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Protein

Protein-lysine methyltransferase METTL21C

Gene

Mettl21c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Protein-lysine methyltransferase.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei76S-adenosyl-L-methionine; via amide nitrogenBy similarity1
Binding sitei125S-adenosyl-L-methionineBy similarity1
Binding sitei156S-adenosyl-L-methionine; via amide nitrogenBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-lysine methyltransferase METTL21C (EC:2.1.1.-)
Alternative name(s):
Methyltransferase-like protein 21C
Gene namesi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:3611450. Mettl21c.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003195911 – 248Protein-lysine methyltransferase METTL21CAdd BLAST248

Proteomic databases

PaxDbiQ8BLU2.
PRIDEiQ8BLU2.

PTM databases

PhosphoSitePlusiQ8BLU2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000047343.
CleanExiMM_A530098C11RIK.
ExpressionAtlasiQ8BLU2. baseline and differential.

Interactioni

Subunit structurei

Interacts with members of the heat shock protein 70 families; these proteins may possibly be methylation substrates for the enzyme.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000061229.

Structurei

3D structure databases

ProteinModelPortaliQ8BLU2.
SMRiQ8BLU2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni104 – 106S-adenosyl-L-methionine bindingBy similarity3

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410KDK7. Eukaryota.
ENOG41121JN. LUCA.
GeneTreeiENSGT00550000074572.
HOVERGENiHBG107723.
InParanoidiQ8BLU2.
OMAiTMVYLSQ.
OrthoDBiEOG091G0NXA.
PhylomeDBiQ8BLU2.
TreeFamiTF354267.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR019410. Methyltransf_16.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF10294. Methyltransf_16. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8BLU2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQHLHIAQQ PLLSGTPQED GFAGPSVEFD RIESSLRSIQ KFVPTDYASY
60 70 80 90 100
TQEHYQFAGK KIIIQESIEN YGTVVWPGAT ALCQYLEDHT EELNLQDAKI
110 120 130 140 150
LEIGAGAGLV SIVSSLLGAQ VTATDLPDVL GNLQYNILKN TLECTAHLPE
160 170 180 190 200
VRELVWGEDL EQSFPKSTCC YDYVLASDVV YHHYFLDKLL ATMVYLSQPG
210 220 230 240
TVVLWANKFR FSADYEFLGK FKQAFDTTLL AEYSESSVKL FKGILKWE
Length:248
Mass (Da):27,892
Last modified:March 1, 2003 - v1
Checksum:i67BA264E04FA0986
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK041301 mRNA. Translation: BAC30895.1.
CCDSiCCDS14927.1.
RefSeqiNP_001013821.1. NM_001013799.1.
XP_006496189.1. XM_006496126.3.
XP_006496190.1. XM_006496127.2.
XP_006496191.1. XM_006496128.2.
UniGeneiMm.123621.

Genome annotation databases

EnsembliENSMUST00000061421; ENSMUSP00000061229; ENSMUSG00000047343.
GeneIDi433294.
KEGGimmu:433294.
UCSCiuc007avv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK041301 mRNA. Translation: BAC30895.1.
CCDSiCCDS14927.1.
RefSeqiNP_001013821.1. NM_001013799.1.
XP_006496189.1. XM_006496126.3.
XP_006496190.1. XM_006496127.2.
XP_006496191.1. XM_006496128.2.
UniGeneiMm.123621.

3D structure databases

ProteinModelPortaliQ8BLU2.
SMRiQ8BLU2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000061229.

PTM databases

PhosphoSitePlusiQ8BLU2.

Proteomic databases

PaxDbiQ8BLU2.
PRIDEiQ8BLU2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000061421; ENSMUSP00000061229; ENSMUSG00000047343.
GeneIDi433294.
KEGGimmu:433294.
UCSCiuc007avv.1. mouse.

Organism-specific databases

CTDi196541.
MGIiMGI:3611450. Mettl21c.

Phylogenomic databases

eggNOGiENOG410KDK7. Eukaryota.
ENOG41121JN. LUCA.
GeneTreeiENSGT00550000074572.
HOVERGENiHBG107723.
InParanoidiQ8BLU2.
OMAiTMVYLSQ.
OrthoDBiEOG091G0NXA.
PhylomeDBiQ8BLU2.
TreeFamiTF354267.

Miscellaneous databases

PROiQ8BLU2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000047343.
CleanExiMM_A530098C11RIK.
ExpressionAtlasiQ8BLU2. baseline and differential.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR019410. Methyltransf_16.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF10294. Methyltransf_16. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMT21C_MOUSE
AccessioniPrimary (citable) accession number: Q8BLU2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.