Q8BLD9 (DRD5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
D(1B) dopamine receptor

Alternative name(s):
D(5) dopamine receptor
Dopamine D5 receptor

Gene names

Name:

Drd5

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	478 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Lipoprotein Palmitate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	adenylate cyclase-activating G-protein coupled receptor signaling pathway Inferred from direct assay PubMed 15598876. Source: MGI adenylate cyclase-activating dopamine receptor signaling pathway Inferred from electronic annotation. Source: Compara associative learning Inferred from mutant phenotype PubMed 15696326. Source: MGI cellular response to catecholamine stimulus Inferred from electronic annotation. Source: Compara long term synaptic depression Inferred from mutant phenotype PubMed 13679419. Source: MGI negative regulation of NAD(P)H oxidase activity Inferred from electronic annotation. Source: Compara negative regulation of blood pressure Inferred from mutant phenotype PubMed 12486173PubMed 15598876. Source: MGI norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure Inferred from mutant phenotype PubMed 12486173. Source: MGI positive regulation of adenylate cyclase activity Inferred from electronic annotation. Source: Compara reactive oxygen species metabolic process Inferred from electronic annotation. Source: Compara regulation of female receptivity Inferred from mutant phenotype PubMed 15696326. Source: MGI regulation of systemic arterial blood pressure by vasopressin Inferred from genetic interaction PubMed 12486173. Source: MGI response to amphetamine Inferred from genetic interaction PubMed 11823893. Source: MGI response to cocaine Inferred from mutant phenotype PubMed 12768268. Source: MGI sensitization Inferred from genetic interaction PubMed 11823893. Source: MGI wound healing Inferred from mutant phenotype PubMed 11595429. Source: MGI
Cellular_component	brush border membrane Inferred from direct assay PubMed 15598876. Source: MGI integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	dopamine binding Inferred from electronic annotation. Source: Compara dopamine neurotransmitter receptor activity, coupled via Gs Inferred from direct assay PubMed 16962565. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 478	478	D(1B) dopamine receptor		PRO_0000069407
Regions
	Topological domain	1 – 38	38	Extracellular Potential
	Transmembrane	39 – 64	26	Helical; Name=1; Potential
	Topological domain	65 – 75	11	Cytoplasmic Potential
	Transmembrane	76 – 102	27	Helical; Name=2; Potential
	Topological domain	103 – 111	9	Extracellular Potential
	Transmembrane	112 – 134	23	Helical; Name=3; Potential
	Topological domain	135 – 153	19	Cytoplasmic Potential
	Transmembrane	154 – 179	26	Helical; Name=4; Potential
	Topological domain	180 – 215	36	Extracellular Potential
	Transmembrane	216 – 240	25	Helical; Name=5; Potential
	Topological domain	241 – 289	49	Cytoplasmic Potential
	Transmembrane	290 – 317	28	Helical; Name=6; Potential
	Topological domain	318 – 335	18	Extracellular Potential
	Transmembrane	336 – 357	22	Helical; Name=7; Potential
	Topological domain	358 – 478	121	Cytoplasmic Potential
Amino acid modifications
	Lipidation	370	1	S-palmitoyl cysteine By similarity
	Glycosylation	7	1	N-linked (GlcNAc...) Potential
	Disulfide bond	111 ↔ 211		By similarity
Experimental info
	Sequence conflict	231	1	P → L in AAA16844. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q8BLD9 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: D39165BC558131DF	FASTA	478	53,076
	10 20 30 40 50 60 MLPPGRNGTA HRARLGLQRQ LAQVDAPGGS AAPLGPAQVV TAGLLTLLIV WTLLGNVLVC 70 80 90 100 110 120 AAIVRSRHLR AKMTNIFIVS LAVSDLFVAL LVMPWKAVAE VAGYWPFGAF CDIWVAFDIM 130 140 150 160 170 180 CSTASILNLC IISVDRYWAI SRPFRYERKM TQRVALVMVA LAWTLSILIS FIPVQLNWHR 190 200 210 220 230 240 DKAGSQGREG LLSNETPWEE GWELDGRTEN CDSSLNRTYA ISSSLISFYI PVAIMIVTYT 250 260 270 280 290 300 RIYRIAQVQI RRISSLERAA EHAQSCRSRG ACEPDPSLRA SIKKETKVFK TLSVIMGVFV 310 320 330 340 350 360 CCWLPFFILN CMVPFCSSGD AQGPRTGFPC VSETTFDIFV WFGWANSSLN PIIYAFNADF 370 380 390 400 410 420 RKVFAQLLGC SHLCFRTPVQ TVNISNELIS YNQDTVFHRE IAAAYVHMIP NAVSSGDREV 430 440 450 460 470 GEEEEAEEEG PFDHMSQISP TTPDGDLAAE SVWELDCEEE VSLGKISPLT PNCFHKTA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Brain.
[2]	"The G protein-coupled receptor repertoires of human and mouse." Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E., Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C., Bergmann J.E., Gaitanaris G.A. Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 112-252.
[3]	"Identification, chromosomal location, and genome organization of mammalian G-protein-coupled receptors." Wilkie T.M., Chen Y., Gilbert D.J., Moore K.J., Yu L., Simon M.I., Copeland N.G., Jenkins N.A. Genomics 18:175-184(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 138-298. Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK045456 mRNA. Translation: BAC32378.1. AY255563 mRNA. Translation: AAO85075.1. L20330 mRNA. Translation: AAA16844.1.
IPI	IPI00222795.
PIR	A48909.
RefSeq	NP_038531.1. NM_013503.2.
UniGene	Mm.167154.
3D structure databases
ProteinModelPortal	Q8BLD9.
SMR	Q8BLD9. Positions 44-369.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Proteomic databases
PaxDb	Q8BLD9.
PRIDE	Q8BLD9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000041646; ENSMUSP00000039691; ENSMUSG00000039358.
GeneID	13492.
KEGG	mmu:13492.
Organism-specific databases
CTD	1816.
MGI	MGI:94927. Drd5.
Phylogenomic databases
eggNOG	NOG262978.
GeneTree	ENSGT00700000104081.
HOGENOM	HOG000239242.
HOVERGEN	HBG106962.
InParanoid	Q8BLD9.
KO	K05840.
OMA	EGPFDRM.
OrthoDB	EOG4PVNZH.
Gene expression databases
ArrayExpress	Q8BLD9.
Bgee	Q8BLD9.
CleanEx	MM_DRD5.
Genevestigator	Q8BLD9.
Family and domain databases
InterPro	IPR000497. Dopa_1B_rcpt. IPR000929. Dopamine_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00566. DOPAMINED1BR. PR00242. DOPAMINER. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	Q8BLD9.
ChEMBL	CHEMBL2737.
NextBio	284013.
SOURCE	Search...

Entry information

Entry name

DRD5_MOUSE

Accession

Primary (citable) accession number: Q8BLD9
Secondary accession number(s): Q61439, Q80UB7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2004
Last sequence update:	March 1, 2003
Last modified:	May 1, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program