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Protein

PH and SEC7 domain-containing protein 4

Gene

Psd4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. Through ARL14 activation, controls the movement of MHC class II-containing vesicles along the actin cytoskeleton in dendritic cells. Involved in membrane recycling. Interacts with several phosphatidylinositol phosphate species, including phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 4,5-bisphosphate (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
PH and SEC7 domain-containing protein 4
Alternative name(s):
Pleckstrin homology and SEC7 domain-containing protein 4
Gene namesi
Name:Psd4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2674093. Psd4.

Subcellular locationi

  • Cell membrane By similarity

  • Note: Accumulates in dynamic actin-rich membrane ruffles and microvilli-like structures. Recruited to membranes via phosphatidylinositol phosphate-binding (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10051005PH and SEC7 domain-containing protein 4PRO_0000251732Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei85 – 851PhosphoserineBy similarity
Modified residuei88 – 881PhosphoserineBy similarity
Modified residuei97 – 971PhosphoserineBy similarity
Modified residuei381 – 3811PhosphoserineBy similarity
Modified residuei435 – 4351PhosphoserineCombined sources
Modified residuei968 – 9681PhosphoserineBy similarity
Modified residuei971 – 9711PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8BLR5.
MaxQBiQ8BLR5.
PaxDbiQ8BLR5.
PeptideAtlasiQ8BLR5.
PRIDEiQ8BLR5.

PTM databases

iPTMnetiQ8BLR5.
PhosphoSiteiQ8BLR5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000026979.
CleanExiMM_PSD4.
ExpressionAtlasiQ8BLR5. baseline and differential.
GenevisibleiQ8BLR5. MM.

Interactioni

Protein-protein interaction databases

IntActiQ8BLR5. 1 interaction.
STRINGi10090.ENSMUSP00000062415.

Structurei

3D structure databases

ProteinModelPortaliQ8BLR5.
SMRiQ8BLR5. Positions 541-689, 730-842.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini493 – 686194SEC7PROSITE-ProRule annotationAdd
BLAST
Domaini726 – 841116PHPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili870 – 92657Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 PH domain.PROSITE-ProRule annotation
Contains 1 SEC7 domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0932. Eukaryota.
COG5307. LUCA.
GeneTreeiENSGT00760000119036.
HOVERGENiHBG080313.
InParanoidiQ8BLR5.
KOiK12494.
OMAiRAELRCC.
OrthoDBiEOG091G06VY.
PhylomeDBiQ8BLR5.
TreeFamiTF319755.

Family and domain databases

Gene3Di1.10.1000.11. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR023394. Sec7_alpha_orthog.
IPR000904. Sec7_dom.
[Graphical view]
PfamiPF01369. Sec7. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00222. Sec7. 1 hit.
[Graphical view]
SUPFAMiSSF48425. SSF48425. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS50190. SEC7. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BLR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMGDHLRPME CLNICLEDNL QPCPEAYPSE IHGHPGPSEP CQEHTCPFDP
60 70 80 90 100
PESARPDAPH GNSGVESTHL ENCLVQVQAR QASASLRSLE DNSSLGSPQQ
110 120 130 140 150
NQSSSTQVVF WAGILQAQMC VLDLEEELEK TEGLRAELRC CIPPPSKDLL
160 170 180 190 200
GDEGLSPSRP EEDEDSGDDS SGPEEENQTW PREKIPGSSL EWGAEEDSIF
210 220 230 240 250
FDNPLFLESP CSDTSTEGEC FSWGYPNSHP DMKTWHQSPQ TLDSPLQKGT
260 270 280 290 300
GLWRQENELD LGSDTADHGG CSTPPFPVPS YKMHPCLALG STEGDPTVPP
310 320 330 340 350
DQEGETSCED DLGHGSPKAP FVDHELIQES DNFEFDLRPA TTHPVQPWGS
360 370 380 390 400
QTSQSLSDLT QPILEDLQRE DPSRSQETLI SQNRGERDAG CFQEPVFCTL
410 420 430 440 450
APWGSQTSLL EPNCPESEGR GSGPQPSPVS SQDSSPRVLL HSPKWPQDAS
460 470 480 490 500
HLLQKDRSEL SSLKEEETEE VPSLRQEAEC EDTSRSEDAS ANQHHVHLAS
510 520 530 540 550
AEGLPESPMP QAQSPEEGWR PSSSREKLAN DIRNDKGAWN LALRLYQLNG
560 570 580 590 600
FRKSEVAAHL RKNNDFSRAV AEAYLSFFQF EGQSLDRALR GFLQALVLSG
610 620 630 640 650
ETQERERILY QFSKRFHYCN PGAFPSVDSV HTLTCAIMLL NTDLHGQNIG
660 670 680 690 700
KSMSCQEFVT NLNGLQDGRN FPKELLKALY WSIRSEKLEW AIDEEDADRP
710 720 730 740 750
EKDQPSPSAG KISSPFLQMA QDPTMPTYKQ GILARKMHHI ADGKKTPWGK
760 770 780 790 800
RGWKMFHTLL RGMVLYFLKG EGQWLDGESL VGHMVDEPVG VHHSLASPAT
810 820 830 840 850
HYTKKPHVFQ LRTADWRLYL FQAPTAKEMA SWIARINLAA ATHSAPPFPA
860 870 880 890 900
AVGSQRRFVR PILPMSPVQS SLEEQHRSHE NCLDAASDDL LDLQRNLPER
910 920 930 940 950
RGRSRELEEY RLRKEYLEHE KTRYETYVQL LVARLHFPLG DLALWEDQLG
960 970 980 990 1000
KETDGSQEPR PSLKKSHSSP SLHQEEAPTT AKVKRNISER RTYRKIIPKR

NRNQL
Length:1,005
Mass (Da):112,733
Last modified:March 1, 2003 - v1
Checksum:i8D03C8C52917EB04
GO

Sequence cautioni

The sequence BAE29402 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti200 – 2001F → L in BAE41415 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK043669 mRNA. Translation: BAC31612.1.
AK148489 mRNA. Translation: BAE28582.1.
AK150238 mRNA. Translation: BAE29402.1. Different initiation.
AK163628 mRNA. Translation: BAE37428.1.
AK169859 mRNA. Translation: BAE41415.1.
AL732528 Genomic DNA. Translation: CAM17807.1.
BC046518 mRNA. Translation: AAH46518.1.
BC068231 mRNA. Translation: AAH68231.1.
CCDSiCCDS15737.1.
RefSeqiNP_808279.1. NM_177611.3.
XP_006497894.1. XM_006497831.2.
XP_006497895.1. XM_006497832.2.
XP_006497896.1. XM_006497833.2.
XP_006497897.1. XM_006497834.2.
XP_006497898.1. XM_006497835.2.
XP_006497899.1. XM_006497836.2.
XP_011237351.1. XM_011239049.1.
UniGeneiMm.490434.

Genome annotation databases

EnsembliENSMUST00000056641; ENSMUSP00000062415; ENSMUSG00000026979.
ENSMUST00000102942; ENSMUSP00000100006; ENSMUSG00000026979.
ENSMUST00000166388; ENSMUSP00000132395; ENSMUSG00000026979.
GeneIDi215632.
KEGGimmu:215632.
UCSCiuc008ioy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK043669 mRNA. Translation: BAC31612.1.
AK148489 mRNA. Translation: BAE28582.1.
AK150238 mRNA. Translation: BAE29402.1. Different initiation.
AK163628 mRNA. Translation: BAE37428.1.
AK169859 mRNA. Translation: BAE41415.1.
AL732528 Genomic DNA. Translation: CAM17807.1.
BC046518 mRNA. Translation: AAH46518.1.
BC068231 mRNA. Translation: AAH68231.1.
CCDSiCCDS15737.1.
RefSeqiNP_808279.1. NM_177611.3.
XP_006497894.1. XM_006497831.2.
XP_006497895.1. XM_006497832.2.
XP_006497896.1. XM_006497833.2.
XP_006497897.1. XM_006497834.2.
XP_006497898.1. XM_006497835.2.
XP_006497899.1. XM_006497836.2.
XP_011237351.1. XM_011239049.1.
UniGeneiMm.490434.

3D structure databases

ProteinModelPortaliQ8BLR5.
SMRiQ8BLR5. Positions 541-689, 730-842.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8BLR5. 1 interaction.
STRINGi10090.ENSMUSP00000062415.

PTM databases

iPTMnetiQ8BLR5.
PhosphoSiteiQ8BLR5.

Proteomic databases

EPDiQ8BLR5.
MaxQBiQ8BLR5.
PaxDbiQ8BLR5.
PeptideAtlasiQ8BLR5.
PRIDEiQ8BLR5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000056641; ENSMUSP00000062415; ENSMUSG00000026979.
ENSMUST00000102942; ENSMUSP00000100006; ENSMUSG00000026979.
ENSMUST00000166388; ENSMUSP00000132395; ENSMUSG00000026979.
GeneIDi215632.
KEGGimmu:215632.
UCSCiuc008ioy.1. mouse.

Organism-specific databases

CTDi23550.
MGIiMGI:2674093. Psd4.

Phylogenomic databases

eggNOGiKOG0932. Eukaryota.
COG5307. LUCA.
GeneTreeiENSGT00760000119036.
HOVERGENiHBG080313.
InParanoidiQ8BLR5.
KOiK12494.
OMAiRAELRCC.
OrthoDBiEOG091G06VY.
PhylomeDBiQ8BLR5.
TreeFamiTF319755.

Miscellaneous databases

PROiQ8BLR5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026979.
CleanExiMM_PSD4.
ExpressionAtlasiQ8BLR5. baseline and differential.
GenevisibleiQ8BLR5. MM.

Family and domain databases

Gene3Di1.10.1000.11. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR023394. Sec7_alpha_orthog.
IPR000904. Sec7_dom.
[Graphical view]
PfamiPF01369. Sec7. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00222. Sec7. 1 hit.
[Graphical view]
SUPFAMiSSF48425. SSF48425. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS50190. SEC7. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPSD4_MOUSE
AccessioniPrimary (citable) accession number: Q8BLR5
Secondary accession number(s): A2AIU4
, Q3TE33, Q3TQF5, Q3UD59, Q3UFH9, Q80V44
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.