ID   DRD5_MOUSE              Reviewed;         478 AA.
AC   Q8BLD9; Q61439; Q80UB7;
DT   10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   27-MAR-2024, entry version 161.
DE   RecName: Full=D(1B) dopamine receptor;
DE   AltName: Full=D(5) dopamine receptor;
DE   AltName: Full=Dopamine D5 receptor;
GN   Name=Drd5;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Brain;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 112-252.
RX   PubMed=12679517; DOI=10.1073/pnas.0230374100;
RA   Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E.,
RA   Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C.,
RA   Bergmann J.E., Gaitanaris G.A.;
RT   "The G protein-coupled receptor repertoires of human and mouse.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 138-298.
RC   TISSUE=Testis;
RX   PubMed=8288218; DOI=10.1006/geno.1993.1452;
RA   Wilkie T.M., Chen Y., Gilbert D.J., Moore K.J., Yu L., Simon M.I.,
RA   Copeland N.G., Jenkins N.A.;
RT   "Identification, chromosomal location, and genome organization of mammalian
RT   G-protein-coupled receptors.";
RL   Genomics 18:175-184(1993).
CC   -!- FUNCTION: Dopamine receptor whose activity is mediated by G proteins
CC       which activate adenylyl cyclase. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; AK045456; BAC32378.1; -; mRNA.
DR   EMBL; AY255563; AAO85075.1; -; mRNA.
DR   EMBL; L20330; AAA16844.1; -; mRNA.
DR   CCDS; CCDS19255.1; -.
DR   PIR; A48909; A48909.
DR   RefSeq; NP_038531.1; NM_013503.3.
DR   AlphaFoldDB; Q8BLD9; -.
DR   SMR; Q8BLD9; -.
DR   STRING; 10090.ENSMUSP00000039691; -.
DR   BindingDB; Q8BLD9; -.
DR   ChEMBL; CHEMBL2737; -.
DR   DrugCentral; Q8BLD9; -.
DR   GlyCosmos; Q8BLD9; 1 site, No reported glycans.
DR   GlyGen; Q8BLD9; 1 site.
DR   iPTMnet; Q8BLD9; -.
DR   PhosphoSitePlus; Q8BLD9; -.
DR   jPOST; Q8BLD9; -.
DR   PaxDb; 10090-ENSMUSP00000039691; -.
DR   ProteomicsDB; 277495; -.
DR   Antibodypedia; 9652; 456 antibodies from 39 providers.
DR   DNASU; 13492; -.
DR   Ensembl; ENSMUST00000041646.4; ENSMUSP00000039691.3; ENSMUSG00000039358.4.
DR   GeneID; 13492; -.
DR   KEGG; mmu:13492; -.
DR   UCSC; uc008xgn.1; mouse.
DR   AGR; MGI:94927; -.
DR   CTD; 1816; -.
DR   MGI; MGI:94927; Drd5.
DR   VEuPathDB; HostDB:ENSMUSG00000039358; -.
DR   eggNOG; KOG3656; Eukaryota.
DR   GeneTree; ENSGT00940000157037; -.
DR   HOGENOM; CLU_009579_11_0_1; -.
DR   InParanoid; Q8BLD9; -.
DR   OMA; HWHRDKA; -.
DR   OrthoDB; 2900736at2759; -.
DR   PhylomeDB; Q8BLD9; -.
DR   TreeFam; TF325181; -.
DR   Reactome; R-MMU-390651; Dopamine receptors.
DR   Reactome; R-MMU-418555; G alpha (s) signalling events.
DR   BioGRID-ORCS; 13492; 7 hits in 77 CRISPR screens.
DR   PRO; PR:Q8BLD9; -.
DR   Proteomes; UP000000589; Chromosome 5.
DR   RNAct; Q8BLD9; Protein.
DR   Bgee; ENSMUSG00000039358; Expressed in trigeminal ganglion and 35 other cell types or tissues.
DR   ExpressionAtlas; Q8BLD9; baseline and differential.
DR   GO; GO:0030424; C:axon; ISO:MGI.
DR   GO; GO:0031526; C:brush border membrane; IDA:MGI.
DR   GO; GO:0060170; C:ciliary membrane; ISO:MGI.
DR   GO; GO:0005929; C:cilium; ISO:MGI.
DR   GO; GO:0030425; C:dendrite; ISO:MGI.
DR   GO; GO:0043197; C:dendritic spine; ISO:MGI.
DR   GO; GO:0098978; C:glutamatergic synapse; ISO:MGI.
DR   GO; GO:0043025; C:neuronal cell body; ISO:MGI.
DR   GO; GO:0097730; C:non-motile cilium; ISO:MGI.
DR   GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR   GO; GO:0098839; C:postsynaptic density membrane; ISO:MGI.
DR   GO; GO:0035240; F:dopamine binding; ISO:MGI.
DR   GO; GO:0004952; F:dopamine neurotransmitter receptor activity; ISO:MGI.
DR   GO; GO:0001588; F:dopamine neurotransmitter receptor activity, coupled via Gs; IDA:MGI.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR   GO; GO:0001965; F:G-protein alpha-subunit binding; ISO:MGI.
DR   GO; GO:0071880; P:adenylate cyclase-activating adrenergic receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0007191; P:adenylate cyclase-activating dopamine receptor signaling pathway; ISO:MGI.
DR   GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IDA:MGI.
DR   GO; GO:0008306; P:associative learning; IMP:MGI.
DR   GO; GO:0071870; P:cellular response to catecholamine stimulus; ISO:MGI.
DR   GO; GO:0007212; P:dopamine receptor signaling pathway; ISO:MGI.
DR   GO; GO:0060292; P:long-term synaptic depression; IMP:MGI.
DR   GO; GO:0007617; P:mating behavior; IMP:MGI.
DR   GO; GO:0045776; P:negative regulation of blood pressure; IMP:MGI.
DR   GO; GO:0030336; P:negative regulation of cell migration; ISO:MGI.
DR   GO; GO:0001994; P:norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure; IMP:MGI.
DR   GO; GO:0072593; P:reactive oxygen species metabolic process; ISO:MGI.
DR   GO; GO:0045924; P:regulation of female receptivity; IMP:MGI.
DR   GO; GO:0099072; P:regulation of postsynaptic membrane neurotransmitter receptor levels; ISO:MGI.
DR   GO; GO:0001992; P:regulation of systemic arterial blood pressure by vasopressin; IGI:MGI.
DR   GO; GO:0001975; P:response to amphetamine; IGI:MGI.
DR   GO; GO:0042220; P:response to cocaine; IMP:MGI.
DR   GO; GO:0046960; P:sensitization; IGI:MGI.
DR   GO; GO:0019226; P:transmission of nerve impulse; IMP:MGI.
DR   GO; GO:0008542; P:visual learning; ISO:MGI.
DR   GO; GO:0042060; P:wound healing; IMP:MGI.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000497; Dopamine_D5_rcpt.
DR   InterPro; IPR000929; Dopamine_rcpt.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   PANTHER; PTHR24248; ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR; 1.
DR   PANTHER; PTHR24248:SF136; D(1B) DOPAMINE RECEPTOR; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00566; DOPAMINED1BR.
DR   PRINTS; PR00242; DOPAMINER.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Lipoprotein; Membrane; Palmitate; Receptor; Reference proteome; Transducer;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..478
FT                   /note="D(1B) dopamine receptor"
FT                   /id="PRO_0000069407"
FT   TOPO_DOM        1..38
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        39..64
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        65..75
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        76..102
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        103..111
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        112..134
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        135..153
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        154..179
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        180..215
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        216..240
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        241..289
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        290..317
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        318..335
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        336..357
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        358..478
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          416..446
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           370
FT                   /note="S-palmitoyl cysteine"
FT                   /evidence="ECO:0000250"
FT   CARBOHYD        7
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        111..211
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   CONFLICT        231
FT                   /note="P -> L (in Ref. 3; AAA16844)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   478 AA;  53076 MW;  D39165BC558131DF CRC64;
     MLPPGRNGTA HRARLGLQRQ LAQVDAPGGS AAPLGPAQVV TAGLLTLLIV WTLLGNVLVC
     AAIVRSRHLR AKMTNIFIVS LAVSDLFVAL LVMPWKAVAE VAGYWPFGAF CDIWVAFDIM
     CSTASILNLC IISVDRYWAI SRPFRYERKM TQRVALVMVA LAWTLSILIS FIPVQLNWHR
     DKAGSQGREG LLSNETPWEE GWELDGRTEN CDSSLNRTYA ISSSLISFYI PVAIMIVTYT
     RIYRIAQVQI RRISSLERAA EHAQSCRSRG ACEPDPSLRA SIKKETKVFK TLSVIMGVFV
     CCWLPFFILN CMVPFCSSGD AQGPRTGFPC VSETTFDIFV WFGWANSSLN PIIYAFNADF
     RKVFAQLLGC SHLCFRTPVQ TVNISNELIS YNQDTVFHRE IAAAYVHMIP NAVSSGDREV
     GEEEEAEEEG PFDHMSQISP TTPDGDLAAE SVWELDCEEE VSLGKISPLT PNCFHKTA
//