession number(s): Q3TM69, Q80V35, Q8BKX0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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