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Q8BLQ7

- CTR4_MOUSE

UniProt

Q8BLQ7 - CTR4_MOUSE

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Protein
Cationic amino acid transporter 4
Gene
Slc7a4
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Involved in the transport of the cationic amino acids (arginine, lysine and ornithine) By similarity.

GO - Molecular functioni

  1. amino acid transmembrane transporter activity Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Cationic amino acid transporter 4
Short name:
CAT-4
Short name:
CAT4
Alternative name(s):
Solute carrier family 7 member 4
Gene namesi
Name:Slc7a4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:2146512. Slc7a4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei42 – 6221Helical; Reviewed prediction
Add
BLAST
Transmembranei66 – 8621Helical; Reviewed prediction
Add
BLAST
Transmembranei113 – 13321Helical; Reviewed prediction
Add
BLAST
Transmembranei197 – 21721Helical; Reviewed prediction
Add
BLAST
Transmembranei229 – 24921Helical; Reviewed prediction
Add
BLAST
Transmembranei270 – 29021Helical; Reviewed prediction
Add
BLAST
Transmembranei318 – 33821Helical; Reviewed prediction
Add
BLAST
Transmembranei365 – 38521Helical; Reviewed prediction
Add
BLAST
Transmembranei391 – 41121Helical; Reviewed prediction
Add
BLAST
Transmembranei478 – 49821Helical; Reviewed prediction
Add
BLAST
Transmembranei508 – 52821Helical; Reviewed prediction
Add
BLAST
Transmembranei539 – 55921Helical; Reviewed prediction
Add
BLAST
Transmembranei567 – 58721Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 635635Cationic amino acid transporter 4
PRO_0000304934Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi146 – 1461N-linked (GlcNAc...) Reviewed prediction
Glycosylationi151 – 1511N-linked (GlcNAc...) Reviewed prediction
Glycosylationi195 – 1951N-linked (GlcNAc...) Reviewed prediction
Glycosylationi221 – 2211N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ8BLQ7.

Expressioni

Gene expression databases

ArrayExpressiQ8BLQ7.
BgeeiQ8BLQ7.
GenevestigatoriQ8BLQ7.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000112347.

Structurei

3D structure databases

ProteinModelPortaliQ8BLQ7.
SMRiQ8BLQ7. Positions 40-419.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0531.
GeneTreeiENSGT00730000110776.
HOGENOMiHOG000250623.
HOVERGENiHBG000280.
KOiK13866.
OMAiDHLQLVG.
OrthoDBiEOG72C501.
PhylomeDBiQ8BLQ7.
TreeFamiTF315212.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
IPR029485. CAT_C.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF13520. AA_permease_2. 1 hit.
PF13906. AA_permease_C. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8BLQ7-1 [UniParc]FASTAAdd to Basket

« Hide

MARGLPSTAC LARFCQKLNR LKPLEESSME TSLRRCLSTL DLTLLGVGGM    50
VGSGLYVLTG TVAKDMAGPA VLLSFLVAAV ASLLAALCYA EFGARVPRTG 100
SAYLFTYVSM GEIWAFLIGW NVLLEYLIGG AAVARAWSGY LDAIFNHSIR 150
NFTESHLGVW QVPFLAHYPD FLAAGILLVA SAFVSCGARV SSWLNHTFSA 200
ISLIVILFII VLGFILARPH NWSAEEGGFA PFGFSGILAG TATCFYAFVG 250
FDVIAASSEE AKNPRWAVPM AIAISLSLAA GAYILVSTVL TLMVPWHSLD 300
PDSALADAFY RRGYSWAGFI VAVGSICAMN TVLLSNLFSL PRIVYAMAAD 350
GLFFQVFARV HPRTQVPVVG ILVFGVLMAL LALLLDLEAL VQFLSIGTLL 400
AYTFVATSII VLRFQKASPP SSPCLASPGP TAKKYDSFSD HIQLVGAEQT 450
SMSEPGQLRP ALKPFLGFLD GCSPGTAVAW ALGILVASAI SLACVLVFGN 500
SDLHLPQWGY VLLLVISGAV FLSSLLVLGA HQQQKKQDTF QIPLVPLTPA 550
LSILLNTCLM LKLSYLTWLR FIFWLLVGLV VYFGYGIWHS KENQREPLEL 600
TTAHYVVFPS GSLEETVQAV QPSSQSPVRE SGCTE 635
Length:635
Mass (Da):68,350
Last modified:March 1, 2003 - v1
Checksum:iB4A13B84EFED7587
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK043772 mRNA. Translation: BAC31651.1.
AK162398 mRNA. Translation: BAE36893.1.
CCDSiCCDS28008.1.
RefSeqiNP_659101.2. NM_144852.3.
UniGeneiMm.298878.

Genome annotation databases

EnsembliENSMUST00000063544; ENSMUSP00000067243; ENSMUSG00000022756.
ENSMUST00000172164; ENSMUSP00000127280; ENSMUSG00000022756.
GeneIDi224022.
KEGGimmu:224022.
UCSCiuc007ylk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK043772 mRNA. Translation: BAC31651.1 .
AK162398 mRNA. Translation: BAE36893.1 .
CCDSi CCDS28008.1.
RefSeqi NP_659101.2. NM_144852.3.
UniGenei Mm.298878.

3D structure databases

ProteinModelPortali Q8BLQ7.
SMRi Q8BLQ7. Positions 40-419.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000112347.

Proteomic databases

PRIDEi Q8BLQ7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000063544 ; ENSMUSP00000067243 ; ENSMUSG00000022756 .
ENSMUST00000172164 ; ENSMUSP00000127280 ; ENSMUSG00000022756 .
GeneIDi 224022.
KEGGi mmu:224022.
UCSCi uc007ylk.1. mouse.

Organism-specific databases

CTDi 6545.
MGIi MGI:2146512. Slc7a4.

Phylogenomic databases

eggNOGi COG0531.
GeneTreei ENSGT00730000110776.
HOGENOMi HOG000250623.
HOVERGENi HBG000280.
KOi K13866.
OMAi DHLQLVG.
OrthoDBi EOG72C501.
PhylomeDBi Q8BLQ7.
TreeFami TF315212.

Miscellaneous databases

NextBioi 377013.
PROi Q8BLQ7.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8BLQ7.
Bgeei Q8BLQ7.
Genevestigatori Q8BLQ7.

Family and domain databases

InterProi IPR002293. AA/rel_permease1.
IPR029485. CAT_C.
[Graphical view ]
PANTHERi PTHR11785. PTHR11785. 1 hit.
Pfami PF13520. AA_permease_2. 1 hit.
PF13906. AA_permease_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF006060. AA_transporter. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain cortex and Diencephalon.

Entry informationi

Entry nameiCTR4_MOUSE
AccessioniPrimary (citable) accession number: Q8BLQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi