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Protein

Cell adhesion molecule 2

Gene

Cadm2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organization, providing regulated trans-synaptic adhesion. Preferentially binds to oligodendrocytes (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-MMU-418990 Adherens junctions interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Cell adhesion molecule 2
Alternative name(s):
Immunoglobulin superfamily member 4D
Short name:
IgSF4D
Nectin-like protein 3
Short name:
NECL-3
Synaptic cell adhesion molecule 2
Short name:
SynCAM 2
Gene namesi
Name:Cadm2
Synonyms:Igsf4d, Necl3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:2442722 Cadm2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 367ExtracellularSequence analysisAdd BLAST343
Transmembranei368 – 388HelicalSequence analysisAdd BLAST21
Topological domaini389 – 435CytoplasmicSequence analysisAdd BLAST47

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000029197125 – 435Cell adhesion molecule 2Add BLAST411

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi31N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi44 ↔ 104PROSITE-ProRule annotation1 Publication
Glycosylationi51N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi146 ↔ 203PROSITE-ProRule annotation
Disulfide bondi248 ↔ 296PROSITE-ProRule annotation
Glycosylationi291N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei423PhosphoserineBy similarity1

Post-translational modificationi

Glycosylation at Asn-51 reduces adhesive binding.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PeptideAtlasiQ8BLQ9
PRIDEiQ8BLQ9

PTM databases

iPTMnetiQ8BLQ9
PhosphoSitePlusiQ8BLQ9

Expressioni

Gene expression databases

BgeeiENSMUSG00000064115
CleanExiMM_CADM2
ExpressionAtlasiQ8BLQ9 baseline and differential
GenevisibleiQ8BLQ9 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ8BLQ9, 2 interactors
MINTiQ8BLQ9

Structurei

Secondary structure

1435
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi32 – 35Combined sources4
Beta strandi40 – 48Combined sources9
Beta strandi54 – 57Combined sources4
Beta strandi63 – 66Combined sources4
Beta strandi77 – 91Combined sources15
Helixi96 – 98Combined sources3
Beta strandi100 – 106Combined sources7
Beta strandi108 – 110Combined sources3
Beta strandi112 – 121Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3M45X-ray2.21A/B/C/D21-124[»]
ProteinModelPortaliQ8BLQ9
SMRiQ8BLQ9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 119Ig-like V-typeAdd BLAST93
Domaini127 – 219Ig-like C2-type 1Add BLAST93
Domaini227 – 312Ig-like C2-type 2Add BLAST86

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi343 – 352Poly-Ser10

Sequence similaritiesi

Belongs to the nectin family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00900000140811
HOVERGENiHBG057086
InParanoidiQ8BLQ9
KOiK06782
TreeFamiTF326804

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR013162 CD80_C2-set
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
IPR003585 Neurexin-like
PfamiView protein in Pfam
PF08205 C2-set_2, 1 hit
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00294 4.1m, 1 hit
SM00409 IG, 2 hits
SM00408 IGc2, 2 hits
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BLQ9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIWKRSAVLR FYSVCGLLLQ GSQGQFPLTQ NVTVVEGGTA ILTCRVDQND
60 70 80 90 100
NTSLQWSNPA QQTLYFDDKK ALRDNRIELV RASWHELSIS VSDVSLSDEG
110 120 130 140 150
QYTCSLFTMP VKTSKAYLTV LGVPEKPQIS GFSSPVMEGD LMQLTCKTSG
160 170 180 190 200
SKPAADIRWF KNDKEIKDVK YLKEEDANRK TFTVSSTLDF RVDRSDDGVA
210 220 230 240 250
VICRVDHESL NATPQVAMQV LEIHYTPSVK IIPSTPFPQE GQALTLTCES
260 270 280 290 300
KGKPLPEPVL WTKDGAELPD PDRMVVSGRE LNILFLNKTD NGTYRCEATN
310 320 330 340 350
TIGQSSAEYV LIVHDVPNTL LPTTIIPSLT TAPVTTSVTI TTSPSTSASS
360 370 380 390 400
SSRRDPNSLA GQNGPDHALI GGIVAVVVFV TLCSIFLLGR YLARHKGTYL
410 420 430
TNEAKGAEDA PDADTAIINA EGSQVNAEEK KEYFI
Length:435
Mass (Da):47,559
Last modified:June 26, 2007 - v2
Checksum:iB5F4AB448B2EA5E1
GO
Isoform 2 (identifier: Q8BLQ9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     20-20: Q → QAAASKSKVK
     315-354: Missing.

Show »
Length:404
Mass (Da):44,388
Checksum:i091E493B82CAFE5B
GO
Isoform 3 (identifier: Q8BLQ9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     315-354: Missing.

Show »
Length:395
Mass (Da):43,517
Checksum:iE57E1BBD6D3672F9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti297E → K in BAC30148 (PubMed:16141072).Curated1
Sequence conflicti308E → K in BAC28533 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02633620Q → QAAASKSKVK in isoform 2. 2 Publications1
Alternative sequenceiVSP_026337315 – 354Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST40

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK038842 mRNA Translation: BAC30148.1
AK046800 mRNA Translation: BAC32876.1
AK033973 mRNA Translation: BAC28533.1
AK043760 mRNA Translation: BAC31646.1
AC154674 Genomic DNA No translation available.
CT010571
, AC105980, AC109233, AC154428 Genomic DNA Translation: CAP19089.1
CT010571
, AC105980, AC109233, AC154196, AC154428 Genomic DNA Translation: CAP19090.1
BC139401 mRNA Translation: AAI39402.1
BC139402 mRNA Translation: AAI39403.1
CCDSiCCDS28270.1 [Q8BLQ9-2]
CCDS49885.1 [Q8BLQ9-3]
CCDS84251.1 [Q8BLQ9-1]
RefSeqiNP_001139449.1, NM_001145977.1 [Q8BLQ9-3]
NP_001334176.1, NM_001347247.1 [Q8BLQ9-1]
NP_848836.2, NM_178721.4 [Q8BLQ9-2]
UniGeneiMm.394300

Genome annotation databases

EnsembliENSMUST00000114292; ENSMUSP00000109931; ENSMUSG00000064115 [Q8BLQ9-2]
ENSMUST00000120594; ENSMUSP00000113500; ENSMUSG00000064115 [Q8BLQ9-1]
ENSMUST00000120898; ENSMUSP00000113178; ENSMUSG00000064115 [Q8BLQ9-3]
GeneIDi239857
KEGGimmu:239857
UCSCiuc007zqn.2 mouse [Q8BLQ9-2]
uc007zqo.2 mouse [Q8BLQ9-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCADM2_MOUSE
AccessioniPrimary (citable) accession number: Q8BLQ9
Secondary accession number(s): B1B1A5
, B1B1A6, B2RTL0, Q8BXJ7, Q8BYP1, Q8BZP4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 26, 2007
Last modified: May 23, 2018
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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