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Protein

TBC domain-containing protein kinase-like protein

Gene

Tbck

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
TBC domain-containing protein kinase-like protein
Gene namesi
Name:Tbck
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2445052. Tbck.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 762762TBC domain-containing protein kinase-like proteinPRO_0000273279Add
BLAST

Proteomic databases

EPDiQ8BM85.
MaxQBiQ8BM85.
PaxDbiQ8BM85.
PRIDEiQ8BM85.

PTM databases

iPTMnetiQ8BM85.
PhosphoSiteiQ8BM85.

Expressioni

Gene expression databases

BgeeiQ8BM85.
CleanExiMM_A630047E20RIK.

Interactioni

Protein-protein interaction databases

BioGridi234859. 11 interactions.
IntActiQ8BM85. 11 interactions.
STRINGi10090.ENSMUSP00000129205.

Structurei

3D structure databases

ProteinModelPortaliQ8BM85.
SMRiQ8BM85. Positions 1-269, 455-682.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 273273Protein kinasePROSITE-ProRule annotationAdd
BLAST
Domaini466 – 651186Rab-GAP TBCPROSITE-ProRule annotationAdd
BLAST

Domaini

The protein kinase domain is predicted to be catalytically inactive.Sequence analysis

Sequence similaritiesi

Belongs to the protein kinase superfamily.Curated
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 Rab-GAP TBC domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1093. Eukaryota.
ENOG410Y9M1. LUCA.
HOGENOMiHOG000007426.
HOVERGENiHBG055536.
InParanoidiQ8BM85.
KOiK17544.
PhylomeDBiQ8BM85.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR000195. Rab-GTPase-TBC_dom.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
PF00566. RabGAP-TBC. 1 hit.
[Graphical view]
SMARTiSM00164. TBC. 1 hit.
[Graphical view]
SUPFAMiSSF47923. SSF47923. 2 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS50086. TBC_RABGAP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q8BM85-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFPLKDAEMG AFTFFASALP HDVCGSNGLP LTPNSIKILG RFQILKTITH
60 70 80 90 100
PRLCQYVDIS RGKHERLVVV AEHCERSLED LLRERKPVSH STVLCIAYEV
110 120 130 140 150
LEGLHYLNKH GIVHRALSPH NILLDRKGHI KLAKFGLYHM TAHGDDVDFP
160 170 180 190 200
IGYPSYLAPE VIAQGIPKTT DHVPSEKPLP SGPKSDVWSL GIILFELCVG
210 220 230 240 250
RKLFQSLDVS ERVKFLLTLG CVDDTIIVLA EEHGCLDIIK ELPENVINIL
260 270 280 290 300
KKCLTFHPSK RPTPDELMKD QVFSEVSPLY TPFIKPASLF SSSLRCADLT
310 320 330 340 350
LPEDISDLCK DIDNDYLAER SIEEVYYLWC LAGGDLEKEL INKEIIRSKP
360 370 380 390 400
PVCTLPNFLF EDGESFGQGR DRSSLLDDTT VTLSLCQLRN RLKDVGGEAF
410 420 430 440 450
YPLLEDDQSN LPHSNSNNEL SAAATLPLII RERDTEYQLN RIILFDRLLK
460 470 480 490 500
AYPYKKNQIW KEARVDIPPL MRGLTWAALL GVEGAIHAKY DAIDKDTPIP
510 520 530 540 550
TDRQIEVDIP RCHQYDELLS SPEGHAKFRR VLKAWVVSHP DLVYWQGLDS
560 570 580 590 600
LCAPFLYLNF NNEALAYACM SAFIPKYLYN FFLKDNSHVI QEYLTVFSQM
610 620 630 640 650
IAFHDPELSN HLNEIGFIPD LYAIPWFLTM FTHVFPLHKI FHLWDTLLLG
660 670 680 690 700
NSSFPFCIGV AILQQLRDRL LANGFNECIL LFSDLPEIDI ERCVRESVNL
710 720 730 740 750
FCWTPKSATY RQHAQPPKPA SESSVVRSSA PYFSAECTDP PKTDLGNKAS
760
PVWKMHCAAP RA
Length:762
Mass (Da):86,371
Last modified:March 1, 2003 - v1
Checksum:i200651B920B1F9D4
GO
Isoform 21 Publication (identifier: Q8BM85-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     687-688: EI → GF
     689-762: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:688
Mass (Da):78,160
Checksum:i5C071DF8B4BB1407
GO

Sequence cautioni

The sequence BAC31100.1 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei687 – 6882EI → GF in isoform 2. 1 PublicationVSP_052276
Alternative sequencei689 – 76274Missing in isoform 2. 1 PublicationVSP_052277Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK034533 mRNA. Translation: BAC28746.1.
AK041928 mRNA. Translation: BAC31100.1. Different initiation.
AK052841 mRNA. Translation: BAC35172.1.
RefSeqiNP_001156927.1. NM_001163455.2.
UniGeneiMm.257864.
Mm.391954.
Mm.440106.

Genome annotation databases

GeneIDi271981.
KEGGimmu:271981.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK034533 mRNA. Translation: BAC28746.1.
AK041928 mRNA. Translation: BAC31100.1. Different initiation.
AK052841 mRNA. Translation: BAC35172.1.
RefSeqiNP_001156927.1. NM_001163455.2.
UniGeneiMm.257864.
Mm.391954.
Mm.440106.

3D structure databases

ProteinModelPortaliQ8BM85.
SMRiQ8BM85. Positions 1-269, 455-682.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi234859. 11 interactions.
IntActiQ8BM85. 11 interactions.
STRINGi10090.ENSMUSP00000129205.

PTM databases

iPTMnetiQ8BM85.
PhosphoSiteiQ8BM85.

Proteomic databases

EPDiQ8BM85.
MaxQBiQ8BM85.
PaxDbiQ8BM85.
PRIDEiQ8BM85.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi271981.
KEGGimmu:271981.

Organism-specific databases

CTDi93627.
MGIiMGI:2445052. Tbck.

Phylogenomic databases

eggNOGiKOG1093. Eukaryota.
ENOG410Y9M1. LUCA.
HOGENOMiHOG000007426.
HOVERGENiHBG055536.
InParanoidiQ8BM85.
KOiK17544.
PhylomeDBiQ8BM85.

Miscellaneous databases

ChiTaRSiTbck. mouse.
NextBioi393536.
PROiQ8BM85.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BM85.
CleanExiMM_A630047E20RIK.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR000195. Rab-GTPase-TBC_dom.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
PF00566. RabGAP-TBC. 1 hit.
[Graphical view]
SMARTiSM00164. TBC. 1 hit.
[Graphical view]
SUPFAMiSSF47923. SSF47923. 2 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS50086. TBC_RABGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6JImported.
    Tissue: EmbryoImported, Mammary glandImported and ThymusImported.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Kidney, Lung, Spleen and Testis.

Entry informationi

Entry nameiTBCK_MOUSE
AccessioniPrimary (citable) accession number: Q8BM85
Secondary accession number(s): Q8BWD3, Q8BY53
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: March 1, 2003
Last modified: April 13, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.