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Protein

Pleckstrin homology domain-containing family M member 3

Gene

Plekhm3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri669 – 722Phorbol-ester/DAG-typeAdd BLAST54

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Pleckstrin homology domain-containing family M member 3
Short name:
PH domain-containing family M member 3
Gene namesi
Name:Plekhm3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2443627 Plekhm3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003260351 – 761Pleckstrin homology domain-containing family M member 3Add BLAST761

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei132PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8BM47
PeptideAtlasiQ8BM47
PRIDEiQ8BM47

PTM databases

iPTMnetiQ8BM47
PhosphoSitePlusiQ8BM47

Expressioni

Gene expression databases

BgeeiENSMUSG00000051344
ExpressionAtlasiQ8BM47 baseline and differential
GenevisibleiQ8BM47 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000095320

Structurei

3D structure databases

ProteinModelPortaliQ8BM47
SMRiQ8BM47
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini212 – 309PH 1PROSITE-ProRule annotationAdd BLAST98
Domaini361 – 456PH 2PROSITE-ProRule annotationAdd BLAST96

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi169 – 176Poly-Gln8

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri669 – 722Phorbol-ester/DAG-typeAdd BLAST54

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1829 Eukaryota
ENOG410ZMB5 LUCA
GeneTreeiENSGT00550000074570
HOGENOMiHOG000090264
HOVERGENiHBG100733
InParanoidiQ8BM47
OMAiQGNTEHK
OrthoDBiEOG091G0HFZ
PhylomeDBiQ8BM47
TreeFamiTF317067

Family and domain databases

CDDicd14674 PH_PLEKHM3_1, 1 hit
Gene3Di2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR037812 PLEKHM3_PH_1
IPR025258 Zf-RING_9
PfamiView protein in Pfam
PF00169 PH, 1 hit
PF13901 zf-RING_9, 1 hit
SMARTiView protein in SMART
SM01175 DUF4206, 1 hit
SM00233 PH, 2 hits
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BM47-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEALEVDDIS PALEVTEDFF STFDSKLEKA VQQAEVYGIQ EVPELVGHEV
60 70 80 90 100
LGNIADNGAL RSVASLGKGT MIWDHCKSRL LETKAQNVFP AKEQLMVQRG
110 120 130 140 150
TAPDNLSWMA QKEASTFNFF NICQRRRDRP RSVNDLLDET TTFKPGHARS
160 170 180 190 200
RSDVTHVDWR VVLSTMPLQQ QQQQQQASLQ GIHFPGPSFL LSSPSKVEDA
210 220 230 240 250
QGNTEHKQTF PNILKKGYLE IRKNHDSYWQ SCYAELSPYN LNFYSLDSSG
260 270 280 290 300
NQNLYATYQL SHFQSISVLG NLEARMVDTV LYDNSQLQLK AESPWEALDW
310 320 330 340 350
GQKLWEVVHA AVPNYMGRQG EMANSPGLIH HGDCAQNHCL QKKSSGLLAS
360 370 380 390 400
PVLDSPKQYQ NILKSGTLYR LTVQNNWKAF TFVLSKAYLM AFHPGKLDED
410 420 430 440 450
PLLSYNVDVC LAVQIDNLDG CDSCFQVIFP QDVLRLRAET RQRAQEWMEA
460 470 480 490 500
LKTAANAARS SEQNLQVTLR NKPKDQLDGR ELRKNKRQSV TTSFLSILTT
510 520 530 540 550
LSLERGLTAQ SFKCAGCQRS IGLSNGKAKV CNYSGWYYCS SCHVDDSFLI
560 570 580 590 600
PARIVHNWDT SKYKVSKQAK EFLEYVYEEP LIDIQQENPM LYLHAEPLAT
610 620 630 640 650
VVRLRQRLKS LRAYLFSCRA AVAEDLRRRI FPREYLLQQI HLYSLADLQQ
660 670 680 690 700
VIEGKLAPFL GKVIKFATAH VYSCSLCSQK GFICEICNNG EILYPFEDIS
710 720 730 740 750
TSRCESCGAV FHSECKEKSV PCPRCVRREL QKKQKSFWRQ LNVDESLEEA
760
CAMFELSYQS T
Length:761
Mass (Da):86,553
Last modified:March 1, 2003 - v1
Checksum:i58EB8DEF72F4E7B0
GO
Isoform 2 (identifier: Q8BM47-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-275: Missing.
     652-761: IEGKLAPFLG...AMFELSYQST → CAQRAFRFHFLSEVTLWIVVWALN

Note: No experimental confirmation available.
Show »
Length:400
Mass (Da):45,862
Checksum:iDF0460B456B3B68D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti617S → C in BAE42889 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0325141 – 275Missing in isoform 2. 1 PublicationAdd BLAST275
Alternative sequenceiVSP_032515652 – 761IEGKL…SYQST → CAQRAFRFHFLSEVTLWIVV WALN in isoform 2. 1 PublicationAdd BLAST110

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK034959 mRNA Translation: BAC28895.1
AK172220 mRNA Translation: BAE42889.1
BC063098 mRNA No translation available.
CCDSiCCDS15009.1 [Q8BM47-1]
RefSeqiNP_001034582.1, NM_001039493.1 [Q8BM47-1]
XP_006496045.1, XM_006495982.1 [Q8BM47-1]
UniGeneiMm.239534

Genome annotation databases

EnsembliENSMUST00000097713; ENSMUSP00000095320; ENSMUSG00000051344 [Q8BM47-1]
ENSMUST00000139649; ENSMUSP00000138002; ENSMUSG00000051344 [Q8BM47-1]
GeneIDi241075
KEGGimmu:241075
UCSCiuc007bha.1 mouse [Q8BM47-1]
uc007bhb.1 mouse [Q8BM47-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPKHM3_MOUSE
AccessioniPrimary (citable) accession number: Q8BM47
Secondary accession number(s): Q3T9Y1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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