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Protein

Lethal(3)malignant brain tumor-like protein 3

Gene

L3mbtl3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility (By similarity). Required for normal maturation of myeloid progenitor cells.By similarity1 Publication

GO - Biological processi

  1. chromatin modification Source: UniProtKB-KW
  2. erythrocyte maturation Source: MGI
  3. granulocyte differentiation Source: MGI
  4. macrophage differentiation Source: MGI
  5. myeloid cell differentiation Source: MGI
  6. regulation of transcription, DNA-templated Source: UniProtKB-KW
  7. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Lethal(3)malignant brain tumor-like protein 3
Short name:
L(3)mbt-like protein 3
Alternative name(s):
MBT-1
Gene namesi
Name:L3mbtl3
Synonyms:Mbt1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:2143628. L3mbtl3.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Death at a late embryonic stage due defective erythropoiesis, defects in the maturation of other types of myeloid lineage cells and anemia.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 883883Lethal(3)malignant brain tumor-like protein 3PRO_0000084451Add
BLAST

Proteomic databases

MaxQBiQ8BLB7.
PRIDEiQ8BLB7.

PTM databases

PhosphoSiteiQ8BLB7.

Expressioni

Tissue specificityi

Detected in hematopoietic progenitor cells in fetal liver. Detected in adult bone marrow, heart, brain, spleen, lung, liver, kidney and testis.1 Publication

Gene expression databases

BgeeiQ8BLB7.
CleanExiMM_L3MBTL3.
ExpressionAtlasiQ8BLB7. baseline and differential.
GenevestigatoriQ8BLB7.

Interactioni

Subunit structurei

Interacts with RNF2.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037619.

Structurei

3D structure databases

ProteinModelPortaliQ8BLB7.
SMRiQ8BLB7. Positions 232-545, 808-865.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati232 – 332101MBT 1Add
BLAST
Repeati340 – 439100MBT 2Add
BLAST
Repeati448 – 54396MBT 3Add
BLAST
Domaini811 – 87565SAMPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi667 – 770104Gln/Pro-richAdd
BLAST

Sequence similaritiesi

Contains 3 MBT repeats.PROSITE-ProRule annotation
Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG281100.
GeneTreeiENSGT00760000119024.
HOGENOMiHOG000231019.
HOVERGENiHBG071375.
InParanoidiQ8BLB7.
OMAiIRDQHAD.
OrthoDBiEOG7FR7FT.
PhylomeDBiQ8BLB7.
TreeFamiTF316498.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
InterProiIPR004092. Mbt.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
[Graphical view]
PfamiPF02820. MBT. 3 hits.
PF00536. SAM_1. 1 hit.
[Graphical view]
SMARTiSM00561. MBT. 3 hits.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
PROSITEiPS51079. MBT. 3 hits.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BLB7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTESASSTSG QEFDVFSVMD WKDGVGTLPG SDLKFRVNEF GALEVITDES
60 70 80 90 100
EMESVKKATA TTTWMVPTAQ DAPTSPPSSR PVFPPAYWTS PPGCPTVFSE
110 120 130 140 150
KTGVPFRLKE QSKADGLQFC ENCCQYGNGD ECLSGGKYCS QNCARHAKDK
160 170 180 190 200
DQKDERDGGE DNDEEDPKCS RKKKPKLSLK ADSKDDGEER DDEMENKQDG
210 220 230 240 250
RILRGSQRAR RKRRGDSAVL KQGLPPKGKK TWCWASYLEE EKAVAVPTKL
260 270 280 290 300
FKEHQSFPYN KNGFKVGMKL EGVDPDHQAM YCVLTVAEVC GYRIKLHFDG
310 320 330 340 350
YSDCYDFWVN ADALDIHPVG WCEKTGHKLR PPKGYKEEEF NWQSYLKTCK
360 370 380 390 400
AQAAPKSLFE NQNITVIPSG FRVGMKLEAA DKKSPSVICV ATVTDMVDNR
410 420 430 440 450
FLVHFDNWDE SYDYWCESNS PHIHPVGWCK EHRRTLITPP GYSHVKHFSW
460 470 480 490 500
DKYLEETNSL PAPARAFKVK PPHGFQKKMK LEAVDKRNPL FIRVATVADT
510 520 530 540 550
DDHRIKVHFD GWSSCYDYWI DADSPDIHPV GWCSKTGHPL QAPLSPAELM
560 570 580 590 600
EPSETGGCPT LGCRGVGHFK KSRYLGTQSG ANCPYSEINL SKERIFPDRL
610 620 630 640 650
SGDTSPPTTP SFPRSKRMDT RESSSSPETR EKHANNFKED SEKKKENEVK
660 670 680 690 700
TSAEAKVVRE EPTPSVQQSQ PPQQVQQVQH AQPPQQAQKA PQAQQAQQAQ
710 720 730 740 750
QAQQAPQAPQ TPQPQQAPQV QQAQQAPQAQ QAQQPQQAQQ PQQAPPVQQP
760 770 780 790 800
QQVQQAQPTQ QQAQTQQQAQ RRSAVFLSFK PPIPCLPLRW EQQSKLLPTV
810 820 830 840 850
AGIPASRVSK WSTDEVSEFI QSLPGCEEHG KVFKDEQIDG EAFLLMTQTD
860 870 880
IVKIMSIKLG PALKIFNSIL MFKAAEKNSH NEL
Length:883
Mass (Da):99,137
Last modified:February 28, 2003 - v1
Checksum:i7A6417202A0E5532
GO
Isoform 2 (identifier: Q8BLB7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     72-96: Missing.

Show »
Length:858
Mass (Da):96,557
Checksum:i1F35B839BCA63AC5
GO
Isoform 3 (identifier: Q8BLB7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     290-302: CGYRIKLHFDGYS → SSALYLFGKRDDG
     303-883: Missing.

Note: No experimental confirmation available.

Show »
Length:302
Mass (Da):33,556
Checksum:iE6BB01D49BB19B4B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti146 – 1461H → Y in BAC98253 (PubMed:14621295).Curated
Sequence conflicti275 – 2751P → H in BAC27386 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei72 – 9625Missing in isoform 2. 1 PublicationVSP_013509Add
BLAST
Alternative sequencei290 – 30213CGYRI…FDGYS → SSALYLFGKRDDG in isoform 3. 1 PublicationVSP_013510Add
BLAST
Alternative sequencei303 – 883581Missing in isoform 3. 1 PublicationVSP_013511Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK031398 mRNA. Translation: BAC27386.1.
AK045667 mRNA. Translation: BAC32449.1.
BC082309 mRNA. Translation: AAH82309.1.
BC085192 mRNA. Translation: AAH85192.1.
AK129443 mRNA. Translation: BAC98253.1.
CCDSiCCDS23756.1. [Q8BLB7-1]
RefSeqiNP_766375.1. NM_172787.2. [Q8BLB7-1]
XP_006512794.1. XM_006512731.2. [Q8BLB7-1]
XP_006512795.1. XM_006512732.2. [Q8BLB7-1]
XP_006512796.1. XM_006512733.2. [Q8BLB7-1]
XP_006512797.1. XM_006512734.2. [Q8BLB7-2]
XP_006512798.1. XM_006512735.2. [Q8BLB7-2]
UniGeneiMm.338439.

Genome annotation databases

EnsembliENSMUST00000040219; ENSMUSP00000037619; ENSMUSG00000039089. [Q8BLB7-1]
ENSMUST00000105519; ENSMUSP00000101158; ENSMUSG00000039089. [Q8BLB7-2]
ENSMUST00000174766; ENSMUSP00000133479; ENSMUSG00000039089. [Q8BLB7-1]
GeneIDi237339.
KEGGimmu:237339.
UCSCiuc007esa.1. mouse. [Q8BLB7-2]
uc007esb.1. mouse. [Q8BLB7-1]
uc007esd.1. mouse. [Q8BLB7-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK031398 mRNA. Translation: BAC27386.1.
AK045667 mRNA. Translation: BAC32449.1.
BC082309 mRNA. Translation: AAH82309.1.
BC085192 mRNA. Translation: AAH85192.1.
AK129443 mRNA. Translation: BAC98253.1.
CCDSiCCDS23756.1. [Q8BLB7-1]
RefSeqiNP_766375.1. NM_172787.2. [Q8BLB7-1]
XP_006512794.1. XM_006512731.2. [Q8BLB7-1]
XP_006512795.1. XM_006512732.2. [Q8BLB7-1]
XP_006512796.1. XM_006512733.2. [Q8BLB7-1]
XP_006512797.1. XM_006512734.2. [Q8BLB7-2]
XP_006512798.1. XM_006512735.2. [Q8BLB7-2]
UniGeneiMm.338439.

3D structure databases

ProteinModelPortaliQ8BLB7.
SMRiQ8BLB7. Positions 232-545, 808-865.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037619.

PTM databases

PhosphoSiteiQ8BLB7.

Proteomic databases

MaxQBiQ8BLB7.
PRIDEiQ8BLB7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040219; ENSMUSP00000037619; ENSMUSG00000039089. [Q8BLB7-1]
ENSMUST00000105519; ENSMUSP00000101158; ENSMUSG00000039089. [Q8BLB7-2]
ENSMUST00000174766; ENSMUSP00000133479; ENSMUSG00000039089. [Q8BLB7-1]
GeneIDi237339.
KEGGimmu:237339.
UCSCiuc007esa.1. mouse. [Q8BLB7-2]
uc007esb.1. mouse. [Q8BLB7-1]
uc007esd.1. mouse. [Q8BLB7-3]

Organism-specific databases

CTDi84456.
MGIiMGI:2143628. L3mbtl3.

Phylogenomic databases

eggNOGiNOG281100.
GeneTreeiENSGT00760000119024.
HOGENOMiHOG000231019.
HOVERGENiHBG071375.
InParanoidiQ8BLB7.
OMAiIRDQHAD.
OrthoDBiEOG7FR7FT.
PhylomeDBiQ8BLB7.
TreeFamiTF316498.

Miscellaneous databases

NextBioi383306.
PROiQ8BLB7.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BLB7.
CleanExiMM_L3MBTL3.
ExpressionAtlasiQ8BLB7. baseline and differential.
GenevestigatoriQ8BLB7.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
InterProiIPR004092. Mbt.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
[Graphical view]
PfamiPF02820. MBT. 3 hits.
PF00536. SAM_1. 1 hit.
[Graphical view]
SMARTiSM00561. MBT. 3 hits.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
PROSITEiPS51079. MBT. 3 hits.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Strain: C57BL/6J.
    Tissue: Corpora quadrigemina and Fetal testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6.
    Tissue: Brain and Eye.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 123-883.
    Tissue: Embryonic tail.
  4. "Impaired maturation of myeloid progenitors in mice lacking novel Polycomb group protein MBT-1."
    Arai S., Miyazaki T.
    EMBO J. 24:1863-1873(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE, FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiLMBL3_MOUSE
AccessioniPrimary (citable) accession number: Q8BLB7
Secondary accession number(s): Q0VGT0
, Q641L7, Q6ZPI2, Q8C0G4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 25, 2005
Last sequence update: February 28, 2003
Last modified: March 31, 2015
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.