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Protein

Heat shock 70 kDa protein 13

Gene

Hspa13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Has peptide-independent ATPase activity.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock 70 kDa protein 13
Alternative name(s):
Microsomal stress-70 protein ATPase core
Stress-70 protein chaperone microsome-associated 60 kDa protein
Gene namesi
Name:Hspa13
Synonyms:Stch
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1309463. Hspa13.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 471449Heat shock 70 kDa protein 13PRO_0000013559Add
BLAST

Proteomic databases

EPDiQ8BM72.
MaxQBiQ8BM72.
PaxDbiQ8BM72.
PRIDEiQ8BM72.

PTM databases

PhosphoSiteiQ8BM72.

Expressioni

Gene expression databases

BgeeiQ8BM72.
ExpressionAtlasiQ8BM72. baseline and differential.
GenevisibleiQ8BM72. MM.

Interactioni

Subunit structurei

Binds UBQLN2.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048817.

Structurei

3D structure databases

ProteinModelPortaliQ8BM72.
SMRiQ8BM72. Positions 34-446.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0101. Eukaryota.
COG0443. LUCA.
GeneTreeiENSGT00840000129922.
HOGENOMiHOG000228135.
HOVERGENiHBG098979.
InParanoidiQ8BM72.
KOiK09491.
OMAiQIYQTYG.
OrthoDBiEOG7VMP5B.
PhylomeDBiQ8BM72.
TreeFamiTF105047.

Family and domain databases

InterProiIPR018181. Heat_shock_70_CS.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 2 hits.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BM72-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGEMTILGS AVLTLLLAGY LAQQYLPLPT PKVIGIDLGT TYCSVGVFFP
60 70 80 90 100
GTGKVKVIPD ENGHISIPSM VSFTDGDVYV GYESLELADS NPQNTIYDAK
110 120 130 140 150
RFIGKIFTPE ELEAEVGRYP FKVLHRNGMA EFSVTSNETI IVSPEFVGSR
160 170 180 190 200
LLLKLKEMAE EYLGMPVANA VISVPAEFDL QQRNSTIQAA NLAGLKILRV
210 220 230 240 250
INEPTAAAMA YGLHKVDVFY VLVIDLGGGT LDVSLLNKQG GMFLTRAMSG
260 270 280 290 300
NNKLGGQDFN QRLLQHLYKE IYQTYGFLPS RKEEIHRLRQ AVEMVKLNLT
310 320 330 340 350
IHQSAQVSVL LTVEGKDSKE PQNGDSELPK DQLTPGDGHH VNRVFRPGLS
360 370 380 390 400
ESKSGKSQVL FETEVSRKLF DALNEDLFQK ILVPIQQVLK EGLLDKTEID
410 420 430 440 450
EVVLVGGSTR IPRIRQVIQE FFGKDPNTSV DPDLAVVTGV AIQAGIDGGS
460 470
WPLQVSALEI PNKHLQKTNF N
Length:471
Mass (Da):51,709
Last modified:March 1, 2003 - v1
Checksum:iF60982FF20A88D55
GO
Isoform 2 (identifier: Q8BM72-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     195-199: LKILR → NSTFD
     200-471: Missing.

Note: No experimental confirmation available.
Show »
Length:199
Mass (Da):21,574
Checksum:iEB267C3B4D864174
GO

Sequence cautioni

The sequence BAE39860.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1 – 11M → V in BAE39860 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei195 – 1995LKILR → NSTFD in isoform 2. 1 PublicationVSP_013912
Alternative sequencei200 – 471272Missing in isoform 2. 1 PublicationVSP_013913Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK021006 mRNA. Translation: BAB32274.1.
AK034643 mRNA. Translation: BAC28781.1.
AK167839 mRNA. Translation: BAE39860.1. Different initiation.
BC085181 mRNA. Translation: AAH85181.1.
CCDSiCCDS28273.1. [Q8BM72-1]
RefSeqiNP_084477.1. NM_030201.3. [Q8BM72-1]
UniGeneiMm.26704.

Genome annotation databases

EnsembliENSMUST00000046283; ENSMUSP00000048817; ENSMUSG00000032932. [Q8BM72-1]
GeneIDi110920.
KEGGimmu:110920.
UCSCiuc007zrp.2. mouse. [Q8BM72-1]
uc007zrr.2. mouse. [Q8BM72-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK021006 mRNA. Translation: BAB32274.1.
AK034643 mRNA. Translation: BAC28781.1.
AK167839 mRNA. Translation: BAE39860.1. Different initiation.
BC085181 mRNA. Translation: AAH85181.1.
CCDSiCCDS28273.1. [Q8BM72-1]
RefSeqiNP_084477.1. NM_030201.3. [Q8BM72-1]
UniGeneiMm.26704.

3D structure databases

ProteinModelPortaliQ8BM72.
SMRiQ8BM72. Positions 34-446.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048817.

PTM databases

PhosphoSiteiQ8BM72.

Proteomic databases

EPDiQ8BM72.
MaxQBiQ8BM72.
PaxDbiQ8BM72.
PRIDEiQ8BM72.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046283; ENSMUSP00000048817; ENSMUSG00000032932. [Q8BM72-1]
GeneIDi110920.
KEGGimmu:110920.
UCSCiuc007zrp.2. mouse. [Q8BM72-1]
uc007zrr.2. mouse. [Q8BM72-2]

Organism-specific databases

CTDi6782.
MGIiMGI:1309463. Hspa13.

Phylogenomic databases

eggNOGiKOG0101. Eukaryota.
COG0443. LUCA.
GeneTreeiENSGT00840000129922.
HOGENOMiHOG000228135.
HOVERGENiHBG098979.
InParanoidiQ8BM72.
KOiK09491.
OMAiQIYQTYG.
OrthoDBiEOG7VMP5B.
PhylomeDBiQ8BM72.
TreeFamiTF105047.

Miscellaneous databases

PROiQ8BM72.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BM72.
ExpressionAtlasiQ8BM72. baseline and differential.
GenevisibleiQ8BM72. MM.

Family and domain databases

InterProiIPR018181. Heat_shock_70_CS.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 2 hits.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: BALB/cJ and C57BL/6J.
    Tissue: Corpora quadrigemina and Embryo.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Head.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Lung, Pancreas and Spleen.

Entry informationi

Entry nameiHSP13_MOUSE
AccessioniPrimary (citable) accession number: Q8BM72
Secondary accession number(s): Q3TII6, Q9D1X5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: March 1, 2003
Last modified: June 8, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.