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Q8BLF2

- CDKL3_MOUSE

UniProt

Q8BLF2 - CDKL3_MOUSE

Protein

Cyclin-dependent kinase-like 3

Gene

Cdkl3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 2 (22 Nov 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei33 – 331ATPPROSITE-ProRule annotation
    Active sitei125 – 1251Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 189ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. dendrite extension Source: MGI
    2. negative regulation of axon extension Source: MGI
    3. positive regulation of dendrite morphogenesis Source: MGI

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-dependent kinase-like 3 (EC:2.7.11.22)
    Gene namesi
    Name:Cdkl3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:2388268. Cdkl3.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 595595Cyclin-dependent kinase-like 3PRO_0000085822Add
    BLAST

    Proteomic databases

    PaxDbiQ8BLF2.
    PRIDEiQ8BLF2.

    PTM databases

    PhosphoSiteiQ8BLF2.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8BLF2.
    BgeeiQ8BLF2.
    CleanExiMM_CDKL3.
    GenevestigatoriQ8BLF2.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BLF2.
    SMRiQ8BLF2. Positions 1-354.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 286283Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi45 – 517[NKR]KIAxRE

    Domaini

    The [NKR]KIAxRE motif seems to be a cyclin-binding region.

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00650000093115.
    HOVERGENiHBG080204.
    KOiK08824.
    OrthoDBiEOG7992PS.
    TreeFamiTF101031.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequences (7)i

    Sequence statusi: Complete.

    This entry describes 7 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8BLF2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEMYETLGKV GEGSYGTVMK CKHKDTGRIV AIKIFYEKPE KSVNKIATRE    50
    IKFLKQFRHE NLVNLIEVFR QKKKIHLVFE FIDHTVLDEL QHYCHGLESK 100
    RLRKYLFQIL RAIEYLHNNN IIHRDIKPEN ILVSQSGITK LCDFGFARTL 150
    AAPGDVYTDY VATRWYRAPE LVLKDTSYGK PVDIWALGCM IIEMATGHPF 200
    LPSSSDLDLL HKIVLKVGNL TPHLHNIFSK SPIFAGVVLP QVQHPKTARK 250
    KYPKLNGLLA DIVHACLQID PAERTSSTDL LRHDYFTRDG FIEKFIPELR 300
    AKLLQEAKVN SFIKPKENFK ENEPVRDEKK SVFTNTLLYG NPSLYGKEVD 350
    RDKRAKELKV RVIKAKGGKG DVPDQKKPEY EGDHRQQGTA DDTQPSSLDK 400
    KPSVLELTNP LNPSENSDGV KEDPHAGGCM IMPPINLTSS NLLAANLSSN 450
    LSHPNSRLTE RTKKRRTSSQ TIGQTLSNSR QEDTGPTQVQ TEKGAFNERT 500
    GQNDQISSGN KRKLNFPKCD RKEFHFPELP FTVQAKEMKG MEVKQIKVLK 550
    RESKKTDSSK IPTLLSMDPN QEKQEGGDGD CEGKNLKRNR FFFSR 595
    Length:595
    Mass (Da):67,739
    Last modified:November 22, 2005 - v2
    Checksum:i3DB415A3EEBC7C4B
    GO
    Isoform 2 (identifier: Q8BLF2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         576-585: GGDGDCEGKN → QSARHLPGQC
         586-595: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:585
    Mass (Da):66,531
    Checksum:i619B377FACD9486D
    GO
    Isoform 3 (identifier: Q8BLF2-7) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         576-581: GGDGDC → SLTMYL
         582-595: Missing.

    Note: Gene prediction based on EST data.

    Show »
    Length:581
    Mass (Da):66,162
    Checksum:i9CC3EAE169D206C9
    GO
    Isoform 4 (identifier: Q8BLF2-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         295-353: FIPELRAKLL...LYGKEVDRDK → KWTETKGPRS...HWTRSLLSWN
         354-595: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:353
    Mass (Da):40,619
    Checksum:i7A645EE9FCAE2328
    GO
    Isoform 5 (identifier: Q8BLF2-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-17: MEMYETLGKVGEGSYGT → MKPLEKWEREVMEP
         576-581: GGDGDC → SLTMYL
         582-595: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:578
    Mass (Da):66,112
    Checksum:iB62583F530F130E8
    GO
    Isoform 6 (identifier: Q8BLF2-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         458-595: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:457
    Mass (Da):51,901
    Checksum:i6FCDD36F51152B61
    GO
    Isoform 7 (identifier: Q8BLF2-8) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         576-595: GGDGDCEGKNLKRNRFFFSR → QPVKQVNSNQ

    Note: No experimental confirmation available.

    Show »
    Length:585
    Mass (Da):66,576
    Checksum:i6126BAAC992E6F42
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti12 – 121E → Q in BAC32701. (PubMed:16141072)Curated
    Sequence conflicti23 – 231H → Y in BAC37400. (PubMed:16141072)Curated
    Sequence conflicti153 – 1531P → H in BAC32324. (PubMed:16141072)Curated
    Sequence conflicti352 – 3521D → E in BAC37400. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 1717MEMYE…GSYGT → MKPLEKWEREVMEP in isoform 5. 1 PublicationVSP_016149Add
    BLAST
    Alternative sequencei295 – 35359FIPEL…VDRDK → KWTETKGPRSSKSESLRPKG AKEMSQTRRSQSMKATTASR AQLMTHSPHHWTRSLLSWN in isoform 4. 1 PublicationVSP_016150Add
    BLAST
    Alternative sequencei354 – 595242Missing in isoform 4. 1 PublicationVSP_016151Add
    BLAST
    Alternative sequencei458 – 595138Missing in isoform 6. 1 PublicationVSP_016152Add
    BLAST
    Alternative sequencei576 – 59520GGDGD…FFFSR → QPVKQVNSNQ in isoform 7. 1 PublicationVSP_030154Add
    BLAST
    Alternative sequencei576 – 58510GGDGDCEGKN → QSARHLPGQC in isoform 2. 1 PublicationVSP_016154
    Alternative sequencei576 – 5816GGDGDC → SLTMYL in isoform 3 and isoform 5. 1 PublicationVSP_016155
    Alternative sequencei582 – 59514Missing in isoform 3 and isoform 5. 1 PublicationVSP_016156Add
    BLAST
    Alternative sequencei586 – 59510Missing in isoform 2. 1 PublicationVSP_016157

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK043995 mRNA. Translation: BAC31729.2.
    AK045356 mRNA. Translation: BAC32324.1.
    AK046394 mRNA. Translation: BAC32701.1.
    AK050990 mRNA. Translation: BAC34488.1.
    AK078804 mRNA. Translation: BAC37400.1.
    AL669920 Genomic DNA. Translation: CAM19001.1.
    AL669920 Genomic DNA. Translation: CAM19002.1.
    AL669920 Genomic DNA. Translation: CAM19003.1.
    AL669920 Genomic DNA. Translation: CAM19004.1.
    AL669920 Genomic DNA. Translation: CAM19005.1.
    BC028871 mRNA. Translation: AAH28871.1.
    CCDSiCCDS24665.1. [Q8BLF2-1]
    CCDS48788.1. [Q8BLF2-7]
    CCDS48790.1. [Q8BLF2-2]
    CCDS48791.1. [Q8BLF2-6]
    CCDS48792.1. [Q8BLF2-4]
    RefSeqiNP_001160125.1. NM_001166653.1.
    NP_001160126.1. NM_001166654.1. [Q8BLF2-2]
    NP_001160127.1. NM_001166655.1. [Q8BLF2-6]
    NP_001160128.1. NM_001166656.1. [Q8BLF2-7]
    NP_001160129.1. NM_001166657.1. [Q8BLF2-4]
    NP_722480.3. NM_153785.4. [Q8BLF2-1]
    UniGeneiMm.280557.

    Genome annotation databases

    EnsembliENSMUST00000063303; ENSMUSP00000064315; ENSMUSG00000020389. [Q8BLF2-1]
    ENSMUST00000063321; ENSMUSP00000065128; ENSMUSG00000020389. [Q8BLF2-7]
    ENSMUST00000109076; ENSMUSP00000104704; ENSMUSG00000020389. [Q8BLF2-4]
    ENSMUST00000109077; ENSMUSP00000104705; ENSMUSG00000020389. [Q8BLF2-4]
    ENSMUST00000109078; ENSMUSP00000104706; ENSMUSG00000020389. [Q8BLF2-6]
    ENSMUST00000109079; ENSMUSP00000104707; ENSMUSG00000020389. [Q8BLF2-7]
    ENSMUST00000109081; ENSMUSP00000104709; ENSMUSG00000020389. [Q8BLF2-2]
    ENSMUST00000121591; ENSMUSP00000112477; ENSMUSG00000020389. [Q8BLF2-2]
    GeneIDi213084.
    KEGGimmu:213084.
    UCSCiuc007iuv.2. mouse. [Q8BLF2-1]
    uc007iux.2. mouse. [Q8BLF2-4]
    uc007iuz.2. mouse. [Q8BLF2-2]
    uc011xul.1. mouse. [Q8BLF2-7]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK043995 mRNA. Translation: BAC31729.2 .
    AK045356 mRNA. Translation: BAC32324.1 .
    AK046394 mRNA. Translation: BAC32701.1 .
    AK050990 mRNA. Translation: BAC34488.1 .
    AK078804 mRNA. Translation: BAC37400.1 .
    AL669920 Genomic DNA. Translation: CAM19001.1 .
    AL669920 Genomic DNA. Translation: CAM19002.1 .
    AL669920 Genomic DNA. Translation: CAM19003.1 .
    AL669920 Genomic DNA. Translation: CAM19004.1 .
    AL669920 Genomic DNA. Translation: CAM19005.1 .
    BC028871 mRNA. Translation: AAH28871.1 .
    CCDSi CCDS24665.1. [Q8BLF2-1 ]
    CCDS48788.1. [Q8BLF2-7 ]
    CCDS48790.1. [Q8BLF2-2 ]
    CCDS48791.1. [Q8BLF2-6 ]
    CCDS48792.1. [Q8BLF2-4 ]
    RefSeqi NP_001160125.1. NM_001166653.1.
    NP_001160126.1. NM_001166654.1. [Q8BLF2-2 ]
    NP_001160127.1. NM_001166655.1. [Q8BLF2-6 ]
    NP_001160128.1. NM_001166656.1. [Q8BLF2-7 ]
    NP_001160129.1. NM_001166657.1. [Q8BLF2-4 ]
    NP_722480.3. NM_153785.4. [Q8BLF2-1 ]
    UniGenei Mm.280557.

    3D structure databases

    ProteinModelPortali Q8BLF2.
    SMRi Q8BLF2. Positions 1-354.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8BLF2.

    Proteomic databases

    PaxDbi Q8BLF2.
    PRIDEi Q8BLF2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000063303 ; ENSMUSP00000064315 ; ENSMUSG00000020389 . [Q8BLF2-1 ]
    ENSMUST00000063321 ; ENSMUSP00000065128 ; ENSMUSG00000020389 . [Q8BLF2-7 ]
    ENSMUST00000109076 ; ENSMUSP00000104704 ; ENSMUSG00000020389 . [Q8BLF2-4 ]
    ENSMUST00000109077 ; ENSMUSP00000104705 ; ENSMUSG00000020389 . [Q8BLF2-4 ]
    ENSMUST00000109078 ; ENSMUSP00000104706 ; ENSMUSG00000020389 . [Q8BLF2-6 ]
    ENSMUST00000109079 ; ENSMUSP00000104707 ; ENSMUSG00000020389 . [Q8BLF2-7 ]
    ENSMUST00000109081 ; ENSMUSP00000104709 ; ENSMUSG00000020389 . [Q8BLF2-2 ]
    ENSMUST00000121591 ; ENSMUSP00000112477 ; ENSMUSG00000020389 . [Q8BLF2-2 ]
    GeneIDi 213084.
    KEGGi mmu:213084.
    UCSCi uc007iuv.2. mouse. [Q8BLF2-1 ]
    uc007iux.2. mouse. [Q8BLF2-4 ]
    uc007iuz.2. mouse. [Q8BLF2-2 ]
    uc011xul.1. mouse. [Q8BLF2-7 ]

    Organism-specific databases

    CTDi 51265.
    MGIi MGI:2388268. Cdkl3.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00650000093115.
    HOVERGENi HBG080204.
    KOi K08824.
    OrthoDBi EOG7992PS.
    TreeFami TF101031.

    Miscellaneous databases

    NextBioi 373855.
    PROi Q8BLF2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8BLF2.
    Bgeei Q8BLF2.
    CleanExi MM_CDKL3.
    Genevestigatori Q8BLF2.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 5 AND 6), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 368-595 (ISOFORM 7).
      Strain: C57BL/6J.
      Tissue: Brain cortex, Corpora quadrigemina, Embryo and Embryonic lung.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
      Strain: FVB/N.
      Tissue: Kidney.

    Entry informationi

    Entry nameiCDKL3_MOUSE
    AccessioniPrimary (citable) accession number: Q8BLF2
    Secondary accession number(s): A2ACR7
    , A2ACR8, A2ACR9, A2ACS0, A2ACS1, Q5M6W2, Q8BKR2, Q8BL49, Q8BLN9, Q8BVE0, Q8K134
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 22, 2005
    Last sequence update: November 22, 2005
    Last modified: October 1, 2014
    This is version 105 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3