Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8BLQ7

- CTR4_MOUSE

UniProt

Q8BLQ7 - CTR4_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Cationic amino acid transporter 4

Gene

Slc7a4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Involved in the transport of the cationic amino acids (arginine, lysine and ornithine).By similarity

GO - Molecular functioni

  1. amino acid transmembrane transporter activity Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Cationic amino acid transporter 4
Short name:
CAT-4
Short name:
CAT4
Alternative name(s):
Solute carrier family 7 member 4
Gene namesi
Name:Slc7a4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:2146512. Slc7a4.

Subcellular locationi

Membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei42 – 6221HelicalSequence AnalysisAdd
BLAST
Transmembranei66 – 8621HelicalSequence AnalysisAdd
BLAST
Transmembranei113 – 13321HelicalSequence AnalysisAdd
BLAST
Transmembranei197 – 21721HelicalSequence AnalysisAdd
BLAST
Transmembranei229 – 24921HelicalSequence AnalysisAdd
BLAST
Transmembranei270 – 29021HelicalSequence AnalysisAdd
BLAST
Transmembranei318 – 33821HelicalSequence AnalysisAdd
BLAST
Transmembranei365 – 38521HelicalSequence AnalysisAdd
BLAST
Transmembranei391 – 41121HelicalSequence AnalysisAdd
BLAST
Transmembranei478 – 49821HelicalSequence AnalysisAdd
BLAST
Transmembranei508 – 52821HelicalSequence AnalysisAdd
BLAST
Transmembranei539 – 55921HelicalSequence AnalysisAdd
BLAST
Transmembranei567 – 58721HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 635635Cationic amino acid transporter 4PRO_0000304934Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi146 – 1461N-linked (GlcNAc...)Sequence Analysis
Glycosylationi151 – 1511N-linked (GlcNAc...)Sequence Analysis
Glycosylationi195 – 1951N-linked (GlcNAc...)Sequence Analysis
Glycosylationi221 – 2211N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ8BLQ7.

Expressioni

Gene expression databases

BgeeiQ8BLQ7.
ExpressionAtlasiQ8BLQ7. baseline and differential.
GenevestigatoriQ8BLQ7.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000112347.

Structurei

3D structure databases

ProteinModelPortaliQ8BLQ7.
SMRiQ8BLQ7. Positions 40-419.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0531.
GeneTreeiENSGT00760000119151.
HOGENOMiHOG000250623.
HOVERGENiHBG000280.
InParanoidiQ8BLQ7.
KOiK13866.
OMAiDHLQLVG.
OrthoDBiEOG72C501.
PhylomeDBiQ8BLQ7.
TreeFamiTF315212.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
IPR029485. CAT_C.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF13520. AA_permease_2. 1 hit.
PF13906. AA_permease_C. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8BLQ7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MARGLPSTAC LARFCQKLNR LKPLEESSME TSLRRCLSTL DLTLLGVGGM
60 70 80 90 100
VGSGLYVLTG TVAKDMAGPA VLLSFLVAAV ASLLAALCYA EFGARVPRTG
110 120 130 140 150
SAYLFTYVSM GEIWAFLIGW NVLLEYLIGG AAVARAWSGY LDAIFNHSIR
160 170 180 190 200
NFTESHLGVW QVPFLAHYPD FLAAGILLVA SAFVSCGARV SSWLNHTFSA
210 220 230 240 250
ISLIVILFII VLGFILARPH NWSAEEGGFA PFGFSGILAG TATCFYAFVG
260 270 280 290 300
FDVIAASSEE AKNPRWAVPM AIAISLSLAA GAYILVSTVL TLMVPWHSLD
310 320 330 340 350
PDSALADAFY RRGYSWAGFI VAVGSICAMN TVLLSNLFSL PRIVYAMAAD
360 370 380 390 400
GLFFQVFARV HPRTQVPVVG ILVFGVLMAL LALLLDLEAL VQFLSIGTLL
410 420 430 440 450
AYTFVATSII VLRFQKASPP SSPCLASPGP TAKKYDSFSD HIQLVGAEQT
460 470 480 490 500
SMSEPGQLRP ALKPFLGFLD GCSPGTAVAW ALGILVASAI SLACVLVFGN
510 520 530 540 550
SDLHLPQWGY VLLLVISGAV FLSSLLVLGA HQQQKKQDTF QIPLVPLTPA
560 570 580 590 600
LSILLNTCLM LKLSYLTWLR FIFWLLVGLV VYFGYGIWHS KENQREPLEL
610 620 630
TTAHYVVFPS GSLEETVQAV QPSSQSPVRE SGCTE
Length:635
Mass (Da):68,350
Last modified:March 1, 2003 - v1
Checksum:iB4A13B84EFED7587
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK043772 mRNA. Translation: BAC31651.1.
AK162398 mRNA. Translation: BAE36893.1.
CCDSiCCDS28008.1.
RefSeqiNP_659101.2. NM_144852.3.
UniGeneiMm.298878.

Genome annotation databases

EnsembliENSMUST00000063544; ENSMUSP00000067243; ENSMUSG00000022756.
ENSMUST00000172164; ENSMUSP00000127280; ENSMUSG00000022756.
GeneIDi224022.
KEGGimmu:224022.
UCSCiuc007ylk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK043772 mRNA. Translation: BAC31651.1 .
AK162398 mRNA. Translation: BAE36893.1 .
CCDSi CCDS28008.1.
RefSeqi NP_659101.2. NM_144852.3.
UniGenei Mm.298878.

3D structure databases

ProteinModelPortali Q8BLQ7.
SMRi Q8BLQ7. Positions 40-419.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000112347.

Proteomic databases

PRIDEi Q8BLQ7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000063544 ; ENSMUSP00000067243 ; ENSMUSG00000022756 .
ENSMUST00000172164 ; ENSMUSP00000127280 ; ENSMUSG00000022756 .
GeneIDi 224022.
KEGGi mmu:224022.
UCSCi uc007ylk.1. mouse.

Organism-specific databases

CTDi 6545.
MGIi MGI:2146512. Slc7a4.

Phylogenomic databases

eggNOGi COG0531.
GeneTreei ENSGT00760000119151.
HOGENOMi HOG000250623.
HOVERGENi HBG000280.
InParanoidi Q8BLQ7.
KOi K13866.
OMAi DHLQLVG.
OrthoDBi EOG72C501.
PhylomeDBi Q8BLQ7.
TreeFami TF315212.

Miscellaneous databases

NextBioi 377013.
PROi Q8BLQ7.
SOURCEi Search...

Gene expression databases

Bgeei Q8BLQ7.
ExpressionAtlasi Q8BLQ7. baseline and differential.
Genevestigatori Q8BLQ7.

Family and domain databases

InterProi IPR002293. AA/rel_permease1.
IPR029485. CAT_C.
[Graphical view ]
PANTHERi PTHR11785. PTHR11785. 1 hit.
Pfami PF13520. AA_permease_2. 1 hit.
PF13906. AA_permease_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF006060. AA_transporter. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain cortex and Diencephalon.

Entry informationi

Entry nameiCTR4_MOUSE
AccessioniPrimary (citable) accession number: Q8BLQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3