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Protein

Ribosomal protein S6 kinase delta-1

Gene

Rps6kc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transmitting sphingosine-1 phosphate (SPP)-mediated signaling into the cell.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei823ATPPROSITE-ProRule annotation1
Active sitei919Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi795 – 803ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal protein S6 kinase delta-1 (EC:2.7.11.1)
Short name:
S6K-delta-1
Alternative name(s):
52 kDa ribosomal protein S6 kinase
Gene namesi
Name:Rps6kc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2443419. Rps6kc1.

Subcellular locationi

  • Cytoplasm
  • Membrane

  • Note: Also found in some small dot-like or ring-shaped early endosome structures.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002331281 – 1056Ribosomal protein S6 kinase delta-1Add BLAST1056

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei281PhosphoserineBy similarity1
Modified residuei422PhosphoserineBy similarity1
Modified residuei423PhosphoserineCombined sources1
Modified residuei426PhosphoserineCombined sources1
Modified residuei446PhosphoserineCombined sources1
Modified residuei448PhosphoserineCombined sources1
Modified residuei454PhosphoserineBy similarity1
Modified residuei493PhosphoserineCombined sources1
Modified residuei527PhosphoserineBy similarity1
Modified residuei577PhosphoserineBy similarity1
Modified residuei599PhosphoserineCombined sources1
Modified residuei602PhosphoserineCombined sources1
Modified residuei634PhosphoserineCombined sources1
Modified residuei655PhosphoserineBy similarity1
Modified residuei658PhosphoserineBy similarity1
Modified residuei661PhosphoserineCombined sources1
Modified residuei787PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8BLK9.
PeptideAtlasiQ8BLK9.
PRIDEiQ8BLK9.

PTM databases

iPTMnetiQ8BLK9.
PhosphoSitePlusiQ8BLK9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000089872.
CleanExiMM_RPS6KC1.
ExpressionAtlasiQ8BLK9. baseline and differential.

Interactioni

Subunit structurei

Interacts with SPHK1 and phosphatidylinositol 3-phosphate.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000061769.

Structurei

3D structure databases

ProteinModelPortaliQ8BLK9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 132PXPROSITE-ProRule annotationAdd BLAST125
Domaini276 – 304MITAdd BLAST29
Domaini343 – 444Protein kinase 1PROSITE-ProRule annotationAdd BLAST102
Domaini789 – 1046Protein kinase 2PROSITE-ProRule annotationAdd BLAST258

Domaini

The first protein kinase domain appears to be a pseudokinase domain as it does not contain the classical characteristics, such as the ATP-binding motif, ATP-binding site and active site.

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. S6 kinase subfamily.PROSITE-ProRule annotation
Contains 1 MIT domain.Curated
Contains 2 protein kinase domains.PROSITE-ProRule annotation
Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0603. Eukaryota.
KOG2101. Eukaryota.
ENOG410XNWQ. LUCA.
GeneTreeiENSGT00530000063268.
HOGENOMiHOG000049101.
HOVERGENiHBG078266.
InParanoidiQ8BLK9.
KOiK20839.
PhylomeDBiQ8BLK9.

Family and domain databases

Gene3Di1.20.58.280. 1 hit.
3.30.1520.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR007330. MIT.
IPR001683. Phox.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamiPF04212. MIT. 1 hit.
PF00069. Pkinase. 1 hit.
PF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00745. MIT. 1 hit.
SM00312. PX. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF116846. SSF116846. 1 hit.
SSF56112. SSF56112. 2 hits.
SSF64268. SSF64268. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS50195. PX. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BLK9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTSPWGHSAD LARFYTVTEP QRHPRGYTVY KVTARVVSRR NPEDVQEIIV
60 70 80 90 100
WRRYSDFKKL HRELWQIHRN AFRHSELFPP FAKGTVFGRF DKTVIEERRQ
110 120 130 140 150
CAEDLLQFSA NIPALYNSRQ LQDFFKGGVI SDGSELIGPA EAYPDSPANA
160 170 180 190 200
FPECGTEGFS SDSDLLSLTV DADSLAEVDD GMASRQGSPS RTFGLSLSTD
210 220 230 240 250
SSAVGAVASD SEPSRVEDRE SRSLFPSSLK PRLGRRDYLE KAGELIKLAL
260 270 280 290 300
KKEEEDDYEA ASDFYRKGVD LLLEGVQGES SPTRREAVKR RTAEYLMRAE
310 320 330 340 350
SICSLRAAPQ LHTGPQPPGS LSSRPPWSLR SPAEELKAFR VLGVIDKVLL
360 370 380 390 400
VMDTRTEQTF ILKGLRKSSE CSRNRKTIIP RCVPNMVCLH TYIISEESVF
410 420 430 440 450
LVLQRAEGGK LWSYISKFLN RSSQESLDIK EGRPSMPPRV CLQQPSASPQ
460 470 480 490 500
GGSSFESRGS DTGSMLKALP LKTSLTPSSQ DDSNQEDDGQ PSSPKWLDSG
510 520 530 540 550
SSSEDECTAG YLTLCNEYGQ EKMDLVSLSE ESVMQPEGDK ADTQAVSSPA
560 570 580 590 600
SLATGSVSPS THLRVFSGGE DLEAVSSPPT SESLSRSKNS PMEFFRIDSK
610 620 630 640 650
DSTSELLGLD FGEKLHSLKP EPLKALFTLE DGDSPSQSLD PGESKRESEA
660 670 680 690 700
QDSVSRGSDD SVPVISFKEA AAEAISGAEE GRPDLLVNLP GELQPTKEAS
710 720 730 740 750
AMDPKFSQAS AGRLDSKLLE APDVLCLRLS SEQCHGLGPE GPEELSDPTE
760 770 780 790 800
FCPGGVIPEH DAQADPGVLF EAAVDHRSSP DQFLFSSLRS ESDRLGQVEV
810 820 830 840 850
VVTAQALQES LFHISSPCSG ANKEHSAYAD TATSEEVLLF TEPTKEEANS
860 870 880 890 900
LFQRGSEAQE RGVGAGEADK EIHQIFEDLD KRLAASSRFF IPEGCIQRWA
910 920 930 940 950
AEMVVALDAL HREGIVCRDL NPNNILLNDG GHIQLTYFSR WSEVEDSCDS
960 970 980 990 1000
DAVARMYCAP EVGAVTEETE ACDWWSLGAV LFELLTGKTL VECHPAGINT
1010 1020 1030 1040 1050
HTTLNMPGCV SEEARSLIQQ LLQFNPMERL GAGVAGVEDI KSHPFFTPVD

WAELTR
Note: No experimental confirmation available.
Length:1,056
Mass (Da):115,712
Last modified:May 2, 2006 - v2
Checksum:i315E6BB9926E4F42
GO
Isoform 2 (identifier: Q8BLK9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     36-47: Missing.
     89-158: Missing.
     961-961: E → G
     962-1056: Missing.

Note: Due to a partial intron retention. No experimental confirmation available.
Show »
Length:879
Mass (Da):96,202
Checksum:i6B5E259A161D99B8
GO
Isoform 3 (identifier: Q8BLK9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     317-347: Missing.
     932-947: HIQLTYFSRWSEVEDS → QELSQMHFFLFAVASN
     948-1056: Missing.

Note: Due to a partial intron retention. No experimental confirmation available.
Show »
Length:916
Mass (Da):100,333
Checksum:i329F9AC0A327F228
GO
Isoform 4 (identifier: Q8BLK9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     279-336: ESSPTRREAV...WSLRSPAEEL → KVRQCHHWLE...IICRSVHSSK
     337-1056: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.
Show »
Length:336
Mass (Da):37,815
Checksum:iEE08EE484A7603DD
GO

Sequence cautioni

The sequence BAC33510 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti855 – 857GSE → DSD in AAH58403 (PubMed:15489334).Curated3
Sequence conflicti855G → D in BAC33510 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01804336 – 47Missing in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_01804489 – 158Missing in isoform 2. 1 PublicationAdd BLAST70
Alternative sequenceiVSP_018045279 – 336ESSPT…PAEEL → KVRQCHHWLESLGSLQKSER NLEKPSHTRAQQDIASPLVT KITKSHHLIICRSVHSSK in isoform 4. 1 PublicationAdd BLAST58
Alternative sequenceiVSP_018046317 – 347Missing in isoform 3. 1 PublicationAdd BLAST31
Alternative sequenceiVSP_018047337 – 1056Missing in isoform 4. 1 PublicationAdd BLAST720
Alternative sequenceiVSP_018048932 – 947HIQLT…EVEDS → QELSQMHFFLFAVASN in isoform 3. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_018049948 – 1056Missing in isoform 3. 1 PublicationAdd BLAST109
Alternative sequenceiVSP_018050961E → G in isoform 2. 1 Publication1
Alternative sequenceiVSP_018051962 – 1056Missing in isoform 2. 1 PublicationAdd BLAST95

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030313 mRNA. Translation: BAC26894.1.
AK044809 mRNA. Translation: BAC32101.1.
AK049003 mRNA. Translation: BAC33510.1. Different initiation.
AK149858 mRNA. Translation: BAE29128.1.
BC058403 mRNA. Translation: AAH58403.1.
RefSeqiNP_848890.3. NM_178775.4.
UniGeneiMm.220912.

Genome annotation databases

EnsembliENSMUST00000159624; ENSMUSP00000125010; ENSMUSG00000089872. [Q8BLK9-4]
GeneIDi320119.
KEGGimmu:320119.
UCSCiuc007ebg.1. mouse. [Q8BLK9-3]
uc007ebh.2. mouse. [Q8BLK9-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030313 mRNA. Translation: BAC26894.1.
AK044809 mRNA. Translation: BAC32101.1.
AK049003 mRNA. Translation: BAC33510.1. Different initiation.
AK149858 mRNA. Translation: BAE29128.1.
BC058403 mRNA. Translation: AAH58403.1.
RefSeqiNP_848890.3. NM_178775.4.
UniGeneiMm.220912.

3D structure databases

ProteinModelPortaliQ8BLK9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000061769.

PTM databases

iPTMnetiQ8BLK9.
PhosphoSitePlusiQ8BLK9.

Proteomic databases

PaxDbiQ8BLK9.
PeptideAtlasiQ8BLK9.
PRIDEiQ8BLK9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000159624; ENSMUSP00000125010; ENSMUSG00000089872. [Q8BLK9-4]
GeneIDi320119.
KEGGimmu:320119.
UCSCiuc007ebg.1. mouse. [Q8BLK9-3]
uc007ebh.2. mouse. [Q8BLK9-2]

Organism-specific databases

CTDi26750.
MGIiMGI:2443419. Rps6kc1.

Phylogenomic databases

eggNOGiKOG0603. Eukaryota.
KOG2101. Eukaryota.
ENOG410XNWQ. LUCA.
GeneTreeiENSGT00530000063268.
HOGENOMiHOG000049101.
HOVERGENiHBG078266.
InParanoidiQ8BLK9.
KOiK20839.
PhylomeDBiQ8BLK9.

Miscellaneous databases

ChiTaRSiRps6kc1. mouse.
PROiQ8BLK9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000089872.
CleanExiMM_RPS6KC1.
ExpressionAtlasiQ8BLK9. baseline and differential.

Family and domain databases

Gene3Di1.20.58.280. 1 hit.
3.30.1520.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR007330. MIT.
IPR001683. Phox.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamiPF04212. MIT. 1 hit.
PF00069. Pkinase. 1 hit.
PF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00745. MIT. 1 hit.
SM00312. PX. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF116846. SSF116846. 1 hit.
SSF56112. SSF56112. 2 hits.
SSF64268. SSF64268. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS50195. PX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKS6C1_MOUSE
AccessioniPrimary (citable) accession number: Q8BLK9
Secondary accession number(s): Q3UDY3
, Q6PDY4, Q8BMQ5, Q8BX49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 2, 2006
Last modified: November 30, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.