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Q8BLB7

- LMBL3_MOUSE

UniProt

Q8BLB7 - LMBL3_MOUSE

Protein

Lethal(3)malignant brain tumor-like protein 3

Gene

L3mbtl3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility By similarity. Required for normal maturation of myeloid progenitor cells.By similarity1 Publication

    GO - Molecular functioni

    1. protein binding Source: MGI

    GO - Biological processi

    1. chromatin modification Source: UniProtKB-KW
    2. erythrocyte maturation Source: MGI
    3. granulocyte differentiation Source: MGI
    4. macrophage differentiation Source: MGI
    5. myeloid cell differentiation Source: MGI
    6. regulation of transcription, DNA-templated Source: UniProtKB-KW
    7. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lethal(3)malignant brain tumor-like protein 3
    Short name:
    L(3)mbt-like protein 3
    Alternative name(s):
    MBT-1
    Gene namesi
    Name:L3mbtl3
    Synonyms:Mbt1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:2143628. L3mbtl3.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Disruption phenotypei

    Death at a late embryonic stage due defective erythropoiesis, defects in the maturation of other types of myeloid lineage cells and anemia.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 883883Lethal(3)malignant brain tumor-like protein 3PRO_0000084451Add
    BLAST

    Proteomic databases

    PRIDEiQ8BLB7.

    PTM databases

    PhosphoSiteiQ8BLB7.

    Expressioni

    Tissue specificityi

    Detected in hematopoietic progenitor cells in fetal liver. Detected in adult bone marrow, heart, brain, spleen, lung, liver, kidney and testis.1 Publication

    Gene expression databases

    ArrayExpressiQ8BLB7.
    BgeeiQ8BLB7.
    CleanExiMM_L3MBTL3.
    GenevestigatoriQ8BLB7.

    Interactioni

    Subunit structurei

    Interacts with RNF2.1 Publication

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000037619.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BLB7.
    SMRiQ8BLB7. Positions 232-545, 808-865.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati232 – 332101MBT 1Add
    BLAST
    Repeati340 – 439100MBT 2Add
    BLAST
    Repeati448 – 54396MBT 3Add
    BLAST
    Domaini811 – 87565SAMPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi667 – 770104Gln/Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 3 MBT repeats.PROSITE-ProRule annotation
    Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG281100.
    GeneTreeiENSGT00740000115269.
    HOGENOMiHOG000231019.
    HOVERGENiHBG071375.
    InParanoidiQ8BLB7.
    OMAiEYQSFPY.
    OrthoDBiEOG7FR7FT.
    PhylomeDBiQ8BLB7.
    TreeFamiTF316498.

    Family and domain databases

    Gene3Di1.10.150.50. 1 hit.
    InterProiIPR004092. Mbt.
    IPR001660. SAM.
    IPR013761. SAM/pointed.
    IPR021129. SAM_type1.
    [Graphical view]
    PfamiPF02820. MBT. 3 hits.
    PF00536. SAM_1. 1 hit.
    [Graphical view]
    SMARTiSM00561. MBT. 3 hits.
    SM00454. SAM. 1 hit.
    [Graphical view]
    SUPFAMiSSF47769. SSF47769. 1 hit.
    PROSITEiPS51079. MBT. 3 hits.
    PS50105. SAM_DOMAIN. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8BLB7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTESASSTSG QEFDVFSVMD WKDGVGTLPG SDLKFRVNEF GALEVITDES    50
    EMESVKKATA TTTWMVPTAQ DAPTSPPSSR PVFPPAYWTS PPGCPTVFSE 100
    KTGVPFRLKE QSKADGLQFC ENCCQYGNGD ECLSGGKYCS QNCARHAKDK 150
    DQKDERDGGE DNDEEDPKCS RKKKPKLSLK ADSKDDGEER DDEMENKQDG 200
    RILRGSQRAR RKRRGDSAVL KQGLPPKGKK TWCWASYLEE EKAVAVPTKL 250
    FKEHQSFPYN KNGFKVGMKL EGVDPDHQAM YCVLTVAEVC GYRIKLHFDG 300
    YSDCYDFWVN ADALDIHPVG WCEKTGHKLR PPKGYKEEEF NWQSYLKTCK 350
    AQAAPKSLFE NQNITVIPSG FRVGMKLEAA DKKSPSVICV ATVTDMVDNR 400
    FLVHFDNWDE SYDYWCESNS PHIHPVGWCK EHRRTLITPP GYSHVKHFSW 450
    DKYLEETNSL PAPARAFKVK PPHGFQKKMK LEAVDKRNPL FIRVATVADT 500
    DDHRIKVHFD GWSSCYDYWI DADSPDIHPV GWCSKTGHPL QAPLSPAELM 550
    EPSETGGCPT LGCRGVGHFK KSRYLGTQSG ANCPYSEINL SKERIFPDRL 600
    SGDTSPPTTP SFPRSKRMDT RESSSSPETR EKHANNFKED SEKKKENEVK 650
    TSAEAKVVRE EPTPSVQQSQ PPQQVQQVQH AQPPQQAQKA PQAQQAQQAQ 700
    QAQQAPQAPQ TPQPQQAPQV QQAQQAPQAQ QAQQPQQAQQ PQQAPPVQQP 750
    QQVQQAQPTQ QQAQTQQQAQ RRSAVFLSFK PPIPCLPLRW EQQSKLLPTV 800
    AGIPASRVSK WSTDEVSEFI QSLPGCEEHG KVFKDEQIDG EAFLLMTQTD 850
    IVKIMSIKLG PALKIFNSIL MFKAAEKNSH NEL 883
    Length:883
    Mass (Da):99,137
    Last modified:March 1, 2003 - v1
    Checksum:i7A6417202A0E5532
    GO
    Isoform 2 (identifier: Q8BLB7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         72-96: Missing.

    Show »
    Length:858
    Mass (Da):96,557
    Checksum:i1F35B839BCA63AC5
    GO
    Isoform 3 (identifier: Q8BLB7-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         290-302: CGYRIKLHFDGYS → SSALYLFGKRDDG
         303-883: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:302
    Mass (Da):33,556
    Checksum:iE6BB01D49BB19B4B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti146 – 1461H → Y in BAC98253. (PubMed:14621295)Curated
    Sequence conflicti275 – 2751P → H in BAC27386. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei72 – 9625Missing in isoform 2. 1 PublicationVSP_013509Add
    BLAST
    Alternative sequencei290 – 30213CGYRI…FDGYS → SSALYLFGKRDDG in isoform 3. 1 PublicationVSP_013510Add
    BLAST
    Alternative sequencei303 – 883581Missing in isoform 3. 1 PublicationVSP_013511Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK031398 mRNA. Translation: BAC27386.1.
    AK045667 mRNA. Translation: BAC32449.1.
    BC082309 mRNA. Translation: AAH82309.1.
    BC085192 mRNA. Translation: AAH85192.1.
    AK129443 mRNA. Translation: BAC98253.1.
    CCDSiCCDS23756.1. [Q8BLB7-1]
    RefSeqiNP_766375.1. NM_172787.2. [Q8BLB7-1]
    XP_006512794.1. XM_006512731.1. [Q8BLB7-1]
    XP_006512795.1. XM_006512732.1. [Q8BLB7-1]
    XP_006512796.1. XM_006512733.1. [Q8BLB7-1]
    XP_006512797.1. XM_006512734.1. [Q8BLB7-2]
    XP_006512798.1. XM_006512735.1. [Q8BLB7-2]
    UniGeneiMm.338439.

    Genome annotation databases

    EnsembliENSMUST00000040219; ENSMUSP00000037619; ENSMUSG00000039089. [Q8BLB7-1]
    ENSMUST00000105519; ENSMUSP00000101158; ENSMUSG00000039089. [Q8BLB7-2]
    ENSMUST00000174766; ENSMUSP00000133479; ENSMUSG00000039089. [Q8BLB7-1]
    GeneIDi237339.
    KEGGimmu:237339.
    UCSCiuc007esa.1. mouse. [Q8BLB7-2]
    uc007esb.1. mouse. [Q8BLB7-1]
    uc007esd.1. mouse. [Q8BLB7-3]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK031398 mRNA. Translation: BAC27386.1 .
    AK045667 mRNA. Translation: BAC32449.1 .
    BC082309 mRNA. Translation: AAH82309.1 .
    BC085192 mRNA. Translation: AAH85192.1 .
    AK129443 mRNA. Translation: BAC98253.1 .
    CCDSi CCDS23756.1. [Q8BLB7-1 ]
    RefSeqi NP_766375.1. NM_172787.2. [Q8BLB7-1 ]
    XP_006512794.1. XM_006512731.1. [Q8BLB7-1 ]
    XP_006512795.1. XM_006512732.1. [Q8BLB7-1 ]
    XP_006512796.1. XM_006512733.1. [Q8BLB7-1 ]
    XP_006512797.1. XM_006512734.1. [Q8BLB7-2 ]
    XP_006512798.1. XM_006512735.1. [Q8BLB7-2 ]
    UniGenei Mm.338439.

    3D structure databases

    ProteinModelPortali Q8BLB7.
    SMRi Q8BLB7. Positions 232-545, 808-865.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000037619.

    PTM databases

    PhosphoSitei Q8BLB7.

    Proteomic databases

    PRIDEi Q8BLB7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000040219 ; ENSMUSP00000037619 ; ENSMUSG00000039089 . [Q8BLB7-1 ]
    ENSMUST00000105519 ; ENSMUSP00000101158 ; ENSMUSG00000039089 . [Q8BLB7-2 ]
    ENSMUST00000174766 ; ENSMUSP00000133479 ; ENSMUSG00000039089 . [Q8BLB7-1 ]
    GeneIDi 237339.
    KEGGi mmu:237339.
    UCSCi uc007esa.1. mouse. [Q8BLB7-2 ]
    uc007esb.1. mouse. [Q8BLB7-1 ]
    uc007esd.1. mouse. [Q8BLB7-3 ]

    Organism-specific databases

    CTDi 84456.
    MGIi MGI:2143628. L3mbtl3.

    Phylogenomic databases

    eggNOGi NOG281100.
    GeneTreei ENSGT00740000115269.
    HOGENOMi HOG000231019.
    HOVERGENi HBG071375.
    InParanoidi Q8BLB7.
    OMAi EYQSFPY.
    OrthoDBi EOG7FR7FT.
    PhylomeDBi Q8BLB7.
    TreeFami TF316498.

    Miscellaneous databases

    NextBioi 383306.
    PROi Q8BLB7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8BLB7.
    Bgeei Q8BLB7.
    CleanExi MM_L3MBTL3.
    Genevestigatori Q8BLB7.

    Family and domain databases

    Gene3Di 1.10.150.50. 1 hit.
    InterProi IPR004092. Mbt.
    IPR001660. SAM.
    IPR013761. SAM/pointed.
    IPR021129. SAM_type1.
    [Graphical view ]
    Pfami PF02820. MBT. 3 hits.
    PF00536. SAM_1. 1 hit.
    [Graphical view ]
    SMARTi SM00561. MBT. 3 hits.
    SM00454. SAM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47769. SSF47769. 1 hit.
    PROSITEi PS51079. MBT. 3 hits.
    PS50105. SAM_DOMAIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
      Strain: C57BL/6J.
      Tissue: Corpora quadrigemina and Fetal testis.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: C57BL/6.
      Tissue: Brain and Eye.
    3. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
      DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 123-883.
      Tissue: Embryonic tail.
    4. "Impaired maturation of myeloid progenitors in mice lacking novel Polycomb group protein MBT-1."
      Arai S., Miyazaki T.
      EMBO J. 24:1863-1873(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE, FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiLMBL3_MOUSE
    AccessioniPrimary (citable) accession number: Q8BLB7
    Secondary accession number(s): Q0VGT0
    , Q641L7, Q6ZPI2, Q8C0G4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3