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Protein

Lethal(3)malignant brain tumor-like protein 3

Gene

L3mbtl3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility (By similarity). Required for normal maturation of myeloid progenitor cells.By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri549 – 593CCHHC-type; degeneratePROSITE-ProRule annotationAdd BLAST45

GO - Molecular functioni

GO - Biological processi

  • chromatin organization Source: UniProtKB-KW
  • erythrocyte maturation Source: MGI
  • granulocyte differentiation Source: MGI
  • macrophage differentiation Source: MGI
  • myeloid cell differentiation Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionChromatin regulator
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Lethal(3)malignant brain tumor-like protein 3
Short name:
L(3)mbt-like protein 3
Alternative name(s):
MBT-1
Gene namesi
Name:L3mbtl3
Synonyms:Mbt1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:2143628 L3mbtl3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Death at a late embryonic stage due defective erythropoiesis, defects in the maturation of other types of myeloid lineage cells and anemia.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000844511 – 883Lethal(3)malignant brain tumor-like protein 3Add BLAST883

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki638Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ8BLB7
PeptideAtlasiQ8BLB7
PRIDEiQ8BLB7

PTM databases

iPTMnetiQ8BLB7
PhosphoSitePlusiQ8BLB7

Expressioni

Tissue specificityi

Detected in hematopoietic progenitor cells in fetal liver. Detected in adult bone marrow, heart, brain, spleen, lung, liver, kidney and testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000039089
CleanExiMM_L3MBTL3
GenevisibleiQ8BLB7 MM

Interactioni

Subunit structurei

Interacts with RNF2.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ8BLB7
SMRiQ8BLB7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati232 – 332MBT 1Add BLAST101
Repeati340 – 439MBT 2Add BLAST100
Repeati448 – 543MBT 3Add BLAST96
Domaini811 – 875SAMPROSITE-ProRule annotationAdd BLAST65

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi667 – 770Gln/Pro-richAdd BLAST104

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri549 – 593CCHHC-type; degeneratePROSITE-ProRule annotationAdd BLAST45

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3766 Eukaryota
ENOG410Y4AQ LUCA
GeneTreeiENSGT00760000119024
HOGENOMiHOG000231019
HOVERGENiHBG071375
InParanoidiQ8BLB7
OMAiDPEHQSV
OrthoDBiEOG091G01BW
PhylomeDBiQ8BLB7
TreeFamiTF316498

Family and domain databases

InterProiView protein in InterPro
IPR004092 Mbt
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR002515 Znf_C2HC
PfamiView protein in Pfam
PF02820 MBT, 3 hits
PF00536 SAM_1, 1 hit
SMARTiView protein in SMART
SM00561 MBT, 3 hits
SM00454 SAM, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
PROSITEiView protein in PROSITE
PS51079 MBT, 3 hits
PS50105 SAM_DOMAIN, 1 hit
PS51802 ZF_CCHHC, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BLB7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTESASSTSG QEFDVFSVMD WKDGVGTLPG SDLKFRVNEF GALEVITDES
60 70 80 90 100
EMESVKKATA TTTWMVPTAQ DAPTSPPSSR PVFPPAYWTS PPGCPTVFSE
110 120 130 140 150
KTGVPFRLKE QSKADGLQFC ENCCQYGNGD ECLSGGKYCS QNCARHAKDK
160 170 180 190 200
DQKDERDGGE DNDEEDPKCS RKKKPKLSLK ADSKDDGEER DDEMENKQDG
210 220 230 240 250
RILRGSQRAR RKRRGDSAVL KQGLPPKGKK TWCWASYLEE EKAVAVPTKL
260 270 280 290 300
FKEHQSFPYN KNGFKVGMKL EGVDPDHQAM YCVLTVAEVC GYRIKLHFDG
310 320 330 340 350
YSDCYDFWVN ADALDIHPVG WCEKTGHKLR PPKGYKEEEF NWQSYLKTCK
360 370 380 390 400
AQAAPKSLFE NQNITVIPSG FRVGMKLEAA DKKSPSVICV ATVTDMVDNR
410 420 430 440 450
FLVHFDNWDE SYDYWCESNS PHIHPVGWCK EHRRTLITPP GYSHVKHFSW
460 470 480 490 500
DKYLEETNSL PAPARAFKVK PPHGFQKKMK LEAVDKRNPL FIRVATVADT
510 520 530 540 550
DDHRIKVHFD GWSSCYDYWI DADSPDIHPV GWCSKTGHPL QAPLSPAELM
560 570 580 590 600
EPSETGGCPT LGCRGVGHFK KSRYLGTQSG ANCPYSEINL SKERIFPDRL
610 620 630 640 650
SGDTSPPTTP SFPRSKRMDT RESSSSPETR EKHANNFKED SEKKKENEVK
660 670 680 690 700
TSAEAKVVRE EPTPSVQQSQ PPQQVQQVQH AQPPQQAQKA PQAQQAQQAQ
710 720 730 740 750
QAQQAPQAPQ TPQPQQAPQV QQAQQAPQAQ QAQQPQQAQQ PQQAPPVQQP
760 770 780 790 800
QQVQQAQPTQ QQAQTQQQAQ RRSAVFLSFK PPIPCLPLRW EQQSKLLPTV
810 820 830 840 850
AGIPASRVSK WSTDEVSEFI QSLPGCEEHG KVFKDEQIDG EAFLLMTQTD
860 870 880
IVKIMSIKLG PALKIFNSIL MFKAAEKNSH NEL
Length:883
Mass (Da):99,137
Last modified:March 1, 2003 - v1
Checksum:i7A6417202A0E5532
GO
Isoform 2 (identifier: Q8BLB7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     72-96: Missing.

Show »
Length:858
Mass (Da):96,557
Checksum:i1F35B839BCA63AC5
GO
Isoform 3 (identifier: Q8BLB7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     290-302: CGYRIKLHFDGYS → SSALYLFGKRDDG
     303-883: Missing.

Note: No experimental confirmation available.
Show »
Length:302
Mass (Da):33,556
Checksum:iE6BB01D49BB19B4B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti146H → Y in BAC98253 (PubMed:14621295).Curated1
Sequence conflicti275P → H in BAC27386 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01350972 – 96Missing in isoform 2. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_013510290 – 302CGYRI…FDGYS → SSALYLFGKRDDG in isoform 3. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_013511303 – 883Missing in isoform 3. 1 PublicationAdd BLAST581

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK031398 mRNA Translation: BAC27386.1
AK045667 mRNA Translation: BAC32449.1
BC082309 mRNA Translation: AAH82309.1
BC085192 mRNA Translation: AAH85192.1
AK129443 mRNA Translation: BAC98253.1
CCDSiCCDS23756.1 [Q8BLB7-1]
CCDS83689.1 [Q8BLB7-2]
RefSeqiNP_001334396.1, NM_001347467.1 [Q8BLB7-2]
NP_766375.1, NM_172787.3 [Q8BLB7-1]
XP_006512794.1, XM_006512731.3
XP_006512795.1, XM_006512732.3 [Q8BLB7-1]
XP_006512796.1, XM_006512733.3 [Q8BLB7-1]
XP_006512798.1, XM_006512735.3 [Q8BLB7-2]
UniGeneiMm.338439

Genome annotation databases

EnsembliENSMUST00000040219; ENSMUSP00000037619; ENSMUSG00000039089 [Q8BLB7-1]
ENSMUST00000105519; ENSMUSP00000101158; ENSMUSG00000039089 [Q8BLB7-2]
ENSMUST00000174766; ENSMUSP00000133479; ENSMUSG00000039089 [Q8BLB7-1]
GeneIDi237339
KEGGimmu:237339
UCSCiuc007esa.1 mouse [Q8BLB7-2]
uc007esb.1 mouse [Q8BLB7-1]
uc007esd.1 mouse [Q8BLB7-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiLMBL3_MOUSE
AccessioniPrimary (citable) accession number: Q8BLB7
Secondary accession number(s): Q0VGT0
, Q641L7, Q6ZPI2, Q8C0G4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: March 1, 2003
Last modified: April 25, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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