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Q8BLN5

- ERG7_MOUSE

UniProt

Q8BLN5 - ERG7_MOUSE

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Protein
Lanosterol synthase
Gene
Lss
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus By similarity.By similarity

Catalytic activityi

(3S)-2,3-epoxy-2,3-dihydrosqualene = lanosterol.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei233 – 2331Proton acceptor By similarity
Active sitei456 – 4561Proton donor By similarity

GO - Molecular functioni

  1. lanosterol synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. cholesterol biosynthetic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis

Enzyme and pathway databases

ReactomeiREACT_198969. Activation of gene expression by SREBF (SREBP).
REACT_208531. Cholesterol biosynthesis.
UniPathwayiUPA00767; UER00753.

Names & Taxonomyi

Protein namesi
Recommended name:
Lanosterol synthase (EC:5.4.99.7)
Alternative name(s):
2,3-epoxysqualene--lanosterol cyclase
Oxidosqualene--lanosterol cyclase
Short name:
OSC
Gene namesi
Name:Lss
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:1336155. Lss.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. lipid particle Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 733732Lanosterol synthase
PRO_0000072660Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylthreonine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ8BLN5.
PaxDbiQ8BLN5.
PRIDEiQ8BLN5.

PTM databases

PhosphoSiteiQ8BLN5.

Expressioni

Gene expression databases

ArrayExpressiQ8BLN5.
BgeeiQ8BLN5.
CleanExiMM_LSS.
GenevestigatoriQ8BLN5.

Interactioni

Subunit structurei

Monomer By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ8BLN5.
SMRiQ8BLN5. Positions 6-732.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati125 – 16642PFTB 1
Add
BLAST
Repeati484 – 52946PFTB 2
Add
BLAST
Repeati561 – 60141PFTB 3
Add
BLAST
Repeati613 – 65442PFTB 4
Add
BLAST

Sequence similaritiesi

Belongs to the terpene cyclase/mutase family.By similarity
Contains 4 PFTB repeats.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG1657.
GeneTreeiENSGT00390000011570.
HOGENOMiHOG000234317.
HOVERGENiHBG005604.
InParanoidiQ8BLN5.
KOiK01852.
OMAiGLNYIYG.
OrthoDBiEOG70W3CN.
PhylomeDBiQ8BLN5.
TreeFamiTF300406.

Family and domain databases

Gene3Di1.50.10.20. 2 hits.
InterProiIPR001330. Prenyltrans.
IPR018333. Squalene_cyclase.
IPR002365. Terpene_synthase_CS.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamiPF00432. Prenyltrans. 1 hit.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 2 hits.
TIGRFAMsiTIGR01787. squalene_cyclas. 1 hit.
PROSITEiPS01074. TERPENE_SYNTHASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BLN5-1 [UniParc]FASTAAdd to Basket

« Hide

MTEGTCLRRR GGPYKTEPAT DLTRWRLQNE LGRQRWTYYQ AEDDPGREQT    50
GLEAHSLGLD TRSYFTDLPK AQTAHEGALN GVTFYAKLQA EDGHWAGDYG 100
GPLFLLPGLL ITCHISHISL PAGYREEMVR YLRSVQLPDG GWGLHIEDKS 150
TVFGTALNYV ALRILGIGPD DPDLVRARNV LHKKGGAVAI PSWGKFWLAV 200
LNVYSWEGLN TLFPEMWLFP EWVPAHPSTL WCHCRQVYLP MSYCYATRLS 250
ASEDPLVQSL RQELYVQDYA SIDWPAQRNN VSPDEMYTPH SWLLHVVYGL 300
LNLYERFHST SLRKWAVQML YEHIAADDCF TKCISIGPIS KTINMLVRWS 350
VDGPSSPAFQ EHVSRIKDYL WLGLDGMKMQ GTNGSQIWDT SFAIQALLEA 400
GAHHRPEFLP CLQKAHEFLR LSQVPENCPD YQKYYRHMRK GGFSFSTLDC 450
GWIVADCTAE GLKAVLLLQN QCPSITEHIP RERLCDAVDV LLSLRNADGG 500
FATYEKKRGG YLLELLNPSE VFGDIMIDYT YVECTSAVMQ ALKHFHEHFP 550
DYRAAEVRET LNQGLDFCRR KQRADGSWEG SWGVCFTYGT WFGLEAFACM 600
GHTYQDGAAC AEVAQACNFL LSQQMADGGW GEDFESCEQR RYVQSARSQV 650
HSTCWALMGL MAVRHPDITA QERGIRCLLG KQLPNGDWPQ ENISGVFNKS 700
CAISYTSYRN IFPIWALGRF SNLYPDNTLA GHI 733
Length:733
Mass (Da):83,141
Last modified:March 29, 2005 - v2
Checksum:i17C3ED638C0D66B0
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti297 – 2971V → A in BAC37102. 1 Publication
Sequence conflicti347 – 3471V → A in BAC31739. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK044016 mRNA. Translation: BAC31739.1.
AK078023 mRNA. Translation: BAC37102.1.
BC029082 mRNA. Translation: AAH29082.1.
CCDSiCCDS23948.1.
RefSeqiNP_666118.1. NM_146006.1.
UniGeneiMm.55075.

Genome annotation databases

EnsembliENSMUST00000048678; ENSMUSP00000046856; ENSMUSG00000033105.
GeneIDi16987.
KEGGimmu:16987.
UCSCiuc007fuq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK044016 mRNA. Translation: BAC31739.1 .
AK078023 mRNA. Translation: BAC37102.1 .
BC029082 mRNA. Translation: AAH29082.1 .
CCDSi CCDS23948.1.
RefSeqi NP_666118.1. NM_146006.1.
UniGenei Mm.55075.

3D structure databases

ProteinModelPortali Q8BLN5.
SMRi Q8BLN5. Positions 6-732.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8BLN5.

Proteomic databases

MaxQBi Q8BLN5.
PaxDbi Q8BLN5.
PRIDEi Q8BLN5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000048678 ; ENSMUSP00000046856 ; ENSMUSG00000033105 .
GeneIDi 16987.
KEGGi mmu:16987.
UCSCi uc007fuq.1. mouse.

Organism-specific databases

CTDi 4047.
MGIi MGI:1336155. Lss.

Phylogenomic databases

eggNOGi COG1657.
GeneTreei ENSGT00390000011570.
HOGENOMi HOG000234317.
HOVERGENi HBG005604.
InParanoidi Q8BLN5.
KOi K01852.
OMAi GLNYIYG.
OrthoDBi EOG70W3CN.
PhylomeDBi Q8BLN5.
TreeFami TF300406.

Enzyme and pathway databases

UniPathwayi UPA00767 ; UER00753 .
Reactomei REACT_198969. Activation of gene expression by SREBF (SREBP).
REACT_208531. Cholesterol biosynthesis.

Miscellaneous databases

NextBioi 291072.
PROi Q8BLN5.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8BLN5.
Bgeei Q8BLN5.
CleanExi MM_LSS.
Genevestigatori Q8BLN5.

Family and domain databases

Gene3Di 1.50.10.20. 2 hits.
InterProi IPR001330. Prenyltrans.
IPR018333. Squalene_cyclase.
IPR002365. Terpene_synthase_CS.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view ]
Pfami PF00432. Prenyltrans. 1 hit.
[Graphical view ]
SUPFAMi SSF48239. SSF48239. 2 hits.
TIGRFAMsi TIGR01787. squalene_cyclas. 1 hit.
PROSITEi PS01074. TERPENE_SYNTHASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain cortex and Head.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary tumor.

Entry informationi

Entry nameiERG7_MOUSE
AccessioniPrimary (citable) accession number: Q8BLN5
Secondary accession number(s): Q8BVJ4, Q8K307
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: March 29, 2005
Last modified: September 3, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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