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Protein

GDP-fucose transporter 1

Gene

Slc35c1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in GDP-fucose import from the cytoplasm into the Golgi lumen.By similarity

GO - Biological processi

  • carbohydrate transport Source: UniProtKB-KW
  • lipid glycosylation Source: MGI
  • mitophagy in response to mitochondrial depolarization Source: Ensembl
  • negative regulation of Notch signaling pathway Source: MGI
  • positive regulation of defense response to virus by host Source: Ensembl
  • xenophagy Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-6787639. GDP-fucose biosynthesis.
R-MMU-727802. Transport of nucleotide sugars.

Names & Taxonomyi

Protein namesi
Recommended name:
GDP-fucose transporter 1
Alternative name(s):
Solute carrier family 35 member C1
Gene namesi
Name:Slc35c1
Synonyms:Fuct1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2443301. Slc35c1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei33 – 55HelicalSequence analysisAdd BLAST23
Transmembranei75 – 97HelicalSequence analysisAdd BLAST23
Transmembranei110 – 129HelicalSequence analysisAdd BLAST20
Transmembranei139 – 161HelicalSequence analysisAdd BLAST23
Transmembranei166 – 184HelicalSequence analysisAdd BLAST19
Transmembranei194 – 213HelicalSequence analysisAdd BLAST20
Transmembranei226 – 248HelicalSequence analysisAdd BLAST23
Transmembranei263 – 285HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003432211 – 363GDP-fucose transporter 1Add BLAST363

Proteomic databases

MaxQBiQ8BLX4.
PaxDbiQ8BLX4.
PRIDEiQ8BLX4.

PTM databases

iPTMnetiQ8BLX4.
PhosphoSitePlusiQ8BLX4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000049922.
ExpressionAtlasiQ8BLX4. baseline and differential.
GenevisibleiQ8BLX4. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000063461.

Structurei

3D structure databases

ProteinModelPortaliQ8BLX4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1442. Eukaryota.
ENOG410XST0. LUCA.
GeneTreeiENSGT00390000013315.
HOGENOMiHOG000021132.
HOVERGENiHBG051670.
InParanoidiQ8BLX4.
KOiK15279.
OMAiVVSLYWV.
OrthoDBiEOG091G0CH6.
TreeFamiTF354269.

Family and domain databases

InterProiIPR004853. Sugar_P_trans_dom.
[Graphical view]
PfamiPF03151. TPT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BLX4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRAPLKRSR ILRMALTGVS AVSEESESGN KPFLLRALQI ALVVSLYWVT
60 70 80 90 100
SISMVFLNKY LLDSPSLQLD TPIFVTFYQC LVTSLLCKGL STLATCCPGM
110 120 130 140 150
VDFPTLNLDL KVARSVLPLS VVFIGMITFN NLCLKYVGVP FYNVGRSLTT
160 170 180 190 200
VFNVLLSYLL LKQTTSFYAL LTCGVIIGGF WLGIDQEGAE GTLSLTGTIF
210 220 230 240 250
GVLASLCVSL NAIYTKKVLP AVDHSIWRLT FYNNVNACVL FLPLMIVLGE
260 270 280 290 300
LRALLAFTHL SSAHFWLMMT LGGLFGFAIG YVTGLQIKFT SPLTHNVSGT
310 320 330 340 350
AKACAQTVLA VLYYEEIKSF LWWTSNLMVL GGSSAYTWVR GWEMQKTQED
360
PSSKDGEKSA IRV
Length:363
Mass (Da):39,967
Last modified:March 1, 2003 - v1
Checksum:iA298B2E9E4DD26D1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti43V → G in BAC38127 (PubMed:16141072).Curated1
Sequence conflicti110L → V in BAE26053 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK040986 mRNA. Translation: BAC30770.1.
AK081068 mRNA. Translation: BAC38127.1.
AK144762 mRNA. Translation: BAE26053.1.
AK151154 mRNA. Translation: BAE30160.1.
AL683814 Genomic DNA. Translation: CAM15995.1.
BC116736 mRNA. Translation: AAI16737.1.
BC119128 mRNA. Translation: AAI19129.1.
CCDSiCCDS16448.1.
RefSeqiNP_997597.1. NM_211358.2.
UniGeneiMm.273990.

Genome annotation databases

EnsembliENSMUST00000067631; ENSMUSP00000063461; ENSMUSG00000049922.
GeneIDi228368.
KEGGimmu:228368.
UCSCiuc008kyb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK040986 mRNA. Translation: BAC30770.1.
AK081068 mRNA. Translation: BAC38127.1.
AK144762 mRNA. Translation: BAE26053.1.
AK151154 mRNA. Translation: BAE30160.1.
AL683814 Genomic DNA. Translation: CAM15995.1.
BC116736 mRNA. Translation: AAI16737.1.
BC119128 mRNA. Translation: AAI19129.1.
CCDSiCCDS16448.1.
RefSeqiNP_997597.1. NM_211358.2.
UniGeneiMm.273990.

3D structure databases

ProteinModelPortaliQ8BLX4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000063461.

PTM databases

iPTMnetiQ8BLX4.
PhosphoSitePlusiQ8BLX4.

Proteomic databases

MaxQBiQ8BLX4.
PaxDbiQ8BLX4.
PRIDEiQ8BLX4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000067631; ENSMUSP00000063461; ENSMUSG00000049922.
GeneIDi228368.
KEGGimmu:228368.
UCSCiuc008kyb.1. mouse.

Organism-specific databases

CTDi55343.
MGIiMGI:2443301. Slc35c1.

Phylogenomic databases

eggNOGiKOG1442. Eukaryota.
ENOG410XST0. LUCA.
GeneTreeiENSGT00390000013315.
HOGENOMiHOG000021132.
HOVERGENiHBG051670.
InParanoidiQ8BLX4.
KOiK15279.
OMAiVVSLYWV.
OrthoDBiEOG091G0CH6.
TreeFamiTF354269.

Enzyme and pathway databases

ReactomeiR-MMU-6787639. GDP-fucose biosynthesis.
R-MMU-727802. Transport of nucleotide sugars.

Miscellaneous databases

PROiQ8BLX4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000049922.
ExpressionAtlasiQ8BLX4. baseline and differential.
GenevisibleiQ8BLX4. MM.

Family and domain databases

InterProiIPR004853. Sugar_P_trans_dom.
[Graphical view]
PfamiPF03151. TPT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFUCT1_MOUSE
AccessioniPrimary (citable) accession number: Q8BLX4
Secondary accession number(s): Q3UMP5, Q8BV24
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: March 1, 2003
Last modified: November 30, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.