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Q8BLX7

- COGA1_MOUSE

UniProt

Q8BLX7 - COGA1_MOUSE

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Protein
Collagen alpha-1(XVI) chain
Gene
Col16a1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Involved in mediating cell attachment and inducing integrin-mediated cellular reactions, such as cell spreading and alterations in cell morphology By similarity.By similarity

GO - Molecular functioni

  1. integrin binding Source: UniProtKB

GO - Biological processi

  1. cell adhesion Source: UniProtKB
  2. cellular response to amino acid stimulus Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

ReactomeiREACT_198984. Collagen biosynthesis and modifying enzymes.
REACT_199055. Collagen degradation.
REACT_216309. Integrin cell surface interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Collagen alpha-1(XVI) chain
Gene namesi
Name:Col16a1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:1095396. Col16a1.

Subcellular locationi

GO - Cellular componenti

  1. collagen trimer Source: UniProtKB-KW
  2. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed prediction
Add
BLAST
Chaini22 – 15801559Collagen alpha-1(XVI) chain
PRO_0000282960Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi47 – 471N-linked (GlcNAc...) Reviewed prediction
Glycosylationi327 – 3271N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
Glycosylated By similarity.By similarity

Keywords - PTMi

Glycoprotein, Hydroxylation

Proteomic databases

PaxDbiQ8BLX7.
PRIDEiQ8BLX7.

PTM databases

PhosphoSiteiQ8BLX7.

Expressioni

Tissue specificityi

Expressed in most tissues examined with highest levels of expression observed in heart. Strongly expressed in cortical and medullar regions of kidney and more weakly expressed in lung. Also detected in the ciliary muscle of the eye, on the serosa layer lining the muscularis externa of intestinal tissue, and in the perimysium membrane lining both the cardiac muscle bundle and the smooth muscle tissue of the small intestine. Strongly stained in particulate or granular structures. Not detected in brain or skeletal muscle.1 Publication

Developmental stagei

At embryonic day 8 (E8) of gestation no significant expression of mRNA or protein is observed, but strong signals are observed in placental trophoblasts. By E11 weak positive signals are observed in heart. During later stages of development, stronger expression is observed in a variety of tissues, particularly in the atrial and ventricular walls of the developing heart, spinal root neural fibers and skin.1 Publication

Gene expression databases

ArrayExpressiQ8BLX7.
BgeeiQ8BLX7.
CleanExiMM_COL16A1.
GenevestigatoriQ8BLX7.

Interactioni

Subunit structurei

Homotrimer. Interacts with FBN1, fibronectin and integrins ITGA1/ITGB1 and ITGA2/ITGB1. Integrin ITGA1/ITGB1 binds to a unique site within COL16A1 located close to its C-terminal end between collagenous domains COL1-COL3 By similarity.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ8BLX7.
SMRiQ8BLX7. Positions 44-242.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini50 – 231182Laminin G-like
Add
BLAST
Domaini375 – 42450Collagen-like 1
Add
BLAST
Domaini590 – 64354Collagen-like 2
Add
BLAST
Domaini676 – 72550Collagen-like 3
Add
BLAST
Domaini797 – 84852Collagen-like 4
Add
BLAST
Domaini1006 – 106358Collagen-like 5
Add
BLAST
Domaini1210 – 126354Collagen-like 6
Add
BLAST
Domaini1350 – 140758Collagen-like 7
Add
BLAST
Domaini1448 – 150053Collagen-like 8
Add
BLAST
Domaini1504 – 155249Collagen-like 9
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni232 – 374143Nonhelical region 10 (NC10)
Add
BLAST
Regioni375 – 509135Triple-helical region 9 (COL9) with 3 imperfections
Add
BLAST
Regioni510 – 52415Nonhelical region 9 (NC9)
Add
BLAST
Regioni525 – 57046Triple-helical region 8 (COL8) with 1 imperfection
Add
BLAST
Regioni571 – 58616Nonhelical region 8 (NC8)
Add
BLAST
Regioni587 – 64054Triple-helical region 7 (COL7) with 1 imperfection
Add
BLAST
Regioni641 – 66121Nonhelical region 7 (NC7)
Add
BLAST
Regioni662 – 73271Triple-helical region 6 (COL6) with 1 imperfection
Add
BLAST
Regioni733 – 74715Nonhelical region 6 (NC6)
Add
BLAST
Regioni748 – 870123Triple-helical region 5 (COL5) with 3 imperfections
Add
BLAST
Regioni871 – 88111Nonhelical region 5 (NC5)
Add
BLAST
Regioni882 – 93352Triple-helical region 4 (COL4) with 2 imperfections
Add
BLAST
Regioni934 – 96734Nonhelical region 4 (NC4)
Add
BLAST
Regioni968 – 98215Triple-helical region 3 (COL3)
Add
BLAST
Regioni983 – 100523Nonhelical region 3 (NC3)
Add
BLAST
Regioni1006 – 1409404Triple-helical region 2 (COL2) with 2 imperfections
Add
BLAST
Regioni1410 – 144839Nonhelical region 2 (NC2)
Add
BLAST
Regioni1449 – 1554106Triple-helical region 1 (COL1) with 2 imperfections
Add
BLAST
Regioni1555 – 158026Nonhelical region 1 (NC1)
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi555 – 5573Cell attachment site Reviewed prediction
Motifi1000 – 10023Cell attachment site Reviewed prediction
Motifi1206 – 12083Cell attachment site Reviewed prediction

Domaini

This sequence defines eighteen different domains, nine triple-helical domains (COL9 to COL1) and ten non-triple-helical domains (NC10 to NC1). The numerous interruptions in the triple helix may make this molecule either elastic or flexible.

Sequence similaritiesi

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00750000117472.
HOGENOMiHOG000085653.
HOVERGENiHBG071631.
InParanoidiQ8BLX7.
OMAiSTWYLFQ.
OrthoDBiEOG779NXQ.
PhylomeDBiQ8BLX7.
TreeFamiTF332900.

Family and domain databases

InterProiIPR008160. Collagen.
IPR008985. ConA-like_lec_gl_sf.
IPR001791. Laminin_G.
[Graphical view]
PfamiPF01391. Collagen. 9 hits.
[Graphical view]
SMARTiSM00210. TSPN. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 11 Publication (identifier: Q8BLX7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MLTSWAPGLW VLGLWATFSH GTNIGERCPT SQQEGLKLEH SSDPSTNVTG     50
FNLIRRLNLM KTSAIKKIRN PKGPLILRLG AAPVTQPTRR VFPRGLPEEF 100
ALVLTVLLKK HTFRNTWYLF QVTDANGYPQ ISLEVNSQER SLELRAQGQD 150
GDFVSCIFPV PQLFDLRWHK LMLSVAGRVA SVHVDCVSAS SQPLGPRQSI 200
RPGGHVFLGL DAEQGKPVSF DLQQAHIYCD PELVLEEGCC EILPGGCPPE 250
TSKSRRDTQS NELIEINPQT EGKVYTRCFC LEEPQNSKVD AQLMGRNIQK 300
AERGTKVHQG TGVNECPPCA HSARESNVTL GPSGLKGGKG ERGLTGPSGP 350
KGEKGARGND CVRVSPDAPL QCVEGPKGEK GESGDLGPPG LPGPTGQKGQ 400
KGEKGDGGLK GLPGKPGRDG RPGEICVIGP KGQKGDPGFV GPEGLAGEPG 450
PPGLPGPPGI GLPGTPGDPG GPPGPKGEKG SSGIPGKEGP GGKPGKPGVP 500
GTKGEKGDPC EVCPTLPEGS QNFVGLPGKP GPKGEPGDPA PAWEGLGTVG 550
LKGDRGDPGI QGMKGEKGEP CSSCSSGVGA QHLGPSPGHG LPGLPGTSGI 600
PGPRGLKGEK GSFGDTGPAG VPGSPGPVGP AGIKGAKGEP CEPCTALSEL 650
QDGDMRVVHL PGPAGEKGEP GSPGFGLPGK QGKAGERGLK GQKGDAGNPG 700
DPGTPGITGQ PGISGEPGIR GPAGPKGEKG DGCTACPSLQ GALTDVSGLP 750
GKPGPKGEPG PEGVGHPGKP GQPGLPGVQG PPGPKGTQGE PGPPGTGAEG 800
PQGEPGTQGL PGTQGLPGPR GPPGSAGEKG AQGSPGPKGA IGPMGPPGAG 850
VSGPPGQKGS RGEKGEPGEC SCPSRGEPIF SGMPGAPGLW MGSSSQPGPQ 900
GPPGVPGPPG PPGMPGLQGV PGHNGLPGQP GLTAELGSLP IEKHLLKSIC 950
GDCAQGQTAH PAFLLEKGEK GDQGIPGVPG FDNCARCFIE RERPRAEEAR 1000
GDNSEGEPGC SGSPGLPGPP GMPGQRGEEG PPGMRGSPGP PGPIGLQGER 1050
GLTGLTGDKG EPGPPGQPGY PGAMGPPGLP GIKGERGYTG PSGEKGESGP 1100
PGSEGLPGPQ GPAGPRGERG PQGSSGEKGD QGFQGQPGFP GPPGPPGFPG 1150
KAGAPGPPGP QAEKGSEGIR GPSGLPGSPG PPGPPGIQGP AGLDGLDGKD 1200
GKPGLRGDPG PAGPPGLMGP PGFKGKTGHP GLPGPKGDCG KPGPPGSSGR 1250
PGAEGEPGAM GPQGRPGPPG HLGPPGQPGP PGLSTVGLKG DRGVPGERGL 1300
AGLPGQPGTP GHPGPPGEPG SDGAAGKEGP PGKQGLYGPP GPKGDPGPAG 1350
QKGQAGEKGR SGMPGGPGKS GSMGPIGPPG PAGERGHPGS PGPAGNPGLP 1400
GLPGSMGDMV NYDDIKRFIR QEIIKLFDER MAYYTSRMQF PMEVAAAPGR 1450
PGPPGKDGAP GRPGAPGSPG LPGQIGREGR QGLPGMRGLP GTKGEKGDIG 1500
VGIAGENGLP GPPGPQGPPG YGKMGATGPM GQQGIPGIPG PPGPMGQPGK 1550
AGHCNPSDCF GAMPMEQQYP PMKSMKGPFG 1580

Note: No experimental confirmation available.

Length:1,580
Mass (Da):155,805
Last modified:April 3, 2007 - v2
Checksum:iFC01635F6E410E3A
GO
Isoform 21 Publication (identifier: Q8BLX7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1430: Missing.

Note: No experimental confirmation available.

Show »
Length:150
Mass (Da):14,823
Checksum:iD956EF9160987FC8
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 14301430Missing in isoform 2. 1 Publication
VSP_052375Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti726 – 7261K → R in BAC30765. 1 Publication
Sequence conflicti1119 – 11191R → Q in BAC30765. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK012212 mRNA. Translation: BAB28100.1.
AK040971 mRNA. Translation: BAC30765.1.
AL606925 Genomic DNA. Translation: CAM45907.1.
CCDSiCCDS38889.1. [Q8BLX7-1]
RefSeqiNP_082542.3. NM_028266.5. [Q8BLX7-1]
UniGeneiMm.41860.

Genome annotation databases

EnsembliENSMUST00000044565; ENSMUSP00000035802; ENSMUSG00000040690. [Q8BLX7-1]
GeneIDi107581.
KEGGimmu:107581.
UCSCiuc008uys.2. mouse. [Q8BLX7-1]
uc008uyv.2. mouse. [Q8BLX7-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK012212 mRNA. Translation: BAB28100.1 .
AK040971 mRNA. Translation: BAC30765.1 .
AL606925 Genomic DNA. Translation: CAM45907.1 .
CCDSi CCDS38889.1. [Q8BLX7-1 ]
RefSeqi NP_082542.3. NM_028266.5. [Q8BLX7-1 ]
UniGenei Mm.41860.

3D structure databases

ProteinModelPortali Q8BLX7.
SMRi Q8BLX7. Positions 44-242.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8BLX7.

Proteomic databases

PaxDbi Q8BLX7.
PRIDEi Q8BLX7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000044565 ; ENSMUSP00000035802 ; ENSMUSG00000040690 . [Q8BLX7-1 ]
GeneIDi 107581.
KEGGi mmu:107581.
UCSCi uc008uys.2. mouse. [Q8BLX7-1 ]
uc008uyv.2. mouse. [Q8BLX7-2 ]

Organism-specific databases

CTDi 1307.
MGIi MGI:1095396. Col16a1.

Phylogenomic databases

eggNOGi NOG12793.
GeneTreei ENSGT00750000117472.
HOGENOMi HOG000085653.
HOVERGENi HBG071631.
InParanoidi Q8BLX7.
OMAi STWYLFQ.
OrthoDBi EOG779NXQ.
PhylomeDBi Q8BLX7.
TreeFami TF332900.

Enzyme and pathway databases

Reactomei REACT_198984. Collagen biosynthesis and modifying enzymes.
REACT_199055. Collagen degradation.
REACT_216309. Integrin cell surface interactions.

Miscellaneous databases

NextBioi 359082.
PROi Q8BLX7.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8BLX7.
Bgeei Q8BLX7.
CleanExi MM_COL16A1.
Genevestigatori Q8BLX7.

Family and domain databases

InterProi IPR008160. Collagen.
IPR008985. ConA-like_lec_gl_sf.
IPR001791. Laminin_G.
[Graphical view ]
Pfami PF01391. Collagen. 9 hits.
[Graphical view ]
SMARTi SM00210. TSPN. 1 hit.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Embryo.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Tissue distribution and developmental expression of type XVI collagen in the mouse."
    Lai C.-H., Chu M.-L.
    Tissue Cell 28:155-164(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiCOGA1_MOUSE
AccessioniPrimary (citable) accession number: Q8BLX7
Secondary accession number(s): A3KFV5, Q9CZS2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: September 3, 2014
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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