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Protein

Cyclin-dependent kinase-like 3

Gene

Cdkl3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei33ATPPROSITE-ProRule annotation1
Active sitei125Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 18ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

  • dendrite extension Source: MGI
  • negative regulation of axon extension Source: MGI
  • positive regulation of dendrite morphogenesis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase-like 3 (EC:2.7.11.22)
Gene namesi
Name:Cdkl3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2388268. Cdkl3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000858221 – 595Cyclin-dependent kinase-like 3Add BLAST595

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei158PhosphothreonineBy similarity1
Modified residuei160PhosphotyrosineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8BLF2.
PRIDEiQ8BLF2.

PTM databases

iPTMnetiQ8BLF2.
PhosphoSitePlusiQ8BLF2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000020389.
CleanExiMM_CDKL3.
ExpressionAtlasiQ8BLF2. baseline and differential.
GenevisibleiQ8BLF2. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000104708.

Structurei

3D structure databases

ProteinModelPortaliQ8BLF2.
SMRiQ8BLF2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 286Protein kinasePROSITE-ProRule annotationAdd BLAST283

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi45 – 51[NKR]KIAxRE7

Domaini

The [NKR]KIAxRE motif seems to be a cyclin-binding region.

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0593. Eukaryota.
ENOG410XNSW. LUCA.
GeneTreeiENSGT00830000128262.
HOVERGENiHBG080204.
InParanoidiQ8BLF2.
KOiK08824.
TreeFamiTF101031.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BLF2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEMYETLGKV GEGSYGTVMK CKHKDTGRIV AIKIFYEKPE KSVNKIATRE
60 70 80 90 100
IKFLKQFRHE NLVNLIEVFR QKKKIHLVFE FIDHTVLDEL QHYCHGLESK
110 120 130 140 150
RLRKYLFQIL RAIEYLHNNN IIHRDIKPEN ILVSQSGITK LCDFGFARTL
160 170 180 190 200
AAPGDVYTDY VATRWYRAPE LVLKDTSYGK PVDIWALGCM IIEMATGHPF
210 220 230 240 250
LPSSSDLDLL HKIVLKVGNL TPHLHNIFSK SPIFAGVVLP QVQHPKTARK
260 270 280 290 300
KYPKLNGLLA DIVHACLQID PAERTSSTDL LRHDYFTRDG FIEKFIPELR
310 320 330 340 350
AKLLQEAKVN SFIKPKENFK ENEPVRDEKK SVFTNTLLYG NPSLYGKEVD
360 370 380 390 400
RDKRAKELKV RVIKAKGGKG DVPDQKKPEY EGDHRQQGTA DDTQPSSLDK
410 420 430 440 450
KPSVLELTNP LNPSENSDGV KEDPHAGGCM IMPPINLTSS NLLAANLSSN
460 470 480 490 500
LSHPNSRLTE RTKKRRTSSQ TIGQTLSNSR QEDTGPTQVQ TEKGAFNERT
510 520 530 540 550
GQNDQISSGN KRKLNFPKCD RKEFHFPELP FTVQAKEMKG MEVKQIKVLK
560 570 580 590
RESKKTDSSK IPTLLSMDPN QEKQEGGDGD CEGKNLKRNR FFFSR
Length:595
Mass (Da):67,739
Last modified:November 22, 2005 - v2
Checksum:i3DB415A3EEBC7C4B
GO
Isoform 2 (identifier: Q8BLF2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     576-585: GGDGDCEGKN → QSARHLPGQC
     586-595: Missing.

Note: No experimental confirmation available.
Show »
Length:585
Mass (Da):66,531
Checksum:i619B377FACD9486D
GO
Isoform 3 (identifier: Q8BLF2-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     576-581: GGDGDC → SLTMYL
     582-595: Missing.

Note: Gene prediction based on EST data.
Show »
Length:581
Mass (Da):66,162
Checksum:i9CC3EAE169D206C9
GO
Isoform 4 (identifier: Q8BLF2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     295-353: FIPELRAKLL...LYGKEVDRDK → KWTETKGPRS...HWTRSLLSWN
     354-595: Missing.

Note: No experimental confirmation available.
Show »
Length:353
Mass (Da):40,619
Checksum:i7A645EE9FCAE2328
GO
Isoform 5 (identifier: Q8BLF2-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MEMYETLGKVGEGSYGT → MKPLEKWEREVMEP
     576-581: GGDGDC → SLTMYL
     582-595: Missing.

Note: No experimental confirmation available.
Show »
Length:578
Mass (Da):66,112
Checksum:iB62583F530F130E8
GO
Isoform 6 (identifier: Q8BLF2-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     458-595: Missing.

Note: No experimental confirmation available.
Show »
Length:457
Mass (Da):51,901
Checksum:i6FCDD36F51152B61
GO
Isoform 7 (identifier: Q8BLF2-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     576-595: GGDGDCEGKNLKRNRFFFSR → QPVKQVNSNQ

Note: No experimental confirmation available.
Show »
Length:585
Mass (Da):66,576
Checksum:i6126BAAC992E6F42
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12E → Q in BAC32701 (PubMed:16141072).Curated1
Sequence conflicti23H → Y in BAC37400 (PubMed:16141072).Curated1
Sequence conflicti153P → H in BAC32324 (PubMed:16141072).Curated1
Sequence conflicti352D → E in BAC37400 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0161491 – 17MEMYE…GSYGT → MKPLEKWEREVMEP in isoform 5. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_016150295 – 353FIPEL…VDRDK → KWTETKGPRSSKSESLRPKG AKEMSQTRRSQSMKATTASR AQLMTHSPHHWTRSLLSWN in isoform 4. 1 PublicationAdd BLAST59
Alternative sequenceiVSP_016151354 – 595Missing in isoform 4. 1 PublicationAdd BLAST242
Alternative sequenceiVSP_016152458 – 595Missing in isoform 6. 1 PublicationAdd BLAST138
Alternative sequenceiVSP_030154576 – 595GGDGD…FFFSR → QPVKQVNSNQ in isoform 7. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_016154576 – 585GGDGDCEGKN → QSARHLPGQC in isoform 2. 1 Publication10
Alternative sequenceiVSP_016155576 – 581GGDGDC → SLTMYL in isoform 3 and isoform 5. 1 Publication6
Alternative sequenceiVSP_016156582 – 595Missing in isoform 3 and isoform 5. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_016157586 – 595Missing in isoform 2. 1 Publication10

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK043995 mRNA. Translation: BAC31729.2.
AK045356 mRNA. Translation: BAC32324.1.
AK046394 mRNA. Translation: BAC32701.1.
AK050990 mRNA. Translation: BAC34488.1.
AK078804 mRNA. Translation: BAC37400.1.
AL669920 Genomic DNA. Translation: CAM19001.1.
AL669920 Genomic DNA. Translation: CAM19002.1.
AL669920 Genomic DNA. Translation: CAM19003.1.
AL669920 Genomic DNA. Translation: CAM19004.1.
AL669920 Genomic DNA. Translation: CAM19005.1.
BC028871 mRNA. Translation: AAH28871.1.
CCDSiCCDS24665.1. [Q8BLF2-1]
CCDS48788.1. [Q8BLF2-7]
CCDS48790.1. [Q8BLF2-2]
CCDS48791.1. [Q8BLF2-6]
CCDS48792.1. [Q8BLF2-4]
RefSeqiNP_001160125.1. NM_001166653.1.
NP_001160126.1. NM_001166654.1. [Q8BLF2-2]
NP_001160127.1. NM_001166655.1. [Q8BLF2-6]
NP_001160128.1. NM_001166656.1. [Q8BLF2-7]
NP_001160129.1. NM_001166657.1. [Q8BLF2-4]
NP_722480.3. NM_153785.4. [Q8BLF2-1]
XP_011247178.1. XM_011248876.1. [Q8BLF2-2]
XP_011247179.1. XM_011248877.2. [Q8BLF2-2]
XP_011247180.1. XM_011248878.1. [Q8BLF2-2]
XP_011247181.1. XM_011248879.1. [Q8BLF2-2]
XP_011247182.1. XM_011248880.2. [Q8BLF2-2]
XP_017169911.1. XM_017314422.1. [Q8BLF2-4]
UniGeneiMm.280557.

Genome annotation databases

EnsembliENSMUST00000063303; ENSMUSP00000064315; ENSMUSG00000020389. [Q8BLF2-1]
ENSMUST00000063321; ENSMUSP00000065128; ENSMUSG00000020389. [Q8BLF2-7]
ENSMUST00000109076; ENSMUSP00000104704; ENSMUSG00000020389. [Q8BLF2-4]
ENSMUST00000109077; ENSMUSP00000104705; ENSMUSG00000020389. [Q8BLF2-4]
ENSMUST00000109078; ENSMUSP00000104706; ENSMUSG00000020389. [Q8BLF2-6]
ENSMUST00000109079; ENSMUSP00000104707; ENSMUSG00000020389. [Q8BLF2-7]
ENSMUST00000109081; ENSMUSP00000104709; ENSMUSG00000020389. [Q8BLF2-2]
ENSMUST00000121591; ENSMUSP00000112477; ENSMUSG00000020389. [Q8BLF2-2]
GeneIDi213084.
KEGGimmu:213084.
UCSCiuc007iuv.2. mouse. [Q8BLF2-1]
uc007iux.2. mouse. [Q8BLF2-4]
uc007iuz.2. mouse. [Q8BLF2-2]
uc011xul.1. mouse. [Q8BLF2-7]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK043995 mRNA. Translation: BAC31729.2.
AK045356 mRNA. Translation: BAC32324.1.
AK046394 mRNA. Translation: BAC32701.1.
AK050990 mRNA. Translation: BAC34488.1.
AK078804 mRNA. Translation: BAC37400.1.
AL669920 Genomic DNA. Translation: CAM19001.1.
AL669920 Genomic DNA. Translation: CAM19002.1.
AL669920 Genomic DNA. Translation: CAM19003.1.
AL669920 Genomic DNA. Translation: CAM19004.1.
AL669920 Genomic DNA. Translation: CAM19005.1.
BC028871 mRNA. Translation: AAH28871.1.
CCDSiCCDS24665.1. [Q8BLF2-1]
CCDS48788.1. [Q8BLF2-7]
CCDS48790.1. [Q8BLF2-2]
CCDS48791.1. [Q8BLF2-6]
CCDS48792.1. [Q8BLF2-4]
RefSeqiNP_001160125.1. NM_001166653.1.
NP_001160126.1. NM_001166654.1. [Q8BLF2-2]
NP_001160127.1. NM_001166655.1. [Q8BLF2-6]
NP_001160128.1. NM_001166656.1. [Q8BLF2-7]
NP_001160129.1. NM_001166657.1. [Q8BLF2-4]
NP_722480.3. NM_153785.4. [Q8BLF2-1]
XP_011247178.1. XM_011248876.1. [Q8BLF2-2]
XP_011247179.1. XM_011248877.2. [Q8BLF2-2]
XP_011247180.1. XM_011248878.1. [Q8BLF2-2]
XP_011247181.1. XM_011248879.1. [Q8BLF2-2]
XP_011247182.1. XM_011248880.2. [Q8BLF2-2]
XP_017169911.1. XM_017314422.1. [Q8BLF2-4]
UniGeneiMm.280557.

3D structure databases

ProteinModelPortaliQ8BLF2.
SMRiQ8BLF2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000104708.

PTM databases

iPTMnetiQ8BLF2.
PhosphoSitePlusiQ8BLF2.

Proteomic databases

PaxDbiQ8BLF2.
PRIDEiQ8BLF2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000063303; ENSMUSP00000064315; ENSMUSG00000020389. [Q8BLF2-1]
ENSMUST00000063321; ENSMUSP00000065128; ENSMUSG00000020389. [Q8BLF2-7]
ENSMUST00000109076; ENSMUSP00000104704; ENSMUSG00000020389. [Q8BLF2-4]
ENSMUST00000109077; ENSMUSP00000104705; ENSMUSG00000020389. [Q8BLF2-4]
ENSMUST00000109078; ENSMUSP00000104706; ENSMUSG00000020389. [Q8BLF2-6]
ENSMUST00000109079; ENSMUSP00000104707; ENSMUSG00000020389. [Q8BLF2-7]
ENSMUST00000109081; ENSMUSP00000104709; ENSMUSG00000020389. [Q8BLF2-2]
ENSMUST00000121591; ENSMUSP00000112477; ENSMUSG00000020389. [Q8BLF2-2]
GeneIDi213084.
KEGGimmu:213084.
UCSCiuc007iuv.2. mouse. [Q8BLF2-1]
uc007iux.2. mouse. [Q8BLF2-4]
uc007iuz.2. mouse. [Q8BLF2-2]
uc011xul.1. mouse. [Q8BLF2-7]

Organism-specific databases

CTDi51265.
MGIiMGI:2388268. Cdkl3.

Phylogenomic databases

eggNOGiKOG0593. Eukaryota.
ENOG410XNSW. LUCA.
GeneTreeiENSGT00830000128262.
HOVERGENiHBG080204.
InParanoidiQ8BLF2.
KOiK08824.
TreeFamiTF101031.

Miscellaneous databases

PROiQ8BLF2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020389.
CleanExiMM_CDKL3.
ExpressionAtlasiQ8BLF2. baseline and differential.
GenevisibleiQ8BLF2. MM.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCDKL3_MOUSE
AccessioniPrimary (citable) accession number: Q8BLF2
Secondary accession number(s): A2ACR7
, A2ACR8, A2ACR9, A2ACS0, A2ACS1, Q5M6W2, Q8BKR2, Q8BL49, Q8BLN9, Q8BVE0, Q8K134
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: November 2, 2016
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.