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Q8BLN5

- ERG7_MOUSE

UniProt

Q8BLN5 - ERG7_MOUSE

Protein

Lanosterol synthase

Gene

Lss

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 2 (29 Mar 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus.By similarity

    Catalytic activityi

    (3S)-2,3-epoxy-2,3-dihydrosqualene = lanosterol.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei233 – 2331Proton acceptorBy similarity
    Active sitei456 – 4561Proton donorBy similarity

    GO - Molecular functioni

    1. lanosterol synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cholesterol biosynthetic process Source: Ensembl

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis

    Enzyme and pathway databases

    ReactomeiREACT_198969. Activation of gene expression by SREBF (SREBP).
    REACT_208531. Cholesterol biosynthesis.
    UniPathwayiUPA00767; UER00753.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lanosterol synthase (EC:5.4.99.7)
    Alternative name(s):
    2,3-epoxysqualene--lanosterol cyclase
    Oxidosqualene--lanosterol cyclase
    Short name:
    OSC
    Gene namesi
    Name:LssImported
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:1336155. Lss.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. lipid particle Source: Ensembl

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 733732Lanosterol synthasePRO_0000072660Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylthreonineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ8BLN5.
    PaxDbiQ8BLN5.
    PRIDEiQ8BLN5.

    PTM databases

    PhosphoSiteiQ8BLN5.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8BLN5.
    BgeeiQ8BLN5.
    CleanExiMM_LSS.
    GenevestigatoriQ8BLN5.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BLN5.
    SMRiQ8BLN5. Positions 6-732.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati125 – 16642PFTB 1Sequence AnalysisAdd
    BLAST
    Repeati484 – 52946PFTB 2Sequence AnalysisAdd
    BLAST
    Repeati561 – 60141PFTB 3Sequence AnalysisAdd
    BLAST
    Repeati613 – 65442PFTB 4Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the terpene cyclase/mutase family.By similarity
    Contains 4 PFTB repeats.Sequence Analysis

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG1657.
    GeneTreeiENSGT00390000011570.
    HOGENOMiHOG000234317.
    HOVERGENiHBG005604.
    InParanoidiQ8BLN5.
    KOiK01852.
    OMAiGLNYIYG.
    OrthoDBiEOG70W3CN.
    PhylomeDBiQ8BLN5.
    TreeFamiTF300406.

    Family and domain databases

    Gene3Di1.50.10.20. 2 hits.
    InterProiIPR001330. Prenyltrans.
    IPR018333. Squalene_cyclase.
    IPR002365. Terpene_synthase_CS.
    IPR008930. Terpenoid_cyclase/PrenylTrfase.
    [Graphical view]
    PfamiPF00432. Prenyltrans. 1 hit.
    [Graphical view]
    SUPFAMiSSF48239. SSF48239. 2 hits.
    TIGRFAMsiTIGR01787. squalene_cyclas. 1 hit.
    PROSITEiPS01074. TERPENE_SYNTHASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8BLN5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTEGTCLRRR GGPYKTEPAT DLTRWRLQNE LGRQRWTYYQ AEDDPGREQT    50
    GLEAHSLGLD TRSYFTDLPK AQTAHEGALN GVTFYAKLQA EDGHWAGDYG 100
    GPLFLLPGLL ITCHISHISL PAGYREEMVR YLRSVQLPDG GWGLHIEDKS 150
    TVFGTALNYV ALRILGIGPD DPDLVRARNV LHKKGGAVAI PSWGKFWLAV 200
    LNVYSWEGLN TLFPEMWLFP EWVPAHPSTL WCHCRQVYLP MSYCYATRLS 250
    ASEDPLVQSL RQELYVQDYA SIDWPAQRNN VSPDEMYTPH SWLLHVVYGL 300
    LNLYERFHST SLRKWAVQML YEHIAADDCF TKCISIGPIS KTINMLVRWS 350
    VDGPSSPAFQ EHVSRIKDYL WLGLDGMKMQ GTNGSQIWDT SFAIQALLEA 400
    GAHHRPEFLP CLQKAHEFLR LSQVPENCPD YQKYYRHMRK GGFSFSTLDC 450
    GWIVADCTAE GLKAVLLLQN QCPSITEHIP RERLCDAVDV LLSLRNADGG 500
    FATYEKKRGG YLLELLNPSE VFGDIMIDYT YVECTSAVMQ ALKHFHEHFP 550
    DYRAAEVRET LNQGLDFCRR KQRADGSWEG SWGVCFTYGT WFGLEAFACM 600
    GHTYQDGAAC AEVAQACNFL LSQQMADGGW GEDFESCEQR RYVQSARSQV 650
    HSTCWALMGL MAVRHPDITA QERGIRCLLG KQLPNGDWPQ ENISGVFNKS 700
    CAISYTSYRN IFPIWALGRF SNLYPDNTLA GHI 733
    Length:733
    Mass (Da):83,141
    Last modified:March 29, 2005 - v2
    Checksum:i17C3ED638C0D66B0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti297 – 2971V → A in BAC37102. (PubMed:16141072)Curated
    Sequence conflicti347 – 3471V → A in BAC31739. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK044016 mRNA. Translation: BAC31739.1.
    AK078023 mRNA. Translation: BAC37102.1.
    BC029082 mRNA. Translation: AAH29082.1.
    CCDSiCCDS23948.1.
    RefSeqiNP_666118.1. NM_146006.1.
    UniGeneiMm.55075.

    Genome annotation databases

    EnsembliENSMUST00000048678; ENSMUSP00000046856; ENSMUSG00000033105.
    GeneIDi16987.
    KEGGimmu:16987.
    UCSCiuc007fuq.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK044016 mRNA. Translation: BAC31739.1 .
    AK078023 mRNA. Translation: BAC37102.1 .
    BC029082 mRNA. Translation: AAH29082.1 .
    CCDSi CCDS23948.1.
    RefSeqi NP_666118.1. NM_146006.1.
    UniGenei Mm.55075.

    3D structure databases

    ProteinModelPortali Q8BLN5.
    SMRi Q8BLN5. Positions 6-732.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8BLN5.

    Proteomic databases

    MaxQBi Q8BLN5.
    PaxDbi Q8BLN5.
    PRIDEi Q8BLN5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000048678 ; ENSMUSP00000046856 ; ENSMUSG00000033105 .
    GeneIDi 16987.
    KEGGi mmu:16987.
    UCSCi uc007fuq.1. mouse.

    Organism-specific databases

    CTDi 4047.
    MGIi MGI:1336155. Lss.

    Phylogenomic databases

    eggNOGi COG1657.
    GeneTreei ENSGT00390000011570.
    HOGENOMi HOG000234317.
    HOVERGENi HBG005604.
    InParanoidi Q8BLN5.
    KOi K01852.
    OMAi GLNYIYG.
    OrthoDBi EOG70W3CN.
    PhylomeDBi Q8BLN5.
    TreeFami TF300406.

    Enzyme and pathway databases

    UniPathwayi UPA00767 ; UER00753 .
    Reactomei REACT_198969. Activation of gene expression by SREBF (SREBP).
    REACT_208531. Cholesterol biosynthesis.

    Miscellaneous databases

    NextBioi 291072.
    PROi Q8BLN5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8BLN5.
    Bgeei Q8BLN5.
    CleanExi MM_LSS.
    Genevestigatori Q8BLN5.

    Family and domain databases

    Gene3Di 1.50.10.20. 2 hits.
    InterProi IPR001330. Prenyltrans.
    IPR018333. Squalene_cyclase.
    IPR002365. Terpene_synthase_CS.
    IPR008930. Terpenoid_cyclase/PrenylTrfase.
    [Graphical view ]
    Pfami PF00432. Prenyltrans. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48239. SSF48239. 2 hits.
    TIGRFAMsi TIGR01787. squalene_cyclas. 1 hit.
    PROSITEi PS01074. TERPENE_SYNTHASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Brain cortex and Head.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary tumorImported.

    Entry informationi

    Entry nameiERG7_MOUSE
    AccessioniPrimary (citable) accession number: Q8BLN5
    Secondary accession number(s): Q8BVJ4, Q8K307
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 29, 2005
    Last sequence update: March 29, 2005
    Last modified: October 1, 2014
    This is version 95 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3