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Protein

PH and SEC7 domain-containing protein 4

Gene

Psd4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. Through ARL14 activation, controls the movement of MHC class II-containing vesicles along the actin cytoskeleton in dendritic cells. Involved in membrane recycling. Interacts with several phosphatidylinositol phosphate species, including phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 4,5-bisphosphate (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGuanine-nucleotide releasing factor
LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
PH and SEC7 domain-containing protein 4
Alternative name(s):
Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 B
Short name:
Exchange factor for ARF6 B
Pleckstrin homology and SEC7 domain-containing protein 4
Gene namesi
Name:Psd4
Synonyms:Efa6b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2674093. Psd4.

Subcellular locationi

  • Cell membrane By similarity
  • Cell projectionruffle membrane By similarity

  • Note: In interphase associated with the plasma membrane, in particular with membrane ruffling regions. Accumulates in dynamic actin-rich membrane ruffles and microvilli-like structures. Recruited to membranes via phosphatidylinositol phosphate-binding.By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002517321 – 1005PH and SEC7 domain-containing protein 4Add BLAST1005

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei85PhosphoserineBy similarity1
Modified residuei88PhosphoserineBy similarity1
Modified residuei97PhosphoserineBy similarity1
Modified residuei381PhosphoserineBy similarity1
Modified residuei435PhosphoserineCombined sources1
Modified residuei968PhosphoserineBy similarity1
Modified residuei971PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8BLR5.
MaxQBiQ8BLR5.
PaxDbiQ8BLR5.
PeptideAtlasiQ8BLR5.
PRIDEiQ8BLR5.

PTM databases

iPTMnetiQ8BLR5.
PhosphoSitePlusiQ8BLR5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000026979.
CleanExiMM_PSD4.
ExpressionAtlasiQ8BLR5. baseline and differential.
GenevisibleiQ8BLR5. MM.

Interactioni

Protein-protein interaction databases

IntActiQ8BLR5. 1 interactor.
STRINGi10090.ENSMUSP00000062415.

Structurei

3D structure databases

ProteinModelPortaliQ8BLR5.
SMRiQ8BLR5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini493 – 686SEC7PROSITE-ProRule annotationAdd BLAST194
Domaini726 – 841PHPROSITE-ProRule annotationAdd BLAST116

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili870 – 926Sequence analysisAdd BLAST57

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0932. Eukaryota.
COG5307. LUCA.
GeneTreeiENSGT00860000133718.
HOVERGENiHBG080313.
InParanoidiQ8BLR5.
KOiK12494.
OMAiRAELRCC.
OrthoDBiEOG091G06VY.
PhylomeDBiQ8BLR5.
TreeFamiTF319755.

Family and domain databases

Gene3Di1.10.1000.11. 1 hit.
2.30.29.30. 1 hit.
InterProiView protein in InterPro
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR023394. Sec7_alpha_orthog.
IPR000904. Sec7_dom.
PfamiView protein in Pfam
PF01369. Sec7. 1 hit.
SMARTiView protein in SMART
SM00233. PH. 1 hit.
SM00222. Sec7. 1 hit.
SUPFAMiSSF48425. SSF48425. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiView protein in PROSITE
PS50003. PH_DOMAIN. 1 hit.
PS50190. SEC7. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8BLR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMGDHLRPME CLNICLEDNL QPCPEAYPSE IHGHPGPSEP CQEHTCPFDP
60 70 80 90 100
PESARPDAPH GNSGVESTHL ENCLVQVQAR QASASLRSLE DNSSLGSPQQ
110 120 130 140 150
NQSSSTQVVF WAGILQAQMC VLDLEEELEK TEGLRAELRC CIPPPSKDLL
160 170 180 190 200
GDEGLSPSRP EEDEDSGDDS SGPEEENQTW PREKIPGSSL EWGAEEDSIF
210 220 230 240 250
FDNPLFLESP CSDTSTEGEC FSWGYPNSHP DMKTWHQSPQ TLDSPLQKGT
260 270 280 290 300
GLWRQENELD LGSDTADHGG CSTPPFPVPS YKMHPCLALG STEGDPTVPP
310 320 330 340 350
DQEGETSCED DLGHGSPKAP FVDHELIQES DNFEFDLRPA TTHPVQPWGS
360 370 380 390 400
QTSQSLSDLT QPILEDLQRE DPSRSQETLI SQNRGERDAG CFQEPVFCTL
410 420 430 440 450
APWGSQTSLL EPNCPESEGR GSGPQPSPVS SQDSSPRVLL HSPKWPQDAS
460 470 480 490 500
HLLQKDRSEL SSLKEEETEE VPSLRQEAEC EDTSRSEDAS ANQHHVHLAS
510 520 530 540 550
AEGLPESPMP QAQSPEEGWR PSSSREKLAN DIRNDKGAWN LALRLYQLNG
560 570 580 590 600
FRKSEVAAHL RKNNDFSRAV AEAYLSFFQF EGQSLDRALR GFLQALVLSG
610 620 630 640 650
ETQERERILY QFSKRFHYCN PGAFPSVDSV HTLTCAIMLL NTDLHGQNIG
660 670 680 690 700
KSMSCQEFVT NLNGLQDGRN FPKELLKALY WSIRSEKLEW AIDEEDADRP
710 720 730 740 750
EKDQPSPSAG KISSPFLQMA QDPTMPTYKQ GILARKMHHI ADGKKTPWGK
760 770 780 790 800
RGWKMFHTLL RGMVLYFLKG EGQWLDGESL VGHMVDEPVG VHHSLASPAT
810 820 830 840 850
HYTKKPHVFQ LRTADWRLYL FQAPTAKEMA SWIARINLAA ATHSAPPFPA
860 870 880 890 900
AVGSQRRFVR PILPMSPVQS SLEEQHRSHE NCLDAASDDL LDLQRNLPER
910 920 930 940 950
RGRSRELEEY RLRKEYLEHE KTRYETYVQL LVARLHFPLG DLALWEDQLG
960 970 980 990 1000
KETDGSQEPR PSLKKSHSSP SLHQEEAPTT AKVKRNISER RTYRKIIPKR

NRNQL
Length:1,005
Mass (Da):112,733
Last modified:March 1, 2003 - v1
Checksum:i8D03C8C52917EB04
GO

Sequence cautioni

The sequence BAE29402 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti200F → L in BAE41415 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK043669 mRNA. Translation: BAC31612.1.
AK148489 mRNA. Translation: BAE28582.1.
AK150238 mRNA. Translation: BAE29402.1. Different initiation.
AK163628 mRNA. Translation: BAE37428.1.
AK169859 mRNA. Translation: BAE41415.1.
AL732528 Genomic DNA. Translation: CAM17807.1.
BC046518 mRNA. Translation: AAH46518.1.
BC068231 mRNA. Translation: AAH68231.1.
CCDSiCCDS15737.1.
RefSeqiNP_808279.1. NM_177611.3.
XP_006497894.1. XM_006497831.3.
XP_006497895.1. XM_006497832.3.
XP_006497896.1. XM_006497833.3.
XP_006497897.1. XM_006497834.3.
XP_006497898.1. XM_006497835.3.
XP_006497899.1. XM_006497836.3.
XP_011237351.1. XM_011239049.2.
XP_017172556.1. XM_017317067.1.
UniGeneiMm.490434.

Genome annotation databases

EnsembliENSMUST00000056641; ENSMUSP00000062415; ENSMUSG00000026979.
ENSMUST00000102942; ENSMUSP00000100006; ENSMUSG00000026979.
ENSMUST00000166388; ENSMUSP00000132395; ENSMUSG00000026979.
GeneIDi215632.
KEGGimmu:215632.
UCSCiuc008ioy.1. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiPSD4_MOUSE
AccessioniPrimary (citable) accession number: Q8BLR5
Secondary accession number(s): A2AIU4
, Q3TE33, Q3TQF5, Q3UD59, Q3UFH9, Q80V44
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: March 1, 2003
Last modified: July 5, 2017
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot