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Protein

Cationic amino acid transporter 4

Gene

Slc7a4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the transport of the cationic amino acids (arginine, lysine and ornithine).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Cationic amino acid transporter 4
Short name:
CAT-4
Short name:
CAT4
Alternative name(s):
Solute carrier family 7 member 4
Gene namesi
Name:Slc7a4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:2146512. Slc7a4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei42 – 62HelicalSequence analysisAdd BLAST21
Transmembranei66 – 86HelicalSequence analysisAdd BLAST21
Transmembranei113 – 133HelicalSequence analysisAdd BLAST21
Transmembranei197 – 217HelicalSequence analysisAdd BLAST21
Transmembranei229 – 249HelicalSequence analysisAdd BLAST21
Transmembranei270 – 290HelicalSequence analysisAdd BLAST21
Transmembranei318 – 338HelicalSequence analysisAdd BLAST21
Transmembranei365 – 385HelicalSequence analysisAdd BLAST21
Transmembranei391 – 411HelicalSequence analysisAdd BLAST21
Transmembranei478 – 498HelicalSequence analysisAdd BLAST21
Transmembranei508 – 528HelicalSequence analysisAdd BLAST21
Transmembranei539 – 559HelicalSequence analysisAdd BLAST21
Transmembranei567 – 587HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003049341 – 635Cationic amino acid transporter 4Add BLAST635

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi146N-linked (GlcNAc...)Sequence analysis1
Glycosylationi151N-linked (GlcNAc...)Sequence analysis1
Glycosylationi195N-linked (GlcNAc...)Sequence analysis1
Glycosylationi221N-linked (GlcNAc...)Sequence analysis1
Modified residuei422PhosphoserineCombined sources1
Modified residuei427PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ8BLQ7.
PRIDEiQ8BLQ7.

PTM databases

iPTMnetiQ8BLQ7.
PhosphoSitePlusiQ8BLQ7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000022756.
ExpressionAtlasiQ8BLQ7. baseline and differential.
GenevisibleiQ8BLQ7. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000067243.

Structurei

3D structure databases

ProteinModelPortaliQ8BLQ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1286. Eukaryota.
COG0531. LUCA.
GeneTreeiENSGT00760000119151.
HOGENOMiHOG000250623.
HOVERGENiHBG000280.
InParanoidiQ8BLQ7.
KOiK13866.
OMAiQDPGHME.
OrthoDBiEOG091G05NM.
PhylomeDBiQ8BLQ7.
TreeFamiTF315212.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
IPR029485. CAT_C.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 3 hits.
PfamiPF13520. AA_permease_2. 1 hit.
PF13906. AA_permease_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BLQ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARGLPSTAC LARFCQKLNR LKPLEESSME TSLRRCLSTL DLTLLGVGGM
60 70 80 90 100
VGSGLYVLTG TVAKDMAGPA VLLSFLVAAV ASLLAALCYA EFGARVPRTG
110 120 130 140 150
SAYLFTYVSM GEIWAFLIGW NVLLEYLIGG AAVARAWSGY LDAIFNHSIR
160 170 180 190 200
NFTESHLGVW QVPFLAHYPD FLAAGILLVA SAFVSCGARV SSWLNHTFSA
210 220 230 240 250
ISLIVILFII VLGFILARPH NWSAEEGGFA PFGFSGILAG TATCFYAFVG
260 270 280 290 300
FDVIAASSEE AKNPRWAVPM AIAISLSLAA GAYILVSTVL TLMVPWHSLD
310 320 330 340 350
PDSALADAFY RRGYSWAGFI VAVGSICAMN TVLLSNLFSL PRIVYAMAAD
360 370 380 390 400
GLFFQVFARV HPRTQVPVVG ILVFGVLMAL LALLLDLEAL VQFLSIGTLL
410 420 430 440 450
AYTFVATSII VLRFQKASPP SSPCLASPGP TAKKYDSFSD HIQLVGAEQT
460 470 480 490 500
SMSEPGQLRP ALKPFLGFLD GCSPGTAVAW ALGILVASAI SLACVLVFGN
510 520 530 540 550
SDLHLPQWGY VLLLVISGAV FLSSLLVLGA HQQQKKQDTF QIPLVPLTPA
560 570 580 590 600
LSILLNTCLM LKLSYLTWLR FIFWLLVGLV VYFGYGIWHS KENQREPLEL
610 620 630
TTAHYVVFPS GSLEETVQAV QPSSQSPVRE SGCTE
Length:635
Mass (Da):68,350
Last modified:March 1, 2003 - v1
Checksum:iB4A13B84EFED7587
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK043772 mRNA. Translation: BAC31651.1.
AK162398 mRNA. Translation: BAE36893.1.
CCDSiCCDS28008.1.
RefSeqiNP_659101.2. NM_144852.3.
XP_017172438.1. XM_017316949.1.
XP_017172439.1. XM_017316950.1.
XP_017172440.1. XM_017316951.1.
UniGeneiMm.298878.

Genome annotation databases

EnsembliENSMUST00000063544; ENSMUSP00000067243; ENSMUSG00000022756.
ENSMUST00000172164; ENSMUSP00000127280; ENSMUSG00000022756.
GeneIDi224022.
KEGGimmu:224022.
UCSCiuc007ylk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK043772 mRNA. Translation: BAC31651.1.
AK162398 mRNA. Translation: BAE36893.1.
CCDSiCCDS28008.1.
RefSeqiNP_659101.2. NM_144852.3.
XP_017172438.1. XM_017316949.1.
XP_017172439.1. XM_017316950.1.
XP_017172440.1. XM_017316951.1.
UniGeneiMm.298878.

3D structure databases

ProteinModelPortaliQ8BLQ7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000067243.

PTM databases

iPTMnetiQ8BLQ7.
PhosphoSitePlusiQ8BLQ7.

Proteomic databases

PaxDbiQ8BLQ7.
PRIDEiQ8BLQ7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000063544; ENSMUSP00000067243; ENSMUSG00000022756.
ENSMUST00000172164; ENSMUSP00000127280; ENSMUSG00000022756.
GeneIDi224022.
KEGGimmu:224022.
UCSCiuc007ylk.1. mouse.

Organism-specific databases

CTDi6545.
MGIiMGI:2146512. Slc7a4.

Phylogenomic databases

eggNOGiKOG1286. Eukaryota.
COG0531. LUCA.
GeneTreeiENSGT00760000119151.
HOGENOMiHOG000250623.
HOVERGENiHBG000280.
InParanoidiQ8BLQ7.
KOiK13866.
OMAiQDPGHME.
OrthoDBiEOG091G05NM.
PhylomeDBiQ8BLQ7.
TreeFamiTF315212.

Miscellaneous databases

PROiQ8BLQ7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022756.
ExpressionAtlasiQ8BLQ7. baseline and differential.
GenevisibleiQ8BLQ7. MM.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
IPR029485. CAT_C.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 3 hits.
PfamiPF13520. AA_permease_2. 1 hit.
PF13906. AA_permease_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCTR4_MOUSE
AccessioniPrimary (citable) accession number: Q8BLQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.