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Q8BLB7 (LMBL3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lethal(3)malignant brain tumor-like protein 3

Short name=L(3)mbt-like protein 3
Alternative name(s):
MBT-1
Gene names
Name:L3mbtl3
Synonyms:Mbt1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length883 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility By similarity. Required for normal maturation of myeloid progenitor cells. Ref.4

Subunit structure

Interacts with RNF2. Ref.4

Subcellular location

Nucleus Ref.4.

Tissue specificity

Detected in hematopoietic progenitor cells in fetal liver. Detected in adult bone marrow, heart, brain, spleen, lung, liver, kidney and testis. Ref.4

Disruption phenotype

Death at a late embryonic stage due defective erythropoiesis, defects in the maturation of other types of myeloid lineage cells and anemia. Ref.4

Sequence similarities

Contains 3 MBT repeats.

Contains 1 SAM (sterile alpha motif) domain.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8BLB7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8BLB7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     72-96: Missing.
Isoform 3 (identifier: Q8BLB7-3)

The sequence of this isoform differs from the canonical sequence as follows:
     290-302: CGYRIKLHFDGYS → SSALYLFGKRDDG
     303-883: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 883883Lethal(3)malignant brain tumor-like protein 3
PRO_0000084451

Regions

Repeat232 – 332101MBT 1
Repeat340 – 439100MBT 2
Repeat448 – 54396MBT 3
Domain811 – 87565SAM
Compositional bias667 – 770104Gln/Pro-rich

Natural variations

Alternative sequence72 – 9625Missing in isoform 2.
VSP_013509
Alternative sequence290 – 30213CGYRI…FDGYS → SSALYLFGKRDDG in isoform 3.
VSP_013510
Alternative sequence303 – 883581Missing in isoform 3.
VSP_013511

Experimental info

Sequence conflict1461H → Y in BAC98253. Ref.3
Sequence conflict2751P → H in BAC27386. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 7A6417202A0E5532

FASTA88399,137
        10         20         30         40         50         60 
MTESASSTSG QEFDVFSVMD WKDGVGTLPG SDLKFRVNEF GALEVITDES EMESVKKATA 

        70         80         90        100        110        120 
TTTWMVPTAQ DAPTSPPSSR PVFPPAYWTS PPGCPTVFSE KTGVPFRLKE QSKADGLQFC 

       130        140        150        160        170        180 
ENCCQYGNGD ECLSGGKYCS QNCARHAKDK DQKDERDGGE DNDEEDPKCS RKKKPKLSLK 

       190        200        210        220        230        240 
ADSKDDGEER DDEMENKQDG RILRGSQRAR RKRRGDSAVL KQGLPPKGKK TWCWASYLEE 

       250        260        270        280        290        300 
EKAVAVPTKL FKEHQSFPYN KNGFKVGMKL EGVDPDHQAM YCVLTVAEVC GYRIKLHFDG 

       310        320        330        340        350        360 
YSDCYDFWVN ADALDIHPVG WCEKTGHKLR PPKGYKEEEF NWQSYLKTCK AQAAPKSLFE 

       370        380        390        400        410        420 
NQNITVIPSG FRVGMKLEAA DKKSPSVICV ATVTDMVDNR FLVHFDNWDE SYDYWCESNS 

       430        440        450        460        470        480 
PHIHPVGWCK EHRRTLITPP GYSHVKHFSW DKYLEETNSL PAPARAFKVK PPHGFQKKMK 

       490        500        510        520        530        540 
LEAVDKRNPL FIRVATVADT DDHRIKVHFD GWSSCYDYWI DADSPDIHPV GWCSKTGHPL 

       550        560        570        580        590        600 
QAPLSPAELM EPSETGGCPT LGCRGVGHFK KSRYLGTQSG ANCPYSEINL SKERIFPDRL 

       610        620        630        640        650        660 
SGDTSPPTTP SFPRSKRMDT RESSSSPETR EKHANNFKED SEKKKENEVK TSAEAKVVRE 

       670        680        690        700        710        720 
EPTPSVQQSQ PPQQVQQVQH AQPPQQAQKA PQAQQAQQAQ QAQQAPQAPQ TPQPQQAPQV 

       730        740        750        760        770        780 
QQAQQAPQAQ QAQQPQQAQQ PQQAPPVQQP QQVQQAQPTQ QQAQTQQQAQ RRSAVFLSFK 

       790        800        810        820        830        840 
PPIPCLPLRW EQQSKLLPTV AGIPASRVSK WSTDEVSEFI QSLPGCEEHG KVFKDEQIDG 

       850        860        870        880 
EAFLLMTQTD IVKIMSIKLG PALKIFNSIL MFKAAEKNSH NEL 

« Hide

Isoform 2 [UniParc].

Checksum: 1F35B839BCA63AC5
Show »

FASTA85896,557
Isoform 3 [UniParc].

Checksum: E6BB01D49BB19B4B
Show »

FASTA30233,556

References

« Hide 'large scale' references
[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
Strain: C57BL/6J.
Tissue: Corpora quadrigemina and Fetal testis.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Strain: C57BL/6.
Tissue: Brain and Eye.
[3]"Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 123-883.
Tissue: Embryonic tail.
[4]"Impaired maturation of myeloid progenitors in mice lacking novel Polycomb group protein MBT-1."
Arai S., Miyazaki T.
EMBO J. 24:1863-1873(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: DISRUPTION PHENOTYPE, FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK031398 mRNA. Translation: BAC27386.1.
AK045667 mRNA. Translation: BAC32449.1.
BC082309 mRNA. Translation: AAH82309.1.
BC085192 mRNA. Translation: AAH85192.1.
AK129443 mRNA. Translation: BAC98253.1.
CCDSCCDS23756.1. [Q8BLB7-1]
RefSeqNP_766375.1. NM_172787.2. [Q8BLB7-1]
XP_006512794.1. XM_006512731.1. [Q8BLB7-1]
XP_006512795.1. XM_006512732.1. [Q8BLB7-1]
XP_006512796.1. XM_006512733.1. [Q8BLB7-1]
XP_006512797.1. XM_006512734.1. [Q8BLB7-2]
XP_006512798.1. XM_006512735.1. [Q8BLB7-2]
UniGeneMm.338439.

3D structure databases

ProteinModelPortalQ8BLB7.
SMRQ8BLB7. Positions 232-545, 808-865.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000037619.

PTM databases

PhosphoSiteQ8BLB7.

Proteomic databases

PRIDEQ8BLB7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000040219; ENSMUSP00000037619; ENSMUSG00000039089. [Q8BLB7-1]
ENSMUST00000105519; ENSMUSP00000101158; ENSMUSG00000039089. [Q8BLB7-2]
ENSMUST00000174766; ENSMUSP00000133479; ENSMUSG00000039089. [Q8BLB7-1]
GeneID237339.
KEGGmmu:237339.
UCSCuc007esa.1. mouse. [Q8BLB7-2]
uc007esb.1. mouse. [Q8BLB7-1]
uc007esd.1. mouse. [Q8BLB7-3]

Organism-specific databases

CTD84456.
MGIMGI:2143628. L3mbtl3.

Phylogenomic databases

eggNOGNOG281100.
GeneTreeENSGT00740000115269.
HOGENOMHOG000231019.
HOVERGENHBG071375.
InParanoidQ8BLB7.
OMAEYQSFPY.
OrthoDBEOG7FR7FT.
PhylomeDBQ8BLB7.
TreeFamTF316498.

Gene expression databases

ArrayExpressQ8BLB7.
BgeeQ8BLB7.
CleanExMM_L3MBTL3.
GenevestigatorQ8BLB7.

Family and domain databases

Gene3D1.10.150.50. 1 hit.
InterProIPR004092. Mbt.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
[Graphical view]
PfamPF02820. MBT. 3 hits.
PF00536. SAM_1. 1 hit.
[Graphical view]
SMARTSM00561. MBT. 3 hits.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMSSF47769. SSF47769. 1 hit.
PROSITEPS51079. MBT. 3 hits.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio383306.
PROQ8BLB7.
SOURCESearch...

Entry information

Entry nameLMBL3_MOUSE
AccessionPrimary (citable) accession number: Q8BLB7
Secondary accession number(s): Q0VGT0 expand/collapse secondary AC list , Q641L7, Q6ZPI2, Q8C0G4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot