Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q8BL74 (TF3C2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
General transcription factor 3C polypeptide 2
Alternative name(s):
TF3C-beta
Transcription factor IIIC 110 kDa subunit
Short name=TFIIIC 110 kDa subunit
Short name=TFIIIC110
Transcription factor IIIC subunit beta
Gene names
Name:Gtf3c2
Synonyms:Kiaa0011
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length907 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. May play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1 By similarity.

Subunit structure

Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and GTF3C6 By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Contains 4 WD repeats.

Sequence caution

The sequence BAC31709.1 differs from that shown. Reason: Intron retention.

The sequence BAC97843.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processTranscription
   Cellular componentNucleus
   DomainRepeat
WD repeat
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtranscription from RNA polymerase III promoter

Inferred from electronic annotation. Source: Ensembl

   Cellular_componenttranscription factor TFIIIC complex

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 907907General transcription factor 3C polypeptide 2
PRO_0000050986

Regions

Repeat461 – 51757WD 1
Repeat548 – 58942WD 2
Repeat607 – 64741WD 3
Repeat828 – 87043WD 4
Compositional bias149 – 1546Poly-Leu

Amino acid modifications

Modified residue621Phosphoserine By similarity
Modified residue1301Phosphoserine By similarity
Modified residue1631Phosphoserine By similarity
Modified residue2191Phosphoserine By similarity
Modified residue8671Phosphoserine By similarity
Modified residue8881Phosphoserine By similarity
Modified residue8911Phosphothreonine By similarity

Experimental info

Sequence conflict391S → SS in AAH34369. Ref.3
Sequence conflict641D → DK in AAH34369. Ref.3
Sequence conflict1461K → E in BAC31709. Ref.1
Sequence conflict3921P → Q in BAC32629. Ref.1
Sequence conflict6221S → N in BAC38975. Ref.1
Sequence conflict7311P → L in AAH34369. Ref.3
Sequence conflict8151Q → L in BAC38975. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8BL74 [UniParc].

Last modified June 7, 2004. Version 2.
Checksum: CEC3D374D3280CA7

FASTA907100,275
        10         20         30         40         50         60 
MDTCGVGYVA LGEADPVGSM IVVDSPGQEE LSQLDVKASE TSGVEASIEM SLPPPLPGFE 

        70         80         90        100        110        120 
DSSDRRLPPD QESLTRLEQQ DLSSEMSKVS NTRASKPSGR RGGRTARGAK RPQQRKPPST 

       130        140        150        160        170        180 
PLVPGLLDQS NPLSTPMPKK RSQKSKGDLL LLKLSKGLDQ PESPHPKRPP EDFETPSGER 

       190        200        210        220        230        240 
PRRRAAQVAL LYLQELAEEL STALPAPPLS GPKSPKVSSP TKPKKTRQAS SQGEEDGSAR 

       250        260        270        280        290        300 
DEDFVLQVEG EDEEESEAPS ENSSDPEPVA PRSTPRGPAA GKQKPHCRGM APNGLPNYIM 

       310        320        330        340        350        360 
APVWKCLHLT KDLREQHHSF WEFAEWIPVA WKWQLLSELE AAPYLPQEEK SPLFSVQREG 

       370        380        390        400        410        420 
IPEDGTIYRI NRFSSITAHP ERWDVSFFTG GPLWALDWCP VPEGSAASQY VALFSSPDMN 

       430        440        450        460        470        480 
ETHPLSQLHS GPGLLQLWGL GTLQQESCPG NRAHFVYGIA CDSGCIWDLK FCPSGAWEHP 

       490        500        510        520        530        540 
ETLRKAPLLP RLGLLALACS DGKVLLFSLP HPEALLAQQP PDAMKPAIYK VQCLATLQVG 

       550        560        570        580        590        600 
SVQASDPSEC GQCLSLAWMP TRPHHHLAAG YYNGMVVFWN LPTNSPLQRI RLSDGSLKLY 

       610        620        630        640        650        660 
PFQCFLAHDQ AVRTIQWCKA NSHFLVSAGS DRKIKFWDLR RPYEPINCIK RFLSTELSWL 

       670        680        690        700        710        720 
LPYNGVTVAQ DNCYASYGLC GIHYIDAGYL GFKAYFTAPR KGTVWSLSGS DWLGTVAAGD 

       730        740        750        760        770        780 
ISGELIAAIL PDMASNPINV KKPAERRFPI YKADLIPYQD SPEDQDYSST SSETPNPPKA 

       790        800        810        820        830        840 
RTYTETINHH YLLFQDTDLS SFHNLLRREP MLRMQEGEGH SQLCLDRLQL EAIHKVRFSP 

       850        860        870        880        890        900 
NLDSYGWLVS GGQSGLVRIH FVRGLTSPLA HRVQLESRAN FNAMFQPSFP TEGPGFSPSS 


HCLLPNP 

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Bone marrow, Brain cortex, Corpora quadrigemina, Embryo and Small intestine.
[2]"Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryonic tail.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK008582 mRNA. Translation: BAB25760.1.
AK012095 mRNA. Translation: BAB28026.1.
AK043944 mRNA. Translation: BAC31709.1. Sequence problems.
AK046192 mRNA. Translation: BAC32629.1.
AK083636 mRNA. Translation: BAC38975.1.
AK151300 mRNA. Translation: BAE30283.1.
AK152439 mRNA. Translation: BAE31220.1.
AK129033 mRNA. Translation: BAC97843.1. Different initiation.
BC034369 mRNA. Translation: AAH34369.1.
CCDSCCDS39053.1.
RefSeqNP_082177.2. NM_027901.2.
XP_006504193.1. XM_006504130.1.
UniGeneMm.271923.

3D structure databases

ProteinModelPortalQ8BL74.
SMRQ8BL74. Positions 832-865.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid214900. 1 interaction.
IntActQ8BL74. 2 interactions.
MINTMINT-4137509.

PTM databases

PhosphoSiteQ8BL74.

Proteomic databases

MaxQBQ8BL74.
PRIDEQ8BL74.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000088010; ENSMUSP00000085325; ENSMUSG00000029144.
GeneID71752.
KEGGmmu:71752.
UCSCuc008wxh.1. mouse.

Organism-specific databases

CTD2976.
MGIMGI:1919002. Gtf3c2.
RougeSearch...

Phylogenomic databases

GeneTreeENSGT00390000018632.
HOVERGENHBG056791.
KOK15200.
PhylomeDBQ8BL74.
TreeFamTF314779.

Gene expression databases

ArrayExpressQ8BL74.
BgeeQ8BL74.
GenevestigatorQ8BL74.

Family and domain databases

Gene3D2.130.10.10. 2 hits.
InterProIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamPF00400. WD40. 1 hit.
[Graphical view]
SMARTSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMSSF50978. SSF50978. 3 hits.
PROSITEPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio334405.
PROQ8BL74.
SOURCESearch...

Entry information

Entry nameTF3C2_MOUSE
AccessionPrimary (citable) accession number: Q8BL74
Secondary accession number(s): Q3U7Z9 expand/collapse secondary AC list , Q80XQ7, Q8BJJ4, Q8BLP3, Q8K1J1, Q9CSS0, Q9CVE6, Q9DBK6
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: July 9, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot