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Protein

Limbic system-associated membrane protein

Gene

Lsamp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates selective neuronal growth and axon targeting. Contributes to the guidance of developing axons and remodeling of mature circuits in the limbic system. Essential for normal growth of the hyppocampal mossy fiber projection (By similarity).By similarity

GO - Biological processi

  • cell adhesion Source: UniProtKB-KW
  • locomotory exploration behavior Source: MGI

Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-MMU-163125 Post-translational modification: synthesis of GPI-anchored proteins

Names & Taxonomyi

Protein namesi
Recommended name:
Limbic system-associated membrane protein
Short name:
LSAMP
Gene namesi
Name:Lsamp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1261760 Lsamp

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_0000015105? – 341Removed in mature formSequence analysis
Signal peptidei1 – 28By similarityAdd BLAST28
ChainiPRO_000001510429 – ?Limbic system-associated membrane protein

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi40N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi53 ↔ 111PROSITE-ProRule annotation
Glycosylationi66N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei94PhosphotyrosineCombined sources1
Glycosylationi136N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi148N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi153 ↔ 197PROSITE-ProRule annotation
Disulfide bondi239 ↔ 290PROSITE-ProRule annotation
Glycosylationi279N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi287N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi300N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ8BLK3
PaxDbiQ8BLK3
PRIDEiQ8BLK3

PTM databases

iPTMnetiQ8BLK3
PhosphoSitePlusiQ8BLK3

Expressioni

Gene expression databases

BgeeiENSMUSG00000061080
CleanExiMM_LSAMP
ExpressionAtlasiQ8BLK3 baseline and differential

Interactioni

Protein-protein interaction databases

BioGridi234574, 2 interactors
IntActiQ8BLK3, 3 interactors
MINTiQ8BLK3

Structurei

3D structure databases

ProteinModelPortaliQ8BLK3
SMRiQ8BLK3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 122Ig-like 1Add BLAST94
Domaini132 – 214Ig-like 2Add BLAST83
Domaini219 – 304Ig-like 3Add BLAST86

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410KD5N Eukaryota
ENOG41100IG LUCA
GeneTreeiENSGT00860000133697
HOGENOMiHOG000019085
HOVERGENiHBG017341
InParanoidiQ8BLK3
OMAiRYECKAS
PhylomeDBiQ8BLK3
TreeFamiTF325565

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF07679 I-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BLK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGRVQPDRK QLPLVLLRLL CLLPTGLPVR SVDFNRGTDN ITVRQGDTAI
60 70 80 90 100
LRCVVEDKNS KVAWLNRSGI IFAGHDKWSL DPRVELEKRH ALEYSLRIQK
110 120 130 140 150
VDVYDEGSYT CSVQTQHEPK TSQVYLIVQV PPKISNISSD VTVNEGSNVT
160 170 180 190 200
LVCMANGRPE PVITWRHLTP LGREFEGEEE YLEILGITRE QSGKYECKAA
210 220 230 240 250
NEVSSADVKQ VKVTVNYPPT ITESKSNEAT TGRQASLKCE ASAVPAPDFE
260 270 280 290 300
WYRDDTRINS ANGLEIKSTE GQSSLTVTNV TEEHYGNYTC VAANKLGVTN
310 320 330 340
ASLVLFSKYA KTEPDSMQVI EFLHIDLKSI RHPLKVNPIQ K
Length:341
Mass (Da):38,086
Last modified:March 1, 2003 - v1
Checksum:i949CE792C67E25C3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044845 mRNA Translation: BAC32117.1
RefSeqiNP_780757.1, NM_175548.3
UniGeneiMm.310524
Mm.396840
Mm.473653

Genome annotation databases

EnsembliENSMUST00000078873; ENSMUSP00000077913; ENSMUSG00000061080
GeneIDi268890
UCSCiuc007zfs.1 mouse

Similar proteinsi

Entry informationi

Entry nameiLSAMP_MOUSE
AccessioniPrimary (citable) accession number: Q8BLK3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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