ID   CF298_MOUSE             Reviewed;         290 AA.
AC   Q8BL95; Q8VCL7;
DT   22-JAN-2014, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   24-JAN-2024, entry version 123.
DE   RecName: Full=Cilia- and flagella-associated protein 298 {ECO:0000305};
DE   AltName: Full=Protein kurly homolog {ECO:0000305};
GN   Name=Cfap298 {ECO:0000250|UniProtKB:P57076};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Corpora quadrigemina;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N; TISSUE=Salivary gland;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Lung, and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: Plays a role in motile cilium function, possibly by acting on
CC       outer dynein arm assembly. Seems to be important for initiation rather
CC       than maintenance of cilium motility. Required for correct positioning
CC       of cilia at the apical cell surface, suggesting an additional role in
CC       the planar cell polarity (PCP) pathway. May suppress canonical Wnt
CC       signaling activity. {ECO:0000250|UniProtKB:Q6DRC3}.
CC   -!- SUBUNIT: Interacts with ZMYND10. {ECO:0000250|UniProtKB:P57076}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q5U3Z0}.
CC       Cytoplasm, cytoskeleton, cilium basal body
CC       {ECO:0000250|UniProtKB:A0A1L8HCK2}. Note=Partially colocalized with
CC       SASS6 in cytoplasmic puncta, suggesting a centrosomal localization.
CC       {ECO:0000250|UniProtKB:Q5U3Z0}.
CC   -!- SIMILARITY: Belongs to the CFAP298 family. {ECO:0000305}.
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DR   EMBL; AK045905; BAC32526.1; -; mRNA.
DR   EMBL; AC134560; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH466602; EDL03846.1; -; Genomic_DNA.
DR   EMBL; BC019533; AAH19533.1; -; mRNA.
DR   CCDS; CCDS28321.1; -.
DR   RefSeq; NP_080778.2; NM_026502.2.
DR   AlphaFoldDB; Q8BL95; -.
DR   BioGRID; 212591; 1.
DR   STRING; 10090.ENSMUSP00000023694; -.
DR   iPTMnet; Q8BL95; -.
DR   PhosphoSitePlus; Q8BL95; -.
DR   REPRODUCTION-2DPAGE; IPI00281363; -.
DR   EPD; Q8BL95; -.
DR   MaxQB; Q8BL95; -.
DR   PaxDb; 10090-ENSMUSP00000023694; -.
DR   PeptideAtlas; Q8BL95; -.
DR   Pumba; Q8BL95; -.
DR   DNASU; 68001; -.
DR   Ensembl; ENSMUST00000023694.11; ENSMUSP00000023694.4; ENSMUSG00000022972.11.
DR   GeneID; 68001; -.
DR   KEGG; mmu:68001; -.
DR   UCSC; uc007zwt.2; mouse.
DR   AGR; MGI:1915251; -.
DR   CTD; 56683; -.
DR   MGI; MGI:1915251; Cfap298.
DR   VEuPathDB; HostDB:ENSMUSG00000022972; -.
DR   eggNOG; ENOG502QQ3Z; Eukaryota.
DR   GeneTree; ENSGT00390000006278; -.
DR   HOGENOM; CLU_064854_0_0_1; -.
DR   InParanoid; Q8BL95; -.
DR   OMA; WAGKQFF; -.
DR   OrthoDB; 5473838at2759; -.
DR   PhylomeDB; Q8BL95; -.
DR   TreeFam; TF323482; -.
DR   BioGRID-ORCS; 68001; 26 hits in 76 CRISPR screens.
DR   ChiTaRS; Cfap298; mouse.
DR   PRO; PR:Q8BL95; -.
DR   Proteomes; UP000000589; Chromosome 16.
DR   RNAct; Q8BL95; Protein.
DR   Bgee; ENSMUSG00000022972; Expressed in animal zygote and 255 other cell types or tissues.
DR   ExpressionAtlas; Q8BL95; baseline and differential.
DR   GO; GO:0005929; C:cilium; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR   GO; GO:0005829; C:cytosol; ISO:MGI.
DR   GO; GO:0060271; P:cilium assembly; ISO:MGI.
DR   GO; GO:0003352; P:regulation of cilium movement; ISO:MGI.
DR   InterPro; IPR021298; CFAP298.
DR   PANTHER; PTHR13238:SF0; CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 298; 1.
DR   PANTHER; PTHR13238; PROTEIN C21ORF59; 1.
DR   Pfam; PF11069; CFAP298; 1.
DR   Genevisible; Q8BL95; MM.
PE   1: Evidence at protein level;
KW   Cell projection; Cilium; Cytoplasm; Cytoskeleton; Reference proteome.
FT   CHAIN           1..290
FT                   /note="Cilia- and flagella-associated protein 298"
FT                   /id="PRO_0000424911"
FT   CONFLICT        59
FT                   /note="P -> H (in Ref. 4; AAH19533)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   290 AA;  33190 MW;  FC6329D384D3CFE9 CRC64;
     MVVLHVKRGD ESQFLLQAPG STELEELTAQ VARVYNGRLK VHRLCSEMEE LAEHGVFLPP
     NMQGLTDEQI EELKLKDEWG EKCVPSGGSV FTKDEIGRRN GQAPNEKMKQ VLKKTVEEAK
     AIVSKKQVEA GVFVTMEMVK DALDQLRGAV MIVYPMGLPP YDPIRMEFEN KEDLSGTQAA
     LEVIQESEAQ LWWAAKELRR TKKLSDYVGK NEKTKIIVKI QQRGQGAPAR EPVISSEEHK
     QLMLFYHRRQ EELKKLEEND DDSCLNSPWA DNTALKRHFH GVKDIKWRPR
//