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Q8BLD9

- DRD5_MOUSE

UniProt

Q8BLD9 - DRD5_MOUSE

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Protein
D(1B) dopamine receptor
Gene
Drd5
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase By similarity.

GO - Molecular functioni

  1. dopamine binding Source: Ensembl
  2. dopamine neurotransmitter receptor activity, coupled via Gs Source: MGI

GO - Biological processi

  1. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: MGI
  2. adenylate cyclase-activating dopamine receptor signaling pathway Source: Ensembl
  3. associative learning Source: MGI
  4. cellular response to catecholamine stimulus Source: Ensembl
  5. long term synaptic depression Source: MGI
  6. mating behavior Source: MGI
  7. negative regulation of NAD(P)H oxidase activity Source: Ensembl
  8. negative regulation of blood pressure Source: MGI
  9. norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure Source: MGI
  10. positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway Source: InterPro
  11. reactive oxygen species metabolic process Source: Ensembl
  12. regulation of female receptivity Source: MGI
  13. regulation of systemic arterial blood pressure by vasopressin Source: MGI
  14. response to amphetamine Source: MGI
  15. response to cocaine Source: MGI
  16. sensitization Source: MGI
  17. transmission of nerve impulse Source: MGI
  18. wound healing Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
D(1B) dopamine receptor
Alternative name(s):
D(5) dopamine receptor
Dopamine D5 receptor
Gene namesi
Name:Drd5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:94927. Drd5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3838Extracellular Reviewed prediction
Add
BLAST
Transmembranei39 – 6426Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini65 – 7511Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei76 – 10227Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini103 – 1119Extracellular Reviewed prediction
Transmembranei112 – 13423Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini135 – 15319Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei154 – 17926Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini180 – 21536Extracellular Reviewed prediction
Add
BLAST
Transmembranei216 – 24025Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini241 – 28949Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei290 – 31728Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini318 – 33518Extracellular Reviewed prediction
Add
BLAST
Transmembranei336 – 35722Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini358 – 478121Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. brush border membrane Source: MGI
  2. integral component of plasma membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 478478D(1B) dopamine receptor
PRO_0000069407Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi7 – 71N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi111 ↔ 211 By similarity
Lipidationi370 – 3701S-palmitoyl cysteine By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ8BLD9.
PRIDEiQ8BLD9.

Expressioni

Gene expression databases

BgeeiQ8BLD9.
CleanExiMM_DRD5.
GenevestigatoriQ8BLD9.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliQ8BLD9.
SMRiQ8BLD9. Positions 44-369.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG262978.
GeneTreeiENSGT00750000117368.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiQ8BLD9.
KOiK05840.
OMAiRAENCDS.
OrthoDBiEOG780RMN.
PhylomeDBiQ8BLD9.
TreeFamiTF325181.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000497. Dopamine_D5_rcpt.
IPR000929. Dopamine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00566. DOPAMINED1BR.
PR00242. DOPAMINER.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BLD9-1 [UniParc]FASTAAdd to Basket

« Hide

MLPPGRNGTA HRARLGLQRQ LAQVDAPGGS AAPLGPAQVV TAGLLTLLIV    50
WTLLGNVLVC AAIVRSRHLR AKMTNIFIVS LAVSDLFVAL LVMPWKAVAE 100
VAGYWPFGAF CDIWVAFDIM CSTASILNLC IISVDRYWAI SRPFRYERKM 150
TQRVALVMVA LAWTLSILIS FIPVQLNWHR DKAGSQGREG LLSNETPWEE 200
GWELDGRTEN CDSSLNRTYA ISSSLISFYI PVAIMIVTYT RIYRIAQVQI 250
RRISSLERAA EHAQSCRSRG ACEPDPSLRA SIKKETKVFK TLSVIMGVFV 300
CCWLPFFILN CMVPFCSSGD AQGPRTGFPC VSETTFDIFV WFGWANSSLN 350
PIIYAFNADF RKVFAQLLGC SHLCFRTPVQ TVNISNELIS YNQDTVFHRE 400
IAAAYVHMIP NAVSSGDREV GEEEEAEEEG PFDHMSQISP TTPDGDLAAE 450
SVWELDCEEE VSLGKISPLT PNCFHKTA 478
Length:478
Mass (Da):53,076
Last modified:March 1, 2003 - v1
Checksum:iD39165BC558131DF
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti231 – 2311P → L in AAA16844. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK045456 mRNA. Translation: BAC32378.1.
AY255563 mRNA. Translation: AAO85075.1.
L20330 mRNA. Translation: AAA16844.1.
CCDSiCCDS19255.1.
PIRiA48909.
RefSeqiNP_038531.1. NM_013503.2.
UniGeneiMm.167154.

Genome annotation databases

EnsembliENSMUST00000041646; ENSMUSP00000039691; ENSMUSG00000039358.
GeneIDi13492.
KEGGimmu:13492.
UCSCiuc008xgn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK045456 mRNA. Translation: BAC32378.1 .
AY255563 mRNA. Translation: AAO85075.1 .
L20330 mRNA. Translation: AAA16844.1 .
CCDSi CCDS19255.1.
PIRi A48909.
RefSeqi NP_038531.1. NM_013503.2.
UniGenei Mm.167154.

3D structure databases

ProteinModelPortali Q8BLD9.
SMRi Q8BLD9. Positions 44-369.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi Q8BLD9.
ChEMBLi CHEMBL2111359.
GuidetoPHARMACOLOGYi 218.

Protein family/group databases

GPCRDBi Search...

Proteomic databases

PaxDbi Q8BLD9.
PRIDEi Q8BLD9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000041646 ; ENSMUSP00000039691 ; ENSMUSG00000039358 .
GeneIDi 13492.
KEGGi mmu:13492.
UCSCi uc008xgn.1. mouse.

Organism-specific databases

CTDi 1816.
MGIi MGI:94927. Drd5.

Phylogenomic databases

eggNOGi NOG262978.
GeneTreei ENSGT00750000117368.
HOGENOMi HOG000239242.
HOVERGENi HBG106962.
InParanoidi Q8BLD9.
KOi K05840.
OMAi RAENCDS.
OrthoDBi EOG780RMN.
PhylomeDBi Q8BLD9.
TreeFami TF325181.

Miscellaneous databases

NextBioi 284013.
PROi Q8BLD9.
SOURCEi Search...

Gene expression databases

Bgeei Q8BLD9.
CleanExi MM_DRD5.
Genevestigatori Q8BLD9.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000497. Dopamine_D5_rcpt.
IPR000929. Dopamine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00566. DOPAMINED1BR.
PR00242. DOPAMINER.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 112-252.
  3. "Identification, chromosomal location, and genome organization of mammalian G-protein-coupled receptors."
    Wilkie T.M., Chen Y., Gilbert D.J., Moore K.J., Yu L., Simon M.I., Copeland N.G., Jenkins N.A.
    Genomics 18:175-184(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 138-298.
    Tissue: Testis.

Entry informationi

Entry nameiDRD5_MOUSE
AccessioniPrimary (citable) accession number: Q8BLD9
Secondary accession number(s): Q61439, Q80UB7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi