Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Mitochondrial basic amino acids transporter

Gene

Slc25a29

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transports arginine, lysine, homoarginine, methylarginine and, to a much lesser extent, ornithine and histidine. Does not transport carnitine nor acylcarnitines. Functions by both counter-exchange and uniport mechanisms (By similarity).By similarity1 Publication

GO - Molecular functioni

  • acyl carnitine transmembrane transporter activity Source: MGI

GO - Biological processi

  • acyl carnitine transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi2.A.29.8.5. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial basic amino acids transporter
Alternative name(s):
Carnitine/acylcarnitine translocase-like
Short name:
CACT-like
Mitochondrial carnitine/acylcarnitine carrier protein CACL
Mitochondrial ornithine transporter 3
Solute carrier family 25 member 29
Gene namesi
Name:Slc25a29
Synonyms:Ornt3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:2444911. Slc25a29.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei2 – 22Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei61 – 81Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei96 – 116Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei153 – 172Helical; Name=4Sequence analysisAdd BLAST20
Transmembranei187 – 207Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei255 – 275Helical; Name=6Sequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: UniProtKB-SubCell
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000906331 – 306Mitochondrial basic amino acids transporterAdd BLAST306

Proteomic databases

MaxQBiQ8BL03.
PaxDbiQ8BL03.
PeptideAtlasiQ8BL03.
PRIDEiQ8BL03.

PTM databases

PhosphoSitePlusiQ8BL03.

Expressioni

Tissue specificityi

Widely expressed, with highest levels in the brain, including cortex, cerebellum, hippocampus and hypothalamus, and moderate levels in liver, kidney, heart and testis.2 Publications

Inductioni

By partial hepactectomy and fasting.1 Publication

Gene expression databases

BgeeiENSMUSG00000021265.
GenevisibleiQ8BL03. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021693.

Structurei

3D structure databases

ProteinModelPortaliQ8BL03.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati2 – 86Solcar 1Add BLAST85
Repeati90 – 178Solcar 2Add BLAST89
Repeati190 – 275Solcar 3Add BLAST86

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0758. Eukaryota.
ENOG410XS86. LUCA.
GeneTreeiENSGT00700000104295.
HOGENOMiHOG000168307.
HOVERGENiHBG003500.
InParanoidiQ8BL03.
KOiK15109.
OMAiETPSFGF.
OrthoDBiEOG091G0HVE.
PhylomeDBiQ8BL03.
TreeFamiTF351739.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BL03-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALDFLAGCA GGVAGVIVGH PFDIVKVRLQ VQSTEKPQYR GTLHCFQSII
60 70 80 90 100
KQESVLGLYK GLGSPLMGLT FINALVFGVQ GNTLRALGQD SPLNQFLAGA
110 120 130 140 150
AAGAIQCVIC CPMELAKTRL QLQAVGPART YKGSLDCLVQ IYRHEGLRGI
160 170 180 190 200
NRGMVSTLLR ETPSFGVYFL TYDVMTRAMG CEPGDRLLVP KLLLAGGTSG
210 220 230 240 250
ITSWLSTYPM DVVKSRLQAD GLQGTPRYRG IVDCMRQSYQ AEGWQVFTRG
260 270 280 290 300
LASTLLRAFP VNAATFATVT VVLTYTRGEE AQVDSEAALG TSPTPAGSAL

AQPSSL
Length:306
Mass (Da):32,672
Last modified:March 1, 2003 - v1
Checksum:iF62E9CA8066B4BC7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK047628 mRNA. Translation: BAC33105.1.
BC006711 mRNA. Translation: AAH06711.1.
CCDSiCCDS26164.1.
RefSeqiNP_851845.1. NM_181328.3.
UniGeneiMm.266264.

Genome annotation databases

EnsembliENSMUST00000021693; ENSMUSP00000021693; ENSMUSG00000021265.
GeneIDi214663.
KEGGimmu:214663.
UCSCiuc007pad.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK047628 mRNA. Translation: BAC33105.1.
BC006711 mRNA. Translation: AAH06711.1.
CCDSiCCDS26164.1.
RefSeqiNP_851845.1. NM_181328.3.
UniGeneiMm.266264.

3D structure databases

ProteinModelPortaliQ8BL03.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021693.

Protein family/group databases

TCDBi2.A.29.8.5. the mitochondrial carrier (mc) family.

PTM databases

PhosphoSitePlusiQ8BL03.

Proteomic databases

MaxQBiQ8BL03.
PaxDbiQ8BL03.
PeptideAtlasiQ8BL03.
PRIDEiQ8BL03.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021693; ENSMUSP00000021693; ENSMUSG00000021265.
GeneIDi214663.
KEGGimmu:214663.
UCSCiuc007pad.1. mouse.

Organism-specific databases

CTDi123096.
MGIiMGI:2444911. Slc25a29.

Phylogenomic databases

eggNOGiKOG0758. Eukaryota.
ENOG410XS86. LUCA.
GeneTreeiENSGT00700000104295.
HOGENOMiHOG000168307.
HOVERGENiHBG003500.
InParanoidiQ8BL03.
KOiK15109.
OMAiETPSFGF.
OrthoDBiEOG091G0HVE.
PhylomeDBiQ8BL03.
TreeFamiTF351739.

Miscellaneous databases

PROiQ8BL03.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021265.
GenevisibleiQ8BL03. MM.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMCATL_MOUSE
AccessioniPrimary (citable) accession number: Q8BL03
Secondary accession number(s): Q922X4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2003
Last sequence update: March 1, 2003
Last modified: November 30, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.