Nyap2

Functionⁱ

Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis.1 Publication

GO - Biological processⁱ

neuron projection morphogenesis
Source: UniProtKB
Inferred from direct assayⁱ
- 21946561
phosphatidylinositol 3-kinase signaling
Source: UniProtKB
Inferred from direct assayⁱ
- 21946561

Complete GO annotation...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2
Gene namesⁱ	Name:Nyap2 Synonyms:Kiaa1486
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Unplaced

Organism-specific databases

MGIⁱ	MGI:2443135. Nyap2.

Subcellular locationⁱ

GO - Cellular componentⁱ

intracellular Source: GOC

Complete GO annotation...

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Triple knockout mice NYAP1/NYAP2/MYO16 are fertile and appear healthy. However, compared to wild-type mice they show a clear reduction in brain size, exhibiting a reduction in the size of the cortex and striatum, but not the olfactory bulb or corpus callosum. The total neurite length of neurons in these mice is also significantly shorter.1 Publication

Mutagenesis

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Mutagenesisⁱ	277 – 277	1	Y → F: Abolishes binding to PIK3R2. Slight reduction of phosphorylation in HEK293T cells. Abolishes phosphorylation in HEK293T cells and in neurons; when associated with F-300. 1 Publication Manual assertion based on experiment inⁱ Ref.1 "NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons." Yokoyama K., Tezuka T., Kotani M., Nakazawa T., Hoshina N., Shimoda Y., Kakuta S., Sudo K., Watanabe K., Iwakura Y., Yamamoto T. EMBO J. 30:4739-4754(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5), FUNCTION, INTERACTION WITH ACOT9; ARHGAP26; CYFIP1; NCKAP1 AND PIK3R2, SUBUNIT, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE, PHOSPHORYLATION, MUTAGENESIS OF TYR-277 AND TYR-300.
Mutagenesisⁱ	300 – 300	1	Y → F: Reduced binding to PIK3R2. Slight reduction of phosphorylation in HEK293T cells. Abolishes phosphorylation in HEK293T cells and neurons; when associated with F-277. 1 Publication Manual assertion based on experiment inⁱ Ref.1 "NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons." Yokoyama K., Tezuka T., Kotani M., Nakazawa T., Hoshina N., Shimoda Y., Kakuta S., Sudo K., Watanabe K., Iwakura Y., Yamamoto T. EMBO J. 30:4739-4754(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5), FUNCTION, INTERACTION WITH ACOT9; ARHGAP26; CYFIP1; NCKAP1 AND PIK3R2, SUBUNIT, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE, PHOSPHORYLATION, MUTAGENESIS OF TYR-277 AND TYR-300.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Chainⁱ	1 – 682	682	Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2		PRO_0000325831	Add BLAST

Amino acid modifications

Feature key	Position(s)	Length	Description
Modified residueⁱ	120 – 120	1	PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ Ref.7 "A tissue-specific atlas of mouse protein phosphorylation and expression." Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P. Cell 143:1174-1189(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-120 AND SER-238, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Modified residueⁱ	238 – 238	1	PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ Ref.7 "A tissue-specific atlas of mouse protein phosphorylation and expression." Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P. Cell 143:1174-1189(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-120 AND SER-238, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Modified residueⁱ	300 – 300	1	PhosphotyrosineCombined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ Ref.6 "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain." Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P. J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-300, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Modified residueⁱ	463 – 463	1	PhosphoserineBy similarity Manual assertion inferred from sequence similarity toⁱ UniProtKB:Q9P242 (NYAP2_HUMAN)

Post-translational modificationⁱ

Phosphorylated on tyrosine residues by FYN upon stimulation with CNTN5. Phosphorylation begins at E16 and persists in adult brain.1 Publication

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

MaxQBⁱ	Q8BM65.
PaxDbⁱ	Q8BM65.
PRIDEⁱ	Q8BM65.

PTM databases

iPTMnetⁱ	Q8BM65.
PhosphoSiteⁱ	Q8BM65.

Expressionⁱ

Tissue specificityⁱ

Expressed predominantly in brain where it is present in the neurons, but not in astrocytes or oligodendrites.1 Publication

Developmental stageⁱ

Expression first detected in the lower neocortex at E18 and decreases thereafter. At postnatal day 1, also expressed in the striatum and the olfactory bulb.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000054976.
CleanExⁱ	MM_9430031J16RIK.

Interactionⁱ

Subunit structureⁱ

Interacts with ACOT9, ARHGAP26 and PIK3R2. Interacts with components of the WAVE1 complex, CYFIP1 and NCKAP1; this interaction mediates PI3K-WAVE1 association and actin cytoskeleton remodeling.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
PIK3R1	P27986	3	EBI-7447598,EBI-79464	From a different organism.

With

Entry

#Exp.

IntAct

Notes

PIK3R1

P27986

3

EBI-7447598,EBI-79464

From a different organism.

Protein-protein interaction databases

IntActⁱ	Q8BM65. 11 interactions.
MINTⁱ	MINT-8308425.
STRINGⁱ	10090.ENSMUSP00000065468.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8BM65.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Regionⁱ	150 – 161	12	Involved in CYFIP1- and NCKAP1-binding			Add BLAST

Compositional bias

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Compositional biasⁱ	344 – 485	142	Pro-rich			Add BLAST
Compositional biasⁱ	413 – 600	188	Ser-rich			Add BLAST

Sequence similaritiesⁱ

Belongs to the NYAP family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410IH9T. Eukaryota. ENOG410YEXE. LUCA.
HOGENOMⁱ	HOG000111596.
HOVERGENⁱ	HBG108036.
InParanoidⁱ	Q8BM65.
PhylomeDBⁱ	Q8BM65.

Family and domain databases

InterProⁱ	IPR026722. NYAP1/NYAP2. IPR026723. NYAP2. IPR029353. NYAP_C. [Graphical view]
PANTHERⁱ	PTHR22633. PTHR22633. 2 hits. PTHR22633:SF1. PTHR22633:SF1. 2 hits.
Pfamⁱ	PF15452. NYAP_C. 1 hit. [Graphical view]

Sequences (5)ⁱ

Sequence statusⁱ: Complete.

This entry describes 5 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: Q8BM65-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MIPSKMMSAN PEEDPLDTFF QYIEDMGMKA YDGLVIQNAS DIARENDRLR 
        60         70         80         90        100
NETKLAYLKE KNEKRRRQEE TIKRIGGEVG RGQDASYAGK HFRMGFMTMP 
       110        120        130        140        150
APQDRLPHPC SSGFTVRSQS LHSVGGTEDD SSCGSRRQPP PKPKRDPSTK 
       160        170        180        190        200
LSTSSETVNS TAASKSGRSL ERAEGKFTVP ASHSPPRAST SGHLFPSPGS 
       210        220        230        240        250
QERNIKVSAK PRPHSDEYSK KIPPPKPKRN PNTQLSTSFD ETYIKKHVPR 
       260        270        280        290        300
RTSLPRDSSL SQVCSPAADP EEEEPVYIEM VGNILRDFRK EEDDQSEAVY 
       310        320        330        340        350
EEMKYPIFDD LGHDSKCDFD HHSCSSQCAT PTVPDLDFVK SSGPCTPKGL 
       360        370        380        390        400
LCDIPPPFPN LLSHRPPLLV FPPAPVHCSP NSDESPLTPL EVTKLPVLEN 
       410        420        430        440        450
VSYMKQPPGA CPSSLPSHGS SHAKDQTGAL GPAPGASILS SSPPPPSTLY 
       460        470        480        490        500
RTQSPHGYPK SHSTSPSPVS MGRSLTPLSL KRPPPYDAVH SGSLSRSSSS 
       510        520        530        540        550
VPHTTPRPVS QDGAKMVNAA VNTYSAAQSG SRSRTPTSPL EELTSLFTSG 
       560        570        580        590        600
RSLLRKSSSG RRSKEPAEKS TEELKVRSHS TEPLPKLDSK ERGHYGSSSS 
       610        620        630        640        650
REPVKAQEWD GTPGPPVVTS RMGRCSVSPT LLAGNHSSEP KVSCKLGRSA 
       660        670        680 
STSGVPPPSV TPLRQASDLQ QSQVPSSLAN RD

Length:682

Mass (Da):73,897

Last modified:March 1, 2003 - v1

Checksum:ⁱ76FDE6609FFDAC8F

GO

Isoform 2 (identifier: Q8BM65-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
175-206: Missing.

« Hide

        10         20         30         40         50
MIPSKMMSAN PEEDPLDTFF QYIEDMGMKA YDGLVIQNAS DIARENDRLR 
        60         70         80         90        100
NETKLAYLKE KNEKRRRQEE TIKRIGGEVG RGQDASYAGK HFRMGFMTMP 
       110        120        130        140        150
APQDRLPHPC SSGFTVRSQS LHSVGGTEDD SSCGSRRQPP PKPKRDPSTK 
       160        170        180        190        200
LSTSSETVNS TAASKSGRSL ERAEVSAKPR PHSDEYSKKI PPPKPKRNPN 
       210        220        230        240        250
TQLSTSFDET YIKKHVPRRT SLPRDSSLSQ VCSPAADPEE EEPVYIEMVG 
       260        270        280        290        300
NILRDFRKEE DDQSEAVYEE MKYPIFDDLG HDSKCDFDHH SCSSQCATPT 
       310        320        330        340        350
VPDLDFVKSS GPCTPKGLLC DIPPPFPNLL SHRPPLLVFP PAPVHCSPNS 
       360        370        380        390        400
DESPLTPLEV TKLPVLENVS YMKQPPGACP SSLPSHGSSH AKDQTGALGP 
       410        420        430        440        450
APGASILSSS PPPPSTLYRT QSPHGYPKSH STSPSPVSMG RSLTPLSLKR 
       460        470        480        490        500
PPPYDAVHSG SLSRSSSSVP HTTPRPVSQD GAKMVNAAVN TYSAAQSGSR 
       510        520        530        540        550
SRTPTSPLEE LTSLFTSGRS LLRKSSSGRR SKEPAEKSTE ELKVRSHSTE 
       560        570        580        590        600
PLPKLDSKER GHYGSSSSRE PVKAQEWDGT PGPPVVTSRM GRCSVSPTLL 
       610        620        630        640        650
AGNHSSEPKV SCKLGRSAST SGVPPPSVTP LRQASDLQQS QVPSSLANRD

Show »

Length:650

Mass (Da):70,539

Checksum:ⁱA4AA76776B304D1E

GO

Isoform 3 (identifier: Q8BM65-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
639-682: EPKVSCKLGR...QVPSSLANRD → GKHDPVLPNG...TGLNSSHCNL

« Hide

        10         20         30         40         50
MIPSKMMSAN PEEDPLDTFF QYIEDMGMKA YDGLVIQNAS DIARENDRLR 
        60         70         80         90        100
NETKLAYLKE KNEKRRRQEE TIKRIGGEVG RGQDASYAGK HFRMGFMTMP 
       110        120        130        140        150
APQDRLPHPC SSGFTVRSQS LHSVGGTEDD SSCGSRRQPP PKPKRDPSTK 
       160        170        180        190        200
LSTSSETVNS TAASKSGRSL ERAEGKFTVP ASHSPPRAST SGHLFPSPGS 
       210        220        230        240        250
QERNIKVSAK PRPHSDEYSK KIPPPKPKRN PNTQLSTSFD ETYIKKHVPR 
       260        270        280        290        300
RTSLPRDSSL SQVCSPAADP EEEEPVYIEM VGNILRDFRK EEDDQSEAVY 
       310        320        330        340        350
EEMKYPIFDD LGHDSKCDFD HHSCSSQCAT PTVPDLDFVK SSGPCTPKGL 
       360        370        380        390        400
LCDIPPPFPN LLSHRPPLLV FPPAPVHCSP NSDESPLTPL EVTKLPVLEN 
       410        420        430        440        450
VSYMKQPPGA CPSSLPSHGS SHAKDQTGAL GPAPGASILS SSPPPPSTLY 
       460        470        480        490        500
RTQSPHGYPK SHSTSPSPVS MGRSLTPLSL KRPPPYDAVH SGSLSRSSSS 
       510        520        530        540        550
VPHTTPRPVS QDGAKMVNAA VNTYSAAQSG SRSRTPTSPL EELTSLFTSG 
       560        570        580        590        600
RSLLRKSSSG RRSKEPAEKS TEELKVRSHS TEPLPKLDSK ERGHYGSSSS 
       610        620        630        640        650
REPVKAQEWD GTPGPPVVTS RMGRCSVSPT LLAGNHSSGK HDPVLPNGSK 
       660        670        680        690        700
SLEAAHMQIS LRKPSPQLSL LPPRLAPQTH TLRSRHMKNA TVPLFIAMAR 
       710        720        730 
ETMLLEALLC SSLQLGKTLY QMSSKMTTGL NSSHCNL

Show »

Length:737

Mass (Da):80,193

Checksum:ⁱD04540CF32970A15

GO

Isoform 4 (identifier: Q8BM65-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
675-682: PSSLANRD → ACMQWFHGDH...QQTVFWDTAI

« Hide

        10         20         30         40         50
MIPSKMMSAN PEEDPLDTFF QYIEDMGMKA YDGLVIQNAS DIARENDRLR 
        60         70         80         90        100
NETKLAYLKE KNEKRRRQEE TIKRIGGEVG RGQDASYAGK HFRMGFMTMP 
       110        120        130        140        150
APQDRLPHPC SSGFTVRSQS LHSVGGTEDD SSCGSRRQPP PKPKRDPSTK 
       160        170        180        190        200
LSTSSETVNS TAASKSGRSL ERAEGKFTVP ASHSPPRAST SGHLFPSPGS 
       210        220        230        240        250
QERNIKVSAK PRPHSDEYSK KIPPPKPKRN PNTQLSTSFD ETYIKKHVPR 
       260        270        280        290        300
RTSLPRDSSL SQVCSPAADP EEEEPVYIEM VGNILRDFRK EEDDQSEAVY 
       310        320        330        340        350
EEMKYPIFDD LGHDSKCDFD HHSCSSQCAT PTVPDLDFVK SSGPCTPKGL 
       360        370        380        390        400
LCDIPPPFPN LLSHRPPLLV FPPAPVHCSP NSDESPLTPL EVTKLPVLEN 
       410        420        430        440        450
VSYMKQPPGA CPSSLPSHGS SHAKDQTGAL GPAPGASILS SSPPPPSTLY 
       460        470        480        490        500
RTQSPHGYPK SHSTSPSPVS MGRSLTPLSL KRPPPYDAVH SGSLSRSSSS 
       510        520        530        540        550
VPHTTPRPVS QDGAKMVNAA VNTYSAAQSG SRSRTPTSPL EELTSLFTSG 
       560        570        580        590        600
RSLLRKSSSG RRSKEPAEKS TEELKVRSHS TEPLPKLDSK ERGHYGSSSS 
       610        620        630        640        650
REPVKAQEWD GTPGPPVVTS RMGRCSVSPT LLAGNHSSEP KVSCKLGRSA 
       660        670        680        690        700
STSGVPPPSV TPLRQASDLQ QSQVACMQWF HGDHTMLEMI EKKRCLCKEI 
       710        720        730        740 
KARQKTEKGL CKQDSMPILP SWKKNAGAKK YSPPPYSKQQ TVFWDTAI

Show »

Length:748

Mass (Da):81,683

Checksum:ⁱ4FB8D1013AB6977A

GO

Isoform 5 (identifier: Q8BM65-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
175-206: Missing.
675-682: PSSLANRD → ACMQWFHGDH...QQTVFWDTAI

« Hide

        10         20         30         40         50
MIPSKMMSAN PEEDPLDTFF QYIEDMGMKA YDGLVIQNAS DIARENDRLR 
        60         70         80         90        100
NETKLAYLKE KNEKRRRQEE TIKRIGGEVG RGQDASYAGK HFRMGFMTMP 
       110        120        130        140        150
APQDRLPHPC SSGFTVRSQS LHSVGGTEDD SSCGSRRQPP PKPKRDPSTK 
       160        170        180        190        200
LSTSSETVNS TAASKSGRSL ERAEVSAKPR PHSDEYSKKI PPPKPKRNPN 
       210        220        230        240        250
TQLSTSFDET YIKKHVPRRT SLPRDSSLSQ VCSPAADPEE EEPVYIEMVG 
       260        270        280        290        300
NILRDFRKEE DDQSEAVYEE MKYPIFDDLG HDSKCDFDHH SCSSQCATPT 
       310        320        330        340        350
VPDLDFVKSS GPCTPKGLLC DIPPPFPNLL SHRPPLLVFP PAPVHCSPNS 
       360        370        380        390        400
DESPLTPLEV TKLPVLENVS YMKQPPGACP SSLPSHGSSH AKDQTGALGP 
       410        420        430        440        450
APGASILSSS PPPPSTLYRT QSPHGYPKSH STSPSPVSMG RSLTPLSLKR 
       460        470        480        490        500
PPPYDAVHSG SLSRSSSSVP HTTPRPVSQD GAKMVNAAVN TYSAAQSGSR 
       510        520        530        540        550
SRTPTSPLEE LTSLFTSGRS LLRKSSSGRR SKEPAEKSTE ELKVRSHSTE 
       560        570        580        590        600
PLPKLDSKER GHYGSSSSRE PVKAQEWDGT PGPPVVTSRM GRCSVSPTLL 
       610        620        630        640        650
AGNHSSEPKV SCKLGRSAST SGVPPPSVTP LRQASDLQQS QVACMQWFHG 
       660        670        680        690        700
DHTMLEMIEK KRCLCKEIKA RQKTEKGLCK QDSMPILPSW KKNAGAKKYS 
       710 
PPPYSKQQTV FWDTAI

Show »

Length:716

Mass (Da):78,325

Checksum:ⁱAE293039FC214184

GO

Experimental Info

Feature key	Position(s)	Length	Description
Sequence conflictⁱ	54 – 54	1	K → N in BAJ19139 (PubMed:21946561).Curated
Sequence conflictⁱ	54 – 54	1	K → N in BAC33918 (PubMed:16141072).Curated
Sequence conflictⁱ	54 – 54	1	K → N in BAE23236 (PubMed:16141072).Curated
Sequence conflictⁱ	54 – 54	1	K → N in AAH82310 (PubMed:15489334).Curated

Alternative sequence

Feature key	Position(s)	Length	Description	Feature identifier	Actions
Alternative sequenceⁱ	175 – 206	32	Missing in isoform 2 and isoform 5. 2 Publications Manual assertion based on opinion inⁱ Ref.1 "NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons." Yokoyama K., Tezuka T., Kotani M., Nakazawa T., Hoshina N., Shimoda Y., Kakuta S., Sudo K., Watanabe K., Iwakura Y., Yamamoto T. EMBO J. 30:4739-4754(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5), FUNCTION, INTERACTION WITH ACOT9; ARHGAP26; CYFIP1; NCKAP1 AND PIK3R2, SUBUNIT, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE, PHOSPHORYLATION, MUTAGENESIS OF TYR-277 AND TYR-300. Ref.2 "The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).	VSP_032436	Add BLAST
Alternative sequenceⁱ	639 – 682	44	EPKVS…LANRD → GKHDPVLPNGSKSLEAAHMQ ISLRKPSPQLSLLPPRLAPQ THTLRSRHMKNATVPLFIAM ARETMLLEALLCSSLQLGKT LYQMSSKMTTGLNSSHCNL in isoform 3. 1 Publication Manual assertion based on opinion inⁱ Ref.4 "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).	VSP_032437	Add BLAST
Alternative sequenceⁱ	675 – 682	8	PSSLANRD → ACMQWFHGDHTMLEMIEKKR CLCKEIKARQKTEKGLCKQD SMPILPSWKKNAGAKKYSPP PYSKQQTVFWDTAI in isoform 4 and isoform 5. 2 Publications Manual assertion based on opinion inⁱ Ref.1 "NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons." Yokoyama K., Tezuka T., Kotani M., Nakazawa T., Hoshina N., Shimoda Y., Kakuta S., Sudo K., Watanabe K., Iwakura Y., Yamamoto T. EMBO J. 30:4739-4754(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5), FUNCTION, INTERACTION WITH ACOT9; ARHGAP26; CYFIP1; NCKAP1 AND PIK3R2, SUBUNIT, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE, PHOSPHORYLATION, MUTAGENESIS OF TYR-277 AND TYR-300. Ref.5 "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries." Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H. DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 257-682 (ISOFORM 4).	VSP_032438

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB429290 mRNA. Translation: BAJ19139.1. AK034747 mRNA. Translation: BAC28819.1. AK049778 mRNA. Translation: BAC33918.1. AK137094 mRNA. Translation: BAE23236.1. AC116105 Genomic DNA. No translation available. AC131336 Genomic DNA. No translation available. AC163450 Genomic DNA. No translation available. BC082310 mRNA. Translation: AAH82310.1. AK129372 mRNA. Translation: BAC98182.1.
CCDSⁱ	CCDS15095.1. [Q8BM65-3]
RefSeqⁱ	NP_766437.2. NM_172849.3. XP_006496550.1. XM_006496487.2. XP_006496553.1. XM_006496490.2. XP_011236988.1. XM_011238686.1.
UniGeneⁱ	Mm.313904.

Genome annotation databases

GeneIDⁱ	241134.
KEGGⁱ	mmu:241134.
UCSCⁱ	uc007brj.1. mouse. [Q8BM65-2] uc007brl.1. mouse. [Q8BM65-3] uc007brn.1. mouse. [Q8BM65-5]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB429290 mRNA. Translation: BAJ19139.1. AK034747 mRNA. Translation: BAC28819.1. AK049778 mRNA. Translation: BAC33918.1. AK137094 mRNA. Translation: BAE23236.1. AC116105 Genomic DNA. No translation available. AC131336 Genomic DNA. No translation available. AC163450 Genomic DNA. No translation available. BC082310 mRNA. Translation: AAH82310.1. AK129372 mRNA. Translation: BAC98182.1.
CCDSⁱ	CCDS15095.1. [Q8BM65-3]
RefSeqⁱ	NP_766437.2. NM_172849.3. XP_006496550.1. XM_006496487.2. XP_006496553.1. XM_006496490.2. XP_011236988.1. XM_011238686.1.
UniGeneⁱ	Mm.313904.

3D structure databases

ProteinModelPortalⁱ	Q8BM65.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q8BM65. 11 interactions.
MINTⁱ	MINT-8308425.
STRINGⁱ	10090.ENSMUSP00000065468.

PTM databases

iPTMnetⁱ	Q8BM65.
PhosphoSiteⁱ	Q8BM65.

Proteomic databases

MaxQBⁱ	Q8BM65.
PaxDbⁱ	Q8BM65.
PRIDEⁱ	Q8BM65.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	241134.
KEGGⁱ	mmu:241134.
UCSCⁱ	uc007brj.1. mouse. [Q8BM65-2] uc007brl.1. mouse. [Q8BM65-3] uc007brn.1. mouse. [Q8BM65-5]

Organism-specific databases

CTDⁱ	57624.
MGIⁱ	MGI:2443135. Nyap2.
Rougeⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IH9T. Eukaryota. ENOG410YEXE. LUCA.
HOGENOMⁱ	HOG000111596.
HOVERGENⁱ	HBG108036.
InParanoidⁱ	Q8BM65.
PhylomeDBⁱ	Q8BM65.

Miscellaneous databases

PROⁱ	Q8BM65.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000054976.
CleanExⁱ	MM_9430031J16RIK.

Family and domain databases

InterProⁱ	IPR026722. NYAP1/NYAP2. IPR026723. NYAP2. IPR029353. NYAP_C. [Graphical view]
PANTHERⁱ	PTHR22633. PTHR22633. 2 hits. PTHR22633:SF1. PTHR22633:SF1. 2 hits.
Pfamⁱ	PF15452. NYAP_C. 1 hit. [Graphical view]
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ

NYAP2_MOUSE

Accessionⁱ

Primary (citable) accession number: Q8BM65
Secondary accession number(s): D3Z7K6

Q8BWV8

Entry historyⁱ

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	March 1, 2003
Last modified:	September 7, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry statusⁱ

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8BM65 (NYAP2_MOUSE)

UniProt

Q8BM65 - NYAP2_MOUSE

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Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2

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<p>Provides any useful information about the protein, mostly biological knowledge.</p><p><a href='../manual/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>Provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.</p><p><a href='../manual/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>Provides information on the location and the topology of the mature protein in the cell.</p><p><a href='../manual/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>Provides information on the disease(s) and phenotype(s) associated with a protein.</p><p><a href='../manual/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

<p>Describes post-translational modifications (PTMs) and/or processing events.</p><p><a href='../manual/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>Provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.</p><p><a href='../manual/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>Provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.</p><p><a href='../manual/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>Provides information on the tertiary and secondary structure of a protein.</p><p><a href='../manual/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>Provides information on sequence similarities with other proteins and the domain(s) present in a protein.</p><p><a href='../manual/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Compositional bias

<p>Provides information about the sequence similarity with other proteins.</p><p><a href='../manual/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>Displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.</p><p><a href='../manual/sequences_section' target='_top'>More...</a></p>Sequences (5)i

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

<p>Is used to point to information related to entries and found in data collections other than UniProtKB.</p><p><a href='../manual/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>Provides general information on the entry.</p><p><a href='../manual/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>Contains any relevant information that doesn’t fit in any other defined sections</p><p><a href='../manual/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequences (5)ⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ