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Protein

Limbic system-associated membrane protein

Gene

Lsamp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Mediates selective neuronal growth and axon targeting. Contributes to the guidance of developing axons and remodeling of mature circuits in the limbic system. Essential for normal growth of the hyppocampal mossy fiber projection (By similarity).By similarity

GO - Biological processi

  • cell adhesion Source: UniProtKB-KW
  • locomotory exploration behavior Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Limbic system-associated membrane protein
Short name:
LSAMP
Gene namesi
Name:Lsamp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1261760. Lsamp.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei? – 341Removed in mature formSequence analysisPRO_0000015105
Signal peptidei1 – 2828By similarityAdd
BLAST
Chaini29 – ?Limbic system-associated membrane proteinPRO_0000015104

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi40 – 401N-linked (GlcNAc...)Sequence analysis
Disulfide bondi53 ↔ 111PROSITE-ProRule annotation
Glycosylationi66 – 661N-linked (GlcNAc...)Sequence analysis
Modified residuei94 – 941PhosphotyrosineCombined sources
Glycosylationi136 – 1361N-linked (GlcNAc...)Sequence analysis
Glycosylationi148 – 1481N-linked (GlcNAc...)Sequence analysis
Disulfide bondi153 ↔ 197PROSITE-ProRule annotation
Disulfide bondi239 ↔ 290PROSITE-ProRule annotation
Glycosylationi279 – 2791N-linked (GlcNAc...)Sequence analysis
Glycosylationi287 – 2871N-linked (GlcNAc...)Sequence analysis
Glycosylationi300 – 3001N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ8BLK3.
PaxDbiQ8BLK3.
PRIDEiQ8BLK3.

PTM databases

iPTMnetiQ8BLK3.
PhosphoSiteiQ8BLK3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000061080.
CleanExiMM_LSAMP.
ExpressionAtlasiQ8BLK3. baseline and differential.

Interactioni

Protein-protein interaction databases

BioGridi234574. 2 interactions.
IntActiQ8BLK3. 3 interactions.
MINTiMINT-1176829.
STRINGi10090.ENSMUSP00000077913.

Structurei

3D structure databases

ProteinModelPortaliQ8BLK3.
SMRiQ8BLK3. Positions 30-328.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 12294Ig-like 1Add
BLAST
Domaini132 – 21483Ig-like 2Add
BLAST
Domaini219 – 30486Ig-like 3Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410KD5N. Eukaryota.
ENOG41100IG. LUCA.
GeneTreeiENSGT00840000129753.
HOGENOMiHOG000019085.
HOVERGENiHBG017341.
InParanoidiQ8BLK3.
KOiK06772.
OMAiQDKWSLD.
PhylomeDBiQ8BLK3.
TreeFamiTF325565.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF07679. I-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BLK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGRVQPDRK QLPLVLLRLL CLLPTGLPVR SVDFNRGTDN ITVRQGDTAI
60 70 80 90 100
LRCVVEDKNS KVAWLNRSGI IFAGHDKWSL DPRVELEKRH ALEYSLRIQK
110 120 130 140 150
VDVYDEGSYT CSVQTQHEPK TSQVYLIVQV PPKISNISSD VTVNEGSNVT
160 170 180 190 200
LVCMANGRPE PVITWRHLTP LGREFEGEEE YLEILGITRE QSGKYECKAA
210 220 230 240 250
NEVSSADVKQ VKVTVNYPPT ITESKSNEAT TGRQASLKCE ASAVPAPDFE
260 270 280 290 300
WYRDDTRINS ANGLEIKSTE GQSSLTVTNV TEEHYGNYTC VAANKLGVTN
310 320 330 340
ASLVLFSKYA KTEPDSMQVI EFLHIDLKSI RHPLKVNPIQ K
Length:341
Mass (Da):38,086
Last modified:March 1, 2003 - v1
Checksum:i949CE792C67E25C3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044845 mRNA. Translation: BAC32117.1.
CCDSiCCDS28176.1.
RefSeqiNP_780757.1. NM_175548.3.
UniGeneiMm.310524.
Mm.396840.
Mm.473653.
Mm.486806.

Genome annotation databases

EnsembliENSMUST00000078873; ENSMUSP00000077913; ENSMUSG00000061080.
GeneIDi268890.
KEGGimmu:268890.
UCSCiuc007zfs.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044845 mRNA. Translation: BAC32117.1.
CCDSiCCDS28176.1.
RefSeqiNP_780757.1. NM_175548.3.
UniGeneiMm.310524.
Mm.396840.
Mm.473653.
Mm.486806.

3D structure databases

ProteinModelPortaliQ8BLK3.
SMRiQ8BLK3. Positions 30-328.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi234574. 2 interactions.
IntActiQ8BLK3. 3 interactions.
MINTiMINT-1176829.
STRINGi10090.ENSMUSP00000077913.

PTM databases

iPTMnetiQ8BLK3.
PhosphoSiteiQ8BLK3.

Proteomic databases

MaxQBiQ8BLK3.
PaxDbiQ8BLK3.
PRIDEiQ8BLK3.

Protocols and materials databases

DNASUi268890.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000078873; ENSMUSP00000077913; ENSMUSG00000061080.
GeneIDi268890.
KEGGimmu:268890.
UCSCiuc007zfs.1. mouse.

Organism-specific databases

CTDi4045.
MGIiMGI:1261760. Lsamp.

Phylogenomic databases

eggNOGiENOG410KD5N. Eukaryota.
ENOG41100IG. LUCA.
GeneTreeiENSGT00840000129753.
HOGENOMiHOG000019085.
HOVERGENiHBG017341.
InParanoidiQ8BLK3.
KOiK06772.
OMAiQDKWSLD.
PhylomeDBiQ8BLK3.
TreeFamiTF325565.

Miscellaneous databases

PROiQ8BLK3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000061080.
CleanExiMM_LSAMP.
ExpressionAtlasiQ8BLK3. baseline and differential.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF07679. I-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLSAMP_MOUSE
AccessioniPrimary (citable) accession number: Q8BLK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.