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Q8BLF2

- CDKL3_MOUSE

UniProt

Q8BLF2 - CDKL3_MOUSE

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Protein

Cyclin-dependent kinase-like 3

Gene
Cdkl3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei33 – 331ATP By similarity
Active sitei125 – 1251Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 189ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase-like 3 (EC:2.7.11.22)
Gene namesi
Name:Cdkl3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:2388268. Cdkl3.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 595595Cyclin-dependent kinase-like 3PRO_0000085822Add
BLAST

Proteomic databases

PaxDbiQ8BLF2.
PRIDEiQ8BLF2.

PTM databases

PhosphoSiteiQ8BLF2.

Expressioni

Gene expression databases

ArrayExpressiQ8BLF2.
BgeeiQ8BLF2.
CleanExiMM_CDKL3.
GenevestigatoriQ8BLF2.

Structurei

3D structure databases

ProteinModelPortaliQ8BLF2.
SMRiQ8BLF2. Positions 1-354.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 286283Protein kinaseAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi45 – 517[NKR]KIAxRE

Domaini

The [NKR]KIAxRE motif seems to be a cyclin-binding region.

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00650000093115.
HOVERGENiHBG080204.
KOiK08824.
OrthoDBiEOG7992PS.
TreeFamiTF101031.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8BLF2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEMYETLGKV GEGSYGTVMK CKHKDTGRIV AIKIFYEKPE KSVNKIATRE    50
IKFLKQFRHE NLVNLIEVFR QKKKIHLVFE FIDHTVLDEL QHYCHGLESK 100
RLRKYLFQIL RAIEYLHNNN IIHRDIKPEN ILVSQSGITK LCDFGFARTL 150
AAPGDVYTDY VATRWYRAPE LVLKDTSYGK PVDIWALGCM IIEMATGHPF 200
LPSSSDLDLL HKIVLKVGNL TPHLHNIFSK SPIFAGVVLP QVQHPKTARK 250
KYPKLNGLLA DIVHACLQID PAERTSSTDL LRHDYFTRDG FIEKFIPELR 300
AKLLQEAKVN SFIKPKENFK ENEPVRDEKK SVFTNTLLYG NPSLYGKEVD 350
RDKRAKELKV RVIKAKGGKG DVPDQKKPEY EGDHRQQGTA DDTQPSSLDK 400
KPSVLELTNP LNPSENSDGV KEDPHAGGCM IMPPINLTSS NLLAANLSSN 450
LSHPNSRLTE RTKKRRTSSQ TIGQTLSNSR QEDTGPTQVQ TEKGAFNERT 500
GQNDQISSGN KRKLNFPKCD RKEFHFPELP FTVQAKEMKG MEVKQIKVLK 550
RESKKTDSSK IPTLLSMDPN QEKQEGGDGD CEGKNLKRNR FFFSR 595
Length:595
Mass (Da):67,739
Last modified:November 22, 2005 - v2
Checksum:i3DB415A3EEBC7C4B
GO
Isoform 2 (identifier: Q8BLF2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     576-585: GGDGDCEGKN → QSARHLPGQC
     586-595: Missing.

Note: No experimental confirmation available.

Show »
Length:585
Mass (Da):66,531
Checksum:i619B377FACD9486D
GO
Isoform 3 (identifier: Q8BLF2-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     576-581: GGDGDC → SLTMYL
     582-595: Missing.

Note: Gene prediction based on EST data.

Show »
Length:581
Mass (Da):66,162
Checksum:i9CC3EAE169D206C9
GO
Isoform 4 (identifier: Q8BLF2-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     295-353: FIPELRAKLL...LYGKEVDRDK → KWTETKGPRS...HWTRSLLSWN
     354-595: Missing.

Note: No experimental confirmation available.

Show »
Length:353
Mass (Da):40,619
Checksum:i7A645EE9FCAE2328
GO
Isoform 5 (identifier: Q8BLF2-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MEMYETLGKVGEGSYGT → MKPLEKWEREVMEP
     576-581: GGDGDC → SLTMYL
     582-595: Missing.

Note: No experimental confirmation available.

Show »
Length:578
Mass (Da):66,112
Checksum:iB62583F530F130E8
GO
Isoform 6 (identifier: Q8BLF2-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     458-595: Missing.

Note: No experimental confirmation available.

Show »
Length:457
Mass (Da):51,901
Checksum:i6FCDD36F51152B61
GO
Isoform 7 (identifier: Q8BLF2-8) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     576-595: GGDGDCEGKNLKRNRFFFSR → QPVKQVNSNQ

Note: No experimental confirmation available.

Show »
Length:585
Mass (Da):66,576
Checksum:i6126BAAC992E6F42
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1717MEMYE…GSYGT → MKPLEKWEREVMEP in isoform 5. VSP_016149Add
BLAST
Alternative sequencei295 – 35359FIPEL…VDRDK → KWTETKGPRSSKSESLRPKG AKEMSQTRRSQSMKATTASR AQLMTHSPHHWTRSLLSWN in isoform 4. VSP_016150Add
BLAST
Alternative sequencei354 – 595242Missing in isoform 4. VSP_016151Add
BLAST
Alternative sequencei458 – 595138Missing in isoform 6. VSP_016152Add
BLAST
Alternative sequencei576 – 59520GGDGD…FFFSR → QPVKQVNSNQ in isoform 7. VSP_030154Add
BLAST
Alternative sequencei576 – 58510GGDGDCEGKN → QSARHLPGQC in isoform 2. VSP_016154
Alternative sequencei576 – 5816GGDGDC → SLTMYL in isoform 3 and isoform 5. VSP_016155
Alternative sequencei582 – 59514Missing in isoform 3 and isoform 5. VSP_016156Add
BLAST
Alternative sequencei586 – 59510Missing in isoform 2. VSP_016157

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti12 – 121E → Q in BAC32701. 1 Publication
Sequence conflicti23 – 231H → Y in BAC37400. 1 Publication
Sequence conflicti153 – 1531P → H in BAC32324. 1 Publication
Sequence conflicti352 – 3521D → E in BAC37400. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK043995 mRNA. Translation: BAC31729.2.
AK045356 mRNA. Translation: BAC32324.1.
AK046394 mRNA. Translation: BAC32701.1.
AK050990 mRNA. Translation: BAC34488.1.
AK078804 mRNA. Translation: BAC37400.1.
AL669920 Genomic DNA. Translation: CAM19001.1.
AL669920 Genomic DNA. Translation: CAM19002.1.
AL669920 Genomic DNA. Translation: CAM19003.1.
AL669920 Genomic DNA. Translation: CAM19004.1.
AL669920 Genomic DNA. Translation: CAM19005.1.
BC028871 mRNA. Translation: AAH28871.1.
CCDSiCCDS24665.1. [Q8BLF2-1]
CCDS48788.1. [Q8BLF2-7]
CCDS48790.1. [Q8BLF2-2]
CCDS48791.1. [Q8BLF2-6]
CCDS48792.1. [Q8BLF2-4]
RefSeqiNP_001160125.1. NM_001166653.1.
NP_001160126.1. NM_001166654.1. [Q8BLF2-2]
NP_001160127.1. NM_001166655.1. [Q8BLF2-6]
NP_001160128.1. NM_001166656.1. [Q8BLF2-7]
NP_001160129.1. NM_001166657.1. [Q8BLF2-4]
NP_722480.3. NM_153785.4. [Q8BLF2-1]
UniGeneiMm.280557.

Genome annotation databases

EnsembliENSMUST00000063303; ENSMUSP00000064315; ENSMUSG00000020389. [Q8BLF2-1]
ENSMUST00000063321; ENSMUSP00000065128; ENSMUSG00000020389. [Q8BLF2-7]
ENSMUST00000109076; ENSMUSP00000104704; ENSMUSG00000020389. [Q8BLF2-4]
ENSMUST00000109077; ENSMUSP00000104705; ENSMUSG00000020389. [Q8BLF2-4]
ENSMUST00000109078; ENSMUSP00000104706; ENSMUSG00000020389. [Q8BLF2-6]
ENSMUST00000109079; ENSMUSP00000104707; ENSMUSG00000020389. [Q8BLF2-7]
ENSMUST00000109081; ENSMUSP00000104709; ENSMUSG00000020389. [Q8BLF2-2]
ENSMUST00000121591; ENSMUSP00000112477; ENSMUSG00000020389. [Q8BLF2-2]
GeneIDi213084.
KEGGimmu:213084.
UCSCiuc007iuv.2. mouse. [Q8BLF2-1]
uc007iux.2. mouse. [Q8BLF2-4]
uc007iuz.2. mouse. [Q8BLF2-2]
uc011xul.1. mouse. [Q8BLF2-7]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK043995 mRNA. Translation: BAC31729.2 .
AK045356 mRNA. Translation: BAC32324.1 .
AK046394 mRNA. Translation: BAC32701.1 .
AK050990 mRNA. Translation: BAC34488.1 .
AK078804 mRNA. Translation: BAC37400.1 .
AL669920 Genomic DNA. Translation: CAM19001.1 .
AL669920 Genomic DNA. Translation: CAM19002.1 .
AL669920 Genomic DNA. Translation: CAM19003.1 .
AL669920 Genomic DNA. Translation: CAM19004.1 .
AL669920 Genomic DNA. Translation: CAM19005.1 .
BC028871 mRNA. Translation: AAH28871.1 .
CCDSi CCDS24665.1. [Q8BLF2-1 ]
CCDS48788.1. [Q8BLF2-7 ]
CCDS48790.1. [Q8BLF2-2 ]
CCDS48791.1. [Q8BLF2-6 ]
CCDS48792.1. [Q8BLF2-4 ]
RefSeqi NP_001160125.1. NM_001166653.1.
NP_001160126.1. NM_001166654.1. [Q8BLF2-2 ]
NP_001160127.1. NM_001166655.1. [Q8BLF2-6 ]
NP_001160128.1. NM_001166656.1. [Q8BLF2-7 ]
NP_001160129.1. NM_001166657.1. [Q8BLF2-4 ]
NP_722480.3. NM_153785.4. [Q8BLF2-1 ]
UniGenei Mm.280557.

3D structure databases

ProteinModelPortali Q8BLF2.
SMRi Q8BLF2. Positions 1-354.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8BLF2.

Proteomic databases

PaxDbi Q8BLF2.
PRIDEi Q8BLF2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000063303 ; ENSMUSP00000064315 ; ENSMUSG00000020389 . [Q8BLF2-1 ]
ENSMUST00000063321 ; ENSMUSP00000065128 ; ENSMUSG00000020389 . [Q8BLF2-7 ]
ENSMUST00000109076 ; ENSMUSP00000104704 ; ENSMUSG00000020389 . [Q8BLF2-4 ]
ENSMUST00000109077 ; ENSMUSP00000104705 ; ENSMUSG00000020389 . [Q8BLF2-4 ]
ENSMUST00000109078 ; ENSMUSP00000104706 ; ENSMUSG00000020389 . [Q8BLF2-6 ]
ENSMUST00000109079 ; ENSMUSP00000104707 ; ENSMUSG00000020389 . [Q8BLF2-7 ]
ENSMUST00000109081 ; ENSMUSP00000104709 ; ENSMUSG00000020389 . [Q8BLF2-2 ]
ENSMUST00000121591 ; ENSMUSP00000112477 ; ENSMUSG00000020389 . [Q8BLF2-2 ]
GeneIDi 213084.
KEGGi mmu:213084.
UCSCi uc007iuv.2. mouse. [Q8BLF2-1 ]
uc007iux.2. mouse. [Q8BLF2-4 ]
uc007iuz.2. mouse. [Q8BLF2-2 ]
uc011xul.1. mouse. [Q8BLF2-7 ]

Organism-specific databases

CTDi 51265.
MGIi MGI:2388268. Cdkl3.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00650000093115.
HOVERGENi HBG080204.
KOi K08824.
OrthoDBi EOG7992PS.
TreeFami TF101031.

Miscellaneous databases

NextBioi 373855.
PROi Q8BLF2.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8BLF2.
Bgeei Q8BLF2.
CleanExi MM_CDKL3.
Genevestigatori Q8BLF2.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 5 AND 6), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 368-595 (ISOFORM 7).
    Strain: C57BL/6J.
    Tissue: Brain cortex, Corpora quadrigemina, Embryo and Embryonic lung.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Strain: FVB/N.
    Tissue: Kidney.

Entry informationi

Entry nameiCDKL3_MOUSE
AccessioniPrimary (citable) accession number: Q8BLF2
Secondary accession number(s): A2ACR7
, A2ACR8, A2ACR9, A2ACS0, A2ACS1, Q5M6W2, Q8BKR2, Q8BL49, Q8BLN9, Q8BVE0, Q8K134
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: July 9, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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