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Q8BL95

- CU059_MOUSE

UniProt

Q8BL95 - CU059_MOUSE

Protein

UPF0769 protein C21orf59 homolog

Gene
N/A
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    May play a role for motile cilia function, possibly by acting on dynein arm assembly.By similarity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UPF0769 protein C21orf59 homolog
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:1915251. 1110004E09Rik.

    Subcellular locationi

    Cytoplasm By similarity
    Note: Partially colocalized with SASS6 in cytoplasmic puncta, suggesting a centrosomal localization.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 290290UPF0769 protein C21orf59 homologPRO_0000424911Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki210 – 210Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

    Keywords - PTMi

    Isopeptide bond, Ubl conjugation

    Proteomic databases

    MaxQBiQ8BL95.
    PRIDEiQ8BL95.

    2D gel databases

    REPRODUCTION-2DPAGEIPI00281363.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8BL95.
    GenevestigatoriQ8BL95.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000023694.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BL95.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UPF0769 family.Curated

    Phylogenomic databases

    eggNOGiNOG74285.
    GeneTreeiENSGT00390000006278.
    HOGENOMiHOG000282965.
    HOVERGENiHBG051236.
    InParanoidiQ8BL95.
    OMAiKKGQGAP.
    OrthoDBiEOG4NS3C2.
    PhylomeDBiQ8BL95.
    TreeFamiTF323482.

    Family and domain databases

    InterProiIPR021298. DUF2870.
    [Graphical view]
    PfamiPF11069. DUF2870. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8BL95-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVVLHVKRGD ESQFLLQAPG STELEELTAQ VARVYNGRLK VHRLCSEMEE    50
    LAEHGVFLPP NMQGLTDEQI EELKLKDEWG EKCVPSGGSV FTKDEIGRRN 100
    GQAPNEKMKQ VLKKTVEEAK AIVSKKQVEA GVFVTMEMVK DALDQLRGAV 150
    MIVYPMGLPP YDPIRMEFEN KEDLSGTQAA LEVIQESEAQ LWWAAKELRR 200
    TKKLSDYVGK NEKTKIIVKI QQRGQGAPAR EPVISSEEHK QLMLFYHRRQ 250
    EELKKLEEND DDSCLNSPWA DNTALKRHFH GVKDIKWRPR 290
    Length:290
    Mass (Da):33,190
    Last modified:March 1, 2003 - v1
    Checksum:iFC6329D384D3CFE9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti59 – 591P → H in AAH19533. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK045905 mRNA. Translation: BAC32526.1.
    AC134560 Genomic DNA. No translation available.
    CH466602 Genomic DNA. Translation: EDL03846.1.
    BC019533 mRNA. Translation: AAH19533.1.
    CCDSiCCDS28321.1.
    RefSeqiNP_080778.2. NM_026502.2.
    UniGeneiMm.45374.

    Genome annotation databases

    EnsembliENSMUST00000023694; ENSMUSP00000023694; ENSMUSG00000022972.
    GeneIDi68001.
    KEGGimmu:68001.
    UCSCiuc007zwt.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK045905 mRNA. Translation: BAC32526.1 .
    AC134560 Genomic DNA. No translation available.
    CH466602 Genomic DNA. Translation: EDL03846.1 .
    BC019533 mRNA. Translation: AAH19533.1 .
    CCDSi CCDS28321.1.
    RefSeqi NP_080778.2. NM_026502.2.
    UniGenei Mm.45374.

    3D structure databases

    ProteinModelPortali Q8BL95.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000023694.

    2D gel databases

    REPRODUCTION-2DPAGE IPI00281363.

    Proteomic databases

    MaxQBi Q8BL95.
    PRIDEi Q8BL95.

    Protocols and materials databases

    DNASUi 68001.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000023694 ; ENSMUSP00000023694 ; ENSMUSG00000022972 .
    GeneIDi 68001.
    KEGGi mmu:68001.
    UCSCi uc007zwt.2. mouse.

    Organism-specific databases

    MGIi MGI:1915251. 1110004E09Rik.

    Phylogenomic databases

    eggNOGi NOG74285.
    GeneTreei ENSGT00390000006278.
    HOGENOMi HOG000282965.
    HOVERGENi HBG051236.
    InParanoidi Q8BL95.
    OMAi KKGQGAP.
    OrthoDBi EOG4NS3C2.
    PhylomeDBi Q8BL95.
    TreeFami TF323482.

    Miscellaneous databases

    NextBioi 326180.

    Gene expression databases

    ArrayExpressi Q8BL95.
    Genevestigatori Q8BL95.

    Family and domain databases

    InterProi IPR021298. DUF2870.
    [Graphical view ]
    Pfami PF11069. DUF2870. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Corpora quadrigemina.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Salivary gland.

    Entry informationi

    Entry nameiCU059_MOUSE
    AccessioniPrimary (citable) accession number: Q8BL95
    Secondary accession number(s): Q8VCL7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 22, 2014
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families
    3. Uncharacterized protein families (UPF)
      List of uncharacterized protein family (UPF) entries

    External Data

    Dasty 3