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Q8BLX7 (COGA1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Collagen alpha-1(XVI) chain
Gene names
Name:Col16a1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1580 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in mediating cell attachment and inducing integrin-mediated cellular reactions, such as cell spreading and alterations in cell morphology By similarity. UniProtKB Q07092

Subunit structure

Homotrimer. Interacts with FBN1, fibronectin and integrins ITGA1/ITGB1 and ITGA2/ITGB1. Integrin ITGA1/ITGB1 binds to a unique site within COL16A1 located close to its C-terminal end between collagenous domains COL1-COL3 By similarity. UniProtKB Q07092

Subcellular location

Secretedextracellular spaceextracellular matrix By similarity.

Tissue specificity

Expressed in most tissues examined with highest levels of expression observed in heart. Strongly expressed in cortical and medullar regions of kidney and more weakly expressed in lung. Also detected in the ciliary muscle of the eye, on the serosa layer lining the muscularis externa of intestinal tissue, and in the perimysium membrane lining both the cardiac muscle bundle and the smooth muscle tissue of the small intestine. Strongly stained in particulate or granular structures. Not detected in brain or skeletal muscle. Ref.3

Developmental stage

At embryonic day 8 (E8) of gestation no significant expression of mRNA or protein is observed, but strong signals are observed in placental trophoblasts. By E11 weak positive signals are observed in heart. During later stages of development, stronger expression is observed in a variety of tissues, particularly in the atrial and ventricular walls of the developing heart, spinal root neural fibers and skin. Ref.3

Domain

This sequence defines eighteen different domains, nine triple-helical domains (COL9 to COL1) and ten non-triple-helical domains (NC10 to NC1). The numerous interruptions in the triple helix may make this molecule either elastic or flexible.

Post-translational modification

Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.

Glycosylated By similarity. UniProtKB Q07092

Sequence similarities

Belongs to the fibril-associated collagens with interrupted helices (FACIT) family.

Contains 9 collagen-like domains.

Contains 1 laminin G-like domain.

Ontologies

Keywords
   Biological processCell adhesion
   Cellular componentExtracellular matrix
Secreted
   Coding sequence diversityAlternative splicing
   DomainCollagen
Repeat
Signal
   PTMGlycoprotein
Hydroxylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell adhesion

Inferred from sequence or structural similarity. Source: UniProtKB

cellular response to amino acid stimulus

Inferred from direct assay PubMed 20548288. Source: MGI

   Cellular_componentcollagen

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionintegrin binding

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 Ref.1 (identifier: Q8BLX7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: No experimental confirmation available.
Isoform 2 Ref.1 (identifier: Q8BLX7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1430: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 15801559Collagen alpha-1(XVI) chain
PRO_0000282960

Regions

Domain50 – 231182Laminin G-like
Domain375 – 42450Collagen-like 1
Domain590 – 64354Collagen-like 2
Domain676 – 72550Collagen-like 3
Domain797 – 84852Collagen-like 4
Domain1006 – 106358Collagen-like 5
Domain1210 – 126354Collagen-like 6
Domain1350 – 140758Collagen-like 7
Domain1448 – 150053Collagen-like 8
Domain1504 – 155249Collagen-like 9
Region232 – 374143Nonhelical region 10 (NC10)
Region375 – 509135Triple-helical region 9 (COL9) with 3 imperfections
Region510 – 52415Nonhelical region 9 (NC9)
Region525 – 57046Triple-helical region 8 (COL8) with 1 imperfection
Region571 – 58616Nonhelical region 8 (NC8)
Region587 – 64054Triple-helical region 7 (COL7) with 1 imperfection
Region641 – 66121Nonhelical region 7 (NC7)
Region662 – 73271Triple-helical region 6 (COL6) with 1 imperfection
Region733 – 74715Nonhelical region 6 (NC6)
Region748 – 870123Triple-helical region 5 (COL5) with 3 imperfections
Region871 – 88111Nonhelical region 5 (NC5)
Region882 – 93352Triple-helical region 4 (COL4) with 2 imperfections
Region934 – 96734Nonhelical region 4 (NC4)
Region968 – 98215Triple-helical region 3 (COL3)
Region983 – 100523Nonhelical region 3 (NC3)
Region1006 – 1409404Triple-helical region 2 (COL2) with 2 imperfections
Region1410 – 144839Nonhelical region 2 (NC2)
Region1449 – 1554106Triple-helical region 1 (COL1) with 2 imperfections
Region1555 – 158026Nonhelical region 1 (NC1)
Motif555 – 5573Cell attachment site Potential
Motif1000 – 10023Cell attachment site Potential
Motif1206 – 12083Cell attachment site Potential

Amino acid modifications

Glycosylation471N-linked (GlcNAc...) Potential
Glycosylation3271N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence1 – 14301430Missing in isoform 2. Ref.1
VSP_052375

Experimental info

Sequence conflict7261K → R in BAC30765. Ref.1
Sequence conflict11191R → Q in BAC30765. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified April 3, 2007. Version 2.
Checksum: FC01635F6E410E3A

FASTA1,580155,805
        10         20         30         40         50         60 
MLTSWAPGLW VLGLWATFSH GTNIGERCPT SQQEGLKLEH SSDPSTNVTG FNLIRRLNLM 

        70         80         90        100        110        120 
KTSAIKKIRN PKGPLILRLG AAPVTQPTRR VFPRGLPEEF ALVLTVLLKK HTFRNTWYLF 

       130        140        150        160        170        180 
QVTDANGYPQ ISLEVNSQER SLELRAQGQD GDFVSCIFPV PQLFDLRWHK LMLSVAGRVA 

       190        200        210        220        230        240 
SVHVDCVSAS SQPLGPRQSI RPGGHVFLGL DAEQGKPVSF DLQQAHIYCD PELVLEEGCC 

       250        260        270        280        290        300 
EILPGGCPPE TSKSRRDTQS NELIEINPQT EGKVYTRCFC LEEPQNSKVD AQLMGRNIQK 

       310        320        330        340        350        360 
AERGTKVHQG TGVNECPPCA HSARESNVTL GPSGLKGGKG ERGLTGPSGP KGEKGARGND 

       370        380        390        400        410        420 
CVRVSPDAPL QCVEGPKGEK GESGDLGPPG LPGPTGQKGQ KGEKGDGGLK GLPGKPGRDG 

       430        440        450        460        470        480 
RPGEICVIGP KGQKGDPGFV GPEGLAGEPG PPGLPGPPGI GLPGTPGDPG GPPGPKGEKG 

       490        500        510        520        530        540 
SSGIPGKEGP GGKPGKPGVP GTKGEKGDPC EVCPTLPEGS QNFVGLPGKP GPKGEPGDPA 

       550        560        570        580        590        600 
PAWEGLGTVG LKGDRGDPGI QGMKGEKGEP CSSCSSGVGA QHLGPSPGHG LPGLPGTSGI 

       610        620        630        640        650        660 
PGPRGLKGEK GSFGDTGPAG VPGSPGPVGP AGIKGAKGEP CEPCTALSEL QDGDMRVVHL 

       670        680        690        700        710        720 
PGPAGEKGEP GSPGFGLPGK QGKAGERGLK GQKGDAGNPG DPGTPGITGQ PGISGEPGIR 

       730        740        750        760        770        780 
GPAGPKGEKG DGCTACPSLQ GALTDVSGLP GKPGPKGEPG PEGVGHPGKP GQPGLPGVQG 

       790        800        810        820        830        840 
PPGPKGTQGE PGPPGTGAEG PQGEPGTQGL PGTQGLPGPR GPPGSAGEKG AQGSPGPKGA 

       850        860        870        880        890        900 
IGPMGPPGAG VSGPPGQKGS RGEKGEPGEC SCPSRGEPIF SGMPGAPGLW MGSSSQPGPQ 

       910        920        930        940        950        960 
GPPGVPGPPG PPGMPGLQGV PGHNGLPGQP GLTAELGSLP IEKHLLKSIC GDCAQGQTAH 

       970        980        990       1000       1010       1020 
PAFLLEKGEK GDQGIPGVPG FDNCARCFIE RERPRAEEAR GDNSEGEPGC SGSPGLPGPP 

      1030       1040       1050       1060       1070       1080 
GMPGQRGEEG PPGMRGSPGP PGPIGLQGER GLTGLTGDKG EPGPPGQPGY PGAMGPPGLP 

      1090       1100       1110       1120       1130       1140 
GIKGERGYTG PSGEKGESGP PGSEGLPGPQ GPAGPRGERG PQGSSGEKGD QGFQGQPGFP 

      1150       1160       1170       1180       1190       1200 
GPPGPPGFPG KAGAPGPPGP QAEKGSEGIR GPSGLPGSPG PPGPPGIQGP AGLDGLDGKD 

      1210       1220       1230       1240       1250       1260 
GKPGLRGDPG PAGPPGLMGP PGFKGKTGHP GLPGPKGDCG KPGPPGSSGR PGAEGEPGAM 

      1270       1280       1290       1300       1310       1320 
GPQGRPGPPG HLGPPGQPGP PGLSTVGLKG DRGVPGERGL AGLPGQPGTP GHPGPPGEPG 

      1330       1340       1350       1360       1370       1380 
SDGAAGKEGP PGKQGLYGPP GPKGDPGPAG QKGQAGEKGR SGMPGGPGKS GSMGPIGPPG 

      1390       1400       1410       1420       1430       1440 
PAGERGHPGS PGPAGNPGLP GLPGSMGDMV NYDDIKRFIR QEIIKLFDER MAYYTSRMQF 

      1450       1460       1470       1480       1490       1500 
PMEVAAAPGR PGPPGKDGAP GRPGAPGSPG LPGQIGREGR QGLPGMRGLP GTKGEKGDIG 

      1510       1520       1530       1540       1550       1560 
VGIAGENGLP GPPGPQGPPG YGKMGATGPM GQQGIPGIPG PPGPMGQPGK AGHCNPSDCF 

      1570       1580 
GAMPMEQQYP PMKSMKGPFG 

« Hide

Isoform 2 [UniParc].

Checksum: D956EF9160987FC8
Show »

FASTA15014,823

References

« Hide 'large scale' references
[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Strain: C57BL/6J.
Tissue: Embryo.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Tissue distribution and developmental expression of type XVI collagen in the mouse."
Lai C.-H., Chu M.-L.
Tissue Cell 28:155-164(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK012212 mRNA. Translation: BAB28100.1.
AK040971 mRNA. Translation: BAC30765.1.
AL606925 Genomic DNA. Translation: CAM45907.1.
RefSeqNP_082542.3. NM_028266.5.
UniGeneMm.41860.

3D structure databases

ProteinModelPortalQ8BLX7.
SMRQ8BLX7. Positions 44-242.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ8BLX7.

Proteomic databases

PaxDbQ8BLX7.
PRIDEQ8BLX7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000044565; ENSMUSP00000035802; ENSMUSG00000040690. [Q8BLX7-1]
GeneID107581.
KEGGmmu:107581.
UCSCuc008uys.2. mouse. [Q8BLX7-1]
uc008uyv.2. mouse. [Q8BLX7-2]

Organism-specific databases

CTD1307.
MGIMGI:1095396. Col16a1.

Phylogenomic databases

eggNOGNOG12793.
GeneTreeENSGT00750000117472.
HOGENOMHOG000085653.
HOVERGENHBG071631.
InParanoidQ8BLX7.
OMASTWYLFQ.
OrthoDBEOG779NXQ.
PhylomeDBQ8BLX7.
TreeFamTF332900.

Gene expression databases

ArrayExpressQ8BLX7.
BgeeQ8BLX7.
CleanExMM_COL16A1.
GenevestigatorQ8BLX7.

Family and domain databases

InterProIPR008160. Collagen.
IPR008985. ConA-like_lec_gl_sf.
IPR001791. Laminin_G.
[Graphical view]
PfamPF01391. Collagen. 9 hits.
[Graphical view]
SMARTSM00210. TSPN. 1 hit.
[Graphical view]
SUPFAMSSF49899. SSF49899. 1 hit.
ProtoNetSearch...

Other

NextBio359082.
PROQ8BLX7.
SOURCESearch...

Entry information

Entry nameCOGA1_MOUSE
AccessionPrimary (citable) accession number: Q8BLX7
Secondary accession number(s): A3KFV5, Q9CZS2
Entry history
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: April 16, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot