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Protein

Copine-4

Gene

Cpne4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Copine-4Curated
Alternative name(s):
Copine IVBy similarityImported
Gene namesi
Name:Cpne4Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1921270. Cpne4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 557557Copine-4PRO_0000144842Add
BLAST

Proteomic databases

EPDiQ8BLR2.
MaxQBiQ8BLR2.
PaxDbiQ8BLR2.
PRIDEiQ8BLR2.

PTM databases

iPTMnetiQ8BLR2.
PhosphoSiteiQ8BLR2.

Expressioni

Gene expression databases

BgeeiQ8BLR2.
CleanExiMM_CPNE4.
ExpressionAtlasiQ8BLR2. baseline and differential.
GenevisibleiQ8BLR2. MM.

Interactioni

Subunit structurei

Interacts (via VWFA domain) with ACTB, BCOR, BICD2, CCDC22, CDC42BPB, CEP162, MYCBP2, NONO, PDCD6, PITPNM2, RDX, SKIL, SKT, SPTBN1, UBE2O and WTAP.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000049663.

Structurei

3D structure databases

ProteinModelPortaliQ8BLR2.
SMRiQ8BLR2. Positions 163-255.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 130107C2 1PROSITE-ProRule annotationAdd
BLAST
Domaini141 – 246106C2 2PROSITE-ProRule annotationAdd
BLAST
Domaini305 – 507203VWFAPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the copine family.Curated
Contains 2 C2 domains.PROSITE-ProRule annotation
Contains 1 VWFA domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1327. Eukaryota.
ENOG410XPC8. LUCA.
GeneTreeiENSGT00760000119085.
HOGENOMiHOG000220898.
HOVERGENiHBG066841.
InParanoidiQ8BLR2.
OMAiFLGAMEC.
OrthoDBiEOG77DJ57.
PhylomeDBiQ8BLR2.
TreeFamiTF316419.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR010734. Copine.
IPR002035. VWF_A.
[Graphical view]
PfamiPF00168. C2. 2 hits.
PF07002. Copine. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 2 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
SSF53300. SSF53300. 1 hit.
PROSITEiPS50004. C2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BLR2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKMSNIYES AANTLGIFNS PCLTKVELRV ACKGISDRDA LSKPDPCVIL
60 70 80 90 100
KMQSHGQWFE VDRTEVIRTC INPVYSKLFT VDFYFEEVQR LRFEVHDISS
110 120 130 140 150
NHNGLKEADF LGGMECTLGQ IVSQRKLSKS LLKHGNTAGK SSITVIAEEL
160 170 180 190 200
SGNDDYVELA FNARKLDDKD FFSKSDPFLE IFRMNDDATQ QLVHRTEVVM
210 220 230 240 250
NNLSPAWKSF KVSVNSLCSG DPDRRLKCIV WDWDSNGKHD FIGEFTSTFK
260 270 280 290 300
EMRGAMEGKQ VQWECINPKY KAKKKNYKNS GMVILNQCKI HKMHSFLDYI
310 320 330 340 350
MGGCQIQFTV AIDFTASNGD PRNSCSLHYI HPYQPNEYLK ALVAVGEICQ
360 370 380 390 400
DYDSDKMFPA FGFGARIPPE YTVSHDFAIN FNEDNPECAG IQGVVEAYQS
410 420 430 440 450
CLPKLQLYGP TNIAPIIQKV AKSASEETNT KEASQYFILL ILTDGVITDM
460 470 480 490 500
ADTREAIVHA SHLPMSVIIV GVGNADFSDM QMLDGDDGIL RSPKGEPVLR
510 520 530 540 550
DIVQFVPFRN FKHASPAALA KSVLAEVPNQ VVDYYNGKGI KPKCSSEVYE

SSRTLAP
Length:557
Mass (Da):62,408
Last modified:March 1, 2003 - v1
Checksum:iB9AAD11F3777F14F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK043692 mRNA. Translation: BAC31619.1.
BC043087 mRNA. Translation: AAH43087.1.
BC063081 mRNA. Translation: AAH63081.1.
CCDSiCCDS23461.1.
RefSeqiNP_082995.1. NM_028719.1.
XP_006511905.1. XM_006511842.1.
UniGeneiMm.326240.
Mm.442109.

Genome annotation databases

EnsembliENSMUST00000057742; ENSMUSP00000049663; ENSMUSG00000032564.
GeneIDi74020.
KEGGimmu:74020.
UCSCiuc009rhr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK043692 mRNA. Translation: BAC31619.1.
BC043087 mRNA. Translation: AAH43087.1.
BC063081 mRNA. Translation: AAH63081.1.
CCDSiCCDS23461.1.
RefSeqiNP_082995.1. NM_028719.1.
XP_006511905.1. XM_006511842.1.
UniGeneiMm.326240.
Mm.442109.

3D structure databases

ProteinModelPortaliQ8BLR2.
SMRiQ8BLR2. Positions 163-255.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000049663.

PTM databases

iPTMnetiQ8BLR2.
PhosphoSiteiQ8BLR2.

Proteomic databases

EPDiQ8BLR2.
MaxQBiQ8BLR2.
PaxDbiQ8BLR2.
PRIDEiQ8BLR2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000057742; ENSMUSP00000049663; ENSMUSG00000032564.
GeneIDi74020.
KEGGimmu:74020.
UCSCiuc009rhr.1. mouse.

Organism-specific databases

CTDi131034.
MGIiMGI:1921270. Cpne4.

Phylogenomic databases

eggNOGiKOG1327. Eukaryota.
ENOG410XPC8. LUCA.
GeneTreeiENSGT00760000119085.
HOGENOMiHOG000220898.
HOVERGENiHBG066841.
InParanoidiQ8BLR2.
OMAiFLGAMEC.
OrthoDBiEOG77DJ57.
PhylomeDBiQ8BLR2.
TreeFamiTF316419.

Miscellaneous databases

NextBioi339554.
PROiQ8BLR2.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BLR2.
CleanExiMM_CPNE4.
ExpressionAtlasiQ8BLR2. baseline and differential.
GenevisibleiQ8BLR2. MM.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR010734. Copine.
IPR002035. VWF_A.
[Graphical view]
PfamiPF00168. C2. 2 hits.
PF07002. Copine. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 2 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
SSF53300. SSF53300. 1 hit.
PROSITEiPS50004. C2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain cortex.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiCPNE4_MOUSE
AccessioniPrimary (citable) accession number: Q8BLR2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: March 1, 2003
Last modified: March 16, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.