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Protein

PH and SEC7 domain-containing protein 4

Gene

Psd4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. Through ARL14 activation, controls the movement of MHC class II-containing vesicles along the actin cytoskeleton in dendritic cells. Involved in membrane recycling. Interacts with several phosphatidylinositol phosphate species, including phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 4,5-bisphosphate (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGuanine-nucleotide releasing factor
LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
PH and SEC7 domain-containing protein 4
Alternative name(s):
Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 B
Short name:
Exchange factor for ARF6 B
Pleckstrin homology and SEC7 domain-containing protein 4
Gene namesi
Name:Psd4
Synonyms:Efa6b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2674093 Psd4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002517321 – 1005PH and SEC7 domain-containing protein 4Add BLAST1005

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei85PhosphoserineBy similarity1
Modified residuei88PhosphoserineBy similarity1
Modified residuei97PhosphoserineBy similarity1
Modified residuei381PhosphoserineBy similarity1
Modified residuei435PhosphoserineCombined sources1
Modified residuei968PhosphoserineBy similarity1
Modified residuei971PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8BLR5
MaxQBiQ8BLR5
PaxDbiQ8BLR5
PeptideAtlasiQ8BLR5
PRIDEiQ8BLR5

PTM databases

iPTMnetiQ8BLR5
PhosphoSitePlusiQ8BLR5

Expressioni

Gene expression databases

BgeeiENSMUSG00000026979
CleanExiMM_PSD4
ExpressionAtlasiQ8BLR5 baseline and differential
GenevisibleiQ8BLR5 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ8BLR5, 1 interactor
STRINGi10090.ENSMUSP00000062415

Structurei

3D structure databases

ProteinModelPortaliQ8BLR5
SMRiQ8BLR5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini493 – 686SEC7PROSITE-ProRule annotationAdd BLAST194
Domaini726 – 841PHPROSITE-ProRule annotationAdd BLAST116

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili870 – 926Sequence analysisAdd BLAST57

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0932 Eukaryota
COG5307 LUCA
GeneTreeiENSGT00760000119036
HOVERGENiHBG080313
InParanoidiQ8BLR5
KOiK12494
OMAiRAELRCC
OrthoDBiEOG091G06VY
PhylomeDBiQ8BLR5
TreeFamiTF319755

Family and domain databases

Gene3Di1.10.1000.11, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR023394 Sec7_C_sf
IPR000904 Sec7_dom
IPR035999 Sec7_dom_sf
PfamiView protein in Pfam
PF01369 Sec7, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00222 Sec7, 1 hit
SUPFAMiSSF48425 SSF48425, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS50190 SEC7, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BLR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMGDHLRPME CLNICLEDNL QPCPEAYPSE IHGHPGPSEP CQEHTCPFDP
60 70 80 90 100
PESARPDAPH GNSGVESTHL ENCLVQVQAR QASASLRSLE DNSSLGSPQQ
110 120 130 140 150
NQSSSTQVVF WAGILQAQMC VLDLEEELEK TEGLRAELRC CIPPPSKDLL
160 170 180 190 200
GDEGLSPSRP EEDEDSGDDS SGPEEENQTW PREKIPGSSL EWGAEEDSIF
210 220 230 240 250
FDNPLFLESP CSDTSTEGEC FSWGYPNSHP DMKTWHQSPQ TLDSPLQKGT
260 270 280 290 300
GLWRQENELD LGSDTADHGG CSTPPFPVPS YKMHPCLALG STEGDPTVPP
310 320 330 340 350
DQEGETSCED DLGHGSPKAP FVDHELIQES DNFEFDLRPA TTHPVQPWGS
360 370 380 390 400
QTSQSLSDLT QPILEDLQRE DPSRSQETLI SQNRGERDAG CFQEPVFCTL
410 420 430 440 450
APWGSQTSLL EPNCPESEGR GSGPQPSPVS SQDSSPRVLL HSPKWPQDAS
460 470 480 490 500
HLLQKDRSEL SSLKEEETEE VPSLRQEAEC EDTSRSEDAS ANQHHVHLAS
510 520 530 540 550
AEGLPESPMP QAQSPEEGWR PSSSREKLAN DIRNDKGAWN LALRLYQLNG
560 570 580 590 600
FRKSEVAAHL RKNNDFSRAV AEAYLSFFQF EGQSLDRALR GFLQALVLSG
610 620 630 640 650
ETQERERILY QFSKRFHYCN PGAFPSVDSV HTLTCAIMLL NTDLHGQNIG
660 670 680 690 700
KSMSCQEFVT NLNGLQDGRN FPKELLKALY WSIRSEKLEW AIDEEDADRP
710 720 730 740 750
EKDQPSPSAG KISSPFLQMA QDPTMPTYKQ GILARKMHHI ADGKKTPWGK
760 770 780 790 800
RGWKMFHTLL RGMVLYFLKG EGQWLDGESL VGHMVDEPVG VHHSLASPAT
810 820 830 840 850
HYTKKPHVFQ LRTADWRLYL FQAPTAKEMA SWIARINLAA ATHSAPPFPA
860 870 880 890 900
AVGSQRRFVR PILPMSPVQS SLEEQHRSHE NCLDAASDDL LDLQRNLPER
910 920 930 940 950
RGRSRELEEY RLRKEYLEHE KTRYETYVQL LVARLHFPLG DLALWEDQLG
960 970 980 990 1000
KETDGSQEPR PSLKKSHSSP SLHQEEAPTT AKVKRNISER RTYRKIIPKR

NRNQL
Length:1,005
Mass (Da):112,733
Last modified:March 1, 2003 - v1
Checksum:i8D03C8C52917EB04
GO

Sequence cautioni

The sequence BAE29402 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti200F → L in BAE41415 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK043669 mRNA Translation: BAC31612.1
AK148489 mRNA Translation: BAE28582.1
AK150238 mRNA Translation: BAE29402.1 Different initiation.
AK163628 mRNA Translation: BAE37428.1
AK169859 mRNA Translation: BAE41415.1
AL732528 Genomic DNA No translation available.
BC046518 mRNA Translation: AAH46518.1
BC068231 mRNA Translation: AAH68231.1
CCDSiCCDS15737.1
RefSeqiNP_808279.1, NM_177611.3
XP_006497894.1, XM_006497831.3
XP_006497895.1, XM_006497832.3
XP_006497896.1, XM_006497833.3
XP_006497897.1, XM_006497834.3
XP_006497898.1, XM_006497835.3
XP_006497899.1, XM_006497836.3
XP_011237351.1, XM_011239049.2
XP_017172556.1, XM_017317067.1
UniGeneiMm.490434

Genome annotation databases

EnsembliENSMUST00000056641; ENSMUSP00000062415; ENSMUSG00000026979
ENSMUST00000102942; ENSMUSP00000100006; ENSMUSG00000026979
ENSMUST00000166388; ENSMUSP00000132395; ENSMUSG00000026979
GeneIDi215632
KEGGimmu:215632
UCSCiuc008ioy.1 mouse

Similar proteinsi

Entry informationi

Entry nameiPSD4_MOUSE
AccessioniPrimary (citable) accession number: Q8BLR5
Secondary accession number(s): A2AIU4
, Q3TE33, Q3TQF5, Q3UD59, Q3UFH9, Q80V44
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health