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Q8BLR2 (CPNE4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Copine-4
Alternative name(s):
Copine IV
Gene names
Name:Cpne4
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length557 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May function in membrane trafficking. Exhibits calcium-dependent phospholipid binding properties By similarity.

Subunit structure

Interacts with CCDC22. Ref.3

Sequence similarities

Belongs to the copine family.

Contains 2 C2 domains.

Contains 1 VWFA domain.

Ontologies

Keywords
   DomainRepeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular functionprotein binding

Inferred from physical interaction Ref.3. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 557557Copine-4
PRO_0000144842

Regions

Domain24 – 130107C2 1
Domain141 – 246106C2 2
Domain305 – 507203VWFA

Sequences

Sequence LengthMass (Da)Tools
Q8BLR2 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: B9AAD11F3777F14F

FASTA55762,408
        10         20         30         40         50         60 
MKKMSNIYES AANTLGIFNS PCLTKVELRV ACKGISDRDA LSKPDPCVIL KMQSHGQWFE 

        70         80         90        100        110        120 
VDRTEVIRTC INPVYSKLFT VDFYFEEVQR LRFEVHDISS NHNGLKEADF LGGMECTLGQ 

       130        140        150        160        170        180 
IVSQRKLSKS LLKHGNTAGK SSITVIAEEL SGNDDYVELA FNARKLDDKD FFSKSDPFLE 

       190        200        210        220        230        240 
IFRMNDDATQ QLVHRTEVVM NNLSPAWKSF KVSVNSLCSG DPDRRLKCIV WDWDSNGKHD 

       250        260        270        280        290        300 
FIGEFTSTFK EMRGAMEGKQ VQWECINPKY KAKKKNYKNS GMVILNQCKI HKMHSFLDYI 

       310        320        330        340        350        360 
MGGCQIQFTV AIDFTASNGD PRNSCSLHYI HPYQPNEYLK ALVAVGEICQ DYDSDKMFPA 

       370        380        390        400        410        420 
FGFGARIPPE YTVSHDFAIN FNEDNPECAG IQGVVEAYQS CLPKLQLYGP TNIAPIIQKV 

       430        440        450        460        470        480 
AKSASEETNT KEASQYFILL ILTDGVITDM ADTREAIVHA SHLPMSVIIV GVGNADFSDM 

       490        500        510        520        530        540 
QMLDGDDGIL RSPKGEPVLR DIVQFVPFRN FKHASPAALA KSVLAEVPNQ VVDYYNGKGI 

       550 
KPKCSSEVYE SSRTLAP

« Hide

References

« Hide 'large scale' references
[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Brain cortex.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
[3]"Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif."
Tomsig J.L., Snyder S.L., Creutz C.E.
J. Biol. Chem. 278:10048-10054(2003) [PubMed: 12522145] [Abstract]
Cited for: INTERACTION WITH CCDC22.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AK043692 mRNA. Translation: BAC31619.1.
BC043087 mRNA. Translation: AAH43087.1.
BC063081 mRNA. Translation: AAH63081.1.
IPIIPI00108980.
RefSeqNP_082995.1. NM_028719.1.
UniGeneMm.326240.
Mm.442109.

3D structure databases

ProteinModelPortalQ8BLR2.
SMRQ8BLR2. Positions 30-134, 137-269, 409-446.
ModBaseSearch...

PTM databases

PhosphoSiteQ8BLR2.

Proteomic databases

PRIDEQ8BLR2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000057742; ENSMUSP00000049663; ENSMUSG00000032564.
GeneID74020.
KEGGmmu:74020.
UCSCuc009rhr.1. mouse.

Organism-specific databases

CTD131034.
MGIMGI:1921270. Cpne4.

Phylogenomic databases

eggNOGmaNOG07601.
GeneTreeENSGT00550000074189.
HOGENOMHBG464786.
HOVERGENHBG066841.
InParanoidQ8BLR2.
OMAFLGAMEC.
OrthoDBEOG4M3986.
PhylomeDBQ8BLR2.

Gene expression databases

ArrayExpressQ8BLR2.
BgeeQ8BLR2.
CleanExMM_CPNE4.
GenevestigatorQ8BLR2.
GermOnlineENSMUSG00000032564. Mus musculus.

Family and domain databases

InterProIPR000008. C2_Ca-dep.
IPR008973. C2_Ca/lipid-bd_dom_CaLB.
IPR018029. C2_membr_targeting.
IPR010734. Copine.
IPR002035. VWF_A.
[Graphical view]
PfamPF00168. C2. 2 hits.
PF07002. Copine. 1 hit.
[Graphical view]
SMARTSM00239. C2. 2 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMSSF49562. C2_CaLB. 2 hits.
PROSITEPS50004. C2. 1 hit.
PS50234. VWFA. False negative.
[Graphical view]
ProtoNetSearch...

Other

NextBio339554.
SOURCESearch...

Entry information

Entry nameCPNE4_MOUSE
AccessionPrimary (citable) accession number: Q8BLR2
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: March 1, 2003
Last modified: November 16, 2011
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents