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Protein

Cathepsin O

Gene

Ctso

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Proteolytic enzyme possibly involved in normal cellular protein degradation and turnover.By similarity

Catalytic activityi

The recombinant human enzyme hydrolyzes synthetic endopeptidase substrates including Z-Phe-Arg-NHMec and Z-Arg-Arg-NHMec.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei123 – 1231By similarity
Active sitei260 – 2601By similarity
Active sitei280 – 2801By similarity

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Protein family/group databases

MEROPSiC01.035.

Names & Taxonomyi

Protein namesi
Recommended name:
Cathepsin O (EC:3.4.22.42)
Gene namesi
Name:Ctso
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:2139628. Ctso.

Subcellular locationi

Lysosome By similarity

GO - Cellular componenti

  1. lysosome Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Propeptidei24 – 9875Activation peptidePRO_0000026323Add
BLAST
Chaini99 – 312214Cathepsin OPRO_0000026324Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi53 – 531N-linked (GlcNAc...)Sequence Analysis
Glycosylationi96 – 961N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi120 ↔ 161By similarity
Disulfide bondi154 ↔ 195By similarity
Disulfide bondi253 ↔ 301By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

MaxQBiQ8BM88.
PRIDEiQ8BM88.

PTM databases

PhosphoSiteiQ8BM88.

Expressioni

Gene expression databases

BgeeiQ8BM88.
CleanExiMM_CTSO.
GenevestigatoriQ8BM88.

Structurei

3D structure databases

ProteinModelPortaliQ8BM88.
SMRiQ8BM88. Positions 24-308.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG4870.
GeneTreeiENSGT00760000118871.
HOGENOMiHOG000230774.
HOVERGENiHBG105050.
InParanoidiQ8BM88.
KOiK01374.
OMAiQEEAMMG.
OrthoDBiEOG72NRQS.
PhylomeDBiQ8BM88.
TreeFamiTF331594.

Family and domain databases

InterProiIPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiPF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BM88-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPQLVNLLL LCCCCLGRHG VAGTWSWSHQ REAAALRESL HRHRYLNSFP
60 70 80 90 100
HENSTAFYGV NQFSYLFPEE FKALYLGSKY AWAPRYPAEG QRPIPNVSLP
110 120 130 140 150
LRFDWRDKHV VNPVRNQEMC GGCWAFSVVS AIESARAIQG KSLDYLSVQQ
160 170 180 190 200
VIDCSFNNSG CLGGSPLCAL RWLNETQLKL VADSQYPFKA VNGQCRHFPQ
210 220 230 240 250
SQAGVSVKDF SAYNFRGQED EMARALLSFG PLVVIVDAMS WQDYLGGIIQ
260 270 280 290 300
HHCSSGEANH AVLITGFDRT GNTPYWMVRN SWGSSWGVEG YAHVKMGGNV
310
CGIADSVAAV FV
Length:312
Mass (Da):34,723
Last modified:March 1, 2003 - v1
Checksum:i4C7C056D0771807C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti63 – 631F → L in BAC33765 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK034490 mRNA. Translation: BAC28728.1.
AK049470 mRNA. Translation: BAC33765.1.
AK165930 mRNA. Translation: BAE38466.1.
AK166103 mRNA. Translation: BAE38573.1.
BC044664 mRNA. Translation: AAH44664.1.
CCDSiCCDS17426.1.
RefSeqiNP_808330.1. NM_177662.2.
UniGeneiMm.254642.

Genome annotation databases

EnsembliENSMUST00000029649; ENSMUSP00000029649; ENSMUSG00000028015.
GeneIDi229445.
KEGGimmu:229445.
UCSCiuc008pon.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK034490 mRNA. Translation: BAC28728.1.
AK049470 mRNA. Translation: BAC33765.1.
AK165930 mRNA. Translation: BAE38466.1.
AK166103 mRNA. Translation: BAE38573.1.
BC044664 mRNA. Translation: AAH44664.1.
CCDSiCCDS17426.1.
RefSeqiNP_808330.1. NM_177662.2.
UniGeneiMm.254642.

3D structure databases

ProteinModelPortaliQ8BM88.
SMRiQ8BM88. Positions 24-308.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiC01.035.

PTM databases

PhosphoSiteiQ8BM88.

Proteomic databases

MaxQBiQ8BM88.
PRIDEiQ8BM88.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029649; ENSMUSP00000029649; ENSMUSG00000028015.
GeneIDi229445.
KEGGimmu:229445.
UCSCiuc008pon.1. mouse.

Organism-specific databases

CTDi1519.
MGIiMGI:2139628. Ctso.

Phylogenomic databases

eggNOGiCOG4870.
GeneTreeiENSGT00760000118871.
HOGENOMiHOG000230774.
HOVERGENiHBG105050.
InParanoidiQ8BM88.
KOiK01374.
OMAiQEEAMMG.
OrthoDBiEOG72NRQS.
PhylomeDBiQ8BM88.
TreeFamiTF331594.

Miscellaneous databases

NextBioi379433.
PROiQ8BM88.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BM88.
CleanExiMM_CTSO.
GenevestigatoriQ8BM88.

Family and domain databases

InterProiIPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiPF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Diencephalon, Embryo and Lung.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 21-312.
    Strain: FVB/N.
    Tissue: Mammary gland.

Entry informationi

Entry nameiCATO_MOUSE
AccessioniPrimary (citable) accession number: Q8BM88
Secondary accession number(s): Q3TM69, Q80V35, Q8BKX0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: March 1, 2003
Last modified: January 7, 2015
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.