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Q8BLD9 (DRD5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
D(1B) dopamine receptor
Alternative name(s):
D(5) dopamine receptor
Dopamine D5 receptor
Gene names
Name:Drd5
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length478 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
Lipoprotein
Palmitate
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processadenylate cyclase-activating G-protein coupled receptor signaling pathway

Inferred from direct assay PubMed 15598876. Source: MGI

adenylate cyclase-activating dopamine receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

associative learning

Inferred from mutant phenotype PubMed 15696326. Source: MGI

cellular response to catecholamine stimulus

Inferred from electronic annotation. Source: Ensembl

long term synaptic depression

Inferred from mutant phenotype PubMed 13679419. Source: MGI

mating behavior

Inferred from mutant phenotype PubMed 15696326. Source: MGI

negative regulation of NAD(P)H oxidase activity

Inferred from electronic annotation. Source: Ensembl

negative regulation of blood pressure

Inferred from mutant phenotype PubMed 12486173PubMed 15598876. Source: MGI

norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure

Inferred from mutant phenotype PubMed 12486173. Source: MGI

positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway

Inferred from electronic annotation. Source: InterPro

reactive oxygen species metabolic process

Inferred from electronic annotation. Source: Ensembl

regulation of female receptivity

Inferred from mutant phenotype PubMed 15696326. Source: MGI

regulation of systemic arterial blood pressure by vasopressin

Inferred from genetic interaction PubMed 12486173. Source: MGI

response to amphetamine

Inferred from genetic interaction PubMed 11823893. Source: MGI

response to cocaine

Inferred from mutant phenotype PubMed 12768268. Source: MGI

sensitization

Inferred from genetic interaction PubMed 11823893. Source: MGI

transmission of nerve impulse

Inferred from mutant phenotype PubMed 12867509. Source: MGI

wound healing

Inferred from mutant phenotype PubMed 11595429. Source: MGI

   Cellular_componentbrush border membrane

Inferred from direct assay PubMed 15598876. Source: MGI

integral component of plasma membrane

Inferred from electronic annotation. Source: InterPro

   Molecular_functiondopamine binding

Inferred from electronic annotation. Source: Ensembl

dopamine neurotransmitter receptor activity, coupled via Gs

Inferred from direct assay PubMed 16962565. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 478478D(1B) dopamine receptor
PRO_0000069407

Regions

Topological domain1 – 3838Extracellular Potential
Transmembrane39 – 6426Helical; Name=1; Potential
Topological domain65 – 7511Cytoplasmic Potential
Transmembrane76 – 10227Helical; Name=2; Potential
Topological domain103 – 1119Extracellular Potential
Transmembrane112 – 13423Helical; Name=3; Potential
Topological domain135 – 15319Cytoplasmic Potential
Transmembrane154 – 17926Helical; Name=4; Potential
Topological domain180 – 21536Extracellular Potential
Transmembrane216 – 24025Helical; Name=5; Potential
Topological domain241 – 28949Cytoplasmic Potential
Transmembrane290 – 31728Helical; Name=6; Potential
Topological domain318 – 33518Extracellular Potential
Transmembrane336 – 35722Helical; Name=7; Potential
Topological domain358 – 478121Cytoplasmic Potential

Amino acid modifications

Lipidation3701S-palmitoyl cysteine By similarity
Glycosylation71N-linked (GlcNAc...) Potential
Disulfide bond111 ↔ 211 By similarity

Experimental info

Sequence conflict2311P → L in AAA16844. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q8BLD9 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: D39165BC558131DF

FASTA47853,076
        10         20         30         40         50         60 
MLPPGRNGTA HRARLGLQRQ LAQVDAPGGS AAPLGPAQVV TAGLLTLLIV WTLLGNVLVC 

        70         80         90        100        110        120 
AAIVRSRHLR AKMTNIFIVS LAVSDLFVAL LVMPWKAVAE VAGYWPFGAF CDIWVAFDIM 

       130        140        150        160        170        180 
CSTASILNLC IISVDRYWAI SRPFRYERKM TQRVALVMVA LAWTLSILIS FIPVQLNWHR 

       190        200        210        220        230        240 
DKAGSQGREG LLSNETPWEE GWELDGRTEN CDSSLNRTYA ISSSLISFYI PVAIMIVTYT 

       250        260        270        280        290        300 
RIYRIAQVQI RRISSLERAA EHAQSCRSRG ACEPDPSLRA SIKKETKVFK TLSVIMGVFV 

       310        320        330        340        350        360 
CCWLPFFILN CMVPFCSSGD AQGPRTGFPC VSETTFDIFV WFGWANSSLN PIIYAFNADF 

       370        380        390        400        410        420 
RKVFAQLLGC SHLCFRTPVQ TVNISNELIS YNQDTVFHRE IAAAYVHMIP NAVSSGDREV 

       430        440        450        460        470 
GEEEEAEEEG PFDHMSQISP TTPDGDLAAE SVWELDCEEE VSLGKISPLT PNCFHKTA 

« Hide

References

« Hide 'large scale' references
[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Brain.
[2]"The G protein-coupled receptor repertoires of human and mouse."
Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E., Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C., Bergmann J.E., Gaitanaris G.A.
Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 112-252.
[3]"Identification, chromosomal location, and genome organization of mammalian G-protein-coupled receptors."
Wilkie T.M., Chen Y., Gilbert D.J., Moore K.J., Yu L., Simon M.I., Copeland N.G., Jenkins N.A.
Genomics 18:175-184(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 138-298.
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK045456 mRNA. Translation: BAC32378.1.
AY255563 mRNA. Translation: AAO85075.1.
L20330 mRNA. Translation: AAA16844.1.
CCDSCCDS19255.1.
PIRA48909.
RefSeqNP_038531.1. NM_013503.2.
UniGeneMm.167154.

3D structure databases

ProteinModelPortalQ8BLD9.
SMRQ8BLD9. Positions 44-369.
ModBaseSearch...
MobiDBSearch...

Chemistry

BindingDBQ8BLD9.
ChEMBLCHEMBL2111359.
GuidetoPHARMACOLOGY218.

Protein family/group databases

GPCRDBSearch...

Proteomic databases

PaxDbQ8BLD9.
PRIDEQ8BLD9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000041646; ENSMUSP00000039691; ENSMUSG00000039358.
GeneID13492.
KEGGmmu:13492.
UCSCuc008xgn.1. mouse.

Organism-specific databases

CTD1816.
MGIMGI:94927. Drd5.

Phylogenomic databases

eggNOGNOG262978.
GeneTreeENSGT00750000117368.
HOGENOMHOG000239242.
HOVERGENHBG106962.
InParanoidQ8BLD9.
KOK05840.
OMARAENCDS.
OrthoDBEOG780RMN.
PhylomeDBQ8BLD9.
TreeFamTF325181.

Gene expression databases

BgeeQ8BLD9.
CleanExMM_DRD5.
GenevestigatorQ8BLD9.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000497. Dopamine_D5_rcpt.
IPR000929. Dopamine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00566. DOPAMINED1BR.
PR00242. DOPAMINER.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio284013.
PROQ8BLD9.
SOURCESearch...

Entry information

Entry nameDRD5_MOUSE
AccessionPrimary (citable) accession number: Q8BLD9
Secondary accession number(s): Q61439, Q80UB7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries