Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processⁱ

• neuron projection morphogenesis Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 21946561
• phosphatidylinositol 3-kinase signaling Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 21946561

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componentⁱ

• intracellular Source: GOC

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypeⁱ

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section"><span class="caps">PTM</span>/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression"><span class="caps">P92958</span></a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression"><span class="caps">Q8TDN4</span></a>, <a href="http://www.uniprot.org/uniprot/O14734#expression"><span class="caps">O14734</span></a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stageⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">‘Interaction’</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the ‘Interaction’ section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Region

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5)ⁱ

<p>This subsection of the ‘Sequence’ section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsⁱ produced by alternative splicing. AlignAdd to basketAdded to basket

        10         20         30         40         50
MIPSKMMSAN PEEDPLDTFF QYIEDMGMKA YDGLVIQNAS DIARENDRLR 
        60         70         80         90        100
NETKLAYLKE KNEKRRRQEE TIKRIGGEVG RGQDASYAGK HFRMGFMTMP 
       110        120        130        140        150
APQDRLPHPC SSGFTVRSQS LHSVGGTEDD SSCGSRRQPP PKPKRDPSTK 
       160        170        180        190        200
LSTSSETVNS TAASKSGRSL ERAEGKFTVP ASHSPPRAST SGHLFPSPGS 
       210        220        230        240        250
QERNIKVSAK PRPHSDEYSK KIPPPKPKRN PNTQLSTSFD ETYIKKHVPR 
       260        270        280        290        300
RTSLPRDSSL SQVCSPAADP EEEEPVYIEM VGNILRDFRK EEDDQSEAVY 
       310        320        330        340        350
EEMKYPIFDD LGHDSKCDFD HHSCSSQCAT PTVPDLDFVK SSGPCTPKGL 
       360        370        380        390        400
LCDIPPPFPN LLSHRPPLLV FPPAPVHCSP NSDESPLTPL EVTKLPVLEN 
       410        420        430        440        450
VSYMKQPPGA CPSSLPSHGS SHAKDQTGAL GPAPGASILS SSPPPPSTLY 
       460        470        480        490        500
RTQSPHGYPK SHSTSPSPVS MGRSLTPLSL KRPPPYDAVH SGSLSRSSSS 
       510        520        530        540        550
VPHTTPRPVS QDGAKMVNAA VNTYSAAQSG SRSRTPTSPL EELTSLFTSG 
       560        570        580        590        600
RSLLRKSSSG RRSKEPAEKS TEELKVRSHS TEPLPKLDSK ERGHYGSSSS 
       610        620        630        640        650
REPVKAQEWD GTPGPPVVTS RMGRCSVSPT LLAGNHSSEP KVSCKLGRSA 
       660        670        680 
STSGVPPPSV TPLRQASDLQ QSQVPSSLAN RD            

        10         20         30         40         50
MIPSKMMSAN PEEDPLDTFF QYIEDMGMKA YDGLVIQNAS DIARENDRLR 
        60         70         80         90        100
NETKLAYLKE KNEKRRRQEE TIKRIGGEVG RGQDASYAGK HFRMGFMTMP 
       110        120        130        140        150
APQDRLPHPC SSGFTVRSQS LHSVGGTEDD SSCGSRRQPP PKPKRDPSTK 
       160        170        180        190        200
LSTSSETVNS TAASKSGRSL ERAEVSAKPR PHSDEYSKKI PPPKPKRNPN 
       210        220        230        240        250
TQLSTSFDET YIKKHVPRRT SLPRDSSLSQ VCSPAADPEE EEPVYIEMVG 
       260        270        280        290        300
NILRDFRKEE DDQSEAVYEE MKYPIFDDLG HDSKCDFDHH SCSSQCATPT 
       310        320        330        340        350
VPDLDFVKSS GPCTPKGLLC DIPPPFPNLL SHRPPLLVFP PAPVHCSPNS 
       360        370        380        390        400
DESPLTPLEV TKLPVLENVS YMKQPPGACP SSLPSHGSSH AKDQTGALGP 
       410        420        430        440        450
APGASILSSS PPPPSTLYRT QSPHGYPKSH STSPSPVSMG RSLTPLSLKR 
       460        470        480        490        500
PPPYDAVHSG SLSRSSSSVP HTTPRPVSQD GAKMVNAAVN TYSAAQSGSR 
       510        520        530        540        550
SRTPTSPLEE LTSLFTSGRS LLRKSSSGRR SKEPAEKSTE ELKVRSHSTE 
       560        570        580        590        600
PLPKLDSKER GHYGSSSSRE PVKAQEWDGT PGPPVVTSRM GRCSVSPTLL 
       610        620        630        640        650
AGNHSSEPKV SCKLGRSAST SGVPPPSVTP LRQASDLQQS QVPSSLANRD 

        10         20         30         40         50
MIPSKMMSAN PEEDPLDTFF QYIEDMGMKA YDGLVIQNAS DIARENDRLR 
        60         70         80         90        100
NETKLAYLKE KNEKRRRQEE TIKRIGGEVG RGQDASYAGK HFRMGFMTMP 
       110        120        130        140        150
APQDRLPHPC SSGFTVRSQS LHSVGGTEDD SSCGSRRQPP PKPKRDPSTK 
       160        170        180        190        200
LSTSSETVNS TAASKSGRSL ERAEGKFTVP ASHSPPRAST SGHLFPSPGS 
       210        220        230        240        250
QERNIKVSAK PRPHSDEYSK KIPPPKPKRN PNTQLSTSFD ETYIKKHVPR 
       260        270        280        290        300
RTSLPRDSSL SQVCSPAADP EEEEPVYIEM VGNILRDFRK EEDDQSEAVY 
       310        320        330        340        350
EEMKYPIFDD LGHDSKCDFD HHSCSSQCAT PTVPDLDFVK SSGPCTPKGL 
       360        370        380        390        400
LCDIPPPFPN LLSHRPPLLV FPPAPVHCSP NSDESPLTPL EVTKLPVLEN 
       410        420        430        440        450
VSYMKQPPGA CPSSLPSHGS SHAKDQTGAL GPAPGASILS SSPPPPSTLY 
       460        470        480        490        500
RTQSPHGYPK SHSTSPSPVS MGRSLTPLSL KRPPPYDAVH SGSLSRSSSS 
       510        520        530        540        550
VPHTTPRPVS QDGAKMVNAA VNTYSAAQSG SRSRTPTSPL EELTSLFTSG 
       560        570        580        590        600
RSLLRKSSSG RRSKEPAEKS TEELKVRSHS TEPLPKLDSK ERGHYGSSSS 
       610        620        630        640        650
REPVKAQEWD GTPGPPVVTS RMGRCSVSPT LLAGNHSSGK HDPVLPNGSK 
       660        670        680        690        700
SLEAAHMQIS LRKPSPQLSL LPPRLAPQTH TLRSRHMKNA TVPLFIAMAR 
       710        720        730 
ETMLLEALLC SSLQLGKTLY QMSSKMTTGL NSSHCNL            

        10         20         30         40         50
MIPSKMMSAN PEEDPLDTFF QYIEDMGMKA YDGLVIQNAS DIARENDRLR 
        60         70         80         90        100
NETKLAYLKE KNEKRRRQEE TIKRIGGEVG RGQDASYAGK HFRMGFMTMP 
       110        120        130        140        150
APQDRLPHPC SSGFTVRSQS LHSVGGTEDD SSCGSRRQPP PKPKRDPSTK 
       160        170        180        190        200
LSTSSETVNS TAASKSGRSL ERAEGKFTVP ASHSPPRAST SGHLFPSPGS 
       210        220        230        240        250
QERNIKVSAK PRPHSDEYSK KIPPPKPKRN PNTQLSTSFD ETYIKKHVPR 
       260        270        280        290        300
RTSLPRDSSL SQVCSPAADP EEEEPVYIEM VGNILRDFRK EEDDQSEAVY 
       310        320        330        340        350
EEMKYPIFDD LGHDSKCDFD HHSCSSQCAT PTVPDLDFVK SSGPCTPKGL 
       360        370        380        390        400
LCDIPPPFPN LLSHRPPLLV FPPAPVHCSP NSDESPLTPL EVTKLPVLEN 
       410        420        430        440        450
VSYMKQPPGA CPSSLPSHGS SHAKDQTGAL GPAPGASILS SSPPPPSTLY 
       460        470        480        490        500
RTQSPHGYPK SHSTSPSPVS MGRSLTPLSL KRPPPYDAVH SGSLSRSSSS 
       510        520        530        540        550
VPHTTPRPVS QDGAKMVNAA VNTYSAAQSG SRSRTPTSPL EELTSLFTSG 
       560        570        580        590        600
RSLLRKSSSG RRSKEPAEKS TEELKVRSHS TEPLPKLDSK ERGHYGSSSS 
       610        620        630        640        650
REPVKAQEWD GTPGPPVVTS RMGRCSVSPT LLAGNHSSEP KVSCKLGRSA 
       660        670        680        690        700
STSGVPPPSV TPLRQASDLQ QSQVACMQWF HGDHTMLEMI EKKRCLCKEI 
       710        720        730        740 
KARQKTEKGL CKQDSMPILP SWKKNAGAKK YSPPPYSKQQ TVFWDTAI 

        10         20         30         40         50
MIPSKMMSAN PEEDPLDTFF QYIEDMGMKA YDGLVIQNAS DIARENDRLR 
        60         70         80         90        100
NETKLAYLKE KNEKRRRQEE TIKRIGGEVG RGQDASYAGK HFRMGFMTMP 
       110        120        130        140        150
APQDRLPHPC SSGFTVRSQS LHSVGGTEDD SSCGSRRQPP PKPKRDPSTK 
       160        170        180        190        200
LSTSSETVNS TAASKSGRSL ERAEVSAKPR PHSDEYSKKI PPPKPKRNPN 
       210        220        230        240        250
TQLSTSFDET YIKKHVPRRT SLPRDSSLSQ VCSPAADPEE EEPVYIEMVG 
       260        270        280        290        300
NILRDFRKEE DDQSEAVYEE MKYPIFDDLG HDSKCDFDHH SCSSQCATPT 
       310        320        330        340        350
VPDLDFVKSS GPCTPKGLLC DIPPPFPNLL SHRPPLLVFP PAPVHCSPNS 
       360        370        380        390        400
DESPLTPLEV TKLPVLENVS YMKQPPGACP SSLPSHGSSH AKDQTGALGP 
       410        420        430        440        450
APGASILSSS PPPPSTLYRT QSPHGYPKSH STSPSPVSMG RSLTPLSLKR 
       460        470        480        490        500
PPPYDAVHSG SLSRSSSSVP HTTPRPVSQD GAKMVNAAVN TYSAAQSGSR 
       510        520        530        540        550
SRTPTSPLEE LTSLFTSGRS LLRKSSSGRR SKEPAEKSTE ELKVRSHSTE 
       560        570        580        590        600
PLPKLDSKER GHYGSSSSRE PVKAQEWDGT PGPPVVTSRM GRCSVSPTLL 
       610        620        630        640        650
AGNHSSEPKV SCKLGRSAST SGVPPPSVTP LRQASDLQQS QVACMQWFHG 
       660        670        680        690        700
DHTMLEMIEK KRCLCKEIKA RQKTEKGLCK QDSMPILPSW KKNAGAKKYS 
       710 
PPPYSKQQTV FWDTAI                                  

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
2. SIMILARITY comments
   Index of protein domains and families