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Protein

General transcription factor 3C polypeptide 2

Gene

Gtf3c2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. May play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1 (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription

Enzyme and pathway databases

ReactomeiR-MMU-76061. RNA Polymerase III Transcription Initiation From Type 1 Promoter.
R-MMU-76066. RNA Polymerase III Transcription Initiation From Type 2 Promoter.

Names & Taxonomyi

Protein namesi
Recommended name:
General transcription factor 3C polypeptide 2
Alternative name(s):
TF3C-beta
Transcription factor IIIC 110 kDa subunit
Short name:
TFIIIC 110 kDa subunit
Short name:
TFIIIC110
Transcription factor IIIC subunit beta
Gene namesi
Name:Gtf3c2
Synonyms:Kiaa0011
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1919002. Gtf3c2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000509861 – 907General transcription factor 3C polypeptide 2Add BLAST907

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei62PhosphoserineBy similarity1
Modified residuei130PhosphoserineBy similarity1
Modified residuei163PhosphoserineBy similarity1
Modified residuei219PhosphoserineBy similarity1
Modified residuei256PhosphoserineBy similarity1
Modified residuei593PhosphoserineBy similarity1
Modified residuei867PhosphoserineBy similarity1
Modified residuei888PhosphoserineBy similarity1
Modified residuei891PhosphothreonineBy similarity1
Modified residuei897PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8BL74.
MaxQBiQ8BL74.
PaxDbiQ8BL74.
PeptideAtlasiQ8BL74.
PRIDEiQ8BL74.

PTM databases

iPTMnetiQ8BL74.
PhosphoSitePlusiQ8BL74.

Expressioni

Gene expression databases

BgeeiENSMUSG00000029144.
ExpressionAtlasiQ8BL74. baseline.
GenevisibleiQ8BL74. MM.

Interactioni

Subunit structurei

Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and GTF3C6.By similarity

Protein-protein interaction databases

BioGridi214900. 15 interactors.
IntActiQ8BL74. 15 interactors.
MINTiMINT-4137509.
STRINGi10090.ENSMUSP00000085325.

Structurei

3D structure databases

ProteinModelPortaliQ8BL74.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati461 – 517WD 1Add BLAST57
Repeati548 – 589WD 2Add BLAST42
Repeati607 – 647WD 3Add BLAST41
Repeati828 – 870WD 4Add BLAST43

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi149 – 154Poly-Leu6

Sequence similaritiesi

Contains 4 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410IG5U. Eukaryota.
ENOG410YFGF. LUCA.
GeneTreeiENSGT00390000018632.
HOVERGENiHBG056791.
InParanoidiQ8BL74.
KOiK15200.
OrthoDBiEOG091G07LV.
PhylomeDBiQ8BL74.
TreeFamiTF314779.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 3 hits.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BL74-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTCGVGYVA LGEADPVGSM IVVDSPGQEE LSQLDVKASE TSGVEASIEM
60 70 80 90 100
SLPPPLPGFE DSSDRRLPPD QESLTRLEQQ DLSSEMSKVS NTRASKPSGR
110 120 130 140 150
RGGRTARGAK RPQQRKPPST PLVPGLLDQS NPLSTPMPKK RSQKSKGDLL
160 170 180 190 200
LLKLSKGLDQ PESPHPKRPP EDFETPSGER PRRRAAQVAL LYLQELAEEL
210 220 230 240 250
STALPAPPLS GPKSPKVSSP TKPKKTRQAS SQGEEDGSAR DEDFVLQVEG
260 270 280 290 300
EDEEESEAPS ENSSDPEPVA PRSTPRGPAA GKQKPHCRGM APNGLPNYIM
310 320 330 340 350
APVWKCLHLT KDLREQHHSF WEFAEWIPVA WKWQLLSELE AAPYLPQEEK
360 370 380 390 400
SPLFSVQREG IPEDGTIYRI NRFSSITAHP ERWDVSFFTG GPLWALDWCP
410 420 430 440 450
VPEGSAASQY VALFSSPDMN ETHPLSQLHS GPGLLQLWGL GTLQQESCPG
460 470 480 490 500
NRAHFVYGIA CDSGCIWDLK FCPSGAWEHP ETLRKAPLLP RLGLLALACS
510 520 530 540 550
DGKVLLFSLP HPEALLAQQP PDAMKPAIYK VQCLATLQVG SVQASDPSEC
560 570 580 590 600
GQCLSLAWMP TRPHHHLAAG YYNGMVVFWN LPTNSPLQRI RLSDGSLKLY
610 620 630 640 650
PFQCFLAHDQ AVRTIQWCKA NSHFLVSAGS DRKIKFWDLR RPYEPINCIK
660 670 680 690 700
RFLSTELSWL LPYNGVTVAQ DNCYASYGLC GIHYIDAGYL GFKAYFTAPR
710 720 730 740 750
KGTVWSLSGS DWLGTVAAGD ISGELIAAIL PDMASNPINV KKPAERRFPI
760 770 780 790 800
YKADLIPYQD SPEDQDYSST SSETPNPPKA RTYTETINHH YLLFQDTDLS
810 820 830 840 850
SFHNLLRREP MLRMQEGEGH SQLCLDRLQL EAIHKVRFSP NLDSYGWLVS
860 870 880 890 900
GGQSGLVRIH FVRGLTSPLA HRVQLESRAN FNAMFQPSFP TEGPGFSPSS

HCLLPNP
Length:907
Mass (Da):100,275
Last modified:June 7, 2004 - v2
Checksum:iCEC3D374D3280CA7
GO

Sequence cautioni

The sequence BAC31709 differs from that shown. Intron retention.Curated
The sequence BAC97843 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti39S → SS in AAH34369 (PubMed:15489334).Curated1
Sequence conflicti64D → DK in AAH34369 (PubMed:15489334).Curated1
Sequence conflicti146K → E in BAC31709 (PubMed:16141072).Curated1
Sequence conflicti392P → Q in BAC32629 (PubMed:16141072).Curated1
Sequence conflicti622S → N in BAC38975 (PubMed:16141072).Curated1
Sequence conflicti731P → L in AAH34369 (PubMed:15489334).Curated1
Sequence conflicti815Q → L in BAC38975 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008582 mRNA. Translation: BAB25760.1.
AK012095 mRNA. Translation: BAB28026.1.
AK043944 mRNA. Translation: BAC31709.1. Sequence problems.
AK046192 mRNA. Translation: BAC32629.1.
AK083636 mRNA. Translation: BAC38975.1.
AK151300 mRNA. Translation: BAE30283.1.
AK152439 mRNA. Translation: BAE31220.1.
AK129033 mRNA. Translation: BAC97843.1. Different initiation.
BC034369 mRNA. Translation: AAH34369.1.
CCDSiCCDS39053.1.
RefSeqiNP_082177.2. NM_027901.2.
UniGeneiMm.271923.

Genome annotation databases

EnsembliENSMUST00000088010; ENSMUSP00000085325; ENSMUSG00000106864.
GeneIDi71752.
KEGGimmu:71752.
UCSCiuc008wxh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008582 mRNA. Translation: BAB25760.1.
AK012095 mRNA. Translation: BAB28026.1.
AK043944 mRNA. Translation: BAC31709.1. Sequence problems.
AK046192 mRNA. Translation: BAC32629.1.
AK083636 mRNA. Translation: BAC38975.1.
AK151300 mRNA. Translation: BAE30283.1.
AK152439 mRNA. Translation: BAE31220.1.
AK129033 mRNA. Translation: BAC97843.1. Different initiation.
BC034369 mRNA. Translation: AAH34369.1.
CCDSiCCDS39053.1.
RefSeqiNP_082177.2. NM_027901.2.
UniGeneiMm.271923.

3D structure databases

ProteinModelPortaliQ8BL74.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi214900. 15 interactors.
IntActiQ8BL74. 15 interactors.
MINTiMINT-4137509.
STRINGi10090.ENSMUSP00000085325.

PTM databases

iPTMnetiQ8BL74.
PhosphoSitePlusiQ8BL74.

Proteomic databases

EPDiQ8BL74.
MaxQBiQ8BL74.
PaxDbiQ8BL74.
PeptideAtlasiQ8BL74.
PRIDEiQ8BL74.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000088010; ENSMUSP00000085325; ENSMUSG00000106864.
GeneIDi71752.
KEGGimmu:71752.
UCSCiuc008wxh.1. mouse.

Organism-specific databases

CTDi2976.
MGIiMGI:1919002. Gtf3c2.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IG5U. Eukaryota.
ENOG410YFGF. LUCA.
GeneTreeiENSGT00390000018632.
HOVERGENiHBG056791.
InParanoidiQ8BL74.
KOiK15200.
OrthoDBiEOG091G07LV.
PhylomeDBiQ8BL74.
TreeFamiTF314779.

Enzyme and pathway databases

ReactomeiR-MMU-76061. RNA Polymerase III Transcription Initiation From Type 1 Promoter.
R-MMU-76066. RNA Polymerase III Transcription Initiation From Type 2 Promoter.

Miscellaneous databases

ChiTaRSiGtf3c2. mouse.
PROiQ8BL74.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029144.
ExpressionAtlasiQ8BL74. baseline.
GenevisibleiQ8BL74. MM.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 3 hits.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTF3C2_MOUSE
AccessioniPrimary (citable) accession number: Q8BL74
Secondary accession number(s): Q3U7Z9
, Q80XQ7, Q8BJJ4, Q8BLP3, Q8K1J1, Q9CSS0, Q9CVE6, Q9DBK6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: November 30, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.