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Q8BLD9

- DRD5_MOUSE

UniProt

Q8BLD9 - DRD5_MOUSE

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Protein

D(1B) dopamine receptor

Gene

Drd5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.By similarity

GO - Molecular functioni

  1. dopamine binding Source: Ensembl
  2. dopamine neurotransmitter receptor activity, coupled via Gs Source: MGI

GO - Biological processi

  1. adenylate cyclase-activating dopamine receptor signaling pathway Source: Ensembl
  2. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: MGI
  3. associative learning Source: MGI
  4. cellular response to catecholamine stimulus Source: Ensembl
  5. long term synaptic depression Source: MGI
  6. mating behavior Source: MGI
  7. negative regulation of blood pressure Source: MGI
  8. negative regulation of NAD(P)H oxidase activity Source: Ensembl
  9. norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure Source: MGI
  10. positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway Source: InterPro
  11. reactive oxygen species metabolic process Source: Ensembl
  12. regulation of female receptivity Source: MGI
  13. regulation of systemic arterial blood pressure by vasopressin Source: MGI
  14. response to amphetamine Source: MGI
  15. response to cocaine Source: MGI
  16. sensitization Source: MGI
  17. transmission of nerve impulse Source: MGI
  18. wound healing Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_242871. G alpha (s) signalling events.
REACT_253535. Dopamine receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
D(1B) dopamine receptor
Alternative name(s):
D(5) dopamine receptor
Dopamine D5 receptor
Gene namesi
Name:Drd5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:94927. Drd5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3838ExtracellularSequence AnalysisAdd
BLAST
Transmembranei39 – 6426Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini65 – 7511CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei76 – 10227Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini103 – 1119ExtracellularSequence Analysis
Transmembranei112 – 13423Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini135 – 15319CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei154 – 17926Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini180 – 21536ExtracellularSequence AnalysisAdd
BLAST
Transmembranei216 – 24025Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini241 – 28949CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei290 – 31728Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini318 – 33518ExtracellularSequence AnalysisAdd
BLAST
Transmembranei336 – 35722Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini358 – 478121CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. brush border membrane Source: MGI
  2. integral component of plasma membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 478478D(1B) dopamine receptorPRO_0000069407Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi7 – 71N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi111 ↔ 211PROSITE-ProRule annotation
Lipidationi370 – 3701S-palmitoyl cysteineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ8BLD9.
PRIDEiQ8BLD9.

Expressioni

Gene expression databases

BgeeiQ8BLD9.
CleanExiMM_DRD5.
ExpressionAtlasiQ8BLD9. baseline.
GenevestigatoriQ8BLD9.

Structurei

3D structure databases

ProteinModelPortaliQ8BLD9.
SMRiQ8BLD9. Positions 44-369.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG262978.
GeneTreeiENSGT00760000118774.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiQ8BLD9.
KOiK05840.
OMAiRAENCDS.
OrthoDBiEOG780RMN.
PhylomeDBiQ8BLD9.
TreeFamiTF325181.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000497. Dopamine_D5_rcpt.
IPR000929. Dopamine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00566. DOPAMINED1BR.
PR00242. DOPAMINER.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BLD9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLPPGRNGTA HRARLGLQRQ LAQVDAPGGS AAPLGPAQVV TAGLLTLLIV
60 70 80 90 100
WTLLGNVLVC AAIVRSRHLR AKMTNIFIVS LAVSDLFVAL LVMPWKAVAE
110 120 130 140 150
VAGYWPFGAF CDIWVAFDIM CSTASILNLC IISVDRYWAI SRPFRYERKM
160 170 180 190 200
TQRVALVMVA LAWTLSILIS FIPVQLNWHR DKAGSQGREG LLSNETPWEE
210 220 230 240 250
GWELDGRTEN CDSSLNRTYA ISSSLISFYI PVAIMIVTYT RIYRIAQVQI
260 270 280 290 300
RRISSLERAA EHAQSCRSRG ACEPDPSLRA SIKKETKVFK TLSVIMGVFV
310 320 330 340 350
CCWLPFFILN CMVPFCSSGD AQGPRTGFPC VSETTFDIFV WFGWANSSLN
360 370 380 390 400
PIIYAFNADF RKVFAQLLGC SHLCFRTPVQ TVNISNELIS YNQDTVFHRE
410 420 430 440 450
IAAAYVHMIP NAVSSGDREV GEEEEAEEEG PFDHMSQISP TTPDGDLAAE
460 470
SVWELDCEEE VSLGKISPLT PNCFHKTA
Length:478
Mass (Da):53,076
Last modified:March 1, 2003 - v1
Checksum:iD39165BC558131DF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti231 – 2311P → L in AAA16844. (PubMed:8288218)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK045456 mRNA. Translation: BAC32378.1.
AY255563 mRNA. Translation: AAO85075.1.
L20330 mRNA. Translation: AAA16844.1.
CCDSiCCDS19255.1.
PIRiA48909.
RefSeqiNP_038531.1. NM_013503.2.
UniGeneiMm.167154.

Genome annotation databases

EnsembliENSMUST00000041646; ENSMUSP00000039691; ENSMUSG00000039358.
GeneIDi13492.
KEGGimmu:13492.
UCSCiuc008xgn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK045456 mRNA. Translation: BAC32378.1 .
AY255563 mRNA. Translation: AAO85075.1 .
L20330 mRNA. Translation: AAA16844.1 .
CCDSi CCDS19255.1.
PIRi A48909.
RefSeqi NP_038531.1. NM_013503.2.
UniGenei Mm.167154.

3D structure databases

ProteinModelPortali Q8BLD9.
SMRi Q8BLD9. Positions 44-369.
ModBasei Search...
MobiDBi Search...

Chemistry

ChEMBLi CHEMBL2111359.
GuidetoPHARMACOLOGYi 218.

Protein family/group databases

GPCRDBi Search...

Proteomic databases

PaxDbi Q8BLD9.
PRIDEi Q8BLD9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000041646 ; ENSMUSP00000039691 ; ENSMUSG00000039358 .
GeneIDi 13492.
KEGGi mmu:13492.
UCSCi uc008xgn.1. mouse.

Organism-specific databases

CTDi 1816.
MGIi MGI:94927. Drd5.

Phylogenomic databases

eggNOGi NOG262978.
GeneTreei ENSGT00760000118774.
HOGENOMi HOG000239242.
HOVERGENi HBG106962.
InParanoidi Q8BLD9.
KOi K05840.
OMAi RAENCDS.
OrthoDBi EOG780RMN.
PhylomeDBi Q8BLD9.
TreeFami TF325181.

Enzyme and pathway databases

Reactomei REACT_242871. G alpha (s) signalling events.
REACT_253535. Dopamine receptors.

Miscellaneous databases

NextBioi 284013.
PROi Q8BLD9.
SOURCEi Search...

Gene expression databases

Bgeei Q8BLD9.
CleanExi MM_DRD5.
ExpressionAtlasi Q8BLD9. baseline.
Genevestigatori Q8BLD9.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000497. Dopamine_D5_rcpt.
IPR000929. Dopamine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00566. DOPAMINED1BR.
PR00242. DOPAMINER.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 112-252.
  3. "Identification, chromosomal location, and genome organization of mammalian G-protein-coupled receptors."
    Wilkie T.M., Chen Y., Gilbert D.J., Moore K.J., Yu L., Simon M.I., Copeland N.G., Jenkins N.A.
    Genomics 18:175-184(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 138-298.
    Tissue: Testis.

Entry informationi

Entry nameiDRD5_MOUSE
AccessioniPrimary (citable) accession number: Q8BLD9
Secondary accession number(s): Q61439, Q80UB7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: March 1, 2003
Last modified: November 26, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3