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Protein

D(1B) dopamine receptor

Gene

Drd5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.By similarity

GO - Molecular functioni

  1. dopamine binding Source: MGI
  2. dopamine neurotransmitter receptor activity Source: MGI
  3. dopamine neurotransmitter receptor activity, coupled via Gs Source: MGI

GO - Biological processi

  1. adenylate cyclase-activating dopamine receptor signaling pathway Source: MGI
  2. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: MGI
  3. associative learning Source: MGI
  4. cellular response to catecholamine stimulus Source: MGI
  5. long term synaptic depression Source: MGI
  6. mating behavior Source: MGI
  7. negative regulation of blood pressure Source: MGI
  8. negative regulation of NAD(P)H oxidase activity Source: MGI
  9. norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure Source: MGI
  10. positive regulation of adenylate cyclase activity Source: MGI
  11. positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway Source: InterPro
  12. reactive oxygen species metabolic process Source: MGI
  13. regulation of female receptivity Source: MGI
  14. regulation of systemic arterial blood pressure by vasopressin Source: MGI
  15. response to amphetamine Source: MGI
  16. response to cocaine Source: MGI
  17. sensitization Source: MGI
  18. transmission of nerve impulse Source: MGI
  19. wound healing Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_242871. G alpha (s) signalling events.
REACT_253535. Dopamine receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
D(1B) dopamine receptor
Alternative name(s):
D(5) dopamine receptor
Dopamine D5 receptor
Gene namesi
Name:Drd5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:94927. Drd5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3838ExtracellularSequence AnalysisAdd
BLAST
Transmembranei39 – 6426Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini65 – 7511CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei76 – 10227Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini103 – 1119ExtracellularSequence Analysis
Transmembranei112 – 13423Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini135 – 15319CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei154 – 17926Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini180 – 21536ExtracellularSequence AnalysisAdd
BLAST
Transmembranei216 – 24025Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini241 – 28949CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei290 – 31728Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini318 – 33518ExtracellularSequence AnalysisAdd
BLAST
Transmembranei336 – 35722Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini358 – 478121CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. brush border membrane Source: MGI
  2. integral component of plasma membrane Source: InterPro
  3. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 478478D(1B) dopamine receptorPRO_0000069407Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi7 – 71N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi111 ↔ 211PROSITE-ProRule annotation
Lipidationi370 – 3701S-palmitoyl cysteineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ8BLD9.
PRIDEiQ8BLD9.

Expressioni

Gene expression databases

BgeeiQ8BLD9.
CleanExiMM_DRD5.
ExpressionAtlasiQ8BLD9. baseline.
GenevestigatoriQ8BLD9.

Structurei

3D structure databases

ProteinModelPortaliQ8BLD9.
SMRiQ8BLD9. Positions 44-369.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG262978.
GeneTreeiENSGT00760000118774.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiQ8BLD9.
KOiK05840.
OMAiRAENCDS.
OrthoDBiEOG780RMN.
PhylomeDBiQ8BLD9.
TreeFamiTF325181.

Family and domain databases

InterProiIPR000497. Dopamine_D5_rcpt.
IPR000929. Dopamine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00566. DOPAMINED1BR.
PR00242. DOPAMINER.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BLD9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLPPGRNGTA HRARLGLQRQ LAQVDAPGGS AAPLGPAQVV TAGLLTLLIV
60 70 80 90 100
WTLLGNVLVC AAIVRSRHLR AKMTNIFIVS LAVSDLFVAL LVMPWKAVAE
110 120 130 140 150
VAGYWPFGAF CDIWVAFDIM CSTASILNLC IISVDRYWAI SRPFRYERKM
160 170 180 190 200
TQRVALVMVA LAWTLSILIS FIPVQLNWHR DKAGSQGREG LLSNETPWEE
210 220 230 240 250
GWELDGRTEN CDSSLNRTYA ISSSLISFYI PVAIMIVTYT RIYRIAQVQI
260 270 280 290 300
RRISSLERAA EHAQSCRSRG ACEPDPSLRA SIKKETKVFK TLSVIMGVFV
310 320 330 340 350
CCWLPFFILN CMVPFCSSGD AQGPRTGFPC VSETTFDIFV WFGWANSSLN
360 370 380 390 400
PIIYAFNADF RKVFAQLLGC SHLCFRTPVQ TVNISNELIS YNQDTVFHRE
410 420 430 440 450
IAAAYVHMIP NAVSSGDREV GEEEEAEEEG PFDHMSQISP TTPDGDLAAE
460 470
SVWELDCEEE VSLGKISPLT PNCFHKTA
Length:478
Mass (Da):53,076
Last modified:March 1, 2003 - v1
Checksum:iD39165BC558131DF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti231 – 2311P → L in AAA16844. (PubMed:8288218)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK045456 mRNA. Translation: BAC32378.1.
AY255563 mRNA. Translation: AAO85075.1.
L20330 mRNA. Translation: AAA16844.1.
CCDSiCCDS19255.1.
PIRiA48909.
RefSeqiNP_038531.1. NM_013503.2.
UniGeneiMm.167154.

Genome annotation databases

EnsembliENSMUST00000041646; ENSMUSP00000039691; ENSMUSG00000039358.
GeneIDi13492.
KEGGimmu:13492.
UCSCiuc008xgn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK045456 mRNA. Translation: BAC32378.1.
AY255563 mRNA. Translation: AAO85075.1.
L20330 mRNA. Translation: AAA16844.1.
CCDSiCCDS19255.1.
PIRiA48909.
RefSeqiNP_038531.1. NM_013503.2.
UniGeneiMm.167154.

3D structure databases

ProteinModelPortaliQ8BLD9.
SMRiQ8BLD9. Positions 44-369.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

ChEMBLiCHEMBL2111359.
GuidetoPHARMACOLOGYi218.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ8BLD9.
PRIDEiQ8BLD9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000041646; ENSMUSP00000039691; ENSMUSG00000039358.
GeneIDi13492.
KEGGimmu:13492.
UCSCiuc008xgn.1. mouse.

Organism-specific databases

CTDi1816.
MGIiMGI:94927. Drd5.

Phylogenomic databases

eggNOGiNOG262978.
GeneTreeiENSGT00760000118774.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiQ8BLD9.
KOiK05840.
OMAiRAENCDS.
OrthoDBiEOG780RMN.
PhylomeDBiQ8BLD9.
TreeFamiTF325181.

Enzyme and pathway databases

ReactomeiREACT_242871. G alpha (s) signalling events.
REACT_253535. Dopamine receptors.

Miscellaneous databases

NextBioi284013.
PROiQ8BLD9.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BLD9.
CleanExiMM_DRD5.
ExpressionAtlasiQ8BLD9. baseline.
GenevestigatoriQ8BLD9.

Family and domain databases

InterProiIPR000497. Dopamine_D5_rcpt.
IPR000929. Dopamine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00566. DOPAMINED1BR.
PR00242. DOPAMINER.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 112-252.
  3. "Identification, chromosomal location, and genome organization of mammalian G-protein-coupled receptors."
    Wilkie T.M., Chen Y., Gilbert D.J., Moore K.J., Yu L., Simon M.I., Copeland N.G., Jenkins N.A.
    Genomics 18:175-184(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 138-298.
    Tissue: Testis.

Entry informationi

Entry nameiDRD5_MOUSE
AccessioniPrimary (citable) accession number: Q8BLD9
Secondary accession number(s): Q61439, Q80UB7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: March 1, 2003
Last modified: February 4, 2015
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.