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Q8BLQ7

- CTR4_MOUSE

UniProt

Q8BLQ7 - CTR4_MOUSE

Protein

Cationic amino acid transporter 4

Gene

Slc7a4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Involved in the transport of the cationic amino acids (arginine, lysine and ornithine).By similarity

    GO - Molecular functioni

    1. amino acid transmembrane transporter activity Source: InterPro

    Keywords - Biological processi

    Amino-acid transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cationic amino acid transporter 4
    Short name:
    CAT-4
    Short name:
    CAT4
    Alternative name(s):
    Solute carrier family 7 member 4
    Gene namesi
    Name:Slc7a4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:2146512. Slc7a4.

    Subcellular locationi

    Membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 635635Cationic amino acid transporter 4PRO_0000304934Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi146 – 1461N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi151 – 1511N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi195 – 1951N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi221 – 2211N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ8BLQ7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8BLQ7.
    BgeeiQ8BLQ7.
    GenevestigatoriQ8BLQ7.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000112347.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BLQ7.
    SMRiQ8BLQ7. Positions 40-419.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei42 – 6221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei66 – 8621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei113 – 13321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei197 – 21721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei229 – 24921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei270 – 29021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei318 – 33821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei365 – 38521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei391 – 41121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei478 – 49821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei508 – 52821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei539 – 55921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei567 – 58721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0531.
    GeneTreeiENSGT00730000110776.
    HOGENOMiHOG000250623.
    HOVERGENiHBG000280.
    KOiK13866.
    OMAiDHLQLVG.
    OrthoDBiEOG72C501.
    PhylomeDBiQ8BLQ7.
    TreeFamiTF315212.

    Family and domain databases

    InterProiIPR002293. AA/rel_permease1.
    IPR029485. CAT_C.
    [Graphical view]
    PANTHERiPTHR11785. PTHR11785. 1 hit.
    PfamiPF13520. AA_permease_2. 1 hit.
    PF13906. AA_permease_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006060. AA_transporter. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8BLQ7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARGLPSTAC LARFCQKLNR LKPLEESSME TSLRRCLSTL DLTLLGVGGM    50
    VGSGLYVLTG TVAKDMAGPA VLLSFLVAAV ASLLAALCYA EFGARVPRTG 100
    SAYLFTYVSM GEIWAFLIGW NVLLEYLIGG AAVARAWSGY LDAIFNHSIR 150
    NFTESHLGVW QVPFLAHYPD FLAAGILLVA SAFVSCGARV SSWLNHTFSA 200
    ISLIVILFII VLGFILARPH NWSAEEGGFA PFGFSGILAG TATCFYAFVG 250
    FDVIAASSEE AKNPRWAVPM AIAISLSLAA GAYILVSTVL TLMVPWHSLD 300
    PDSALADAFY RRGYSWAGFI VAVGSICAMN TVLLSNLFSL PRIVYAMAAD 350
    GLFFQVFARV HPRTQVPVVG ILVFGVLMAL LALLLDLEAL VQFLSIGTLL 400
    AYTFVATSII VLRFQKASPP SSPCLASPGP TAKKYDSFSD HIQLVGAEQT 450
    SMSEPGQLRP ALKPFLGFLD GCSPGTAVAW ALGILVASAI SLACVLVFGN 500
    SDLHLPQWGY VLLLVISGAV FLSSLLVLGA HQQQKKQDTF QIPLVPLTPA 550
    LSILLNTCLM LKLSYLTWLR FIFWLLVGLV VYFGYGIWHS KENQREPLEL 600
    TTAHYVVFPS GSLEETVQAV QPSSQSPVRE SGCTE 635
    Length:635
    Mass (Da):68,350
    Last modified:March 1, 2003 - v1
    Checksum:iB4A13B84EFED7587
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK043772 mRNA. Translation: BAC31651.1.
    AK162398 mRNA. Translation: BAE36893.1.
    CCDSiCCDS28008.1.
    RefSeqiNP_659101.2. NM_144852.3.
    UniGeneiMm.298878.

    Genome annotation databases

    EnsembliENSMUST00000063544; ENSMUSP00000067243; ENSMUSG00000022756.
    ENSMUST00000172164; ENSMUSP00000127280; ENSMUSG00000022756.
    GeneIDi224022.
    KEGGimmu:224022.
    UCSCiuc007ylk.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK043772 mRNA. Translation: BAC31651.1 .
    AK162398 mRNA. Translation: BAE36893.1 .
    CCDSi CCDS28008.1.
    RefSeqi NP_659101.2. NM_144852.3.
    UniGenei Mm.298878.

    3D structure databases

    ProteinModelPortali Q8BLQ7.
    SMRi Q8BLQ7. Positions 40-419.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000112347.

    Proteomic databases

    PRIDEi Q8BLQ7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000063544 ; ENSMUSP00000067243 ; ENSMUSG00000022756 .
    ENSMUST00000172164 ; ENSMUSP00000127280 ; ENSMUSG00000022756 .
    GeneIDi 224022.
    KEGGi mmu:224022.
    UCSCi uc007ylk.1. mouse.

    Organism-specific databases

    CTDi 6545.
    MGIi MGI:2146512. Slc7a4.

    Phylogenomic databases

    eggNOGi COG0531.
    GeneTreei ENSGT00730000110776.
    HOGENOMi HOG000250623.
    HOVERGENi HBG000280.
    KOi K13866.
    OMAi DHLQLVG.
    OrthoDBi EOG72C501.
    PhylomeDBi Q8BLQ7.
    TreeFami TF315212.

    Miscellaneous databases

    NextBioi 377013.
    PROi Q8BLQ7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8BLQ7.
    Bgeei Q8BLQ7.
    Genevestigatori Q8BLQ7.

    Family and domain databases

    InterProi IPR002293. AA/rel_permease1.
    IPR029485. CAT_C.
    [Graphical view ]
    PANTHERi PTHR11785. PTHR11785. 1 hit.
    Pfami PF13520. AA_permease_2. 1 hit.
    PF13906. AA_permease_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006060. AA_transporter. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Brain cortex and Diencephalon.

    Entry informationi

    Entry nameiCTR4_MOUSE
    AccessioniPrimary (citable) accession number: Q8BLQ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 2, 2007
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3