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Protein

Cationic amino acid transporter 4

Gene

Slc7a4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the transport of the cationic amino acids (arginine, lysine and ornithine).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAmino-acid transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Cationic amino acid transporter 4
Short name:
CAT-4
Short name:
CAT4
Alternative name(s):
Solute carrier family 7 member 4
Gene namesi
Name:Slc7a4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:2146512 Slc7a4

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei42 – 62HelicalSequence analysisAdd BLAST21
Transmembranei66 – 86HelicalSequence analysisAdd BLAST21
Transmembranei113 – 133HelicalSequence analysisAdd BLAST21
Transmembranei197 – 217HelicalSequence analysisAdd BLAST21
Transmembranei229 – 249HelicalSequence analysisAdd BLAST21
Transmembranei270 – 290HelicalSequence analysisAdd BLAST21
Transmembranei318 – 338HelicalSequence analysisAdd BLAST21
Transmembranei365 – 385HelicalSequence analysisAdd BLAST21
Transmembranei391 – 411HelicalSequence analysisAdd BLAST21
Transmembranei478 – 498HelicalSequence analysisAdd BLAST21
Transmembranei508 – 528HelicalSequence analysisAdd BLAST21
Transmembranei539 – 559HelicalSequence analysisAdd BLAST21
Transmembranei567 – 587HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003049341 – 635Cationic amino acid transporter 4Add BLAST635

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi146N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi151N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi195N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi221N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei422PhosphoserineCombined sources1
Modified residuei427PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ8BLQ7
PRIDEiQ8BLQ7

PTM databases

iPTMnetiQ8BLQ7
PhosphoSitePlusiQ8BLQ7

Expressioni

Gene expression databases

BgeeiENSMUSG00000022756
ExpressionAtlasiQ8BLQ7 baseline and differential
GenevisibleiQ8BLQ7 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000067243

Structurei

3D structure databases

ProteinModelPortaliQ8BLQ7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1286 Eukaryota
COG0531 LUCA
GeneTreeiENSGT00760000119151
HOGENOMiHOG000250623
HOVERGENiHBG000280
InParanoidiQ8BLQ7
KOiK13866
OMAiAVTWVRF
OrthoDBiEOG091G05NM
PhylomeDBiQ8BLQ7
TreeFamiTF315212

Family and domain databases

InterProiView protein in InterPro
IPR002293 AA/rel_permease1
IPR029485 CAT_C
PfamiView protein in Pfam
PF13520 AA_permease_2, 1 hit
PF13906 AA_permease_C, 1 hit
PIRSFiPIRSF006060 AA_transporter, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BLQ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARGLPSTAC LARFCQKLNR LKPLEESSME TSLRRCLSTL DLTLLGVGGM
60 70 80 90 100
VGSGLYVLTG TVAKDMAGPA VLLSFLVAAV ASLLAALCYA EFGARVPRTG
110 120 130 140 150
SAYLFTYVSM GEIWAFLIGW NVLLEYLIGG AAVARAWSGY LDAIFNHSIR
160 170 180 190 200
NFTESHLGVW QVPFLAHYPD FLAAGILLVA SAFVSCGARV SSWLNHTFSA
210 220 230 240 250
ISLIVILFII VLGFILARPH NWSAEEGGFA PFGFSGILAG TATCFYAFVG
260 270 280 290 300
FDVIAASSEE AKNPRWAVPM AIAISLSLAA GAYILVSTVL TLMVPWHSLD
310 320 330 340 350
PDSALADAFY RRGYSWAGFI VAVGSICAMN TVLLSNLFSL PRIVYAMAAD
360 370 380 390 400
GLFFQVFARV HPRTQVPVVG ILVFGVLMAL LALLLDLEAL VQFLSIGTLL
410 420 430 440 450
AYTFVATSII VLRFQKASPP SSPCLASPGP TAKKYDSFSD HIQLVGAEQT
460 470 480 490 500
SMSEPGQLRP ALKPFLGFLD GCSPGTAVAW ALGILVASAI SLACVLVFGN
510 520 530 540 550
SDLHLPQWGY VLLLVISGAV FLSSLLVLGA HQQQKKQDTF QIPLVPLTPA
560 570 580 590 600
LSILLNTCLM LKLSYLTWLR FIFWLLVGLV VYFGYGIWHS KENQREPLEL
610 620 630
TTAHYVVFPS GSLEETVQAV QPSSQSPVRE SGCTE
Length:635
Mass (Da):68,350
Last modified:March 1, 2003 - v1
Checksum:iB4A13B84EFED7587
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK043772 mRNA Translation: BAC31651.1
AK162398 mRNA Translation: BAE36893.1
CCDSiCCDS28008.1
RefSeqiNP_659101.2, NM_144852.3
XP_017172438.1, XM_017316949.1
XP_017172439.1, XM_017316950.1
XP_017172440.1, XM_017316951.1
UniGeneiMm.298878

Genome annotation databases

EnsembliENSMUST00000063544; ENSMUSP00000067243; ENSMUSG00000022756
ENSMUST00000172164; ENSMUSP00000127280; ENSMUSG00000022756
GeneIDi224022
KEGGimmu:224022
UCSCiuc007ylk.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCTR4_MOUSE
AccessioniPrimary (citable) accession number: Q8BLQ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome