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Protein

Zinc finger protein 410

Gene

Znf410

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor that activates transcription of matrix-remodeling genes such as MMP1 during fibroblast senescence.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri219 – 24325C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri249 – 27325C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri279 – 30325C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri309 – 33325C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri339 – 36224C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 410
Alternative name(s):
Another partner for ARF 1
Zinc finger protein APA-1
Gene namesi
Name:Znf410
Synonyms:Apa1, D12Ertd748e, Zfp410
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1289280. Zfp410.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 478478Zinc finger protein 410PRO_0000047572Add
BLAST

Post-translational modificationi

Sumoylated. Sumoylation increases its half-life, possibly by blocking ubiquitin-mediated degradation (By similarity).By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ8BKX7.
PRIDEiQ8BKX7.

PTM databases

iPTMnetiQ8BKX7.

Expressioni

Gene expression databases

BgeeiQ8BKX7.
CleanExiMM_ZFP410.
GenevisibleiQ8BKX7. MM.

Interactioni

Subunit structurei

Interacts with CDKN2A/p14ARF.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045550.

Structurei

3D structure databases

ProteinModelPortaliQ8BKX7.
SMRiQ8BKX7. Positions 226-362.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri219 – 24325C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri249 – 27325C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri279 – 30325C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri309 – 33325C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri339 – 36224C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118771.
HOGENOMiHOG000069877.
HOVERGENiHBG055280.
InParanoidiQ8BKX7.
OMAiDDTPNHT.
OrthoDBiEOG7RFTGZ.
PhylomeDBiQ8BKX7.
TreeFamiTF333498.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BKX7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLSDELESKP ELLVQFVQNT SIPLGQGLVE SEAKDITCLS LLPVTEASEC
60 70 80 90 100
SRLMLPDETP NHANSSKEVP SSAVLRSLQV NVGPDGEETR AQTVQKSPEF
110 120 130 140 150
LTTPESPSLL QDLQPSDSTS FILLNLTRAG LGSSAEHFVF VQDETEDSGA
160 170 180 190 200
DFLSAESTDS SIPWFLRVQE LAHDSLIAAT RAQLAKNAKT GSNGENVHLG
210 220 230 240 250
SGDGQPKDSG PLPQAEKKLK CTVEGCDRTF VWPAHFKYHL KTHRNERSFI
260 270 280 290 300
CPAEGCGKSF YVLQRLKVHM RTHNGEKPFM CHESGCGKQF TTAGNLKNHR
310 320 330 340 350
RIHTGEKPFL CEAQGCGRSF AEYSSLRKHL VVHSGEKPHQ CQVCGKTFSQ
360 370 380 390 400
SGSRNVHMRK HHLQLGTTGS QEQDQTAEPL MGSSLLEDAS VPNKNLVSMN
410 420 430 440 450
SQSSLGGESL NLSNTNSILG VDDEVLTERA SRPLSSVPDV THHLVTMQSG
460 470
RQSYEVSVLT AVNPQELLNQ GDLTERQT
Length:478
Mass (Da):52,208
Last modified:October 3, 2003 - v2
Checksum:i187BE9F24D9609CB
GO
Isoform 2 (identifier: Q8BKX7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     335-347: GEKPHQCQVCGKT → GTRTCAICRPQIQ
     348-478: Missing.

Note: No experimental confirmation available.
Show »
Length:347
Mass (Da):38,074
Checksum:iE596B2194966A352
GO
Isoform 3 (identifier: Q8BKX7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     335-345: GEKPHQCQVCG → ELEIEPRASRV
     346-478: Missing.

Show »
Length:345
Mass (Da):37,926
Checksum:iDD9F525FD7184872
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti52 – 521R → P in AAL82191 (PubMed:12370286).Curated
Sequence conflicti141 – 1411V → G in AAL82191 (PubMed:12370286).Curated
Sequence conflicti264 – 2641Q → K in BAC28148 (PubMed:16141072).Curated
Sequence conflicti289 – 2891Q → P in AAL82191 (PubMed:12370286).Curated
Sequence conflicti317 – 3171G → A in AAL82191 (PubMed:12370286).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei335 – 34713GEKPH…VCGKT → GTRTCAICRPQIQ in isoform 2. 1 PublicationVSP_008490Add
BLAST
Alternative sequencei335 – 34511GEKPHQCQVCG → ELEIEPRASRV in isoform 3. 2 PublicationsVSP_008492Add
BLAST
Alternative sequencei346 – 478133Missing in isoform 3. 2 PublicationsVSP_008493Add
BLAST
Alternative sequencei348 – 478131Missing in isoform 2. 1 PublicationVSP_008491Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF295806 mRNA. Translation: AAL82191.1.
AK033090 mRNA. Translation: BAC28148.1.
AK053001 mRNA. Translation: BAC35235.1.
BC021528 mRNA. Translation: AAH21528.1.
BC052080 mRNA. Translation: AAH52080.1.
CCDSiCCDS26042.1. [Q8BKX7-1]
RefSeqiNP_001239511.1. NM_001252582.1. [Q8BKX7-2]
NP_001239512.1. NM_001252583.1. [Q8BKX7-3]
NP_659082.1. NM_144833.3. [Q8BKX7-1]
XP_006516148.1. XM_006516085.2. [Q8BKX7-1]
XP_006516149.1. XM_006516086.2. [Q8BKX7-1]
UniGeneiMm.255150.

Genome annotation databases

EnsembliENSMUST00000045931; ENSMUSP00000045550; ENSMUSG00000042472. [Q8BKX7-1]
GeneIDi52708.
KEGGimmu:52708.
UCSCiuc007oet.2. mouse. [Q8BKX7-2]
uc007oev.2. mouse. [Q8BKX7-1]
uc007oew.2. mouse. [Q8BKX7-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF295806 mRNA. Translation: AAL82191.1.
AK033090 mRNA. Translation: BAC28148.1.
AK053001 mRNA. Translation: BAC35235.1.
BC021528 mRNA. Translation: AAH21528.1.
BC052080 mRNA. Translation: AAH52080.1.
CCDSiCCDS26042.1. [Q8BKX7-1]
RefSeqiNP_001239511.1. NM_001252582.1. [Q8BKX7-2]
NP_001239512.1. NM_001252583.1. [Q8BKX7-3]
NP_659082.1. NM_144833.3. [Q8BKX7-1]
XP_006516148.1. XM_006516085.2. [Q8BKX7-1]
XP_006516149.1. XM_006516086.2. [Q8BKX7-1]
UniGeneiMm.255150.

3D structure databases

ProteinModelPortaliQ8BKX7.
SMRiQ8BKX7. Positions 226-362.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045550.

PTM databases

iPTMnetiQ8BKX7.

Proteomic databases

PaxDbiQ8BKX7.
PRIDEiQ8BKX7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000045931; ENSMUSP00000045550; ENSMUSG00000042472. [Q8BKX7-1]
GeneIDi52708.
KEGGimmu:52708.
UCSCiuc007oet.2. mouse. [Q8BKX7-2]
uc007oev.2. mouse. [Q8BKX7-1]
uc007oew.2. mouse. [Q8BKX7-3]

Organism-specific databases

CTDi52708.
MGIiMGI:1289280. Zfp410.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118771.
HOGENOMiHOG000069877.
HOVERGENiHBG055280.
InParanoidiQ8BKX7.
OMAiDDTPNHT.
OrthoDBiEOG7RFTGZ.
PhylomeDBiQ8BKX7.
TreeFamiTF333498.

Miscellaneous databases

PROiQ8BKX7.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BKX7.
CleanExiMM_ZFP410.
GenevisibleiQ8BKX7. MM.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Induction of extracellular matrix-remodeling genes by the senescence-associated protein APA-1."
    Benanti J.A., Williams D.K., Robinson K.L., Ozer H.L., Galloway D.A.
    Mol. Cell. Biol. 22:7385-7397(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Embryo.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Strain: C57BL/6J.
    Tissue: Embryonic head and Embryonic testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Strain: C57BL/6J and FVB/N.
    Tissue: Brain and Mammary gland.

Entry informationi

Entry nameiZN410_MOUSE
AccessioniPrimary (citable) accession number: Q8BKX7
Secondary accession number(s): Q8BWB3
, Q8BZZ7, Q8R5L2, Q8VDL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: October 3, 2003
Last modified: June 8, 2016
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.