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Protein

Lysophosphatidic acid receptor 4

Gene

Lpar4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Transduces a signal by increasing the intracellular calcium ions and by stimulating adenylyl cyclase activity. The rank order of potency for agonists of this receptor is 1-oleoyl- > 1-stearoyl- > 1-palmitoyl- > 1-myristoyl- > 1-alkyl- > 1-alkenyl-LPA (By similarity).By similarity

GO - Molecular functioni

  • lysophosphatidic acid binding Source: MGI
  • lysophosphatidic acid receptor activity Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

ReactomeiR-MMU-416476. G alpha (q) signalling events.
R-MMU-417957. P2Y receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophosphatidic acid receptor 4
Short name:
LPA receptor 4
Short name:
LPA-4
Alternative name(s):
G-protein coupled receptor 23
P2Y purinoceptor 9
Short name:
P2Y9
Purinergic receptor 9
Gene namesi
Name:Lpar4
Synonyms:Gpr23, Lpa4, P2y9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1925384. Lpar4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4343ExtracellularSequence analysisAdd
BLAST
Transmembranei44 – 6421Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini65 – 739CytoplasmicSequence analysis
Transmembranei74 – 9421Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini95 – 11218ExtracellularSequence analysisAdd
BLAST
Transmembranei113 – 13321Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini134 – 15522CytoplasmicSequence analysisAdd
BLAST
Transmembranei156 – 17621Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini177 – 20327ExtracellularSequence analysisAdd
BLAST
Transmembranei204 – 22421Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini225 – 25430CytoplasmicSequence analysisAdd
BLAST
Transmembranei255 – 27521Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini276 – 29419ExtracellularSequence analysisAdd
BLAST
Transmembranei295 – 31521Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini316 – 37055CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL3321650.
GuidetoPHARMACOLOGYi94.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 370370Lysophosphatidic acid receptor 4PRO_0000250204Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi15 – 151N-linked (GlcNAc...)Sequence analysis
Glycosylationi24 – 241N-linked (GlcNAc...)Sequence analysis
Glycosylationi28 – 281N-linked (GlcNAc...)Sequence analysis
Disulfide bondi111 ↔ 188PROSITE-ProRule annotation
Glycosylationi183 – 1831N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ8BLG2.
PaxDbiQ8BLG2.
PRIDEiQ8BLG2.

Expressioni

Gene expression databases

BgeeiQ8BLG2.
GenevisibleiQ8BLG2. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000053986.

Structurei

3D structure databases

ProteinModelPortaliQ8BLG2.
SMRiQ8BLG2. Positions 44-322.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFM0. Eukaryota.
ENOG41115C6. LUCA.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000231307.
HOVERGENiHBG101917.
InParanoidiQ8BLG2.
KOiK04275.
OMAiSTTCFEG.
OrthoDBiEOG7K3TM5.
TreeFamiTF350009.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BLG2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDRRFIDFQ FQDLNSSLRP RLGNATANNT CIVDDSFKYN LNGAVYSVVF
60 70 80 90 100
ILGLITNSAS LFVFCFRMKM RSETAIFITN LALSDLLFVC TLPFKIFYNF
110 120 130 140 150
NRHWPFGDTL CKISGTAFLT NIYGSMLFLT CISVDRFLAI VYPFRSRTIR
160 170 180 190 200
TRRNSAIVCA GVWILVLSGG ISASLFSTTN VNNATTTCFE GFSKRVWKTY
210 220 230 240 250
LSKITIFIEV VGFIIPLILN VSCSSVVLRT LRKPATLSQI GTNKKKVLKM
260 270 280 290 300
ITVHMAVFVV CFVPYNSVLF LYALVRSQAI TNCLLERFAK IMYPITLCLA
310 320 330 340 350
TLNCCFDPFI YYFTLESFQK SFYINTHIRM ESLFKTETPL TPKPSLPAIQ
360 370
EEVSDQTTNN GGELMLESTF
Length:370
Mass (Da):41,899
Last modified:July 27, 2011 - v2
Checksum:i05998ED7D8F1F5A0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti27 – 271A → T in BAC34729 (PubMed:16141072).Curated
Sequence conflicti57 – 571N → S in BAC32299 (PubMed:16141072).Curated
Sequence conflicti168 – 1681S → N in BAC34729 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK045289 mRNA. Translation: BAC32299.1.
AK051709 mRNA. Translation: BAC34729.1.
AL670943 Genomic DNA. Translation: CAM18227.1.
CH466564 Genomic DNA. Translation: EDL14046.1.
BC019743 mRNA. Translation: AAH19743.1.
BC138893 mRNA. Translation: AAI38894.1.
BC138894 mRNA. Translation: AAI38895.1.
CCDSiCCDS30345.1.
RefSeqiNP_780480.2. NM_175271.4.
UniGeneiMm.90147.

Genome annotation databases

EnsembliENSMUST00000060576; ENSMUSP00000053986; ENSMUSG00000049929.
GeneIDi78134.
KEGGimmu:78134.
UCSCiuc009ubx.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK045289 mRNA. Translation: BAC32299.1.
AK051709 mRNA. Translation: BAC34729.1.
AL670943 Genomic DNA. Translation: CAM18227.1.
CH466564 Genomic DNA. Translation: EDL14046.1.
BC019743 mRNA. Translation: AAH19743.1.
BC138893 mRNA. Translation: AAI38894.1.
BC138894 mRNA. Translation: AAI38895.1.
CCDSiCCDS30345.1.
RefSeqiNP_780480.2. NM_175271.4.
UniGeneiMm.90147.

3D structure databases

ProteinModelPortaliQ8BLG2.
SMRiQ8BLG2. Positions 44-322.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000053986.

Chemistry

ChEMBLiCHEMBL3321650.
GuidetoPHARMACOLOGYi94.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

MaxQBiQ8BLG2.
PaxDbiQ8BLG2.
PRIDEiQ8BLG2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000060576; ENSMUSP00000053986; ENSMUSG00000049929.
GeneIDi78134.
KEGGimmu:78134.
UCSCiuc009ubx.2. mouse.

Organism-specific databases

CTDi2846.
MGIiMGI:1925384. Lpar4.

Phylogenomic databases

eggNOGiENOG410IFM0. Eukaryota.
ENOG41115C6. LUCA.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000231307.
HOVERGENiHBG101917.
InParanoidiQ8BLG2.
KOiK04275.
OMAiSTTCFEG.
OrthoDBiEOG7K3TM5.
TreeFamiTF350009.

Enzyme and pathway databases

ReactomeiR-MMU-416476. G alpha (q) signalling events.
R-MMU-417957. P2Y receptors.

Miscellaneous databases

NextBioi348273.
PROiQ8BLG2.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BLG2.
GenevisibleiQ8BLG2. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo and Spinal ganglion.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Brain and Mammary gland.

Entry informationi

Entry nameiLPAR4_MOUSE
AccessioniPrimary (citable) accession number: Q8BLG2
Secondary accession number(s): A2ADM5, Q8BKK1, Q8VE54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: July 27, 2011
Last modified: May 11, 2016
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.