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Protein

GDP-fucose transporter 1

Gene

Slc35c1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in GDP-fucose import from the cytoplasm into the Golgi lumen.By similarity

GO - Molecular functioni

GO - Biological processi

  • carbohydrate transport Source: UniProtKB-KW
  • GDP-fucose import into Golgi lumen Source: InterPro
  • lipid glycosylation Source: MGI
  • negative regulation of Notch signaling pathway Source: MGI

Keywordsi

Biological processSugar transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-6787639 GDP-fucose biosynthesis
R-MMU-727802 Transport of nucleotide sugars

Names & Taxonomyi

Protein namesi
Recommended name:
GDP-fucose transporter 1
Alternative name(s):
Solute carrier family 35 member C1
Gene namesi
Name:Slc35c1
Synonyms:Fuct1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2443301 Slc35c1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei33 – 55HelicalSequence analysisAdd BLAST23
Transmembranei75 – 97HelicalSequence analysisAdd BLAST23
Transmembranei110 – 129HelicalSequence analysisAdd BLAST20
Transmembranei139 – 161HelicalSequence analysisAdd BLAST23
Transmembranei166 – 184HelicalSequence analysisAdd BLAST19
Transmembranei194 – 213HelicalSequence analysisAdd BLAST20
Transmembranei226 – 248HelicalSequence analysisAdd BLAST23
Transmembranei263 – 285HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003432211 – 363GDP-fucose transporter 1Add BLAST363

Proteomic databases

MaxQBiQ8BLX4
PaxDbiQ8BLX4
PRIDEiQ8BLX4

PTM databases

iPTMnetiQ8BLX4
PhosphoSitePlusiQ8BLX4
SwissPalmiQ8BLX4

Expressioni

Gene expression databases

BgeeiENSMUSG00000049922
ExpressionAtlasiQ8BLX4 baseline and differential
GenevisibleiQ8BLX4 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000063461

Structurei

3D structure databases

ProteinModelPortaliQ8BLX4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1442 Eukaryota
ENOG410XST0 LUCA
GeneTreeiENSGT00390000013315
HOGENOMiHOG000021132
HOVERGENiHBG051670
InParanoidiQ8BLX4
KOiK15279
OMAiSSAYTWV
OrthoDBiEOG091G0CH6
TreeFamiTF354269

Family and domain databases

InterProiView protein in InterPro
IPR029666 GDP-fucose_transp
IPR004853 Sugar_P_trans_dom
PANTHERiPTHR44132 PTHR44132, 1 hit
PfamiView protein in Pfam
PF03151 TPT, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BLX4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRAPLKRSR ILRMALTGVS AVSEESESGN KPFLLRALQI ALVVSLYWVT
60 70 80 90 100
SISMVFLNKY LLDSPSLQLD TPIFVTFYQC LVTSLLCKGL STLATCCPGM
110 120 130 140 150
VDFPTLNLDL KVARSVLPLS VVFIGMITFN NLCLKYVGVP FYNVGRSLTT
160 170 180 190 200
VFNVLLSYLL LKQTTSFYAL LTCGVIIGGF WLGIDQEGAE GTLSLTGTIF
210 220 230 240 250
GVLASLCVSL NAIYTKKVLP AVDHSIWRLT FYNNVNACVL FLPLMIVLGE
260 270 280 290 300
LRALLAFTHL SSAHFWLMMT LGGLFGFAIG YVTGLQIKFT SPLTHNVSGT
310 320 330 340 350
AKACAQTVLA VLYYEEIKSF LWWTSNLMVL GGSSAYTWVR GWEMQKTQED
360
PSSKDGEKSA IRV
Length:363
Mass (Da):39,967
Last modified:March 1, 2003 - v1
Checksum:iA298B2E9E4DD26D1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti43V → G in BAC38127 (PubMed:16141072).Curated1
Sequence conflicti110L → V in BAE26053 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK040986 mRNA Translation: BAC30770.1
AK081068 mRNA Translation: BAC38127.1
AK144762 mRNA Translation: BAE26053.1
AK151154 mRNA Translation: BAE30160.1
AL683814 Genomic DNA No translation available.
BC116736 mRNA Translation: AAI16737.1
BC119128 mRNA Translation: AAI19129.1
CCDSiCCDS16448.1
RefSeqiNP_997597.1, NM_211358.2
UniGeneiMm.273990

Genome annotation databases

EnsembliENSMUST00000067631; ENSMUSP00000063461; ENSMUSG00000049922
GeneIDi228368
KEGGimmu:228368
UCSCiuc008kyb.1 mouse

Similar proteinsi

Entry informationi

Entry nameiFUCT1_MOUSE
AccessioniPrimary (citable) accession number: Q8BLX4
Secondary accession number(s): Q3UMP5, Q8BV24
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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