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Protein

Protein-lysine methyltransferase METTL21C

Gene

Mettl21c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Protein-lysine methyltransferase.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei76S-adenosyl-L-methionine; via amide nitrogenBy similarity1
Binding sitei125S-adenosyl-L-methionineBy similarity1
Binding sitei156S-adenosyl-L-methionine; via amide nitrogenBy similarity1

GO - Molecular functioni

GO - Biological processi

  • cellular response to dexamethasone stimulus Source: MGI
  • hormone-mediated apoptotic signaling pathway Source: MGI
  • protein methylation Source: UniProtKB
  • regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum Source: MGI
  • skeletal muscle tissue development Source: MGI

Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-lysine methyltransferase METTL21C (EC:2.1.1.-)
Alternative name(s):
Methyltransferase-like protein 21C
Gene namesi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:3611450 Mettl21c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003195911 – 248Protein-lysine methyltransferase METTL21CAdd BLAST248

Proteomic databases

PaxDbiQ8BLU2
PRIDEiQ8BLU2

PTM databases

PhosphoSitePlusiQ8BLU2

Expressioni

Gene expression databases

BgeeiENSMUSG00000047343
CleanExiMM_A530098C11RIK
ExpressionAtlasiQ8BLU2 baseline and differential

Interactioni

Subunit structurei

Interacts with members of the heat shock protein 70 families; these proteins may possibly be methylation substrates for the enzyme.By similarity

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ8BLU2
SMRiQ8BLU2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni104 – 106S-adenosyl-L-methionine bindingBy similarity3

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410KDK7 Eukaryota
ENOG41121JN LUCA
GeneTreeiENSGT00550000074572
HOVERGENiHBG107723
InParanoidiQ8BLU2
KOiK21805
OMAiTMVYLSQ
OrthoDBiEOG091G0NXA
PhylomeDBiQ8BLU2
TreeFamiTF354267

Family and domain databases

InterProiView protein in InterPro
IPR019410 Methyltransf_16
IPR029063 SAM-dependent_MTases
PfamiView protein in Pfam
PF10294 Methyltransf_16, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BLU2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQHLHIAQQ PLLSGTPQED GFAGPSVEFD RIESSLRSIQ KFVPTDYASY
60 70 80 90 100
TQEHYQFAGK KIIIQESIEN YGTVVWPGAT ALCQYLEDHT EELNLQDAKI
110 120 130 140 150
LEIGAGAGLV SIVSSLLGAQ VTATDLPDVL GNLQYNILKN TLECTAHLPE
160 170 180 190 200
VRELVWGEDL EQSFPKSTCC YDYVLASDVV YHHYFLDKLL ATMVYLSQPG
210 220 230 240
TVVLWANKFR FSADYEFLGK FKQAFDTTLL AEYSESSVKL FKGILKWE
Length:248
Mass (Da):27,892
Last modified:March 1, 2003 - v1
Checksum:i67BA264E04FA0986
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK041301 mRNA Translation: BAC30895.1
CCDSiCCDS14927.1
RefSeqiNP_001013821.1, NM_001013799.1
XP_006496189.1, XM_006496126.3
XP_006496190.1, XM_006496127.2
XP_006496191.1, XM_006496128.2
UniGeneiMm.123621

Genome annotation databases

EnsembliENSMUST00000061421; ENSMUSP00000061229; ENSMUSG00000047343
GeneIDi433294
KEGGimmu:433294
UCSCiuc007avv.1 mouse

Similar proteinsi

Entry informationi

Entry nameiMT21C_MOUSE
AccessioniPrimary (citable) accession number: Q8BLU2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 1, 2003
Last modified: April 25, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health