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Q8BL74

- TF3C2_MOUSE

UniProt

Q8BL74 - TF3C2_MOUSE

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Protein

General transcription factor 3C polypeptide 2

Gene

Gtf3c2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. May play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1 (By similarity).By similarity

GO - Biological processi

  1. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription

Names & Taxonomyi

Protein namesi
Recommended name:
General transcription factor 3C polypeptide 2
Alternative name(s):
TF3C-beta
Transcription factor IIIC 110 kDa subunit
Short name:
TFIIIC 110 kDa subunit
Short name:
TFIIIC110
Transcription factor IIIC subunit beta
Gene namesi
Name:Gtf3c2
Synonyms:Kiaa0011
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:1919002. Gtf3c2.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 907907General transcription factor 3C polypeptide 2PRO_0000050986Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei62 – 621PhosphoserineBy similarity
Modified residuei130 – 1301PhosphoserineBy similarity
Modified residuei163 – 1631PhosphoserineBy similarity
Modified residuei219 – 2191PhosphoserineBy similarity
Modified residuei867 – 8671PhosphoserineBy similarity
Modified residuei888 – 8881PhosphoserineBy similarity
Modified residuei891 – 8911PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8BL74.
PRIDEiQ8BL74.

PTM databases

PhosphoSiteiQ8BL74.

Expressioni

Gene expression databases

BgeeiQ8BL74.
ExpressionAtlasiQ8BL74. baseline and differential.
GenevestigatoriQ8BL74.

Interactioni

Subunit structurei

Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and GTF3C6.By similarity

Protein-protein interaction databases

BioGridi214900. 1 interaction.
IntActiQ8BL74. 2 interactions.
MINTiMINT-4137509.

Structurei

3D structure databases

ProteinModelPortaliQ8BL74.
SMRiQ8BL74. Positions 553-640, 830-864.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati461 – 51757WD 1Add
BLAST
Repeati548 – 58942WD 2Add
BLAST
Repeati607 – 64741WD 3Add
BLAST
Repeati828 – 87043WD 4Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi149 – 1546Poly-Leu

Sequence similaritiesi

Contains 4 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

GeneTreeiENSGT00390000018632.
HOVERGENiHBG056791.
InParanoidiQ8BL74.
KOiK15200.
PhylomeDBiQ8BL74.
TreeFamiTF314779.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 3 hits.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BL74-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDTCGVGYVA LGEADPVGSM IVVDSPGQEE LSQLDVKASE TSGVEASIEM
60 70 80 90 100
SLPPPLPGFE DSSDRRLPPD QESLTRLEQQ DLSSEMSKVS NTRASKPSGR
110 120 130 140 150
RGGRTARGAK RPQQRKPPST PLVPGLLDQS NPLSTPMPKK RSQKSKGDLL
160 170 180 190 200
LLKLSKGLDQ PESPHPKRPP EDFETPSGER PRRRAAQVAL LYLQELAEEL
210 220 230 240 250
STALPAPPLS GPKSPKVSSP TKPKKTRQAS SQGEEDGSAR DEDFVLQVEG
260 270 280 290 300
EDEEESEAPS ENSSDPEPVA PRSTPRGPAA GKQKPHCRGM APNGLPNYIM
310 320 330 340 350
APVWKCLHLT KDLREQHHSF WEFAEWIPVA WKWQLLSELE AAPYLPQEEK
360 370 380 390 400
SPLFSVQREG IPEDGTIYRI NRFSSITAHP ERWDVSFFTG GPLWALDWCP
410 420 430 440 450
VPEGSAASQY VALFSSPDMN ETHPLSQLHS GPGLLQLWGL GTLQQESCPG
460 470 480 490 500
NRAHFVYGIA CDSGCIWDLK FCPSGAWEHP ETLRKAPLLP RLGLLALACS
510 520 530 540 550
DGKVLLFSLP HPEALLAQQP PDAMKPAIYK VQCLATLQVG SVQASDPSEC
560 570 580 590 600
GQCLSLAWMP TRPHHHLAAG YYNGMVVFWN LPTNSPLQRI RLSDGSLKLY
610 620 630 640 650
PFQCFLAHDQ AVRTIQWCKA NSHFLVSAGS DRKIKFWDLR RPYEPINCIK
660 670 680 690 700
RFLSTELSWL LPYNGVTVAQ DNCYASYGLC GIHYIDAGYL GFKAYFTAPR
710 720 730 740 750
KGTVWSLSGS DWLGTVAAGD ISGELIAAIL PDMASNPINV KKPAERRFPI
760 770 780 790 800
YKADLIPYQD SPEDQDYSST SSETPNPPKA RTYTETINHH YLLFQDTDLS
810 820 830 840 850
SFHNLLRREP MLRMQEGEGH SQLCLDRLQL EAIHKVRFSP NLDSYGWLVS
860 870 880 890 900
GGQSGLVRIH FVRGLTSPLA HRVQLESRAN FNAMFQPSFP TEGPGFSPSS

HCLLPNP
Length:907
Mass (Da):100,275
Last modified:June 7, 2004 - v2
Checksum:iCEC3D374D3280CA7
GO

Sequence cautioni

The sequence BAC31709.1 differs from that shown. Reason: Intron retention.
The sequence BAC97843.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti39 – 391S → SS in AAH34369. (PubMed:15489334)Curated
Sequence conflicti64 – 641D → DK in AAH34369. (PubMed:15489334)Curated
Sequence conflicti146 – 1461K → E in BAC31709. (PubMed:16141072)Curated
Sequence conflicti392 – 3921P → Q in BAC32629. (PubMed:16141072)Curated
Sequence conflicti622 – 6221S → N in BAC38975. (PubMed:16141072)Curated
Sequence conflicti731 – 7311P → L in AAH34369. (PubMed:15489334)Curated
Sequence conflicti815 – 8151Q → L in BAC38975. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK008582 mRNA. Translation: BAB25760.1.
AK012095 mRNA. Translation: BAB28026.1.
AK043944 mRNA. Translation: BAC31709.1. Sequence problems.
AK046192 mRNA. Translation: BAC32629.1.
AK083636 mRNA. Translation: BAC38975.1.
AK151300 mRNA. Translation: BAE30283.1.
AK152439 mRNA. Translation: BAE31220.1.
AK129033 mRNA. Translation: BAC97843.1. Different initiation.
BC034369 mRNA. Translation: AAH34369.1.
CCDSiCCDS39053.1.
RefSeqiNP_082177.2. NM_027901.2.
XP_006504193.1. XM_006504130.1.
UniGeneiMm.271923.

Genome annotation databases

EnsembliENSMUST00000088010; ENSMUSP00000085325; ENSMUSG00000029144.
GeneIDi71752.
KEGGimmu:71752.
UCSCiuc008wxh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK008582 mRNA. Translation: BAB25760.1 .
AK012095 mRNA. Translation: BAB28026.1 .
AK043944 mRNA. Translation: BAC31709.1 . Sequence problems.
AK046192 mRNA. Translation: BAC32629.1 .
AK083636 mRNA. Translation: BAC38975.1 .
AK151300 mRNA. Translation: BAE30283.1 .
AK152439 mRNA. Translation: BAE31220.1 .
AK129033 mRNA. Translation: BAC97843.1 . Different initiation.
BC034369 mRNA. Translation: AAH34369.1 .
CCDSi CCDS39053.1.
RefSeqi NP_082177.2. NM_027901.2.
XP_006504193.1. XM_006504130.1.
UniGenei Mm.271923.

3D structure databases

ProteinModelPortali Q8BL74.
SMRi Q8BL74. Positions 553-640, 830-864.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 214900. 1 interaction.
IntActi Q8BL74. 2 interactions.
MINTi MINT-4137509.

PTM databases

PhosphoSitei Q8BL74.

Proteomic databases

MaxQBi Q8BL74.
PRIDEi Q8BL74.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000088010 ; ENSMUSP00000085325 ; ENSMUSG00000029144 .
GeneIDi 71752.
KEGGi mmu:71752.
UCSCi uc008wxh.1. mouse.

Organism-specific databases

CTDi 2976.
MGIi MGI:1919002. Gtf3c2.
Rougei Search...

Phylogenomic databases

GeneTreei ENSGT00390000018632.
HOVERGENi HBG056791.
InParanoidi Q8BL74.
KOi K15200.
PhylomeDBi Q8BL74.
TreeFami TF314779.

Miscellaneous databases

NextBioi 334405.
PROi Q8BL74.
SOURCEi Search...

Gene expression databases

Bgeei Q8BL74.
ExpressionAtlasi Q8BL74. baseline and differential.
Genevestigatori Q8BL74.

Family and domain databases

Gene3Di 2.130.10.10. 2 hits.
InterProi IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF00400. WD40. 1 hit.
[Graphical view ]
SMARTi SM00320. WD40. 4 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 3 hits.
PROSITEi PS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone marrow, Brain cortex, Corpora quadrigemina, Embryo and Small intestine.
  2. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryonic tail.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary tumor.

Entry informationi

Entry nameiTF3C2_MOUSE
AccessioniPrimary (citable) accession number: Q8BL74
Secondary accession number(s): Q3U7Z9
, Q80XQ7, Q8BJJ4, Q8BLP3, Q8K1J1, Q9CSS0, Q9CVE6, Q9DBK6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: October 29, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3