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Q8BLX7

- COGA1_MOUSE

UniProt

Q8BLX7 - COGA1_MOUSE

Protein

Collagen alpha-1(XVI) chain

Gene

Col16a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 2 (03 Apr 2007)
      Previous versions | rss
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    Functioni

    Involved in mediating cell attachment and inducing integrin-mediated cellular reactions, such as cell spreading and alterations in cell morphology.By similarity

    GO - Molecular functioni

    1. integrin binding Source: UniProtKB

    GO - Biological processi

    1. cell adhesion Source: UniProtKB
    2. cellular response to amino acid stimulus Source: MGI

    Keywords - Biological processi

    Cell adhesion

    Enzyme and pathway databases

    ReactomeiREACT_198984. Collagen biosynthesis and modifying enzymes.
    REACT_199055. Collagen degradation.
    REACT_216309. Integrin cell surface interactions.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Collagen alpha-1(XVI) chain
    Gene namesi
    Name:Col16a1Imported
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:1095396. Col16a1.

    Subcellular locationi

    GO - Cellular componenti

    1. collagen trimer Source: UniProtKB-KW
    2. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 15801559Collagen alpha-1(XVI) chainSequence AnalysisPRO_0000282960Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi47 – 471N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi327 – 3271N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.Curated
    Glycosylated.By similarity

    Keywords - PTMi

    Glycoprotein, Hydroxylation

    Proteomic databases

    PaxDbiQ8BLX7.
    PRIDEiQ8BLX7.

    PTM databases

    PhosphoSiteiQ8BLX7.

    Expressioni

    Tissue specificityi

    Expressed in most tissues examined with highest levels of expression observed in heart. Strongly expressed in cortical and medullar regions of kidney and more weakly expressed in lung. Also detected in the ciliary muscle of the eye, on the serosa layer lining the muscularis externa of intestinal tissue, and in the perimysium membrane lining both the cardiac muscle bundle and the smooth muscle tissue of the small intestine. Strongly stained in particulate or granular structures. Not detected in brain or skeletal muscle.1 Publication

    Developmental stagei

    At embryonic day 8 (E8) of gestation no significant expression of mRNA or protein is observed, but strong signals are observed in placental trophoblasts. By E11 weak positive signals are observed in heart. During later stages of development, stronger expression is observed in a variety of tissues, particularly in the atrial and ventricular walls of the developing heart, spinal root neural fibers and skin.1 Publication

    Gene expression databases

    ArrayExpressiQ8BLX7.
    BgeeiQ8BLX7.
    CleanExiMM_COL16A1.
    GenevestigatoriQ8BLX7.

    Interactioni

    Subunit structurei

    Homotrimer. Interacts with FBN1, fibronectin and integrins ITGA1/ITGB1 and ITGA2/ITGB1. Integrin ITGA1/ITGB1 binds to a unique site within COL16A1 located close to its C-terminal end between collagenous domains COL1-COL3 By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BLX7.
    SMRiQ8BLX7. Positions 44-242.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini50 – 231182Laminin G-likeAdd
    BLAST
    Domaini375 – 42450Collagen-like 1Add
    BLAST
    Domaini590 – 64354Collagen-like 2Add
    BLAST
    Domaini676 – 72550Collagen-like 3Add
    BLAST
    Domaini797 – 84852Collagen-like 4Add
    BLAST
    Domaini1006 – 106358Collagen-like 5Add
    BLAST
    Domaini1210 – 126354Collagen-like 6Add
    BLAST
    Domaini1350 – 140758Collagen-like 7Add
    BLAST
    Domaini1448 – 150053Collagen-like 8Add
    BLAST
    Domaini1504 – 155249Collagen-like 9Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni232 – 374143Nonhelical region 10 (NC10)Sequence AnalysisAdd
    BLAST
    Regioni375 – 509135Triple-helical region 9 (COL9) with 3 imperfectionsSequence AnalysisAdd
    BLAST
    Regioni510 – 52415Nonhelical region 9 (NC9)Sequence AnalysisAdd
    BLAST
    Regioni525 – 57046Triple-helical region 8 (COL8) with 1 imperfectionSequence AnalysisAdd
    BLAST
    Regioni571 – 58616Nonhelical region 8 (NC8)Sequence AnalysisAdd
    BLAST
    Regioni587 – 64054Triple-helical region 7 (COL7) with 1 imperfectionSequence AnalysisAdd
    BLAST
    Regioni641 – 66121Nonhelical region 7 (NC7)Sequence AnalysisAdd
    BLAST
    Regioni662 – 73271Triple-helical region 6 (COL6) with 1 imperfectionSequence AnalysisAdd
    BLAST
    Regioni733 – 74715Nonhelical region 6 (NC6)Sequence AnalysisAdd
    BLAST
    Regioni748 – 870123Triple-helical region 5 (COL5) with 3 imperfectionsSequence AnalysisAdd
    BLAST
    Regioni871 – 88111Nonhelical region 5 (NC5)Sequence AnalysisAdd
    BLAST
    Regioni882 – 93352Triple-helical region 4 (COL4) with 2 imperfectionsSequence AnalysisAdd
    BLAST
    Regioni934 – 96734Nonhelical region 4 (NC4)Sequence AnalysisAdd
    BLAST
    Regioni968 – 98215Triple-helical region 3 (COL3)Sequence AnalysisAdd
    BLAST
    Regioni983 – 100523Nonhelical region 3 (NC3)Sequence AnalysisAdd
    BLAST
    Regioni1006 – 1409404Triple-helical region 2 (COL2) with 2 imperfectionsSequence AnalysisAdd
    BLAST
    Regioni1410 – 144839Nonhelical region 2 (NC2)Sequence AnalysisAdd
    BLAST
    Regioni1449 – 1554106Triple-helical region 1 (COL1) with 2 imperfectionsSequence AnalysisAdd
    BLAST
    Regioni1555 – 158026Nonhelical region 1 (NC1)Sequence AnalysisAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi555 – 5573Cell attachment siteSequence Analysis
    Motifi1000 – 10023Cell attachment siteSequence Analysis
    Motifi1206 – 12083Cell attachment siteSequence Analysis

    Domaini

    This sequence defines eighteen different domains, nine triple-helical domains (COL9 to COL1) and ten non-triple-helical domains (NC10 to NC1). The numerous interruptions in the triple helix may make this molecule either elastic or flexible.Sequence Analysis

    Sequence similaritiesi

    Contains 9 collagen-like domains.Curated
    Contains 1 laminin G-like domain.Curated

    Keywords - Domaini

    Collagen, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG12793.
    GeneTreeiENSGT00750000117472.
    HOGENOMiHOG000085653.
    HOVERGENiHBG071631.
    InParanoidiQ8BLX7.
    OMAiSTWYLFQ.
    OrthoDBiEOG779NXQ.
    PhylomeDBiQ8BLX7.
    TreeFamiTF332900.

    Family and domain databases

    InterProiIPR008160. Collagen.
    IPR008985. ConA-like_lec_gl_sf.
    IPR001791. Laminin_G.
    [Graphical view]
    PfamiPF01391. Collagen. 9 hits.
    [Graphical view]
    SMARTiSM00210. TSPN. 1 hit.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 11 Publication (identifier: Q8BLX7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLTSWAPGLW VLGLWATFSH GTNIGERCPT SQQEGLKLEH SSDPSTNVTG     50
    FNLIRRLNLM KTSAIKKIRN PKGPLILRLG AAPVTQPTRR VFPRGLPEEF 100
    ALVLTVLLKK HTFRNTWYLF QVTDANGYPQ ISLEVNSQER SLELRAQGQD 150
    GDFVSCIFPV PQLFDLRWHK LMLSVAGRVA SVHVDCVSAS SQPLGPRQSI 200
    RPGGHVFLGL DAEQGKPVSF DLQQAHIYCD PELVLEEGCC EILPGGCPPE 250
    TSKSRRDTQS NELIEINPQT EGKVYTRCFC LEEPQNSKVD AQLMGRNIQK 300
    AERGTKVHQG TGVNECPPCA HSARESNVTL GPSGLKGGKG ERGLTGPSGP 350
    KGEKGARGND CVRVSPDAPL QCVEGPKGEK GESGDLGPPG LPGPTGQKGQ 400
    KGEKGDGGLK GLPGKPGRDG RPGEICVIGP KGQKGDPGFV GPEGLAGEPG 450
    PPGLPGPPGI GLPGTPGDPG GPPGPKGEKG SSGIPGKEGP GGKPGKPGVP 500
    GTKGEKGDPC EVCPTLPEGS QNFVGLPGKP GPKGEPGDPA PAWEGLGTVG 550
    LKGDRGDPGI QGMKGEKGEP CSSCSSGVGA QHLGPSPGHG LPGLPGTSGI 600
    PGPRGLKGEK GSFGDTGPAG VPGSPGPVGP AGIKGAKGEP CEPCTALSEL 650
    QDGDMRVVHL PGPAGEKGEP GSPGFGLPGK QGKAGERGLK GQKGDAGNPG 700
    DPGTPGITGQ PGISGEPGIR GPAGPKGEKG DGCTACPSLQ GALTDVSGLP 750
    GKPGPKGEPG PEGVGHPGKP GQPGLPGVQG PPGPKGTQGE PGPPGTGAEG 800
    PQGEPGTQGL PGTQGLPGPR GPPGSAGEKG AQGSPGPKGA IGPMGPPGAG 850
    VSGPPGQKGS RGEKGEPGEC SCPSRGEPIF SGMPGAPGLW MGSSSQPGPQ 900
    GPPGVPGPPG PPGMPGLQGV PGHNGLPGQP GLTAELGSLP IEKHLLKSIC 950
    GDCAQGQTAH PAFLLEKGEK GDQGIPGVPG FDNCARCFIE RERPRAEEAR 1000
    GDNSEGEPGC SGSPGLPGPP GMPGQRGEEG PPGMRGSPGP PGPIGLQGER 1050
    GLTGLTGDKG EPGPPGQPGY PGAMGPPGLP GIKGERGYTG PSGEKGESGP 1100
    PGSEGLPGPQ GPAGPRGERG PQGSSGEKGD QGFQGQPGFP GPPGPPGFPG 1150
    KAGAPGPPGP QAEKGSEGIR GPSGLPGSPG PPGPPGIQGP AGLDGLDGKD 1200
    GKPGLRGDPG PAGPPGLMGP PGFKGKTGHP GLPGPKGDCG KPGPPGSSGR 1250
    PGAEGEPGAM GPQGRPGPPG HLGPPGQPGP PGLSTVGLKG DRGVPGERGL 1300
    AGLPGQPGTP GHPGPPGEPG SDGAAGKEGP PGKQGLYGPP GPKGDPGPAG 1350
    QKGQAGEKGR SGMPGGPGKS GSMGPIGPPG PAGERGHPGS PGPAGNPGLP 1400
    GLPGSMGDMV NYDDIKRFIR QEIIKLFDER MAYYTSRMQF PMEVAAAPGR 1450
    PGPPGKDGAP GRPGAPGSPG LPGQIGREGR QGLPGMRGLP GTKGEKGDIG 1500
    VGIAGENGLP GPPGPQGPPG YGKMGATGPM GQQGIPGIPG PPGPMGQPGK 1550
    AGHCNPSDCF GAMPMEQQYP PMKSMKGPFG 1580

    Note: No experimental confirmation available.Curated

    Length:1,580
    Mass (Da):155,805
    Last modified:April 3, 2007 - v2
    Checksum:iFC01635F6E410E3A
    GO
    Isoform 21 Publication (identifier: Q8BLX7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1430: Missing.

    Note: No experimental confirmation available.Curated

    Show »
    Length:150
    Mass (Da):14,823
    Checksum:iD956EF9160987FC8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti726 – 7261K → R in BAC30765. (PubMed:16141072)Curated
    Sequence conflicti1119 – 11191R → Q in BAC30765. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 14301430Missing in isoform 2. 1 PublicationVSP_052375Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK012212 mRNA. Translation: BAB28100.1.
    AK040971 mRNA. Translation: BAC30765.1.
    AL606925 Genomic DNA. Translation: CAM45907.1.
    CCDSiCCDS38889.1. [Q8BLX7-1]
    RefSeqiNP_082542.3. NM_028266.5. [Q8BLX7-1]
    UniGeneiMm.41860.

    Genome annotation databases

    EnsembliENSMUST00000044565; ENSMUSP00000035802; ENSMUSG00000040690. [Q8BLX7-1]
    GeneIDi107581.
    KEGGimmu:107581.
    UCSCiuc008uys.2. mouse. [Q8BLX7-1]
    uc008uyv.2. mouse. [Q8BLX7-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK012212 mRNA. Translation: BAB28100.1 .
    AK040971 mRNA. Translation: BAC30765.1 .
    AL606925 Genomic DNA. Translation: CAM45907.1 .
    CCDSi CCDS38889.1. [Q8BLX7-1 ]
    RefSeqi NP_082542.3. NM_028266.5. [Q8BLX7-1 ]
    UniGenei Mm.41860.

    3D structure databases

    ProteinModelPortali Q8BLX7.
    SMRi Q8BLX7. Positions 44-242.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8BLX7.

    Proteomic databases

    PaxDbi Q8BLX7.
    PRIDEi Q8BLX7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000044565 ; ENSMUSP00000035802 ; ENSMUSG00000040690 . [Q8BLX7-1 ]
    GeneIDi 107581.
    KEGGi mmu:107581.
    UCSCi uc008uys.2. mouse. [Q8BLX7-1 ]
    uc008uyv.2. mouse. [Q8BLX7-2 ]

    Organism-specific databases

    CTDi 1307.
    MGIi MGI:1095396. Col16a1.

    Phylogenomic databases

    eggNOGi NOG12793.
    GeneTreei ENSGT00750000117472.
    HOGENOMi HOG000085653.
    HOVERGENi HBG071631.
    InParanoidi Q8BLX7.
    OMAi STWYLFQ.
    OrthoDBi EOG779NXQ.
    PhylomeDBi Q8BLX7.
    TreeFami TF332900.

    Enzyme and pathway databases

    Reactomei REACT_198984. Collagen biosynthesis and modifying enzymes.
    REACT_199055. Collagen degradation.
    REACT_216309. Integrin cell surface interactions.

    Miscellaneous databases

    NextBioi 359082.
    PROi Q8BLX7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8BLX7.
    Bgeei Q8BLX7.
    CleanExi MM_COL16A1.
    Genevestigatori Q8BLX7.

    Family and domain databases

    InterProi IPR008160. Collagen.
    IPR008985. ConA-like_lec_gl_sf.
    IPR001791. Laminin_G.
    [Graphical view ]
    Pfami PF01391. Collagen. 9 hits.
    [Graphical view ]
    SMARTi SM00210. TSPN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6JImported.
      Tissue: EmbryoImported.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Tissue distribution and developmental expression of type XVI collagen in the mouse."
      Lai C.-H., Chu M.-L.
      Tissue Cell 28:155-164(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiCOGA1_MOUSE
    AccessioniPrimary (citable) accession number: Q8BLX7
    Secondary accession number(s): A3KFV5, Q9CZS2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2007
    Last sequence update: April 3, 2007
    Last modified: October 1, 2014
    This is version 100 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3