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Protein

ADAMTS-like protein 1

Gene

Adamtsl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-5173214. O-glycosylation of TSR domain-containing proteins.

Names & Taxonomyi

Protein namesi
Recommended name:
ADAMTS-like protein 1
Short name:
ADAMTSL-1
Alternative name(s):
Punctin-1
Gene namesi
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1924989. Adamtsl1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828By similarityAdd
BLAST
Chaini29 – 17451717ADAMTS-like protein 1PRO_0000035861Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi45 ↔ 76By similarity
Disulfide bondi49 ↔ 81By similarity
Disulfide bondi60 ↔ 66By similarity
Glycosylationi251 – 2511N-linked (GlcNAc...)Sequence analysis
Glycosylationi310 – 3101O-linked (Fuc...)By similarity
Glycosylationi391 – 3911O-linked (Fuc...)By similarity
Glycosylationi451 – 4511O-linked (Fuc...)By similarity
Disulfide bondi534 ↔ 578By similarity
Disulfide bondi538 ↔ 583By similarity
Disulfide bondi549 ↔ 567By similarity
Disulfide bondi775 ↔ 819By similarity
Disulfide bondi779 ↔ 824By similarity
Disulfide bondi790 ↔ 807By similarity
Disulfide bondi874 ↔ 922By similarity
Disulfide bondi1177 ↔ 1225By similarity
Disulfide bondi1283 ↔ 1336By similarity
Disulfide bondi1401 ↔ 1452By similarity

Post-translational modificationi

Glycosylated (By similarity). O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).By similarity
Disulfide bonds are present.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ8BLI0.
PaxDbiQ8BLI0.
PRIDEiQ8BLI0.

PTM databases

iPTMnetiQ8BLI0.
PhosphoSiteiQ8BLI0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000066113.
CleanExiMM_ADAMTSL1.
ExpressionAtlasiQ8BLI0. baseline and differential.
GenevisibleiQ8BLI0. MM.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000102796.

Structurei

3D structure databases

ProteinModelPortaliQ8BLI0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 8250TSP type-1 1PROSITE-ProRule annotationAdd
BLAST
Domaini376 – 42449TSP type-1 2PROSITE-ProRule annotationAdd
BLAST
Domaini436 – 49358TSP type-1 3PROSITE-ProRule annotationAdd
BLAST
Domaini522 – 58463TSP type-1 4PROSITE-ProRule annotationAdd
BLAST
Domaini607 – 66761TSP type-1 5PROSITE-ProRule annotationAdd
BLAST
Domaini703 – 76260TSP type-1 6PROSITE-ProRule annotationAdd
BLAST
Domaini763 – 82563TSP type-1 7PROSITE-ProRule annotationAdd
BLAST
Domaini836 – 938103Ig-like C2-type 1Add
BLAST
Domaini1139 – 1241103Ig-like C2-type 2Add
BLAST
Domaini1261 – 135292Ig-like C2-type 3Add
BLAST
Domaini1378 – 146891Ig-like C2-type 4Add
BLAST
Domaini1528 – 159164TSP type-1 8PROSITE-ProRule annotationAdd
BLAST
Domaini1649 – 170961TSP type-1 9PROSITE-ProRule annotationAdd
BLAST
Domaini1709 – 174537PLACPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 PLAC domain.PROSITE-ProRule annotation
Contains 9 TSP type-1 domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiKOG3538. Eukaryota.
ENOG410YY5R. LUCA.
GeneTreeiENSGT00760000118885.
HOGENOMiHOG000013139.
HOVERGENiHBG079989.
InParanoidiQ8BLI0.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013273. Peptidase_M12B_ADAM-TS.
IPR010909. PLAC.
IPR000884. TSP1_rpt.
[Graphical view]
PfamiPF07679. I-set. 4 hits.
PF08686. PLAC. 1 hit.
PF00090. TSP_1. 7 hits.
[Graphical view]
PRINTSiPR01857. ADAMTSFAMILY.
SMARTiSM00409. IG. 4 hits.
SM00408. IGc2. 4 hits.
SM00209. TSP1. 12 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
SSF82895. SSF82895. 10 hits.
PROSITEiPS50835. IG_LIKE. 4 hits.
PS50900. PLAC. 1 hit.
PS50092. TSP1. 9 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BLI0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MECCRRAAPG TPLLVLAFLL LSSRTARSEE DREGLWDAWG PWSECSRTCG
60 70 80 90 100
GGASYSLRRC LSSKSCEGRN IRYRTCSNVD CPPEAGDFRA QQCSAHNDVK
110 120 130 140 150
YHGQLYEWLP VSNDPDNPCS LKCQAKGTSL VVELAPKVLD GTRCYTESLD
160 170 180 190 200
MCISGLCQIV GCDHQLGSTV KEDNCGVCNG DGSTCRLVRG QYKSQLSASK
210 220 230 240 250
SDDTVVAIPY GSRHIRLVLK GPDHLYLETK TLQGTKGENS LSSTGIFLVD
260 270 280 290 300
NSTVDFQKLP DKEILRMTGP LTADFIIKIH DLGPADSTVQ FIFYQPIIHR
310 320 330 340 350
WRETDFFPCS ATCGGGYQLT SAECYDLRSN RVVADQYCHY YPENVKPKPK
360 370 380 390 400
LQECNLDPCP ASDGYKQIMP YDLYHPLPRW EATPWTACSS SCGGGIQSRA
410 420 430 440 450
VSCVEEDIQG HVTSVEEWKC MYTPKMPVVQ PCNIFDCPKW LAQEWSPCTV
460 470 480 490 500
TCGQGLRYRV VLCIDHRGMH TGGCSAKTKP HIKEECIIPT PCYKPREKLP
510 520 530 540 550
IEAKLPWFKQ AQELEEGAAV SEEPSFIPEA WSACTVTCGV GTQVRIIRCQ
560 570 580 590 600
VLLPFSQSVA DLPADECEGP KPASQRACYA GPCNGETPEF NPDNGDGLLG
610 620 630 640 650
GLQDLDELYD WEYEGFTKCS ESCGGGVQEA VVSCLNKQTR ELADENLCVT
660 670 680 690 700
SRRPPQLLKS CNLDPCPASH LLSREMNEVV VLADELCHHP KPSTVQACNR
710 720 730 740 750
FNCPPAWYPA QWQLCSRTCG GGIQKRDVLC KQRMADGSFL ELPETFCSAS
760 770 780 790 800
KPTSHQGCKK DDCPSEWLLS EWSECSVSCG EGTQTRSAIC QRVLKTGVST
810 820 830 840 850
VVNSTLCPPL PFSSSIRPCM LATCARPGRP STKHSPHIAA ARNIYIQTRR
860 870 880 890 900
QRKLHFVVGG FAYLLPKTTV VLRCPTRRFR KPLITWEKDG QHSISSAHVT
910 920 930 940 950
VAPFGYLKIH RLKPSDAGIY TCSAGPAREQ FVIKLIGGNR KLVARPLSLW
960 970 980 990 1000
SEEEEALQVR KTNPKEALQT HKHQNGIFSN GSKAEKRGLT ADPGNRYDDI
1010 1020 1030 1040 1050
VSRLLEQGGW PGELLASWEV QDSAERNASS EEDPNAEQAL LHLPFTMVAE
1060 1070 1080 1090 1100
QKRLDDILRN LSQQPEELRD LYSKHLVAQL AQDIFRSHLE NQDLLPKPSE
1110 1120 1130 1140 1150
QRFPPMAVPA HKHVSGFSSS LRSSSGEAGG GSRRPHRKPA ILRKISAAQQ
1160 1170 1180 1190 1200
LSASEVVTHL GQTVALASGT LSVLLHCEAV GNPRPTIHWT RNGEAVQFSD
1210 1220 1230 1240 1250
RILLQPDDSL QILAPVEADV GFYTCNATNA LGYDSVSIAV TLAGKPLVKT
1260 1270 1280 1290 1300
SRMTVLNTEK PTVTVDIGGT VRTVRGVNVT INCQVAGVPE AEVTWFRNKS
1310 1320 1330 1340 1350
KLGSSHHLHE GSSHHLHEGS LLLTDVSFSD QGLYSCRAAN LHGEQTESTQ
1360 1370 1380 1390 1400
LLILDPPQVP TQLEDIRALL LATGPNLPSV LMSPLGTQLV LDPGNSALLG
1410 1420 1430 1440 1450
CPIKGHPTPN ITWFQNGQPI ATAPGLTHHI WGAGQILRVA NLSGGPQGEF
1460 1470 1480 1490 1500
SCLAQNEAGT LLQKASLVIQ DYWWSVDRLA TCSASCGNRG IHQPRLRCLL
1510 1520 1530 1540 1550
NTTEVDPEHC TGKPRPAVQP VACNRRDCPS RWMVTSWSAC TRSCGGGVQT
1560 1570 1580 1590 1600
RRVTCQKLKA SGISTPVSND MCSQLAKRPV DTQACNQQLC VEWAFSSWGQ
1610 1620 1630 1640 1650
CNGPCIGPRL AVQHRQVFCQ TRDGITLPSE QCSALPRPVS TQNCWSEACS
1660 1670 1680 1690 1700
VHWRVSLWTL CTATCGNYGF QSRRVECVHV RTNKAVPEHL CSWGPRPANW
1710 1720 1730 1740
QRCNVTPCEN TECRDTTRYC EKVRQLKLCQ LGQFRSRCCG TCGKA
Length:1,745
Mass (Da):192,008
Last modified:June 15, 2010 - v2
Checksum:i5A9E6EBC3C220ABB
GO
Isoform 2 (identifier: Q8BLI0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     362-377: SDGYKQIMPYDLYHPL → RSVQFTCLCMINQVPS
     378-1745: Missing.

Note: No experimental confirmation available.
Show »
Length:377
Mass (Da):41,751
Checksum:iBC96FCE4C5B36259
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei362 – 37716SDGYK…LYHPL → RSVQFTCLCMINQVPS in isoform 2. 1 PublicationVSP_039332Add
BLAST
Alternative sequencei378 – 17451368Missing in isoform 2. 1 PublicationVSP_039333Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK045085 mRNA. Translation: BAC32213.1.
AL824705, AL772130, AL807242 Genomic DNA. Translation: CAM13345.2.
AL807242, AL772130, AL824705 Genomic DNA. Translation: CAM15556.2.
AL772130, AL807242, AL824705 Genomic DNA. Translation: CAX15654.1.
RefSeqiNP_084243.3. NM_029967.3.
UniGeneiMm.331690.

Genome annotation databases

EnsembliENSMUST00000141889; ENSMUSP00000119278; ENSMUSG00000066113. [Q8BLI0-1]
GeneIDi77739.
KEGGimmu:77739.
UCSCiuc008tlr.2. mouse. [Q8BLI0-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK045085 mRNA. Translation: BAC32213.1.
AL824705, AL772130, AL807242 Genomic DNA. Translation: CAM13345.2.
AL807242, AL772130, AL824705 Genomic DNA. Translation: CAM15556.2.
AL772130, AL807242, AL824705 Genomic DNA. Translation: CAX15654.1.
RefSeqiNP_084243.3. NM_029967.3.
UniGeneiMm.331690.

3D structure databases

ProteinModelPortaliQ8BLI0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000102796.

PTM databases

iPTMnetiQ8BLI0.
PhosphoSiteiQ8BLI0.

Proteomic databases

MaxQBiQ8BLI0.
PaxDbiQ8BLI0.
PRIDEiQ8BLI0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000141889; ENSMUSP00000119278; ENSMUSG00000066113. [Q8BLI0-1]
GeneIDi77739.
KEGGimmu:77739.
UCSCiuc008tlr.2. mouse. [Q8BLI0-2]

Organism-specific databases

CTDi92949.
MGIiMGI:1924989. Adamtsl1.

Phylogenomic databases

eggNOGiKOG3538. Eukaryota.
ENOG410YY5R. LUCA.
GeneTreeiENSGT00760000118885.
HOGENOMiHOG000013139.
HOVERGENiHBG079989.
InParanoidiQ8BLI0.

Enzyme and pathway databases

ReactomeiR-MMU-5173214. O-glycosylation of TSR domain-containing proteins.

Miscellaneous databases

ChiTaRSiAdamtsl1. mouse.
PROiQ8BLI0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000066113.
CleanExiMM_ADAMTSL1.
ExpressionAtlasiQ8BLI0. baseline and differential.
GenevisibleiQ8BLI0. MM.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013273. Peptidase_M12B_ADAM-TS.
IPR010909. PLAC.
IPR000884. TSP1_rpt.
[Graphical view]
PfamiPF07679. I-set. 4 hits.
PF08686. PLAC. 1 hit.
PF00090. TSP_1. 7 hits.
[Graphical view]
PRINTSiPR01857. ADAMTSFAMILY.
SMARTiSM00409. IG. 4 hits.
SM00408. IGc2. 4 hits.
SM00209. TSP1. 12 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
SSF82895. SSF82895. 10 hits.
PROSITEiPS50835. IG_LIKE. 4 hits.
PS50900. PLAC. 1 hit.
PS50092. TSP1. 9 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATL1_MOUSE
AccessioniPrimary (citable) accession number: Q8BLI0
Secondary accession number(s): A2AM52
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: June 15, 2010
Last modified: September 7, 2016
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Although strongly similar to members of the ADAMTS family it lacks the metalloprotease and disintegrin-like domains which are typical of that family.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.