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Q8BLD9

- DRD5_MOUSE

UniProt

Q8BLD9 - DRD5_MOUSE

Protein

D(1B) dopamine receptor

Gene

Drd5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.By similarity

    GO - Molecular functioni

    1. dopamine binding Source: Ensembl
    2. dopamine neurotransmitter receptor activity, coupled via Gs Source: MGI

    GO - Biological processi

    1. adenylate cyclase-activating dopamine receptor signaling pathway Source: Ensembl
    2. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: MGI
    3. associative learning Source: MGI
    4. cellular response to catecholamine stimulus Source: Ensembl
    5. long term synaptic depression Source: MGI
    6. mating behavior Source: MGI
    7. negative regulation of blood pressure Source: MGI
    8. negative regulation of NAD(P)H oxidase activity Source: Ensembl
    9. norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure Source: MGI
    10. positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway Source: InterPro
    11. reactive oxygen species metabolic process Source: Ensembl
    12. regulation of female receptivity Source: MGI
    13. regulation of systemic arterial blood pressure by vasopressin Source: MGI
    14. response to amphetamine Source: MGI
    15. response to cocaine Source: MGI
    16. sensitization Source: MGI
    17. transmission of nerve impulse Source: MGI
    18. wound healing Source: MGI

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    D(1B) dopamine receptor
    Alternative name(s):
    D(5) dopamine receptor
    Dopamine D5 receptor
    Gene namesi
    Name:Drd5
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:94927. Drd5.

    Subcellular locationi

    GO - Cellular componenti

    1. brush border membrane Source: MGI
    2. integral component of plasma membrane Source: InterPro

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 478478D(1B) dopamine receptorPRO_0000069407Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi7 – 71N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi111 ↔ 211PROSITE-ProRule annotation
    Lipidationi370 – 3701S-palmitoyl cysteineBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PaxDbiQ8BLD9.
    PRIDEiQ8BLD9.

    Expressioni

    Gene expression databases

    BgeeiQ8BLD9.
    CleanExiMM_DRD5.
    GenevestigatoriQ8BLD9.

    Interactioni

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BLD9.
    SMRiQ8BLD9. Positions 44-369.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3838ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini65 – 7511CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini103 – 1119ExtracellularSequence Analysis
    Topological domaini135 – 15319CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini180 – 21536ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini241 – 28949CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini318 – 33518ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini358 – 478121CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei39 – 6426Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei76 – 10227Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei112 – 13423Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei154 – 17926Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei216 – 24025Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei290 – 31728Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei336 – 35722Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG262978.
    GeneTreeiENSGT00750000117368.
    HOGENOMiHOG000239242.
    HOVERGENiHBG106962.
    InParanoidiQ8BLD9.
    KOiK05840.
    OMAiRAENCDS.
    OrthoDBiEOG780RMN.
    PhylomeDBiQ8BLD9.
    TreeFamiTF325181.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000497. Dopamine_D5_rcpt.
    IPR000929. Dopamine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00566. DOPAMINED1BR.
    PR00242. DOPAMINER.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8BLD9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLPPGRNGTA HRARLGLQRQ LAQVDAPGGS AAPLGPAQVV TAGLLTLLIV    50
    WTLLGNVLVC AAIVRSRHLR AKMTNIFIVS LAVSDLFVAL LVMPWKAVAE 100
    VAGYWPFGAF CDIWVAFDIM CSTASILNLC IISVDRYWAI SRPFRYERKM 150
    TQRVALVMVA LAWTLSILIS FIPVQLNWHR DKAGSQGREG LLSNETPWEE 200
    GWELDGRTEN CDSSLNRTYA ISSSLISFYI PVAIMIVTYT RIYRIAQVQI 250
    RRISSLERAA EHAQSCRSRG ACEPDPSLRA SIKKETKVFK TLSVIMGVFV 300
    CCWLPFFILN CMVPFCSSGD AQGPRTGFPC VSETTFDIFV WFGWANSSLN 350
    PIIYAFNADF RKVFAQLLGC SHLCFRTPVQ TVNISNELIS YNQDTVFHRE 400
    IAAAYVHMIP NAVSSGDREV GEEEEAEEEG PFDHMSQISP TTPDGDLAAE 450
    SVWELDCEEE VSLGKISPLT PNCFHKTA 478
    Length:478
    Mass (Da):53,076
    Last modified:March 1, 2003 - v1
    Checksum:iD39165BC558131DF
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti231 – 2311P → L in AAA16844. (PubMed:8288218)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK045456 mRNA. Translation: BAC32378.1.
    AY255563 mRNA. Translation: AAO85075.1.
    L20330 mRNA. Translation: AAA16844.1.
    CCDSiCCDS19255.1.
    PIRiA48909.
    RefSeqiNP_038531.1. NM_013503.2.
    UniGeneiMm.167154.

    Genome annotation databases

    EnsembliENSMUST00000041646; ENSMUSP00000039691; ENSMUSG00000039358.
    GeneIDi13492.
    KEGGimmu:13492.
    UCSCiuc008xgn.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK045456 mRNA. Translation: BAC32378.1 .
    AY255563 mRNA. Translation: AAO85075.1 .
    L20330 mRNA. Translation: AAA16844.1 .
    CCDSi CCDS19255.1.
    PIRi A48909.
    RefSeqi NP_038531.1. NM_013503.2.
    UniGenei Mm.167154.

    3D structure databases

    ProteinModelPortali Q8BLD9.
    SMRi Q8BLD9. Positions 44-369.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi Q8BLD9.
    ChEMBLi CHEMBL2111359.
    GuidetoPHARMACOLOGYi 218.

    Protein family/group databases

    GPCRDBi Search...

    Proteomic databases

    PaxDbi Q8BLD9.
    PRIDEi Q8BLD9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000041646 ; ENSMUSP00000039691 ; ENSMUSG00000039358 .
    GeneIDi 13492.
    KEGGi mmu:13492.
    UCSCi uc008xgn.1. mouse.

    Organism-specific databases

    CTDi 1816.
    MGIi MGI:94927. Drd5.

    Phylogenomic databases

    eggNOGi NOG262978.
    GeneTreei ENSGT00750000117368.
    HOGENOMi HOG000239242.
    HOVERGENi HBG106962.
    InParanoidi Q8BLD9.
    KOi K05840.
    OMAi RAENCDS.
    OrthoDBi EOG780RMN.
    PhylomeDBi Q8BLD9.
    TreeFami TF325181.

    Miscellaneous databases

    NextBioi 284013.
    PROi Q8BLD9.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8BLD9.
    CleanExi MM_DRD5.
    Genevestigatori Q8BLD9.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000497. Dopamine_D5_rcpt.
    IPR000929. Dopamine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00566. DOPAMINED1BR.
    PR00242. DOPAMINER.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Brain.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 112-252.
    3. "Identification, chromosomal location, and genome organization of mammalian G-protein-coupled receptors."
      Wilkie T.M., Chen Y., Gilbert D.J., Moore K.J., Yu L., Simon M.I., Copeland N.G., Jenkins N.A.
      Genomics 18:175-184(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 138-298.
      Tissue: Testis.

    Entry informationi

    Entry nameiDRD5_MOUSE
    AccessioniPrimary (citable) accession number: Q8BLD9
    Secondary accession number(s): Q61439, Q80UB7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2004
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3