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Protein

Lysophosphatidic acid receptor 4

Gene

Lpar4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Transduces a signal by increasing the intracellular calcium ions and by stimulating adenylyl cyclase activity. The rank order of potency for agonists of this receptor is 1-oleoyl- > 1-stearoyl- > 1-palmitoyl- > 1-myristoyl- > 1-alkyl- > 1-alkenyl-LPA (By similarity).By similarity

GO - Molecular functioni

  • lysophosphatidic acid binding Source: MGI
  • lysophosphatidic acid receptor activity Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

ReactomeiR-MMU-416476. G alpha (q) signalling events.
R-MMU-417957. P2Y receptors.

Chemistry databases

SwissLipidsiSLP:000001576.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophosphatidic acid receptor 4
Short name:
LPA receptor 4
Short name:
LPA-4
Alternative name(s):
G-protein coupled receptor 23
P2Y purinoceptor 9
Short name:
P2Y9
Purinergic receptor 9
Gene namesi
Name:Lpar4
Synonyms:Gpr23, Lpa4, P2y9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1925384. Lpar4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 43ExtracellularSequence analysisAdd BLAST43
Transmembranei44 – 64Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini65 – 73CytoplasmicSequence analysis9
Transmembranei74 – 94Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini95 – 112ExtracellularSequence analysisAdd BLAST18
Transmembranei113 – 133Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini134 – 155CytoplasmicSequence analysisAdd BLAST22
Transmembranei156 – 176Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini177 – 203ExtracellularSequence analysisAdd BLAST27
Transmembranei204 – 224Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini225 – 254CytoplasmicSequence analysisAdd BLAST30
Transmembranei255 – 275Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini276 – 294ExtracellularSequence analysisAdd BLAST19
Transmembranei295 – 315Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini316 – 370CytoplasmicSequence analysisAdd BLAST55

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3321650.
GuidetoPHARMACOLOGYi94.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002502041 – 370Lysophosphatidic acid receptor 4Add BLAST370

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi15N-linked (GlcNAc...)Sequence analysis1
Glycosylationi24N-linked (GlcNAc...)Sequence analysis1
Glycosylationi28N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi111 ↔ 188PROSITE-ProRule annotation
Glycosylationi183N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ8BLG2.
PaxDbiQ8BLG2.
PRIDEiQ8BLG2.

PTM databases

PhosphoSitePlusiQ8BLG2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000049929.
GenevisibleiQ8BLG2. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000053986.

Chemistry databases

BindingDBiQ8BLG2.

Structurei

3D structure databases

ProteinModelPortaliQ8BLG2.
SMRiQ8BLG2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFM0. Eukaryota.
ENOG41115C6. LUCA.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000231307.
HOVERGENiHBG101917.
InParanoidiQ8BLG2.
KOiK04275.
OMAiSTTCFEG.
OrthoDBiEOG091G0BRE.
TreeFamiTF350009.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BLG2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDRRFIDFQ FQDLNSSLRP RLGNATANNT CIVDDSFKYN LNGAVYSVVF
60 70 80 90 100
ILGLITNSAS LFVFCFRMKM RSETAIFITN LALSDLLFVC TLPFKIFYNF
110 120 130 140 150
NRHWPFGDTL CKISGTAFLT NIYGSMLFLT CISVDRFLAI VYPFRSRTIR
160 170 180 190 200
TRRNSAIVCA GVWILVLSGG ISASLFSTTN VNNATTTCFE GFSKRVWKTY
210 220 230 240 250
LSKITIFIEV VGFIIPLILN VSCSSVVLRT LRKPATLSQI GTNKKKVLKM
260 270 280 290 300
ITVHMAVFVV CFVPYNSVLF LYALVRSQAI TNCLLERFAK IMYPITLCLA
310 320 330 340 350
TLNCCFDPFI YYFTLESFQK SFYINTHIRM ESLFKTETPL TPKPSLPAIQ
360 370
EEVSDQTTNN GGELMLESTF
Length:370
Mass (Da):41,899
Last modified:July 27, 2011 - v2
Checksum:i05998ED7D8F1F5A0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti27A → T in BAC34729 (PubMed:16141072).Curated1
Sequence conflicti57N → S in BAC32299 (PubMed:16141072).Curated1
Sequence conflicti168S → N in BAC34729 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK045289 mRNA. Translation: BAC32299.1.
AK051709 mRNA. Translation: BAC34729.1.
AL670943 Genomic DNA. Translation: CAM18227.1.
CH466564 Genomic DNA. Translation: EDL14046.1.
BC019743 mRNA. Translation: AAH19743.1.
BC138893 mRNA. Translation: AAI38894.1.
BC138894 mRNA. Translation: AAI38895.1.
CCDSiCCDS30345.1.
RefSeqiNP_780480.2. NM_175271.4.
UniGeneiMm.90147.

Genome annotation databases

EnsembliENSMUST00000060576; ENSMUSP00000053986; ENSMUSG00000049929.
GeneIDi78134.
KEGGimmu:78134.
UCSCiuc009ubx.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK045289 mRNA. Translation: BAC32299.1.
AK051709 mRNA. Translation: BAC34729.1.
AL670943 Genomic DNA. Translation: CAM18227.1.
CH466564 Genomic DNA. Translation: EDL14046.1.
BC019743 mRNA. Translation: AAH19743.1.
BC138893 mRNA. Translation: AAI38894.1.
BC138894 mRNA. Translation: AAI38895.1.
CCDSiCCDS30345.1.
RefSeqiNP_780480.2. NM_175271.4.
UniGeneiMm.90147.

3D structure databases

ProteinModelPortaliQ8BLG2.
SMRiQ8BLG2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000053986.

Chemistry databases

BindingDBiQ8BLG2.
ChEMBLiCHEMBL3321650.
GuidetoPHARMACOLOGYi94.
SwissLipidsiSLP:000001576.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ8BLG2.

Proteomic databases

MaxQBiQ8BLG2.
PaxDbiQ8BLG2.
PRIDEiQ8BLG2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000060576; ENSMUSP00000053986; ENSMUSG00000049929.
GeneIDi78134.
KEGGimmu:78134.
UCSCiuc009ubx.2. mouse.

Organism-specific databases

CTDi2846.
MGIiMGI:1925384. Lpar4.

Phylogenomic databases

eggNOGiENOG410IFM0. Eukaryota.
ENOG41115C6. LUCA.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000231307.
HOVERGENiHBG101917.
InParanoidiQ8BLG2.
KOiK04275.
OMAiSTTCFEG.
OrthoDBiEOG091G0BRE.
TreeFamiTF350009.

Enzyme and pathway databases

ReactomeiR-MMU-416476. G alpha (q) signalling events.
R-MMU-417957. P2Y receptors.

Miscellaneous databases

PROiQ8BLG2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000049929.
GenevisibleiQ8BLG2. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLPAR4_MOUSE
AccessioniPrimary (citable) accession number: Q8BLG2
Secondary accession number(s): A2ADM5, Q8BKK1, Q8VE54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: July 27, 2011
Last modified: November 30, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.