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Q8BL74

- TF3C2_MOUSE

UniProt

Q8BL74 - TF3C2_MOUSE

Protein

General transcription factor 3C polypeptide 2

Gene

Gtf3c2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 2 (07 Jun 2004)
      Previous versions | rss
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    Functioni

    Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. May play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1 By similarity.By similarity

    GO - Molecular functioni

    1. DNA binding Source: Ensembl

    GO - Biological processi

    1. transcription from RNA polymerase III promoter Source: Ensembl

    Keywords - Biological processi

    Transcription

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    General transcription factor 3C polypeptide 2
    Alternative name(s):
    TF3C-beta
    Transcription factor IIIC 110 kDa subunit
    Short name:
    TFIIIC 110 kDa subunit
    Short name:
    TFIIIC110
    Transcription factor IIIC subunit beta
    Gene namesi
    Name:Gtf3c2
    Synonyms:Kiaa0011
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:1919002. Gtf3c2.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. transcription factor TFIIIC complex Source: Ensembl

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 907907General transcription factor 3C polypeptide 2PRO_0000050986Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei62 – 621PhosphoserineBy similarity
    Modified residuei130 – 1301PhosphoserineBy similarity
    Modified residuei163 – 1631PhosphoserineBy similarity
    Modified residuei219 – 2191PhosphoserineBy similarity
    Modified residuei867 – 8671PhosphoserineBy similarity
    Modified residuei888 – 8881PhosphoserineBy similarity
    Modified residuei891 – 8911PhosphothreonineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8BL74.
    PRIDEiQ8BL74.

    PTM databases

    PhosphoSiteiQ8BL74.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8BL74.
    BgeeiQ8BL74.
    GenevestigatoriQ8BL74.

    Interactioni

    Subunit structurei

    Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and GTF3C6.By similarity

    Protein-protein interaction databases

    BioGridi214900. 1 interaction.
    IntActiQ8BL74. 2 interactions.
    MINTiMINT-4137509.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BL74.
    SMRiQ8BL74. Positions 832-865.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati461 – 51757WD 1Add
    BLAST
    Repeati548 – 58942WD 2Add
    BLAST
    Repeati607 – 64741WD 3Add
    BLAST
    Repeati828 – 87043WD 4Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi149 – 1546Poly-Leu

    Sequence similaritiesi

    Contains 4 WD repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, WD repeat

    Phylogenomic databases

    GeneTreeiENSGT00390000018632.
    HOVERGENiHBG056791.
    KOiK15200.
    PhylomeDBiQ8BL74.
    TreeFamiTF314779.

    Family and domain databases

    Gene3Di2.130.10.10. 2 hits.
    InterProiIPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF00400. WD40. 1 hit.
    [Graphical view]
    SMARTiSM00320. WD40. 4 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 3 hits.
    PROSITEiPS00678. WD_REPEATS_1. 2 hits.
    PS50082. WD_REPEATS_2. 1 hit.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8BL74-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDTCGVGYVA LGEADPVGSM IVVDSPGQEE LSQLDVKASE TSGVEASIEM    50
    SLPPPLPGFE DSSDRRLPPD QESLTRLEQQ DLSSEMSKVS NTRASKPSGR 100
    RGGRTARGAK RPQQRKPPST PLVPGLLDQS NPLSTPMPKK RSQKSKGDLL 150
    LLKLSKGLDQ PESPHPKRPP EDFETPSGER PRRRAAQVAL LYLQELAEEL 200
    STALPAPPLS GPKSPKVSSP TKPKKTRQAS SQGEEDGSAR DEDFVLQVEG 250
    EDEEESEAPS ENSSDPEPVA PRSTPRGPAA GKQKPHCRGM APNGLPNYIM 300
    APVWKCLHLT KDLREQHHSF WEFAEWIPVA WKWQLLSELE AAPYLPQEEK 350
    SPLFSVQREG IPEDGTIYRI NRFSSITAHP ERWDVSFFTG GPLWALDWCP 400
    VPEGSAASQY VALFSSPDMN ETHPLSQLHS GPGLLQLWGL GTLQQESCPG 450
    NRAHFVYGIA CDSGCIWDLK FCPSGAWEHP ETLRKAPLLP RLGLLALACS 500
    DGKVLLFSLP HPEALLAQQP PDAMKPAIYK VQCLATLQVG SVQASDPSEC 550
    GQCLSLAWMP TRPHHHLAAG YYNGMVVFWN LPTNSPLQRI RLSDGSLKLY 600
    PFQCFLAHDQ AVRTIQWCKA NSHFLVSAGS DRKIKFWDLR RPYEPINCIK 650
    RFLSTELSWL LPYNGVTVAQ DNCYASYGLC GIHYIDAGYL GFKAYFTAPR 700
    KGTVWSLSGS DWLGTVAAGD ISGELIAAIL PDMASNPINV KKPAERRFPI 750
    YKADLIPYQD SPEDQDYSST SSETPNPPKA RTYTETINHH YLLFQDTDLS 800
    SFHNLLRREP MLRMQEGEGH SQLCLDRLQL EAIHKVRFSP NLDSYGWLVS 850
    GGQSGLVRIH FVRGLTSPLA HRVQLESRAN FNAMFQPSFP TEGPGFSPSS 900
    HCLLPNP 907
    Length:907
    Mass (Da):100,275
    Last modified:June 7, 2004 - v2
    Checksum:iCEC3D374D3280CA7
    GO

    Sequence cautioni

    The sequence BAC31709.1 differs from that shown. Reason: Intron retention.
    The sequence BAC97843.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti39 – 391S → SS in AAH34369. (PubMed:15489334)Curated
    Sequence conflicti64 – 641D → DK in AAH34369. (PubMed:15489334)Curated
    Sequence conflicti146 – 1461K → E in BAC31709. (PubMed:16141072)Curated
    Sequence conflicti392 – 3921P → Q in BAC32629. (PubMed:16141072)Curated
    Sequence conflicti622 – 6221S → N in BAC38975. (PubMed:16141072)Curated
    Sequence conflicti731 – 7311P → L in AAH34369. (PubMed:15489334)Curated
    Sequence conflicti815 – 8151Q → L in BAC38975. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK008582 mRNA. Translation: BAB25760.1.
    AK012095 mRNA. Translation: BAB28026.1.
    AK043944 mRNA. Translation: BAC31709.1. Sequence problems.
    AK046192 mRNA. Translation: BAC32629.1.
    AK083636 mRNA. Translation: BAC38975.1.
    AK151300 mRNA. Translation: BAE30283.1.
    AK152439 mRNA. Translation: BAE31220.1.
    AK129033 mRNA. Translation: BAC97843.1. Different initiation.
    BC034369 mRNA. Translation: AAH34369.1.
    CCDSiCCDS39053.1.
    RefSeqiNP_082177.2. NM_027901.2.
    XP_006504193.1. XM_006504130.1.
    UniGeneiMm.271923.

    Genome annotation databases

    EnsembliENSMUST00000088010; ENSMUSP00000085325; ENSMUSG00000029144.
    GeneIDi71752.
    KEGGimmu:71752.
    UCSCiuc008wxh.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK008582 mRNA. Translation: BAB25760.1 .
    AK012095 mRNA. Translation: BAB28026.1 .
    AK043944 mRNA. Translation: BAC31709.1 . Sequence problems.
    AK046192 mRNA. Translation: BAC32629.1 .
    AK083636 mRNA. Translation: BAC38975.1 .
    AK151300 mRNA. Translation: BAE30283.1 .
    AK152439 mRNA. Translation: BAE31220.1 .
    AK129033 mRNA. Translation: BAC97843.1 . Different initiation.
    BC034369 mRNA. Translation: AAH34369.1 .
    CCDSi CCDS39053.1.
    RefSeqi NP_082177.2. NM_027901.2.
    XP_006504193.1. XM_006504130.1.
    UniGenei Mm.271923.

    3D structure databases

    ProteinModelPortali Q8BL74.
    SMRi Q8BL74. Positions 832-865.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 214900. 1 interaction.
    IntActi Q8BL74. 2 interactions.
    MINTi MINT-4137509.

    PTM databases

    PhosphoSitei Q8BL74.

    Proteomic databases

    MaxQBi Q8BL74.
    PRIDEi Q8BL74.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000088010 ; ENSMUSP00000085325 ; ENSMUSG00000029144 .
    GeneIDi 71752.
    KEGGi mmu:71752.
    UCSCi uc008wxh.1. mouse.

    Organism-specific databases

    CTDi 2976.
    MGIi MGI:1919002. Gtf3c2.
    Rougei Search...

    Phylogenomic databases

    GeneTreei ENSGT00390000018632.
    HOVERGENi HBG056791.
    KOi K15200.
    PhylomeDBi Q8BL74.
    TreeFami TF314779.

    Miscellaneous databases

    NextBioi 334405.
    PROi Q8BL74.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8BL74.
    Bgeei Q8BL74.
    Genevestigatori Q8BL74.

    Family and domain databases

    Gene3Di 2.130.10.10. 2 hits.
    InterProi IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF00400. WD40. 1 hit.
    [Graphical view ]
    SMARTi SM00320. WD40. 4 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 3 hits.
    PROSITEi PS00678. WD_REPEATS_1. 2 hits.
    PS50082. WD_REPEATS_2. 1 hit.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Bone marrow, Brain cortex, Corpora quadrigemina, Embryo and Small intestine.
    2. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
      DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryonic tail.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiTF3C2_MOUSE
    AccessioniPrimary (citable) accession number: Q8BL74
    Secondary accession number(s): Q3U7Z9
    , Q80XQ7, Q8BJJ4, Q8BLP3, Q8K1J1, Q9CSS0, Q9CVE6, Q9DBK6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2004
    Last sequence update: June 7, 2004
    Last modified: October 1, 2014
    This is version 103 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3