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Protein

Pleckstrin homology domain-containing family M member 3

Gene

Plekhm3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri669 – 72254Phorbol-ester/DAG-typeAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Pleckstrin homology domain-containing family M member 3
Short name:
PH domain-containing family M member 3
Gene namesi
Name:Plekhm3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2443627. Plekhm3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 761761Pleckstrin homology domain-containing family M member 3PRO_0000326035Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei132 – 1321PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8BM47.
PaxDbiQ8BM47.
PeptideAtlasiQ8BM47.
PRIDEiQ8BM47.

PTM databases

iPTMnetiQ8BM47.
PhosphoSiteiQ8BM47.

Expressioni

Gene expression databases

BgeeiQ8BM47.
ExpressionAtlasiQ8BM47. baseline and differential.
GenevisibleiQ8BM47. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000095320.

Structurei

3D structure databases

ProteinModelPortaliQ8BM47.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini212 – 30998PH 1PROSITE-ProRule annotationAdd
BLAST
Domaini361 – 45696PH 2PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi169 – 1768Poly-Gln

Sequence similaritiesi

Contains 2 PH domains.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri669 – 72254Phorbol-ester/DAG-typeAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1829. Eukaryota.
ENOG410ZMB5. LUCA.
GeneTreeiENSGT00550000074570.
HOGENOMiHOG000090264.
HOVERGENiHBG100733.
InParanoidiQ8BM47.
OMAiQGNTEHK.
OrthoDBiEOG72VH72.
PhylomeDBiQ8BM47.
TreeFamiTF317067.

Family and domain databases

Gene3Di2.30.29.30. 2 hits.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR025258. Zf-RING_9.
[Graphical view]
PfamiPF00169. PH. 1 hit.
PF13901. zf-RING_9. 1 hit.
[Graphical view]
SMARTiSM01175. DUF4206. 1 hit.
SM00233. PH. 2 hits.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 2 hits.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BM47-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEALEVDDIS PALEVTEDFF STFDSKLEKA VQQAEVYGIQ EVPELVGHEV
60 70 80 90 100
LGNIADNGAL RSVASLGKGT MIWDHCKSRL LETKAQNVFP AKEQLMVQRG
110 120 130 140 150
TAPDNLSWMA QKEASTFNFF NICQRRRDRP RSVNDLLDET TTFKPGHARS
160 170 180 190 200
RSDVTHVDWR VVLSTMPLQQ QQQQQQASLQ GIHFPGPSFL LSSPSKVEDA
210 220 230 240 250
QGNTEHKQTF PNILKKGYLE IRKNHDSYWQ SCYAELSPYN LNFYSLDSSG
260 270 280 290 300
NQNLYATYQL SHFQSISVLG NLEARMVDTV LYDNSQLQLK AESPWEALDW
310 320 330 340 350
GQKLWEVVHA AVPNYMGRQG EMANSPGLIH HGDCAQNHCL QKKSSGLLAS
360 370 380 390 400
PVLDSPKQYQ NILKSGTLYR LTVQNNWKAF TFVLSKAYLM AFHPGKLDED
410 420 430 440 450
PLLSYNVDVC LAVQIDNLDG CDSCFQVIFP QDVLRLRAET RQRAQEWMEA
460 470 480 490 500
LKTAANAARS SEQNLQVTLR NKPKDQLDGR ELRKNKRQSV TTSFLSILTT
510 520 530 540 550
LSLERGLTAQ SFKCAGCQRS IGLSNGKAKV CNYSGWYYCS SCHVDDSFLI
560 570 580 590 600
PARIVHNWDT SKYKVSKQAK EFLEYVYEEP LIDIQQENPM LYLHAEPLAT
610 620 630 640 650
VVRLRQRLKS LRAYLFSCRA AVAEDLRRRI FPREYLLQQI HLYSLADLQQ
660 670 680 690 700
VIEGKLAPFL GKVIKFATAH VYSCSLCSQK GFICEICNNG EILYPFEDIS
710 720 730 740 750
TSRCESCGAV FHSECKEKSV PCPRCVRREL QKKQKSFWRQ LNVDESLEEA
760
CAMFELSYQS T
Length:761
Mass (Da):86,553
Last modified:March 1, 2003 - v1
Checksum:i58EB8DEF72F4E7B0
GO
Isoform 2 (identifier: Q8BM47-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-275: Missing.
     652-761: IEGKLAPFLG...AMFELSYQST → CAQRAFRFHFLSEVTLWIVVWALN

Note: No experimental confirmation available.
Show »
Length:400
Mass (Da):45,862
Checksum:iDF0460B456B3B68D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti617 – 6171S → C in BAE42889 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 275275Missing in isoform 2. 1 PublicationVSP_032514Add
BLAST
Alternative sequencei652 – 761110IEGKL…SYQST → CAQRAFRFHFLSEVTLWIVV WALN in isoform 2. 1 PublicationVSP_032515Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK034959 mRNA. Translation: BAC28895.1.
AK172220 mRNA. Translation: BAE42889.1.
BC063098 mRNA. No translation available.
CCDSiCCDS15009.1. [Q8BM47-1]
RefSeqiNP_001034582.1. NM_001039493.1. [Q8BM47-1]
XP_006496045.1. XM_006495982.1. [Q8BM47-1]
UniGeneiMm.239534.

Genome annotation databases

EnsembliENSMUST00000097713; ENSMUSP00000095320; ENSMUSG00000051344. [Q8BM47-1]
ENSMUST00000139649; ENSMUSP00000138002; ENSMUSG00000051344. [Q8BM47-1]
GeneIDi241075.
KEGGimmu:241075.
UCSCiuc007bha.1. mouse. [Q8BM47-1]
uc007bhb.1. mouse. [Q8BM47-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK034959 mRNA. Translation: BAC28895.1.
AK172220 mRNA. Translation: BAE42889.1.
BC063098 mRNA. No translation available.
CCDSiCCDS15009.1. [Q8BM47-1]
RefSeqiNP_001034582.1. NM_001039493.1. [Q8BM47-1]
XP_006496045.1. XM_006495982.1. [Q8BM47-1]
UniGeneiMm.239534.

3D structure databases

ProteinModelPortaliQ8BM47.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000095320.

PTM databases

iPTMnetiQ8BM47.
PhosphoSiteiQ8BM47.

Proteomic databases

MaxQBiQ8BM47.
PaxDbiQ8BM47.
PeptideAtlasiQ8BM47.
PRIDEiQ8BM47.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000097713; ENSMUSP00000095320; ENSMUSG00000051344. [Q8BM47-1]
ENSMUST00000139649; ENSMUSP00000138002; ENSMUSG00000051344. [Q8BM47-1]
GeneIDi241075.
KEGGimmu:241075.
UCSCiuc007bha.1. mouse. [Q8BM47-1]
uc007bhb.1. mouse. [Q8BM47-2]

Organism-specific databases

CTDi389072.
MGIiMGI:2443627. Plekhm3.

Phylogenomic databases

eggNOGiKOG1829. Eukaryota.
ENOG410ZMB5. LUCA.
GeneTreeiENSGT00550000074570.
HOGENOMiHOG000090264.
HOVERGENiHBG100733.
InParanoidiQ8BM47.
OMAiQGNTEHK.
OrthoDBiEOG72VH72.
PhylomeDBiQ8BM47.
TreeFamiTF317067.

Miscellaneous databases

PROiQ8BM47.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BM47.
ExpressionAtlasiQ8BM47. baseline and differential.
GenevisibleiQ8BM47. MM.

Family and domain databases

Gene3Di2.30.29.30. 2 hits.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR025258. Zf-RING_9.
[Graphical view]
PfamiPF00169. PH. 1 hit.
PF13901. zf-RING_9. 1 hit.
[Graphical view]
SMARTiSM01175. DUF4206. 1 hit.
SM00233. PH. 2 hits.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 2 hits.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J and NOD.
    Tissue: Embryo and Spleen.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-132, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Lung.

Entry informationi

Entry nameiPKHM3_MOUSE
AccessioniPrimary (citable) accession number: Q8BM47
Secondary accession number(s): Q3T9Y1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 1, 2003
Last modified: July 6, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.