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Q8BLQ7 (CTR4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cationic amino acid transporter 4

Short name=CAT-4
Short name=CAT4
Alternative name(s):
Solute carrier family 7 member 4
Gene names
Name:Slc7a4
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length635 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in the transport of the cationic amino acids (arginine, lysine and ornithine) By similarity.

Subcellular location

Membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family. [View classification]

Ontologies

Keywords
   Biological processAmino-acid transport
Transport
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionamino acid transmembrane transporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 635635Cationic amino acid transporter 4
PRO_0000304934

Regions

Transmembrane42 – 6221Helical; Potential
Transmembrane66 – 8621Helical; Potential
Transmembrane113 – 13321Helical; Potential
Transmembrane197 – 21721Helical; Potential
Transmembrane229 – 24921Helical; Potential
Transmembrane270 – 29021Helical; Potential
Transmembrane318 – 33821Helical; Potential
Transmembrane365 – 38521Helical; Potential
Transmembrane391 – 41121Helical; Potential
Transmembrane478 – 49821Helical; Potential
Transmembrane508 – 52821Helical; Potential
Transmembrane539 – 55921Helical; Potential
Transmembrane567 – 58721Helical; Potential

Amino acid modifications

Glycosylation1461N-linked (GlcNAc...) Potential
Glycosylation1511N-linked (GlcNAc...) Potential
Glycosylation1951N-linked (GlcNAc...) Potential
Glycosylation2211N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q8BLQ7 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: B4A13B84EFED7587

FASTA63568,350
        10         20         30         40         50         60 
MARGLPSTAC LARFCQKLNR LKPLEESSME TSLRRCLSTL DLTLLGVGGM VGSGLYVLTG 

        70         80         90        100        110        120 
TVAKDMAGPA VLLSFLVAAV ASLLAALCYA EFGARVPRTG SAYLFTYVSM GEIWAFLIGW 

       130        140        150        160        170        180 
NVLLEYLIGG AAVARAWSGY LDAIFNHSIR NFTESHLGVW QVPFLAHYPD FLAAGILLVA 

       190        200        210        220        230        240 
SAFVSCGARV SSWLNHTFSA ISLIVILFII VLGFILARPH NWSAEEGGFA PFGFSGILAG 

       250        260        270        280        290        300 
TATCFYAFVG FDVIAASSEE AKNPRWAVPM AIAISLSLAA GAYILVSTVL TLMVPWHSLD 

       310        320        330        340        350        360 
PDSALADAFY RRGYSWAGFI VAVGSICAMN TVLLSNLFSL PRIVYAMAAD GLFFQVFARV 

       370        380        390        400        410        420 
HPRTQVPVVG ILVFGVLMAL LALLLDLEAL VQFLSIGTLL AYTFVATSII VLRFQKASPP 

       430        440        450        460        470        480 
SSPCLASPGP TAKKYDSFSD HIQLVGAEQT SMSEPGQLRP ALKPFLGFLD GCSPGTAVAW 

       490        500        510        520        530        540 
ALGILVASAI SLACVLVFGN SDLHLPQWGY VLLLVISGAV FLSSLLVLGA HQQQKKQDTF 

       550        560        570        580        590        600 
QIPLVPLTPA LSILLNTCLM LKLSYLTWLR FIFWLLVGLV VYFGYGIWHS KENQREPLEL 

       610        620        630 
TTAHYVVFPS GSLEETVQAV QPSSQSPVRE SGCTE 

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Brain cortex and Diencephalon.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK043772 mRNA. Translation: BAC31651.1.
AK162398 mRNA. Translation: BAE36893.1.
CCDSCCDS28008.1.
RefSeqNP_659101.2. NM_144852.3.
UniGeneMm.298878.

3D structure databases

ProteinModelPortalQ8BLQ7.
SMRQ8BLQ7. Positions 40-419.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000112347.

Proteomic databases

PRIDEQ8BLQ7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000063544; ENSMUSP00000067243; ENSMUSG00000022756.
ENSMUST00000172164; ENSMUSP00000127280; ENSMUSG00000022756.
GeneID224022.
KEGGmmu:224022.
UCSCuc007ylk.1. mouse.

Organism-specific databases

CTD6545.
MGIMGI:2146512. Slc7a4.

Phylogenomic databases

eggNOGCOG0531.
GeneTreeENSGT00730000110776.
HOGENOMHOG000250623.
HOVERGENHBG000280.
KOK13866.
OMADHLQLVG.
OrthoDBEOG72C501.
PhylomeDBQ8BLQ7.
TreeFamTF315212.

Gene expression databases

ArrayExpressQ8BLQ7.
BgeeQ8BLQ7.
GenevestigatorQ8BLQ7.

Family and domain databases

InterProIPR002293. AA/rel_permease1.
IPR029485. CAT_C.
[Graphical view]
PANTHERPTHR11785. PTHR11785. 1 hit.
PfamPF13520. AA_permease_2. 1 hit.
PF13906. AA_permease_C. 1 hit.
[Graphical view]
PIRSFPIRSF006060. AA_transporter. 1 hit.
ProtoNetSearch...

Other

NextBio377013.
PROQ8BLQ7.
SOURCESearch...

Entry information

Entry nameCTR4_MOUSE
AccessionPrimary (citable) accession number: Q8BLQ7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot