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Protein

D(1B) dopamine receptor

Gene

Drd5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.By similarity

GO - Molecular functioni

GO - Biological processi

  • adenylate cyclase-activating dopamine receptor signaling pathway Source: MGI
  • adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: MGI
  • associative learning Source: MGI
  • cellular response to catecholamine stimulus Source: MGI
  • long term synaptic depression Source: MGI
  • mating behavior Source: MGI
  • negative regulation of blood pressure Source: MGI
  • negative regulation of NAD(P)H oxidase activity Source: MGI
  • norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure Source: MGI
  • phospholipase C-activating dopamine receptor signaling pathway Source: GO_Central
  • positive regulation of adenylate cyclase activity Source: MGI
  • positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway Source: InterPro
  • reactive oxygen species metabolic process Source: MGI
  • regulation of female receptivity Source: MGI
  • regulation of systemic arterial blood pressure by vasopressin Source: MGI
  • response to amphetamine Source: MGI
  • response to cocaine Source: MGI
  • sensitization Source: MGI
  • synaptic transmission, dopaminergic Source: GO_Central
  • transmission of nerve impulse Source: MGI
  • wound healing Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-390651. Dopamine receptors.
R-MMU-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
D(1B) dopamine receptor
Alternative name(s):
D(5) dopamine receptor
Dopamine D5 receptor
Gene namesi
Name:Drd5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:94927. Drd5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 38ExtracellularSequence analysisAdd BLAST38
Transmembranei39 – 64Helical; Name=1Sequence analysisAdd BLAST26
Topological domaini65 – 75CytoplasmicSequence analysisAdd BLAST11
Transmembranei76 – 102Helical; Name=2Sequence analysisAdd BLAST27
Topological domaini103 – 111ExtracellularSequence analysis9
Transmembranei112 – 134Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini135 – 153CytoplasmicSequence analysisAdd BLAST19
Transmembranei154 – 179Helical; Name=4Sequence analysisAdd BLAST26
Topological domaini180 – 215ExtracellularSequence analysisAdd BLAST36
Transmembranei216 – 240Helical; Name=5Sequence analysisAdd BLAST25
Topological domaini241 – 289CytoplasmicSequence analysisAdd BLAST49
Transmembranei290 – 317Helical; Name=6Sequence analysisAdd BLAST28
Topological domaini318 – 335ExtracellularSequence analysisAdd BLAST18
Transmembranei336 – 357Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini358 – 478CytoplasmicSequence analysisAdd BLAST121

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2111359.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000694071 – 478D(1B) dopamine receptorAdd BLAST478

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi7N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi111 ↔ 211PROSITE-ProRule annotation
Lipidationi370S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ8BLD9.
PRIDEiQ8BLD9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000039358.
CleanExiMM_DRD5.
ExpressionAtlasiQ8BLD9. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039691.

Structurei

3D structure databases

ProteinModelPortaliQ8BLD9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118774.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiQ8BLD9.
KOiK05840.
OMAiEGPFDRM.
OrthoDBiEOG091G06VI.
PhylomeDBiQ8BLD9.
TreeFamiTF325181.

Family and domain databases

InterProiIPR000497. Dopamine_D5_rcpt.
IPR000929. Dopamine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00566. DOPAMINED1BR.
PR00242. DOPAMINER.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BLD9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPPGRNGTA HRARLGLQRQ LAQVDAPGGS AAPLGPAQVV TAGLLTLLIV
60 70 80 90 100
WTLLGNVLVC AAIVRSRHLR AKMTNIFIVS LAVSDLFVAL LVMPWKAVAE
110 120 130 140 150
VAGYWPFGAF CDIWVAFDIM CSTASILNLC IISVDRYWAI SRPFRYERKM
160 170 180 190 200
TQRVALVMVA LAWTLSILIS FIPVQLNWHR DKAGSQGREG LLSNETPWEE
210 220 230 240 250
GWELDGRTEN CDSSLNRTYA ISSSLISFYI PVAIMIVTYT RIYRIAQVQI
260 270 280 290 300
RRISSLERAA EHAQSCRSRG ACEPDPSLRA SIKKETKVFK TLSVIMGVFV
310 320 330 340 350
CCWLPFFILN CMVPFCSSGD AQGPRTGFPC VSETTFDIFV WFGWANSSLN
360 370 380 390 400
PIIYAFNADF RKVFAQLLGC SHLCFRTPVQ TVNISNELIS YNQDTVFHRE
410 420 430 440 450
IAAAYVHMIP NAVSSGDREV GEEEEAEEEG PFDHMSQISP TTPDGDLAAE
460 470
SVWELDCEEE VSLGKISPLT PNCFHKTA
Length:478
Mass (Da):53,076
Last modified:March 1, 2003 - v1
Checksum:iD39165BC558131DF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti231P → L in AAA16844 (PubMed:8288218).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK045456 mRNA. Translation: BAC32378.1.
AY255563 mRNA. Translation: AAO85075.1.
L20330 mRNA. Translation: AAA16844.1.
CCDSiCCDS19255.1.
PIRiA48909.
RefSeqiNP_038531.1. NM_013503.3.
UniGeneiMm.167154.

Genome annotation databases

EnsembliENSMUST00000041646; ENSMUSP00000039691; ENSMUSG00000039358.
GeneIDi13492.
KEGGimmu:13492.
UCSCiuc008xgn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK045456 mRNA. Translation: BAC32378.1.
AY255563 mRNA. Translation: AAO85075.1.
L20330 mRNA. Translation: AAA16844.1.
CCDSiCCDS19255.1.
PIRiA48909.
RefSeqiNP_038531.1. NM_013503.3.
UniGeneiMm.167154.

3D structure databases

ProteinModelPortaliQ8BLD9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039691.

Chemistry databases

ChEMBLiCHEMBL2111359.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ8BLD9.
PRIDEiQ8BLD9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000041646; ENSMUSP00000039691; ENSMUSG00000039358.
GeneIDi13492.
KEGGimmu:13492.
UCSCiuc008xgn.1. mouse.

Organism-specific databases

CTDi1816.
MGIiMGI:94927. Drd5.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118774.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiQ8BLD9.
KOiK05840.
OMAiEGPFDRM.
OrthoDBiEOG091G06VI.
PhylomeDBiQ8BLD9.
TreeFamiTF325181.

Enzyme and pathway databases

ReactomeiR-MMU-390651. Dopamine receptors.
R-MMU-418555. G alpha (s) signalling events.

Miscellaneous databases

PROiQ8BLD9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039358.
CleanExiMM_DRD5.
ExpressionAtlasiQ8BLD9. baseline and differential.

Family and domain databases

InterProiIPR000497. Dopamine_D5_rcpt.
IPR000929. Dopamine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00566. DOPAMINED1BR.
PR00242. DOPAMINER.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDRD5_MOUSE
AccessioniPrimary (citable) accession number: Q8BLD9
Secondary accession number(s): Q61439, Q80UB7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: March 1, 2003
Last modified: November 30, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.