Nyap2

Functionⁱ

Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis.1 Publication

GO - Biological processⁱ

neuron projection morphogenesis
Source: UniProtKB
Inferred from direct assayⁱ
- 21946561
phosphatidylinositol 3-kinase signaling
Source: UniProtKB
Inferred from direct assayⁱ
- 21946561

Complete GO annotation...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2
Gene namesⁱ	Name:Nyap2 Synonyms:Kiaa1486
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Unplaced

Organism-specific databases

MGIⁱ	MGI:2443135. Nyap2.

Subcellular locationⁱ

GO - Cellular componentⁱ

intracellular Source: GOC

Complete GO annotation...

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Triple knockout mice NYAP1/NYAP2/MYO16 are fertile and appear healthy. However, compared to wild-type mice they show a clear reduction in brain size, exhibiting a reduction in the size of the cortex and striatum, but not the olfactory bulb or corpus callosum. The total neurite length of neurons in these mice is also significantly shorter.1 Publication

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	277	Y → F: Abolishes binding to PIK3R2. Slight reduction of phosphorylation in HEK293T cells. Abolishes phosphorylation in HEK293T cells and in neurons; when associated with F-300. 1 Publication		1
Mutagenesisⁱ	300	Y → F: Reduced binding to PIK3R2. Slight reduction of phosphorylation in HEK293T cells. Abolishes phosphorylation in HEK293T cells and neurons; when associated with F-277. 1 Publication		1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000325831	1 – 682	Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2Add BLAST		682

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	81	Omega-N-methylarginineCombined sources	1
Modified residueⁱ	120	PhosphoserineCombined sources	1
Modified residueⁱ	238	PhosphoserineCombined sources	1
Modified residueⁱ	300	PhosphotyrosineCombined sources	1
Modified residueⁱ	463	PhosphoserineBy similarity	1

Post-translational modificationⁱ

Phosphorylated on tyrosine residues by FYN upon stimulation with CNTN5. Phosphorylation begins at E16 and persists in adult brain.1 Publication

Keywords - PTMⁱ

Methylation, Phosphoprotein

Proteomic databases

PaxDbⁱ	Q8BM65.
PRIDEⁱ	Q8BM65.

PTM databases

iPTMnetⁱ	Q8BM65.
PhosphoSitePlusⁱ	Q8BM65.

Expressionⁱ

Tissue specificityⁱ

Expressed predominantly in brain where it is present in the neurons, but not in astrocytes or oligodendrites.1 Publication

Developmental stageⁱ

Expression first detected in the lower neocortex at E18 and decreases thereafter. At postnatal day 1, also expressed in the striatum and the olfactory bulb.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000054976.
CleanExⁱ	MM_9430031J16RIK.

Interactionⁱ

Subunit structureⁱ

Interacts with ACOT9, ARHGAP26 and PIK3R2. Interacts with components of the WAVE1 complex, CYFIP1 and NCKAP1; this interaction mediates PI3K-WAVE1 association and actin cytoskeleton remodeling.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
PIK3R1	P27986	3	EBI-7447598,EBI-79464	From Homo sapiens.

With

Entry

#Exp.

IntAct

Notes

PIK3R1

P27986

3

EBI-7447598,EBI-79464

From Homo sapiens.

Protein-protein interaction databases

IntActⁱ	Q8BM65. 11 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-8308425.
STRINGⁱ	10090.ENSMUSP00000065468.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8BM65.
SMRⁱ	Q8BM65.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	150 – 161	Involved in CYFIP1- and NCKAP1-bindingAdd BLAST		12

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	344 – 485	Pro-richAdd BLAST		142
Compositional biasⁱ	413 – 600	Ser-richAdd BLAST		188

Sequence similaritiesⁱ

Belongs to the NYAP family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410IH9T. Eukaryota. ENOG410YEXE. LUCA.
HOGENOMⁱ	HOG000111596.
HOVERGENⁱ	HBG108036.
InParanoidⁱ	Q8BM65.
PhylomeDBⁱ	Q8BM65.

Family and domain databases

InterProⁱ	View protein in InterPro IPR026722. NYAP1/NYAP2. IPR026723. NYAP2. IPR029353. NYAP_C.
PANTHERⁱ	PTHR22633. PTHR22633. 1 hit. PTHR22633:SF6. PTHR22633:SF6. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF15452. NYAP_C. 1 hit.

Sequences (5)ⁱ

Sequence statusⁱ: Complete.

This entry describes 5 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: Q8BM65-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIPSKMMSAN PEEDPLDTFF QYIEDMGMKA YDGLVIQNAS DIARENDRLR 
        60         70         80         90        100
NETKLAYLKE KNEKRRRQEE TIKRIGGEVG RGQDASYAGK HFRMGFMTMP 
       110        120        130        140        150
APQDRLPHPC SSGFTVRSQS LHSVGGTEDD SSCGSRRQPP PKPKRDPSTK 
       160        170        180        190        200
LSTSSETVNS TAASKSGRSL ERAEGKFTVP ASHSPPRAST SGHLFPSPGS 
       210        220        230        240        250
QERNIKVSAK PRPHSDEYSK KIPPPKPKRN PNTQLSTSFD ETYIKKHVPR 
       260        270        280        290        300
RTSLPRDSSL SQVCSPAADP EEEEPVYIEM VGNILRDFRK EEDDQSEAVY 
       310        320        330        340        350
EEMKYPIFDD LGHDSKCDFD HHSCSSQCAT PTVPDLDFVK SSGPCTPKGL 
       360        370        380        390        400
LCDIPPPFPN LLSHRPPLLV FPPAPVHCSP NSDESPLTPL EVTKLPVLEN 
       410        420        430        440        450
VSYMKQPPGA CPSSLPSHGS SHAKDQTGAL GPAPGASILS SSPPPPSTLY 
       460        470        480        490        500
RTQSPHGYPK SHSTSPSPVS MGRSLTPLSL KRPPPYDAVH SGSLSRSSSS 
       510        520        530        540        550
VPHTTPRPVS QDGAKMVNAA VNTYSAAQSG SRSRTPTSPL EELTSLFTSG 
       560        570        580        590        600
RSLLRKSSSG RRSKEPAEKS TEELKVRSHS TEPLPKLDSK ERGHYGSSSS 
       610        620        630        640        650
REPVKAQEWD GTPGPPVVTS RMGRCSVSPT LLAGNHSSEP KVSCKLGRSA 
       660        670        680 
STSGVPPPSV TPLRQASDLQ QSQVPSSLAN RD

Length:682

Mass (Da):73,897

Last modified:March 1, 2003 - v1

Checksum:ⁱ76FDE6609FFDAC8F

GO

Isoform 2 (identifier: Q8BM65-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
175-206: Missing.

« Hide

        10         20         30         40         50
MIPSKMMSAN PEEDPLDTFF QYIEDMGMKA YDGLVIQNAS DIARENDRLR 
        60         70         80         90        100
NETKLAYLKE KNEKRRRQEE TIKRIGGEVG RGQDASYAGK HFRMGFMTMP 
       110        120        130        140        150
APQDRLPHPC SSGFTVRSQS LHSVGGTEDD SSCGSRRQPP PKPKRDPSTK 
       160        170        180        190        200
LSTSSETVNS TAASKSGRSL ERAEVSAKPR PHSDEYSKKI PPPKPKRNPN 
       210        220        230        240        250
TQLSTSFDET YIKKHVPRRT SLPRDSSLSQ VCSPAADPEE EEPVYIEMVG 
       260        270        280        290        300
NILRDFRKEE DDQSEAVYEE MKYPIFDDLG HDSKCDFDHH SCSSQCATPT 
       310        320        330        340        350
VPDLDFVKSS GPCTPKGLLC DIPPPFPNLL SHRPPLLVFP PAPVHCSPNS 
       360        370        380        390        400
DESPLTPLEV TKLPVLENVS YMKQPPGACP SSLPSHGSSH AKDQTGALGP 
       410        420        430        440        450
APGASILSSS PPPPSTLYRT QSPHGYPKSH STSPSPVSMG RSLTPLSLKR 
       460        470        480        490        500
PPPYDAVHSG SLSRSSSSVP HTTPRPVSQD GAKMVNAAVN TYSAAQSGSR 
       510        520        530        540        550
SRTPTSPLEE LTSLFTSGRS LLRKSSSGRR SKEPAEKSTE ELKVRSHSTE 
       560        570        580        590        600
PLPKLDSKER GHYGSSSSRE PVKAQEWDGT PGPPVVTSRM GRCSVSPTLL 
       610        620        630        640        650
AGNHSSEPKV SCKLGRSAST SGVPPPSVTP LRQASDLQQS QVPSSLANRD

Show »

Length:650

Mass (Da):70,539

Checksum:ⁱA4AA76776B304D1E

GO

Isoform 3 (identifier: Q8BM65-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
639-682: EPKVSCKLGR...QVPSSLANRD → GKHDPVLPNG...TGLNSSHCNL

« Hide

        10         20         30         40         50
MIPSKMMSAN PEEDPLDTFF QYIEDMGMKA YDGLVIQNAS DIARENDRLR 
        60         70         80         90        100
NETKLAYLKE KNEKRRRQEE TIKRIGGEVG RGQDASYAGK HFRMGFMTMP 
       110        120        130        140        150
APQDRLPHPC SSGFTVRSQS LHSVGGTEDD SSCGSRRQPP PKPKRDPSTK 
       160        170        180        190        200
LSTSSETVNS TAASKSGRSL ERAEGKFTVP ASHSPPRAST SGHLFPSPGS 
       210        220        230        240        250
QERNIKVSAK PRPHSDEYSK KIPPPKPKRN PNTQLSTSFD ETYIKKHVPR 
       260        270        280        290        300
RTSLPRDSSL SQVCSPAADP EEEEPVYIEM VGNILRDFRK EEDDQSEAVY 
       310        320        330        340        350
EEMKYPIFDD LGHDSKCDFD HHSCSSQCAT PTVPDLDFVK SSGPCTPKGL 
       360        370        380        390        400
LCDIPPPFPN LLSHRPPLLV FPPAPVHCSP NSDESPLTPL EVTKLPVLEN 
       410        420        430        440        450
VSYMKQPPGA CPSSLPSHGS SHAKDQTGAL GPAPGASILS SSPPPPSTLY 
       460        470        480        490        500
RTQSPHGYPK SHSTSPSPVS MGRSLTPLSL KRPPPYDAVH SGSLSRSSSS 
       510        520        530        540        550
VPHTTPRPVS QDGAKMVNAA VNTYSAAQSG SRSRTPTSPL EELTSLFTSG 
       560        570        580        590        600
RSLLRKSSSG RRSKEPAEKS TEELKVRSHS TEPLPKLDSK ERGHYGSSSS 
       610        620        630        640        650
REPVKAQEWD GTPGPPVVTS RMGRCSVSPT LLAGNHSSGK HDPVLPNGSK 
       660        670        680        690        700
SLEAAHMQIS LRKPSPQLSL LPPRLAPQTH TLRSRHMKNA TVPLFIAMAR 
       710        720        730 
ETMLLEALLC SSLQLGKTLY QMSSKMTTGL NSSHCNL

Show »

Length:737

Mass (Da):80,193

Checksum:ⁱD04540CF32970A15

GO

Isoform 4 (identifier: Q8BM65-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
675-682: PSSLANRD → ACMQWFHGDH...QQTVFWDTAI

« Hide

        10         20         30         40         50
MIPSKMMSAN PEEDPLDTFF QYIEDMGMKA YDGLVIQNAS DIARENDRLR 
        60         70         80         90        100
NETKLAYLKE KNEKRRRQEE TIKRIGGEVG RGQDASYAGK HFRMGFMTMP 
       110        120        130        140        150
APQDRLPHPC SSGFTVRSQS LHSVGGTEDD SSCGSRRQPP PKPKRDPSTK 
       160        170        180        190        200
LSTSSETVNS TAASKSGRSL ERAEGKFTVP ASHSPPRAST SGHLFPSPGS 
       210        220        230        240        250
QERNIKVSAK PRPHSDEYSK KIPPPKPKRN PNTQLSTSFD ETYIKKHVPR 
       260        270        280        290        300
RTSLPRDSSL SQVCSPAADP EEEEPVYIEM VGNILRDFRK EEDDQSEAVY 
       310        320        330        340        350
EEMKYPIFDD LGHDSKCDFD HHSCSSQCAT PTVPDLDFVK SSGPCTPKGL 
       360        370        380        390        400
LCDIPPPFPN LLSHRPPLLV FPPAPVHCSP NSDESPLTPL EVTKLPVLEN 
       410        420        430        440        450
VSYMKQPPGA CPSSLPSHGS SHAKDQTGAL GPAPGASILS SSPPPPSTLY 
       460        470        480        490        500
RTQSPHGYPK SHSTSPSPVS MGRSLTPLSL KRPPPYDAVH SGSLSRSSSS 
       510        520        530        540        550
VPHTTPRPVS QDGAKMVNAA VNTYSAAQSG SRSRTPTSPL EELTSLFTSG 
       560        570        580        590        600
RSLLRKSSSG RRSKEPAEKS TEELKVRSHS TEPLPKLDSK ERGHYGSSSS 
       610        620        630        640        650
REPVKAQEWD GTPGPPVVTS RMGRCSVSPT LLAGNHSSEP KVSCKLGRSA 
       660        670        680        690        700
STSGVPPPSV TPLRQASDLQ QSQVACMQWF HGDHTMLEMI EKKRCLCKEI 
       710        720        730        740 
KARQKTEKGL CKQDSMPILP SWKKNAGAKK YSPPPYSKQQ TVFWDTAI

Show »

Length:748

Mass (Da):81,683

Checksum:ⁱ4FB8D1013AB6977A

GO

Isoform 5 (identifier: Q8BM65-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
175-206: Missing.
675-682: PSSLANRD → ACMQWFHGDH...QQTVFWDTAI

« Hide

        10         20         30         40         50
MIPSKMMSAN PEEDPLDTFF QYIEDMGMKA YDGLVIQNAS DIARENDRLR 
        60         70         80         90        100
NETKLAYLKE KNEKRRRQEE TIKRIGGEVG RGQDASYAGK HFRMGFMTMP 
       110        120        130        140        150
APQDRLPHPC SSGFTVRSQS LHSVGGTEDD SSCGSRRQPP PKPKRDPSTK 
       160        170        180        190        200
LSTSSETVNS TAASKSGRSL ERAEVSAKPR PHSDEYSKKI PPPKPKRNPN 
       210        220        230        240        250
TQLSTSFDET YIKKHVPRRT SLPRDSSLSQ VCSPAADPEE EEPVYIEMVG 
       260        270        280        290        300
NILRDFRKEE DDQSEAVYEE MKYPIFDDLG HDSKCDFDHH SCSSQCATPT 
       310        320        330        340        350
VPDLDFVKSS GPCTPKGLLC DIPPPFPNLL SHRPPLLVFP PAPVHCSPNS 
       360        370        380        390        400
DESPLTPLEV TKLPVLENVS YMKQPPGACP SSLPSHGSSH AKDQTGALGP 
       410        420        430        440        450
APGASILSSS PPPPSTLYRT QSPHGYPKSH STSPSPVSMG RSLTPLSLKR 
       460        470        480        490        500
PPPYDAVHSG SLSRSSSSVP HTTPRPVSQD GAKMVNAAVN TYSAAQSGSR 
       510        520        530        540        550
SRTPTSPLEE LTSLFTSGRS LLRKSSSGRR SKEPAEKSTE ELKVRSHSTE 
       560        570        580        590        600
PLPKLDSKER GHYGSSSSRE PVKAQEWDGT PGPPVVTSRM GRCSVSPTLL 
       610        620        630        640        650
AGNHSSEPKV SCKLGRSAST SGVPPPSVTP LRQASDLQQS QVACMQWFHG 
       660        670        680        690        700
DHTMLEMIEK KRCLCKEIKA RQKTEKGLCK QDSMPILPSW KKNAGAKKYS 
       710 
PPPYSKQQTV FWDTAI

Show »

Length:716

Mass (Da):78,325

Checksum:ⁱAE293039FC214184

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	54	K → N in BAJ19139 (PubMed:21946561).Curated	1
Sequence conflictⁱ	54	K → N in BAC33918 (PubMed:16141072).Curated	1
Sequence conflictⁱ	54	K → N in BAE23236 (PubMed:16141072).Curated	1
Sequence conflictⁱ	54	K → N in AAH82310 (PubMed:15489334).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_032436	175 – 206	Missing in isoform 2 and isoform 5. 2 PublicationsAdd BLAST	32
Alternative sequenceⁱVSP_032437	639 – 682	EPKVS…LANRD → GKHDPVLPNGSKSLEAAHMQ ISLRKPSPQLSLLPPRLAPQ THTLRSRHMKNATVPLFIAM ARETMLLEALLCSSLQLGKT LYQMSSKMTTGLNSSHCNL in isoform 3. 1 PublicationAdd BLAST	44
Alternative sequenceⁱVSP_032438	675 – 682	PSSLANRD → ACMQWFHGDHTMLEMIEKKR CLCKEIKARQKTEKGLCKQD SMPILPSWKKNAGAKKYSPP PYSKQQTVFWDTAI in isoform 4 and isoform 5. 2 Publications	8

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB429290 mRNA. Translation: BAJ19139.1. AK034747 mRNA. Translation: BAC28819.1. AK049778 mRNA. Translation: BAC33918.1. AK137094 mRNA. Translation: BAE23236.1. AC116105 Genomic DNA. No translation available. AC131336 Genomic DNA. No translation available. AC163450 Genomic DNA. No translation available. BC082310 mRNA. Translation: AAH82310.1. AK129372 mRNA. Translation: BAC98182.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS15095.1. [Q8BM65-3]
NCBI Reference Sequences More...RefSeqⁱ	NP_766437.2. NM_172849.3. XP_006496550.1. XM_006496487.3. XP_006496553.1. XM_006496490.3.
UniGeneⁱ	Mm.313904.

Genome annotation databases

GeneIDⁱ	241134.
KEGGⁱ	mmu:241134.
UCSC genome browser More...UCSCⁱ	uc007brj.1. mouse. [Q8BM65-2] uc007brl.1. mouse. [Q8BM65-3] uc007brn.1. mouse. [Q8BM65-5]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB429290 mRNA. Translation: BAJ19139.1. AK034747 mRNA. Translation: BAC28819.1. AK049778 mRNA. Translation: BAC33918.1. AK137094 mRNA. Translation: BAE23236.1. AC116105 Genomic DNA. No translation available. AC131336 Genomic DNA. No translation available. AC163450 Genomic DNA. No translation available. BC082310 mRNA. Translation: AAH82310.1. AK129372 mRNA. Translation: BAC98182.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS15095.1. [Q8BM65-3]
NCBI Reference Sequences More...RefSeqⁱ	NP_766437.2. NM_172849.3. XP_006496550.1. XM_006496487.3. XP_006496553.1. XM_006496490.3.
UniGeneⁱ	Mm.313904.

3D structure databases

ProteinModelPortalⁱ	Q8BM65.
SMRⁱ	Q8BM65.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q8BM65. 11 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-8308425.
STRINGⁱ	10090.ENSMUSP00000065468.

PTM databases

iPTMnetⁱ	Q8BM65.
PhosphoSitePlusⁱ	Q8BM65.

Proteomic databases

PaxDbⁱ	Q8BM65.
PRIDEⁱ	Q8BM65.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	241134.
KEGGⁱ	mmu:241134.
UCSC genome browser More...UCSCⁱ	uc007brj.1. mouse. [Q8BM65-2] uc007brl.1. mouse. [Q8BM65-3] uc007brn.1. mouse. [Q8BM65-5]

Organism-specific databases

CTDⁱ	57624.
MGIⁱ	MGI:2443135. Nyap2.
Rougeⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IH9T. Eukaryota. ENOG410YEXE. LUCA.
HOGENOMⁱ	HOG000111596.
HOVERGENⁱ	HBG108036.
InParanoidⁱ	Q8BM65.
PhylomeDBⁱ	Q8BM65.

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q8BM65.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000054976.
CleanExⁱ	MM_9430031J16RIK.

Family and domain databases

InterProⁱ	View protein in InterPro IPR026722. NYAP1/NYAP2. IPR026723. NYAP2. IPR029353. NYAP_C.
PANTHERⁱ	PTHR22633. PTHR22633. 1 hit. PTHR22633:SF6. PTHR22633:SF6. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF15452. NYAP_C. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NYAP2_MOUSE
Accessionⁱ	Q8BM65Primary (citable) accession number: Q8BM65 Secondary accession number(s): D3Z7K6 , Q641L6, Q6ZPP8, Q8BWV8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
	Last sequence update:	March 1, 2003
	Last modified:	May 10, 2017
	This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8BM65 (NYAP2_MOUSE)

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Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5)i

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequences (5)ⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ